GREMLIN Database
YCFT - Inner membrane protein YcfT
UniProt: P75955 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13438
Length: 357 (305)
Sequences: 15090 (13395)
Seq/√Len: 767.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
272_V276_N3.5651.00
329_L333_K3.5221.00
20_V280_I3.3601.00
15_C61_V3.2221.00
283_T331_V3.1811.00
87_I91_F3.1121.00
71_R202_A3.0791.00
83_L158_K2.9161.00
9_N275_S2.7211.00
272_V329_L2.6271.00
324_C328_G2.5881.00
13_G274_G2.5681.00
276_N329_L2.5631.00
79_W83_L2.4951.00
129_S132_E2.4541.00
333_K337_R2.4041.00
126_Y129_S2.3711.00
146_Y150_L2.3671.00
94_L144_L2.2981.00
80_G84_D2.2511.00
97_W283_T2.2091.00
60_P197_Y2.1641.00
79_W158_K2.1541.00
10_Q265_R2.1441.00
24_S288_V2.1331.00
272_V333_K2.1121.00
131_G135_H2.0731.00
91_F95_A2.0421.00
55_A58_R1.9781.00
123_N126_Y1.9671.00
72_R205_G1.9391.00
132_E135_H1.9341.00
13_G277_T1.9021.00
330_L334_L1.8341.00
69_L72_R1.7951.00
63_F149_A1.7631.00
78_P81_N1.7511.00
9_N271_N1.7491.00
84_D88_W1.7151.00
13_G273_I1.7041.00
219_R223_M1.6961.00
16_I280_I1.6951.00
142_T285_R1.6531.00
279_A332_R1.6461.00
97_W282_T1.6341.00
11_I61_V1.6331.00
251_I254_L1.6211.00
166_P170_L1.6181.00
280_I324_C1.6061.00
64_F204_F1.5941.00
194_N197_Y1.5861.00
130_T133_F1.5761.00
10_Q266_S1.5751.00
71_R157_C1.5731.00
8_I65_I1.5331.00
8_I69_L1.5231.00
22_Y55_A1.5101.00
125_A129_S1.4751.00
249_V252_M1.4711.00
93_V282_T1.4711.00
220_H224_A1.4621.00
136_G139_T1.4581.00
251_I255_F1.4361.00
249_V253_K1.4271.00
68_Y205_G1.4231.00
332_R337_R1.4221.00
126_Y131_G1.4171.00
72_R76_S1.4171.00
77_V81_N1.4081.00
71_R75_D1.4081.00
334_L338_A1.4061.00
267_T270_L1.4031.00
337_R340_S1.3991.00
19_V59_M1.3981.00
132_E136_G1.3861.00
162_R165_L1.3631.00
74_I157_C1.3581.00
86_R154_F1.3561.00
96_L335_S1.3551.00
129_S135_H1.3471.00
192_I196_P1.3401.00
69_L73_Y1.3381.00
279_A331_V1.3381.00
126_Y130_T1.3291.00
276_N280_I1.3261.00
272_V275_S1.3251.00
128_D132_E1.3171.00
230_L233_G1.3081.00
276_N328_G1.3001.00
77_V85_K1.2991.00
172_V175_S1.2981.00
332_R336_Q1.2961.00
280_I328_G1.2851.00
153_Y198_Y1.2811.00
100_V283_T1.2791.00
93_V331_V1.2791.00
148_Y152_V1.2771.00
101_Q286_I1.2761.00
130_T134_L1.2751.00
337_R341_D1.2721.00
71_R206_A1.2661.00
157_C198_Y1.2621.00
5_E68_Y1.2481.00
81_N85_K1.2431.00
269_L273_I1.2261.00
70_I157_C1.2251.00
66_S150_L1.2221.00
208_I212_V1.2201.00
293_L297_A1.2161.00
123_N129_S1.2131.00
230_L234_A1.2081.00
314_L318_F1.2001.00
271_N275_S1.2001.00
252_M256_Y1.1991.00
70_I154_F1.1991.00
126_Y132_E1.1941.00
15_C58_R1.1911.00
136_G140_A1.1801.00
326_V330_L1.1761.00
276_N279_A1.1761.00
320_S324_C1.1751.00
13_G17_C1.1751.00
143_S285_R1.1731.00
135_H139_T1.1731.00
150_L154_F1.1621.00
126_Y135_H1.1421.00
73_Y77_V1.1391.00
13_G270_L1.1381.00
222_L226_L1.1371.00
175_S178_V1.1361.00
123_N128_D1.1351.00
18_L58_R1.1261.00
155_V158_K1.1251.00
10_Q270_L1.1231.00
284_H288_V1.1221.00
221_L225_S1.1131.00
268_S272_V1.1091.00
322_F326_V1.1031.00
129_S133_F1.0981.00
71_R205_G1.0981.00
60_P194_N1.0811.00
247_S251_I1.0751.00
339_F342_L1.0741.00
91_F151_I1.0721.00
97_W144_L1.0691.00
97_W101_Q1.0631.00
243_L247_S1.0611.00
248_I251_I1.0501.00
170_L174_L1.0351.00
127_A131_G1.0331.00
318_F322_F1.0291.00
145_W149_A1.0261.00
224_A228_T1.0261.00
257_Q260_Q1.0251.00
123_N132_E1.0241.00
83_L151_I1.0211.00
125_A128_D1.0201.00
94_L278_I1.0121.00
63_F150_L1.0111.00
291_F295_L1.0051.00
328_G332_R1.0001.00
291_F320_S0.9971.00
208_I211_C0.9911.00
210_T213_K0.9881.00
92_W96_L0.9861.00
87_I151_I0.9811.00
250_V253_K0.9801.00
157_C202_A0.9781.00
279_A336_Q0.9781.00
129_S136_G0.9751.00
138_I141_S0.9751.00
70_I73_Y0.9741.00
82_C154_F0.9731.00
331_V335_S0.9731.00
171_F175_S0.9661.00
288_V320_S0.9641.00
137_M141_S0.9521.00
128_D131_G0.9501.00
335_S339_F0.9431.00
16_I146_Y0.9371.00
149_A194_N0.9301.00
287_L291_F0.9301.00
81_N84_D0.9281.00
127_A130_T0.9231.00
198_Y202_A0.9231.00
287_L327_A0.9221.00
123_N130_T0.9211.00
186_W190_S0.9211.00
9_N12_K0.9191.00
280_I325_T0.9191.00
99_V103_L0.9171.00
227_L231_A0.9101.00
172_V176_V0.9091.00
124_A128_D0.9071.00
247_S250_V0.9041.00
18_L57_F0.8991.00
231_A234_A0.8931.00
144_L282_T0.8921.00
173_L177_A0.8881.00
16_I62_F0.8881.00
88_W91_F0.8861.00
250_V254_L0.8841.00
218_R222_L0.8791.00
181_V185_W0.8781.00
283_T286_I0.8761.00
199_S202_A0.8741.00
216_P219_R0.8711.00
136_G141_S0.8701.00
250_V257_Q0.8691.00
179_N184_P0.8671.00
20_V284_H0.8671.00
333_K338_A0.8651.00
229_V233_G0.8641.00
210_T214_E0.8621.00
126_Y133_F0.8611.00
125_A130_T0.8591.00
315_V318_F0.8581.00
90_I154_F0.8551.00
179_N183_T0.8551.00
135_H141_S0.8541.00
278_I282_T0.8541.00
168_F175_S0.8521.00
147_L282_T0.8521.00
19_V58_R0.8461.00
190_S193_R0.8461.00
137_M140_A0.8381.00
93_V279_A0.8341.00
256_Y260_Q0.8301.00
246_V249_V0.8281.00
131_G134_L0.8271.00
12_K65_I0.8261.00
223_M227_L0.8251.00
143_S281_Y0.8201.00
276_N333_K0.8201.00
241_L244_S0.8191.00
13_G16_I0.8171.00
317_P320_S0.8141.00
98_G102_W0.8091.00
268_S271_N0.8001.00
233_G237_F0.7971.00
266_S271_N0.7861.00
103_L107_A0.7851.00
240_S244_S0.7851.00
327_A331_V0.7831.00
103_L106_S0.7801.00
88_W339_F0.7771.00
265_R268_S0.7771.00
266_S269_L0.7751.00
235_W239_I0.7751.00
250_V258_Y0.7741.00
290_I293_L0.7731.00
225_S229_V0.7661.00
188_M191_V0.7651.00
317_P321_L0.7641.00
246_V250_V0.7641.00
64_F197_Y0.7641.00
22_Y58_R0.7621.00
20_V321_L0.7611.00
9_N274_G0.7591.00
188_M194_N0.7591.00
22_Y56_P0.7571.00
244_S247_S0.7551.00
196_P199_S0.7551.00
17_C21_I0.7541.00
240_S243_L0.7501.00
67_G202_A0.7481.00
143_S284_H0.7471.00
129_S139_T0.7451.00
68_Y208_I0.7441.00
242_L245_L0.7441.00
82_C86_R0.7421.00
267_T271_N0.7421.00
209_M212_V0.7371.00
125_A132_E0.7371.00
70_I198_Y0.7371.00
104_A108_L0.7351.00
63_F146_Y0.7331.00
89_N336_Q0.7331.00
55_A59_M0.7321.00
143_S286_I0.7291.00
275_S337_R0.7281.00
12_K146_Y0.7251.00
125_A131_G0.7241.00
283_T327_A0.7241.00
276_N332_R0.7211.00
16_I273_I0.7201.00
125_A135_H0.7191.00
10_Q267_T0.7191.00
226_L230_L0.7181.00
82_C158_K0.7181.00
248_I252_M0.7161.00
273_I325_T0.7141.00
127_A134_L0.7141.00
219_R226_L0.7131.00
209_M213_K0.7131.00
168_F172_V0.7121.00
124_A133_F0.7071.00
18_L22_Y0.7071.00
88_W342_L0.7061.00
124_A127_A0.7041.00
260_Q263_G0.6981.00
228_T232_V0.6951.00
74_I161_S0.6951.00
20_V324_C0.6941.00
218_R221_L0.6931.00
287_L290_I0.6901.00
100_V104_A0.6891.00
170_L173_L0.6881.00
24_S320_S0.6871.00
153_Y194_N0.6871.00
243_L246_V0.6851.00
218_R223_M0.6851.00
316_Y320_S0.6841.00
262_F266_S0.6831.00
6_L9_N0.6821.00
66_S70_I0.6801.00
149_A153_Y0.6781.00
63_F194_N0.6751.00
331_V334_L0.6731.00
11_I65_I0.6731.00
24_S317_P0.6721.00
245_L249_V0.6691.00
166_P175_S0.6681.00
96_L100_V0.6681.00
75_D206_A0.6661.00
94_L98_G0.6631.00
129_S134_L0.6631.00
60_P193_R0.6631.00
153_Y158_K0.6631.00
66_S198_Y0.6611.00
124_A130_T0.6601.00
7_W10_Q0.6571.00
132_E137_M0.6561.00
149_A191_V0.6551.00
271_N274_G0.6521.00
243_L251_I0.6511.00
130_T135_H0.6511.00
287_L323_I0.6511.00
270_L274_G0.6501.00
179_N185_W0.6491.00
59_M62_F0.6481.00
202_A206_A0.6411.00
268_S275_S0.6401.00
180_F184_P0.6401.00
167_L170_L0.6381.00
251_I257_Q0.6361.00
5_E72_R0.6301.00
101_Q105_L0.6291.00
66_S146_Y0.6281.00
199_S203_W0.6231.00
251_I258_Y0.6201.00
218_R224_A0.6171.00
244_S248_I0.6161.00
246_V257_Q0.6151.00
8_I68_Y0.6151.00
22_Y60_P0.6131.00
125_A134_L0.6131.00
261_R264_M0.6111.00
217_L220_H0.6111.00
12_K150_L0.6091.00
111_W114_P0.6091.00
179_N182_P0.6081.00
240_S247_S0.6061.00
129_S138_I0.6061.00
287_L320_S0.6041.00
291_F294_T0.6031.00
187_G191_V0.6021.00
124_A131_G0.5991.00
123_N135_H0.5991.00
16_I20_V0.5981.00
191_V194_N0.5971.00
291_F316_Y0.5971.00
58_R153_Y0.5971.00
14_L18_L0.5961.00
203_W207_T0.5951.00
168_F171_F0.5941.00
248_I256_Y0.5931.00
80_G83_L0.5921.00
63_F153_Y0.5901.00
214_E218_R0.5901.00
283_T324_C0.5901.00
289_E293_L0.5901.00
110_Q113_A0.5851.00
236_L239_I0.5851.00
6_L266_S0.5851.00
284_H324_C0.5851.00
180_F185_W0.5841.00
166_P169_A0.5831.00
89_N150_L0.5821.00
90_I278_I0.5781.00
50_F54_L0.5731.00
123_N133_F0.5711.00
316_Y319_V0.5711.00
131_G140_A0.5661.00
186_W192_I0.5621.00
126_Y137_M0.5601.00
102_W105_L0.5591.00
24_S324_C0.5591.00
166_P176_V0.5581.00
193_R197_Y0.5581.00
174_L178_V0.5561.00
63_F145_W0.5561.00
227_L230_L0.5531.00
134_L137_M0.5501.00
228_T231_A0.5501.00
256_Y259_E0.5501.00
54_L58_R0.5491.00
233_G236_L0.5491.00
224_A227_L0.5491.00
254_L258_Y0.5471.00
311_T314_L0.5471.00
153_Y157_C0.5471.00
56_P60_P0.5451.00
232_V236_L0.5421.00
99_V102_W0.5421.00
215_V218_R0.5411.00
151_I155_V0.5411.00
70_I74_I0.5411.00
253_K257_Q0.5411.00
132_E138_I0.5401.00
269_L272_V0.5391.00
70_I82_C0.5381.00
10_Q13_G0.5371.00
102_W106_S0.5361.00
294_T297_A0.5361.00
95_A151_I0.5361.00
96_L331_V0.5361.00
101_Q143_S0.5311.00
203_W206_A0.5301.00
243_L258_Y0.5291.00
106_S110_Q0.5281.00
242_L247_S0.5271.00
182_P185_W0.5251.00
275_S285_R0.5251.00
126_Y136_G0.5231.00
290_I294_T0.5201.00
123_N131_G0.5191.00
134_L138_I0.5191.00
57_F61_V0.5181.00
149_A152_V0.5181.00
16_I277_T0.5161.00
90_I151_I0.5141.00
109_N113_A0.5131.00
10_Q14_L0.5131.00
204_F207_T0.5111.00
242_L246_V0.5101.00
129_S140_A0.5101.00
255_F259_E0.5081.00
259_E262_F0.5071.00
88_W340_S0.5061.00
90_I150_L0.5051.00
91_F94_L0.5051.00
95_A99_V0.5041.00
213_K217_L0.5041.00
166_P178_V0.5041.00
151_I198_Y0.5031.00
212_V216_P0.5001.00
220_H223_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4j72A 2 0.1036 7.4 0.954 Contact Map
2kluA 1 0.1457 4.7 0.958 Contact Map
3udcA 3 0.1345 4.6 0.958 Contact Map
2kv5A 1 0.0924 4.1 0.959 Contact Map
3ffvA 1 0.1681 3.1 0.962 Contact Map
2dgcA 2 0.042 3.1 0.962 Contact Map
4p02A 1 0.3529 2.7 0.963 Contact Map
5ajiA 3 0.1457 2.6 0.963 Contact Map
4pj0R 1 0.0952 2.6 0.963 Contact Map
4px7A 1 0.6471 2.2 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0108 seconds.