GREMLIN Database
NPD - NAD-dependent protein deacylase
UniProt: P75960 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13443
Length: 242 (223)
Sequences: 5764 (4016)
Seq/√Len: 268.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_E222_S3.7341.00
18_S70_N2.9591.00
88_L166_A2.8211.00
71_A226_P2.6501.00
99_E108_H2.4941.00
176_I221_A2.4491.00
80_Q104_T2.4471.00
14_I72_A2.4261.00
78_K81_D2.3621.00
219_G224_V2.3531.00
42_E154_G2.2721.00
115_K149_H2.2461.00
192_A197_A2.1801.00
183_Y187_G2.0851.00
16_A22_T2.0561.00
77_A81_D2.0531.00
219_G223_Q2.0401.00
8_V76_L2.0211.00
183_Y186_A2.0071.00
34_R37_D1.9821.00
80_Q105_N1.9751.00
72_A225_V1.9721.00
118_C121_S1.9651.00
80_Q103_N1.9351.00
123_Q141_Q1.9231.00
220_P223_Q1.9171.00
125_L146_L1.8831.00
204_L220_P1.8641.00
5_R169_M1.8251.00
76_L89_L1.8041.00
78_K82_A1.8041.00
5_R87_F1.8021.00
5_R86_R1.7881.00
72_A221_A1.7681.00
121_S142_F1.7251.00
17_E220_P1.6951.00
227_E230_E1.6911.00
68_Q100_R1.6721.00
123_Q140_C1.6631.00
139_C142_F1.6591.00
8_V174_I1.6521.00
124_V149_H1.6211.00
71_A74_L1.6211.00
88_L107_I1.6161.00
75_A225_V1.6031.00
41_P45_D1.6021.00
159_G162_E1.5571.00
107_I162_E1.5511.00
44_F119_S1.5171.00
75_A229_V1.5061.00
7_L170_A1.4711.00
202_L224_V1.4701.00
193_K214_A1.4491.00
198_H214_A1.4441.00
172_I200_V1.4331.00
167_L188_F1.3971.00
89_L103_N1.3571.00
49_E53_A1.3541.00
22_T25_A1.3511.00
10_T98_H1.3501.00
112_E115_K1.3401.00
117_R149_H1.3351.00
103_N106_V1.3131.00
207_S210_G1.3111.00
109_M185_A1.3101.00
10_T14_I1.3051.00
53_A57_A1.3021.00
40_T43_G1.3001.00
82_A85_D1.2841.00
75_A226_P1.2811.00
68_Q74_L1.2721.00
117_R124_V1.2711.00
167_L173_F1.2671.00
165_M169_M1.2671.00
164_Y191_E1.2551.00
75_A79_L1.2441.00
108_H112_E1.2431.00
107_I166_A1.2281.00
176_I225_V1.2241.00
168_S191_E1.2241.00
217_Y224_V1.2181.00
172_I198_H1.2181.00
201_E207_S1.2171.00
79_L229_V1.2051.00
125_L140_C1.2001.00
74_L78_K1.2001.00
77_A101_A1.1991.00
201_E213_F1.1841.00
118_C142_F1.1801.00
5_R166_A1.1781.00
198_H215_E1.1721.00
47_D50_L1.1711.00
78_K229_V1.1601.00
99_E106_V1.1511.00
10_T76_L1.1501.00
96_N100_R1.1451.00
20_I67_I1.1421.00
176_I202_L1.1391.00
45_D119_S1.1321.00
70_N222_S1.1191.00
10_T89_L1.1181.00
201_E210_G1.1151.00
5_R171_D1.1091.00
25_A31_E1.0931.00
21_R32_E1.0791.00
6_V85_D1.0711.00
75_A78_K1.0681.00
96_N114_L1.0641.00
7_L90_V1.0641.00
44_F48_P1.0611.00
118_C139_C1.0601.00
147_R155_E1.0601.00
160_M188_F1.0551.00
162_E165_M1.0411.00
96_N108_H1.0411.00
115_K124_V1.0371.00
199_T213_F1.0301.00
109_M156_M1.0241.00
98_H103_N1.0171.00
210_G216_K1.0131.00
8_V86_R1.0101.00
40_T155_E1.0091.00
116_V146_L1.0041.00
55_Y58_R1.0011.00
162_E166_A0.9941.00
21_R61_Q0.9891.00
62_L67_I0.9841.00
109_M163_I0.9841.00
44_F147_R0.9831.00
206_P218_Y0.9801.00
219_G227_E0.9731.00
77_A103_N0.9671.00
57_A61_Q0.9661.00
33_H37_D0.9651.00
223_Q227_E0.9651.00
27_D31_E0.9621.00
226_P229_V0.9611.00
119_S144_A0.9611.00
51_V152_W0.9601.00
38_V43_G0.9551.00
24_R28_G0.9311.00
9_L185_A0.9301.00
174_I200_V0.9251.00
81_D104_T0.9241.00
39_A43_G0.9231.00
52_Q137_C0.9201.00
39_A152_W0.9181.00
50_L53_A0.9181.00
30_W39_A0.9161.00
120_Q144_A0.9141.00
96_N99_E0.9141.00
40_T44_F0.9131.00
37_D50_L0.9021.00
41_P154_G0.9021.00
210_G213_F0.8861.00
119_S145_P0.8851.00
164_Y168_S0.8771.00
7_L173_F0.8731.00
193_K196_G0.8681.00
96_N112_E0.8651.00
4_P171_D0.8631.00
127_W130_D0.8631.00
136_K139_C0.8481.00
117_R147_R0.8471.00
44_F152_W0.8421.00
56_N59_R0.8380.99
72_A220_P0.8380.99
192_A198_H0.8370.99
121_S139_C0.8320.99
71_A75_A0.8300.99
39_A58_R0.8210.99
57_A60_R0.8120.99
223_Q226_P0.8120.99
6_V172_I0.8110.99
10_T176_I0.8050.99
180_G201_E0.8000.99
105_N162_E0.7980.99
175_A178_T0.7860.99
21_R27_D0.7820.99
202_L217_Y0.7800.99
90_V185_A0.7790.99
137_C142_F0.7750.99
138_H145_P0.7750.99
151_V155_E0.7710.99
72_A176_I0.7710.99
7_L167_L0.7710.99
202_L228_F0.7700.99
166_A169_M0.7650.99
33_H50_L0.7620.99
5_R88_L0.7620.99
9_L173_F0.7610.99
12_A15_S0.7560.99
37_D43_G0.7530.99
158_L161_D0.7470.99
54_F58_R0.7440.99
9_L188_F0.7410.99
71_A222_S0.7410.99
205_E216_K0.7390.99
207_S213_F0.7370.99
179_S182_V0.7370.99
78_K230_E0.7370.99
50_L54_F0.7260.99
153_F182_V0.7240.99
100_R114_L0.7230.99
37_D46_R0.7220.99
82_A229_V0.7220.99
127_W131_V0.7170.98
76_L176_I0.7160.98
163_I188_F0.7140.98
205_E218_Y0.7140.98
225_V229_V0.7080.98
14_I98_H0.7050.98
200_V215_E0.7040.98
138_H143_P0.7020.98
42_E46_R0.7000.98
224_V228_F0.7000.98
7_L166_A0.6990.98
35_V38_V0.6970.98
89_L98_H0.6960.98
17_E70_N0.6960.98
121_S144_A0.6940.98
170_A197_A0.6880.98
128_T131_V0.6880.98
147_R152_W0.6860.98
190_H212_E0.6840.98
137_C140_C0.6830.98
170_A173_F0.6830.98
72_A222_S0.6820.98
6_V171_D0.6760.98
94_I150_V0.6740.98
175_A209_V0.6710.98
15_S95_D0.6660.97
8_V87_F0.6620.97
14_I176_I0.6600.97
161_D164_Y0.6580.97
184_P189_V0.6540.97
94_I113_L0.6530.97
174_I228_F0.6480.97
30_W153_F0.6470.97
160_M164_Y0.6440.97
222_S226_P0.6420.97
121_S126_D0.6420.97
47_D51_V0.6400.97
175_A199_T0.6400.97
201_E216_K0.6360.97
34_R43_G0.6350.97
175_A180_G0.6350.97
118_C144_A0.6320.97
156_M184_P0.6300.96
116_V127_W0.6290.96
6_V87_F0.6280.96
44_F52_Q0.6260.96
90_V163_I0.6250.96
86_R105_N0.6220.96
63_Q66_E0.6120.96
96_N113_L0.6080.96
16_A25_A0.6070.96
204_L218_Y0.6040.96
62_L114_L0.6030.96
149_H158_L0.6020.95
183_Y190_H0.5990.95
88_L105_N0.5950.95
43_G47_D0.5950.95
21_R25_A0.5930.95
121_S125_L0.5910.95
91_T108_H0.5910.95
62_L113_L0.5900.95
41_P44_F0.5870.95
152_W155_E0.5850.95
161_D165_M0.5830.95
148_P155_E0.5820.95
7_L188_F0.5800.94
21_R31_E0.5780.94
60_R66_E0.5750.94
121_S124_V0.5730.94
217_Y228_F0.5730.94
87_F166_A0.5720.94
25_A205_E0.5710.94
135_D138_H0.5690.94
38_V54_F0.5670.94
220_P224_V0.5660.94
90_V166_A0.5650.94
9_L89_L0.5630.94
55_Y150_V0.5620.94
40_T47_D0.5610.93
39_A44_F0.5610.93
63_Q128_T0.5590.93
132_T135_D0.5590.93
108_H114_L0.5580.93
48_P52_Q0.5550.93
76_L87_F0.5550.93
6_V79_L0.5520.93
126_D129_G0.5520.93
148_P152_W0.5480.93
8_V176_I0.5480.93
51_V55_Y0.5470.93
44_F145_P0.5470.93
164_Y188_F0.5440.92
163_I167_L0.5430.92
200_V228_F0.5420.92
167_L189_V0.5410.92
173_F189_V0.5400.92
76_L103_N0.5400.92
226_P230_E0.5390.92
193_K197_A0.5380.92
8_V79_L0.5330.92
190_H209_V0.5330.92
43_G50_L0.5320.92
123_Q126_D0.5290.91
173_F197_A0.5270.91
39_A153_F0.5260.91
60_R63_Q0.5260.91
75_A176_I0.5240.91
73_H92_Q0.5240.91
61_Q66_E0.5230.91
204_L219_G0.5220.91
55_Y152_W0.5210.91
168_S195_H0.5190.91
16_A221_A0.5170.90
80_Q98_H0.5160.90
210_G218_Y0.5160.90
12_A22_T0.5160.90
193_K199_T0.5140.90
151_V182_V0.5140.90
26_A31_E0.5120.90
77_A80_Q0.5110.90
44_F47_D0.5100.90
4_P85_D0.5100.90
51_V150_V0.5070.90
130_D133_P0.5050.89
63_Q114_L0.5050.89
200_V203_N0.5040.89
87_F169_M0.5030.89
14_I70_N0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1s5pA 1 0.9298 100 0.132 Contact Map
1m2kA 1 0.9752 100 0.137 Contact Map
1yc5A 1 0.905 100 0.14 Contact Map
3riyA 1 0.938 100 0.146 Contact Map
3u31A 1 0.9752 100 0.147 Contact Map
1q14A 3 0.9215 100 0.152 Contact Map
5btrA 1 0.9628 100 0.152 Contact Map
4twjA 1 0.9008 100 0.153 Contact Map
4iaoA 1 0.9711 100 0.156 Contact Map
1q1aA 1 0.9752 100 0.16 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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