GREMLIN Database
LOLE - Lipoprotein-releasing system transmembrane protein LolE
UniProt: P75958 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13441
Length: 414 (360)
Sequences: 35999 (30903)
Seq/√Len: 1628.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
165_W186_R3.6651.00
152_K194_Q3.6301.00
165_W188_H3.4011.00
302_I319_F3.3311.00
167_S186_R3.2961.00
152_K156_D3.0121.00
147_Q188_H2.7751.00
406_D409_R2.7131.00
147_Q190_A2.7041.00
78_W81_A2.7031.00
298_K322_Y2.6731.00
238_V242_G2.6291.00
149_I191_G2.5001.00
155_A192_I2.4921.00
148_I204_A2.4861.00
82_L86_Q2.4481.00
131_S194_Q2.4091.00
331_S384_L2.3731.00
306_R312_D2.3721.00
311_K314_L2.3721.00
233_N236_K2.3341.00
15_R18_R2.3331.00
396_W400_R2.2741.00
148_I187_L2.2521.00
400_R404_N2.1881.00
149_I193_L2.1641.00
323_G395_S2.1391.00
150_I155_A2.1211.00
327_G391_S2.0991.00
154_V158_L2.0601.00
92_A229_T2.0581.00
334_G338_G1.9961.00
83_D86_Q1.9801.00
136_D190_A1.9611.00
31_T35_A1.9531.00
236_K240_D1.9351.00
376_H379_D1.9191.00
207_P210_D1.8871.00
90_G229_T1.8871.00
35_A333_C1.8731.00
146_Q210_D1.8521.00
144_G147_Q1.8461.00
209_A212_Q1.8421.00
148_I206_I1.8211.00
298_K301_D1.8111.00
90_G240_D1.7851.00
316_R400_R1.7811.00
240_D243_E1.7521.00
79_Q83_D1.7511.00
84_H87_K1.7321.00
42_I338_G1.7251.00
206_I211_A1.7221.00
253_S256_G1.7221.00
235_N238_V1.6941.00
187_L210_D1.6901.00
234_A238_V1.6581.00
153_G195_L1.6351.00
53_R57_N1.6261.00
118_V122_Q1.6141.00
239_R242_G1.6021.00
35_A337_I1.5981.00
150_I189_V1.5741.00
12_R15_R1.5711.00
149_I190_A1.5701.00
150_I154_V1.5621.00
133_V152_K1.5571.00
161_K164_D1.5561.00
80_E84_H1.5521.00
39_A337_I1.5411.00
239_R243_E1.5381.00
162_Q192_I1.5331.00
169_M184_R1.5321.00
92_A227_K1.5231.00
228_M237_L1.5191.00
153_G156_D1.5121.00
148_I166_V1.5101.00
151_G193_L1.4921.00
167_S184_R1.4881.00
150_I204_A1.4851.00
31_T330_G1.4791.00
314_L317_A1.4711.00
313_G317_A1.4611.00
330_G334_G1.4611.00
340_V344_Q1.4591.00
235_N239_R1.4491.00
377_W381_F1.4401.00
394_A398_P1.4291.00
160_V164_D1.4261.00
13_F322_Y1.4191.00
312_D403_S1.4181.00
49_N376_H1.4121.00
81_A84_H1.4011.00
65_H69_E1.3991.00
206_I210_D1.3851.00
146_Q185_V1.3581.00
399_A403_S1.3571.00
299_S410_V1.3451.00
208_L212_Q1.3371.00
378_L382_Y1.3361.00
151_G154_V1.3341.00
80_E83_D1.3341.00
133_V194_Q1.3221.00
327_G331_S1.3071.00
273_Y277_V1.3031.00
35_A39_A1.3021.00
38_V334_G1.2821.00
336_I340_V1.2691.00
224_I228_M1.2661.00
10_G321_W1.2611.00
136_D147_Q1.2591.00
303_A410_V1.2541.00
301_D305_L1.2491.00
310_A314_L1.2481.00
121_Q124_Q1.2451.00
93_A227_K1.2431.00
88_V240_D1.2411.00
83_D87_K1.2381.00
58_R61_A1.2371.00
151_G202_S1.2331.00
340_V343_L1.2261.00
57_N60_L1.2251.00
14_S27_S1.2231.00
79_Q82_L1.2231.00
302_I315_I1.2221.00
305_L318_I1.2201.00
338_G342_S1.2171.00
150_I192_I1.2161.00
332_L336_I1.2101.00
49_N52_E1.2061.00
66_G70_A1.1981.00
53_R374_E1.1831.00
381_F385_V1.1821.00
73_Q77_N1.1811.00
230_D233_N1.1761.00
34_I330_G1.1751.00
259_G263_R1.1721.00
78_W82_L1.1651.00
42_I383_V1.1531.00
401_R404_N1.1451.00
374_E377_W1.1451.00
299_S405_I1.1431.00
39_A341_V1.1391.00
303_A307_T1.1371.00
160_V189_V1.1361.00
317_A321_W1.1361.00
57_N61_A1.1341.00
106_S109_N1.1311.00
305_L310_A1.1301.00
245_T248_Y1.1241.00
132_F191_G1.1221.00
52_E56_N1.1191.00
284_C394_A1.1191.00
153_G157_A1.1131.00
240_D244_V1.1131.00
270_A274_L1.1081.00
162_Q190_A1.1041.00
97_Y223_G1.0981.00
90_G237_L1.0961.00
228_M234_A1.0941.00
46_S342_S1.0901.00
88_V237_L1.0901.00
39_A338_G1.0901.00
39_A334_G1.0771.00
17_R297_D1.0761.00
400_R403_S1.0751.00
27_S326_A1.0661.00
26_I297_D1.0661.00
291_L323_G1.0611.00
152_K195_L1.0591.00
333_C336_I1.0441.00
134_Q162_Q1.0401.00
81_A85_V1.0401.00
241_A244_V1.0401.00
344_Q347_P1.0371.00
378_L381_F1.0341.00
143_A147_Q1.0331.00
28_V32_I1.0291.00
237_L241_A1.0271.00
84_H88_V1.0251.00
279_V286_N1.0211.00
49_N53_R1.0191.00
128_A131_S1.0121.00
19_R28_V1.0091.00
143_A146_Q1.0071.00
49_N379_D1.0061.00
67_E71_V1.0021.00
236_K239_R1.0011.00
52_E269_R0.9981.00
37_G276_M0.9901.00
210_D213_Q0.9891.00
243_E246_N0.9891.00
238_V253_S0.9841.00
401_R405_I0.9841.00
405_I409_R0.9661.00
266_Q270_A0.9661.00
54_E58_R0.9651.00
84_H244_V0.9641.00
408_A412_S0.9601.00
228_M231_V0.9591.00
327_G387_A0.9591.00
115_V206_I0.9581.00
331_S387_A0.9581.00
252_K257_T0.9561.00
298_K319_F0.9551.00
344_Q348_I0.9541.00
88_V244_V0.9521.00
35_A38_V0.9511.00
335_V380_V0.9501.00
11_L15_R0.9481.00
316_R396_W0.9461.00
399_A402_A0.9431.00
86_Q94_A0.9391.00
310_A315_I0.9371.00
211_A215_L0.9371.00
242_G246_N0.9361.00
250_Y253_S0.9311.00
284_C390_L0.9261.00
263_R266_Q0.9261.00
323_G327_G0.9251.00
343_L347_P0.9241.00
31_T329_F0.9231.00
375_L380_V0.9191.00
324_L392_L0.9141.00
46_S50_G0.9121.00
119_N122_Q0.9091.00
31_T333_C0.9091.00
33_G37_G0.9071.00
134_Q192_I0.9041.00
82_L94_A0.9041.00
82_L96_P0.8951.00
288_V292_V0.8941.00
113_I204_A0.8901.00
256_G259_G0.8851.00
243_E247_S0.8841.00
67_E70_A0.8841.00
265_I269_R0.8831.00
126_L129_L0.8791.00
312_D316_R0.8771.00
336_I339_V0.8691.00
56_N60_L0.8651.00
312_D404_N0.8621.00
95_A119_N0.8611.00
97_Y225_A0.8601.00
254_W257_T0.8561.00
214_Y217_M0.8531.00
229_T233_N0.8531.00
34_I38_V0.8521.00
383_V387_A0.8511.00
35_A330_G0.8501.00
29_I33_G0.8451.00
387_A391_S0.8451.00
77_N81_A0.8431.00
405_I410_V0.8421.00
129_L193_L0.8421.00
53_R56_N0.8411.00
30_S33_G0.8411.00
96_P119_N0.8391.00
299_S303_A0.8391.00
66_G69_E0.8351.00
258_Y262_Y0.8341.00
232_F237_L0.8331.00
151_G201_H0.8331.00
150_I160_V0.8311.00
397_Y400_R0.8281.00
382_Y385_V0.8251.00
41_L45_L0.8211.00
202_S205_M0.8191.00
244_V248_Y0.8151.00
237_L240_D0.8141.00
385_V389_L0.8111.00
152_K155_A0.8101.00
407_P410_V0.8061.00
306_R407_P0.8051.00
145_E209_A0.8041.00
339_V375_L0.8041.00
267_M271_I0.8021.00
324_L391_S0.8021.00
111_R157_A0.8011.00
224_I227_K0.7991.00
379_D382_Y0.7971.00
300_G304_V0.7951.00
82_L224_I0.7951.00
91_I94_A0.7931.00
241_A246_N0.7911.00
150_I166_V0.7901.00
335_V384_L0.7891.00
288_V394_A0.7881.00
142_K147_Q0.7821.00
159_K164_D0.7811.00
113_I154_V0.7791.00
151_G195_L0.7781.00
38_V387_A0.7771.00
162_Q191_G0.7761.00
102_G106_S0.7751.00
296_K299_S0.7731.00
320_V392_L0.7701.00
102_G115_V0.7671.00
294_A298_K0.7661.00
316_R399_A0.7641.00
237_L244_V0.7621.00
132_F149_I0.7611.00
168_I187_L0.7601.00
331_S335_V0.7581.00
203_F206_I0.7571.00
331_S391_S0.7571.00
132_F193_L0.7561.00
124_Q127_S0.7551.00
115_V204_A0.7551.00
151_G203_F0.7541.00
223_G226_L0.7541.00
389_L393_L0.7531.00
208_L211_A0.7531.00
303_A407_P0.7521.00
295_V302_I0.7481.00
306_R315_I0.7481.00
33_G286_N0.7471.00
342_S373_S0.7461.00
84_H248_Y0.7421.00
43_V341_V0.7421.00
96_P221_V0.7401.00
262_Y266_Q0.7361.00
277_V281_G0.7351.00
294_A322_Y0.7341.00
232_F236_K0.7341.00
13_F298_K0.7331.00
145_E207_P0.7331.00
82_L85_V0.7331.00
386_T389_L0.7321.00
329_F332_L0.7311.00
397_Y401_R0.7301.00
88_V91_I0.7301.00
382_Y386_T0.7291.00
9_I318_I0.7261.00
117_G211_A0.7261.00
316_R403_S0.7261.00
321_W324_L0.7251.00
276_M280_I0.7241.00
156_D161_K0.7221.00
241_A245_T0.7201.00
380_V384_L0.7191.00
221_V224_I0.7181.00
225_A228_M0.7171.00
244_V247_S0.7151.00
65_H227_K0.7141.00
54_E57_N0.7121.00
323_G391_S0.7121.00
155_A158_L0.7101.00
118_V205_M0.7081.00
114_Q117_G0.7081.00
193_L205_M0.7061.00
132_F136_D0.7061.00
133_V193_L0.7051.00
259_G262_Y0.7031.00
60_L63_V0.6991.00
55_L59_I0.6981.00
386_T390_L0.6961.00
342_S346_T0.6951.00
200_D203_F0.6951.00
286_N289_S0.6941.00
93_A124_Q0.6931.00
289_S293_M0.6921.00
395_S399_A0.6901.00
48_M269_R0.6901.00
64_P67_E0.6891.00
323_G398_P0.6881.00
203_F207_P0.6881.00
265_I268_I0.6881.00
337_I340_V0.6871.00
238_V244_V0.6861.00
66_G228_M0.6851.00
86_Q93_A0.6841.00
163_G188_H0.6821.00
321_W325_L0.6811.00
9_I13_F0.6791.00
220_S224_I0.6791.00
18_R28_V0.6781.00
60_L64_P0.6781.00
146_Q188_H0.6761.00
238_V256_G0.6761.00
105_E167_S0.6741.00
134_Q161_K0.6741.00
98_I211_A0.6731.00
408_A411_L0.6731.00
379_D383_V0.6701.00
132_F135_G0.6701.00
163_G166_V0.6691.00
13_F301_D0.6681.00
301_D322_Y0.6671.00
323_G399_A0.6651.00
283_A286_N0.6651.00
384_L388_L0.6641.00
155_A161_K0.6611.00
117_G208_L0.6611.00
260_Y263_R0.6601.00
398_P402_A0.6591.00
34_I287_I0.6581.00
304_V307_T0.6581.00
85_V88_V0.6581.00
185_V213_Q0.6571.00
43_V338_G0.6561.00
119_N208_L0.6541.00
211_A214_Y0.6541.00
123_E126_L0.6531.00
30_S290_T0.6531.00
331_S388_L0.6521.00
166_V187_L0.6521.00
251_I254_W0.6521.00
343_L346_T0.6511.00
398_P403_S0.6511.00
42_I46_S0.6501.00
149_I205_M0.6471.00
141_F147_Q0.6461.00
222_S226_L0.6431.00
118_V123_E0.6401.00
42_I334_G0.6391.00
368_I371_L0.6381.00
56_N59_I0.6381.00
141_F144_G0.6341.00
343_L373_S0.6341.00
291_L294_A0.6331.00
301_D304_V0.6281.00
85_V241_A0.6261.00
252_K256_G0.6241.00
134_Q155_A0.6241.00
374_E378_L0.6231.00
327_G395_S0.6231.00
10_G318_I0.6221.00
339_V343_L0.6201.00
91_I226_L0.6201.00
322_Y325_L0.6191.00
17_R26_I0.6191.00
37_G40_V0.6191.00
152_K192_I0.6181.00
307_T407_P0.6181.00
367_F370_F0.6181.00
92_A96_P0.6171.00
27_S31_T0.6171.00
255_I259_G0.6161.00
19_R29_I0.6151.00
234_A237_L0.6151.00
59_I64_P0.6141.00
69_E252_K0.6121.00
197_G201_H0.6121.00
301_D318_I0.6101.00
290_T294_A0.6091.00
222_S225_A0.6061.00
295_V402_A0.6041.00
304_V308_L0.6031.00
132_F194_Q0.6001.00
242_G251_I0.6001.00
223_G227_K0.5981.00
30_S34_I0.5981.00
155_A162_Q0.5971.00
269_R273_Y0.5961.00
202_S207_P0.5931.00
9_I305_L0.5911.00
11_L325_L0.5911.00
148_I189_V0.5901.00
390_L394_A0.5901.00
115_V118_V0.5881.00
295_V319_F0.5871.00
113_I116_K0.5871.00
318_I321_W0.5871.00
97_Y100_F0.5861.00
229_T232_F0.5861.00
299_S401_R0.5861.00
86_Q89_P0.5851.00
69_E72_D0.5841.00
282_V286_N0.5831.00
316_R320_V0.5811.00
68_I226_L0.5761.00
59_I62_V0.5721.00
328_L388_L0.5721.00
296_K401_R0.5701.00
377_W380_V0.5691.00
55_L58_R0.5671.00
68_I71_V0.5671.00
189_V192_I0.5651.00
291_L395_S0.5641.00
320_V396_W0.5641.00
94_A226_L0.5641.00
93_A121_Q0.5641.00
228_M233_N0.5591.00
242_G245_T0.5591.00
155_A189_V0.5591.00
26_I294_A0.5571.00
37_G286_N0.5551.00
133_V192_I0.5521.00
339_V380_V0.5501.00
263_R267_M0.5481.00
104_V113_I0.5471.00
33_G293_M0.5451.00
145_E210_D0.5451.00
142_K149_I0.5431.00
90_G233_N0.5411.00
279_V283_A0.5401.00
66_G238_V0.5371.00
94_A97_Y0.5361.00
201_H206_I0.5361.00
65_H68_I0.5361.00
238_V241_A0.5361.00
89_P92_A0.5351.00
319_F322_Y0.5341.00
283_A387_A0.5331.00
112_A115_V0.5321.00
221_V225_A0.5311.00
111_R115_V0.5311.00
391_S394_A0.5291.00
141_F149_I0.5281.00
61_A64_P0.5281.00
375_L379_D0.5261.00
187_L206_I0.5251.00
105_E110_L0.5241.00
99_N114_Q0.5231.00
58_R62_V0.5231.00
33_G289_S0.5221.00
46_S338_G0.5211.00
43_V46_S0.5211.00
98_I212_Q0.5201.00
65_H70_A0.5201.00
66_G226_L0.5201.00
319_F323_G0.5201.00
199_L202_S0.5191.00
45_L48_M0.5191.00
271_I275_A0.5171.00
92_A95_A0.5171.00
306_R410_V0.5161.00
198_Q201_H0.5161.00
88_V241_A0.5151.00
381_F384_L0.5141.00
268_I272_M0.5131.00
323_G394_A0.5111.00
136_D191_G0.5091.00
320_V324_L0.5081.00
213_Q216_D0.5071.00
142_K145_E0.5061.00
155_A160_V0.5061.00
66_G72_D0.5061.00
92_A228_M0.5061.00
328_L331_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ftjA 1 0.4686 99.4 0.732 Contact Map
3is6A 2 0.5242 98.9 0.784 Contact Map
4av3A 2 0.2609 16 0.948 Contact Map
2l66A 2 0.128 14.4 0.949 Contact Map
2f95B 2 0.128 10.8 0.951 Contact Map
3o27A 2 0.1377 10.5 0.952 Contact Map
1yfbA 2 0.1256 9.1 0.953 Contact Map
1rz2A 1 0.4179 7.4 0.955 Contact Map
3ne5A 3 0.8188 7.3 0.955 Contact Map
2kogA 1 0.099 6.7 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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