GREMLIN Database
NAGK - N-acetyl-D-glucosamine kinase
UniProt: P75959 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13442
Length: 303 (288)
Sequences: 12546 (9659)
Seq/√Len: 569.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_P90_A3.2131.00
103_D146_T3.0481.00
26_E290_A2.9791.00
18_D22_Q2.9391.00
44_C95_R2.9351.00
122_Y248_L2.5711.00
248_L283_E2.5601.00
231_D268_R2.5321.00
17_F297_A2.4981.00
15_G293_M2.4311.00
185_I236_C2.4241.00
119_F125_V2.3291.00
126_M240_I2.2951.00
89_R93_S2.2421.00
149_S245_D2.2041.00
110_A137_G2.1471.00
69_E72_D2.1411.00
227_E264_Q2.1121.00
14_L46_L2.0771.00
27_K49_E2.0691.00
59_S300_H2.0561.00
127_G252_G2.0521.00
109_F127_G2.0191.00
103_D107_N1.9291.00
148_K247_D1.9221.00
197_L228_R1.9161.00
124_L247_D1.8741.00
140_F145_I1.8641.00
158_M239_N1.8361.00
103_D108_C1.8341.00
3_Y47_V1.8331.00
268_R271_R1.8321.00
176_R182_H1.8261.00
110_A139_I1.8241.00
116_D298_F1.8181.00
41_D95_R1.8091.00
262_T266_A1.7841.00
237_L249_V1.7741.00
179_C184_C1.7621.00
269_L282_I1.7581.00
86_K91_D1.7481.00
91_D94_A1.7441.00
60_V96_L1.7371.00
234_A268_R1.7151.00
25_W53_R1.7101.00
90_A94_A1.7071.00
48_A95_R1.7011.00
248_L281_R1.6861.00
214_L219_D1.6791.00
123_P141_N1.6471.00
62_I92_L1.6021.00
207_Q210_E1.5921.00
123_P247_D1.5911.00
266_A270_P1.5871.00
230_L264_Q1.5841.00
14_L50_A1.5831.00
63_G108_C1.5771.00
114_A125_V1.5741.00
112_S287_H1.5541.00
27_K53_R1.5441.00
128_L237_L1.5241.00
177_C184_C1.5191.00
230_L234_A1.5181.00
60_V98_R1.5111.00
122_Y247_D1.5071.00
213_A217_Q1.4881.00
32_P42_A1.4801.00
259_P262_T1.4491.00
11_K28_R1.4481.00
25_W50_A1.4351.00
130_L233_L1.4341.00
241_L269_L1.4261.00
194_F229_Y1.4251.00
268_R272_H1.4191.00
227_E268_R1.4041.00
175_R196_W1.4041.00
197_L200_H1.3971.00
4_G293_M1.3961.00
264_Q267_D1.3871.00
209_P213_A1.3721.00
262_T284_R1.3711.00
230_L265_L1.3701.00
159_R239_N1.3691.00
91_D95_R1.3551.00
235_V239_N1.3511.00
15_G23_L1.3331.00
259_P284_R1.3311.00
177_C180_G1.3181.00
201_Y224_A1.3181.00
5_F14_L1.3081.00
115_W298_F1.3051.00
27_K46_L1.3051.00
125_V139_I1.3051.00
41_D45_E1.3001.00
134_V189_L1.2971.00
122_Y125_V1.2921.00
260_A263_T1.2851.00
198_Y225_H1.2831.00
44_C96_L1.2771.00
40_L91_D1.2741.00
124_L140_F1.2591.00
29_V46_L1.2571.00
103_D299_L1.2461.00
240_I243_I1.2411.00
264_Q268_R1.2381.00
46_L49_E1.2361.00
114_A139_I1.2341.00
35_S38_A1.2281.00
44_C48_A1.2251.00
110_A125_V1.2231.00
162_V235_V1.2171.00
157_H179_C1.2071.00
48_A96_L1.1971.00
126_M136_G1.1891.00
241_L249_V1.1821.00
215_Y226_V1.1751.00
124_L145_I1.1741.00
197_L201_Y1.1581.00
29_V42_A1.1541.00
17_F23_L1.1441.00
5_F47_V1.1391.00
216_D260_A1.1381.00
136_G155_F1.1371.00
107_N144_P1.1291.00
4_G296_A1.1241.00
197_L225_H1.1141.00
126_M138_L1.1121.00
108_C296_A1.1111.00
210_E213_A1.1001.00
18_D24_Q1.0991.00
87_P91_D1.0901.00
215_Y223_R1.0711.00
223_R227_E1.0631.00
29_V49_E1.0631.00
13_A28_R1.0601.00
74_T87_P1.0601.00
267_D271_R1.0561.00
36_Y91_D1.0551.00
29_V45_E1.0531.00
175_R197_L1.0521.00
42_A45_E1.0481.00
198_Y202_Y1.0471.00
63_G292_G1.0461.00
101_R300_H1.0441.00
114_A142_G1.0241.00
230_L268_R1.0161.00
123_P142_G1.0071.00
202_Y221_Q1.0041.00
202_Y206_L1.0041.00
25_W54_F1.0001.00
37_D91_D1.0001.00
235_V272_H0.9951.00
138_L145_I0.9951.00
175_R200_H0.9931.00
161_P235_V0.9921.00
125_V250_V0.9841.00
5_F43_V0.9821.00
16_V54_F0.9821.00
74_T85_G0.9791.00
234_A272_H0.9791.00
228_R232_L0.9751.00
175_R188_Y0.9691.00
9_G132_T0.9681.00
231_D235_V0.9681.00
116_D294_R0.9651.00
212_I216_D0.9641.00
138_L244_V0.9571.00
110_A127_G0.9571.00
212_I226_V0.9571.00
157_H177_C0.9551.00
257_N289_D0.9541.00
237_L251_I0.9511.00
49_E53_R0.9491.00
250_V283_E0.9491.00
11_K191_G0.9471.00
175_R187_N0.9441.00
257_N284_R0.9411.00
45_E49_E0.9391.00
122_Y281_R0.9341.00
106_A129_I0.9261.00
23_L26_E0.9231.00
251_I256_S0.9211.00
120_T286_R0.9211.00
270_P279_V0.9191.00
263_T267_D0.9171.00
64_I75_L0.9161.00
16_V50_A0.9131.00
113_E117_D0.9081.00
4_G297_A0.9071.00
124_L141_N0.9061.00
125_V248_L0.9061.00
93_S100_V0.9011.00
157_H184_C0.9011.00
201_Y221_Q0.8991.00
38_A41_D0.8931.00
227_E267_D0.8931.00
199_Q204_Q0.8931.00
231_D272_H0.8901.00
69_E76_Y0.8861.00
198_Y222_A0.8831.00
92_L100_V0.8821.00
210_E214_L0.8811.00
93_S99_D0.8801.00
262_T265_L0.8791.00
14_L27_K0.8761.00
73_G89_R0.8761.00
51_D57_K0.8671.00
198_Y211_I0.8671.00
138_L153_G0.8661.00
238_G272_H0.8651.00
213_A216_D0.8651.00
263_T266_A0.8631.00
7_I43_V0.8571.00
36_Y86_K0.8571.00
4_G61_G0.8561.00
214_L222_A0.8521.00
214_L217_Q0.8471.00
107_N154_E0.8421.00
104_N154_E0.8381.00
44_C91_D0.8371.00
13_A26_E0.8331.00
12_I31_T0.8331.00
118_E286_R0.8301.00
147_G152_T0.8301.00
221_Q224_A0.8291.00
241_L280_P0.8291.00
7_I64_I0.8271.00
219_D222_A0.8211.00
17_F294_R0.8141.00
126_M249_V0.8121.00
77_A80_V0.8101.00
48_A51_D0.8081.00
109_F292_G0.8061.00
188_Y232_L0.8051.00
54_F57_K0.7991.00
160_L232_L0.7931.00
206_L210_E0.7921.00
117_D120_T0.7911.00
93_S97_D0.7901.00
126_M246_P0.7871.00
259_P263_T0.7851.00
250_V285_A0.7841.00
283_E286_R0.7831.00
224_A228_R0.7821.00
127_G250_V0.7821.00
193_G196_W0.7761.00
124_L148_K0.7751.00
201_Y225_H0.7741.00
78_A81_P0.7721.00
39_F83_A0.7711.00
141_N145_I0.7701.00
242_T274_L0.7651.00
15_G26_E0.7571.00
220_E224_A0.7571.00
51_D98_R0.7561.00
212_I258_F0.7541.00
111_L114_A0.7521.00
237_L269_L0.7501.00
161_P188_Y0.7491.00
147_G245_D0.7411.00
45_E48_A0.7411.00
233_L265_L0.7401.00
161_P164_A0.7401.00
288_G291_G0.7391.00
40_L95_R0.7391.00
117_D121_Q0.7361.00
64_I68_P0.7351.00
197_L229_Y0.7351.00
108_C299_L0.7341.00
119_F250_V0.7341.00
234_A269_L0.7321.00
59_S99_D0.7281.00
61_G108_C0.7271.00
106_A137_G0.7211.00
184_C187_N0.7211.00
118_E283_E0.7191.00
159_R235_V0.7191.00
48_A52_Q0.7181.00
251_I282_I0.7141.00
158_M236_C0.7071.00
238_G242_T0.7071.00
191_G195_A0.7041.00
5_F60_V0.7041.00
118_E250_V0.7011.00
14_L29_V0.7001.00
225_H229_Y0.7001.00
215_Y222_A0.6991.00
220_E223_R0.6941.00
3_Y51_D0.6941.00
195_A199_Q0.6941.00
46_L50_A0.6911.00
181_Q272_H0.6911.00
225_H228_R0.6891.00
38_A42_A0.6891.00
42_A46_L0.6891.00
7_I39_F0.6881.00
162_V231_D0.6851.00
194_F255_L0.6831.00
40_L86_K0.6811.00
160_L236_C0.6711.00
195_A211_I0.6671.00
94_A97_D0.6641.00
77_A84_S0.6641.00
223_R264_Q0.6641.00
160_L188_Y0.6631.00
161_P175_R0.6621.00
89_R102_L0.6621.00
234_A238_G0.6591.00
147_G153_G0.6591.00
41_D44_C0.6591.00
73_G93_S0.6541.00
197_L232_L0.6541.00
12_I29_V0.6531.00
159_R162_V0.6511.00
145_I244_V0.6491.00
51_D56_C0.6461.00
116_D287_H0.6441.00
37_D41_D0.6431.00
159_R181_Q0.6421.00
32_P38_A0.6401.00
261_I264_Q0.6401.00
287_H294_R0.6381.00
267_D270_P0.6371.00
194_F211_I0.6361.00
215_Y218_G0.6361.00
12_I43_V0.6351.00
199_Q205_P0.6351.00
185_I229_Y0.6341.00
290_A294_R0.6341.00
159_R164_A0.6331.00
189_L229_Y0.6331.00
231_D271_R0.6321.00
265_L269_L0.6321.00
181_Q184_C0.6271.00
129_I292_G0.6261.00
192_R196_W0.6251.00
164_A175_R0.6251.00
7_I12_I0.6251.00
90_A93_S0.6221.00
177_C181_Q0.6211.00
237_L265_L0.6211.00
238_G273_L0.6201.00
61_G300_H0.6121.00
10_T132_T0.6121.00
194_F225_H0.6101.00
13_A293_M0.6091.00
266_A281_R0.6081.00
133_G186_E0.6081.00
238_G269_L0.6081.00
101_R299_L0.6051.00
49_E52_Q0.6051.00
50_A54_F0.6031.00
113_E285_A0.6011.00
92_L96_L0.5981.00
8_G132_T0.5961.00
44_C92_L0.5961.00
218_G223_R0.5941.00
83_A86_K0.5921.00
128_L240_I0.5841.00
287_H291_G0.5841.00
180_G184_C0.5831.00
195_A208_A0.5821.00
177_C183_G0.5801.00
161_P232_L0.5751.00
163_D231_D0.5741.00
294_R297_A0.5741.00
89_R100_V0.5710.99
148_K245_D0.5700.99
128_L155_F0.5680.99
246_P249_V0.5670.99
104_N107_N0.5650.99
68_P75_L0.5640.99
152_T245_D0.5640.99
131_G254_G0.5620.99
67_M76_Y0.5610.99
148_K279_V0.5610.99
196_W200_H0.5580.99
177_C187_N0.5550.99
157_H180_G0.5550.99
230_L261_I0.5530.99
105_D135_G0.5450.99
193_G197_L0.5450.99
104_N133_G0.5450.99
113_E286_R0.5440.99
43_V92_L0.5410.99
252_G285_A0.5390.99
113_E287_H0.5380.99
76_Y85_G0.5370.99
40_L88_L0.5350.99
23_L294_R0.5340.99
128_L136_G0.5340.99
155_F243_I0.5330.99
158_M240_I0.5320.99
109_F129_I0.5310.99
70_T146_T0.5300.99
159_R272_H0.5300.99
97_D100_V0.5300.99
198_Y214_L0.5280.99
280_P284_R0.5270.99
3_Y16_V0.5250.99
229_Y261_I0.5240.99
199_Q202_Y0.5240.99
204_Q210_E0.5230.99
73_G87_P0.5230.99
28_R289_D0.5210.99
290_A293_M0.5190.99
158_M242_T0.5180.99
8_G254_G0.5160.99
231_D264_Q0.5150.99
111_L115_W0.5150.99
160_L185_I0.5150.99
31_T39_F0.5140.99
60_V92_L0.5140.99
187_N196_W0.5110.99
137_G144_P0.5110.99
77_A81_P0.5110.99
51_D96_L0.5110.99
155_F240_I0.5110.99
27_K50_A0.5090.99
112_S298_F0.5090.99
164_A188_Y0.5080.99
47_V96_L0.5080.99
186_E190_S0.5080.99
260_A264_Q0.5080.99
127_G131_G0.5080.99
201_Y228_R0.5070.99
109_F252_G0.5060.99
191_G255_L0.5060.99
67_M77_A0.5020.99
211_I215_Y0.5020.99
242_T277_A0.5010.99
12_I42_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ap1A 2 1 100 0.168 Contact Map
1z05A 2 0.9637 100 0.18 Contact Map
4db3A 2 0.9736 100 0.183 Contact Map
1z6rA 3 0.9637 100 0.191 Contact Map
3vovA 3 0.9538 100 0.196 Contact Map
3vglA 3 0.9604 100 0.199 Contact Map
2yhwA 2 0.9472 100 0.199 Contact Map
2qm1A 2 0.967 100 0.205 Contact Map
4htlA 4 0.9373 100 0.215 Contact Map
2aa4A 2 0.9439 100 0.217 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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