GREMLIN Database
COMR - HTH-type transcriptional repressor ComR
UniProt: P75952 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13435
Length: 210 (186)
Sequences: 46035 (36080)
Seq/√Len: 2645.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_H44_D3.9561.00
43_A53_A3.8611.00
30_K48_A3.4931.00
61_T65_G2.7041.00
32_F40_T2.3731.00
62_N65_G2.3141.00
149_Q168_T2.1921.00
46_V56_L2.1271.00
21_R69_A2.0111.00
31_L48_A1.9791.00
34_Q48_A1.9771.00
31_L40_T1.9571.00
149_Q153_C1.9571.00
27_K48_A1.9511.00
20_D23_A1.9331.00
22_D73_R1.9301.00
96_A154_Q1.9051.00
23_A27_K1.8921.00
31_L44_D1.8911.00
31_L35_H1.8761.00
92_S95_S1.8621.00
43_A47_E1.8261.00
14_G17_K1.7341.00
153_C167_V1.7151.00
153_C157_A1.6981.00
27_K30_K1.6951.00
52_K55_T1.6851.00
29_M73_R1.6291.00
22_D26_D1.5951.00
153_C156_Q1.5811.00
44_D48_A1.5511.00
25_L69_A1.5381.00
41_S44_D1.5341.00
29_M74_Y1.5201.00
30_K34_Q1.5181.00
21_R59_E1.4911.00
42_L57_Y1.4901.00
69_A72_D1.4881.00
83_E147_T1.4581.00
28_A32_F1.4531.00
72_D136_T1.4431.00
44_D47_E1.4411.00
73_R77_R1.4371.00
154_Q158_R1.4121.00
68_R72_D1.3871.00
42_L53_A1.3861.00
173_F177_I1.3621.00
40_T45_L1.3481.00
36_G40_T1.3361.00
102_A195_M1.3191.00
29_M70_V1.3091.00
60_F69_A1.3011.00
19_F23_A1.2781.00
28_A66_L1.2731.00
68_R136_T1.2711.00
26_D73_R1.2651.00
156_Q163_P1.2641.00
55_T58_A1.2301.00
98_A199_G1.2241.00
81_K103_A1.2151.00
145_E172_E1.2141.00
155_R161_I1.2121.00
102_A198_A1.2071.00
42_L56_L1.2031.00
169_H196_Q1.2001.00
35_H39_A1.1961.00
36_G39_A1.1871.00
95_S99_D1.1591.00
19_F22_D1.1581.00
51_A55_T1.1491.00
94_E98_A1.1471.00
166_D169_H1.1471.00
27_K31_L1.1461.00
145_E149_Q1.1411.00
98_A202_L1.1381.00
155_R160_E1.1381.00
64_E68_R1.1361.00
96_A151_F1.1331.00
56_L66_L1.1321.00
65_G69_A1.1261.00
32_F37_Y1.1241.00
98_A102_A1.1231.00
64_E130_S1.0971.00
99_D102_A1.0921.00
20_D59_E1.0801.00
156_Q165_C1.0751.00
27_K49_T1.0661.00
136_T139_S1.0631.00
45_L66_L1.0621.00
52_K58_A1.0591.00
53_A57_Y1.0591.00
25_L60_F1.0581.00
64_E132_D1.0541.00
54_P58_A1.0451.00
26_D30_K1.0421.00
147_T150_Q1.0391.00
72_D76_D1.0331.00
25_L70_V1.0281.00
55_T59_E1.0281.00
149_Q167_V1.0161.00
37_Y67_F1.0041.00
29_M33_W1.0011.00
65_G68_R1.0001.00
162_P165_C0.9971.00
91_K99_D0.9911.00
28_A70_V0.9851.00
35_H48_A0.9831.00
92_S160_E0.9701.00
151_F155_R0.9491.00
199_G203_R0.9421.00
156_Q167_V0.9421.00
198_A202_L0.9391.00
73_R76_D0.9381.00
117_C121_N0.9351.00
146_R150_Q0.9321.00
17_K58_A0.9311.00
168_T172_E0.9311.00
90_E96_A0.9291.00
79_A143_M0.9291.00
93_V158_R0.9241.00
57_Y62_N0.9181.00
156_Q159_G0.9171.00
69_A73_R0.9151.00
107_C111_K0.9141.00
185_A188_G0.9131.00
150_Q154_Q0.9121.00
81_K84_A0.9081.00
80_A84_A0.9071.00
46_V53_A0.9061.00
151_F154_Q0.9031.00
95_S98_A0.9021.00
135_N139_S0.9021.00
142_A146_R0.9021.00
139_S143_M0.8981.00
18_V22_D0.8951.00
176_C180_G0.8911.00
149_Q171_A0.8891.00
99_D103_A0.8821.00
193_K196_Q0.8761.00
145_E168_T0.8701.00
31_L34_Q0.8701.00
165_C170_L0.8651.00
192_E196_Q0.8651.00
20_D51_A0.8611.00
156_Q161_I0.8541.00
102_A106_N0.8531.00
150_Q153_C0.8491.00
85_Q99_D0.8471.00
103_A106_N0.8471.00
79_A83_E0.8411.00
74_Y77_R0.8411.00
134_A138_K0.8331.00
15_R19_F0.8291.00
154_Q157_A0.8241.00
191_L195_M0.8221.00
129_D132_D0.8131.00
14_G18_V0.8031.00
169_H172_E0.8021.00
76_D80_A0.8011.00
38_E125_T0.8001.00
195_M199_G0.7931.00
136_T140_R0.7851.00
23_A49_T0.7851.00
16_P19_F0.7831.00
93_V155_R0.7821.00
169_H200_T0.7821.00
24_A56_L0.7771.00
23_A26_D0.7761.00
116_G120_I0.7761.00
72_D140_R0.7731.00
176_C179_Q0.7681.00
197_I201_T0.7601.00
30_K113_T0.7561.00
192_E195_M0.7541.00
91_K95_S0.7541.00
146_R149_Q0.7521.00
194_L197_I0.7511.00
131_G135_N0.7481.00
37_Y63_K0.7471.00
42_L46_V0.7441.00
196_Q199_G0.7441.00
47_E53_A0.7421.00
169_H173_F0.7401.00
101_F174_L0.7391.00
17_K20_D0.7311.00
152_L174_L0.7221.00
24_A49_T0.7211.00
77_R80_A0.7201.00
199_G202_L0.7191.00
85_Q103_A0.7191.00
25_L73_R0.7181.00
16_P20_D0.7181.00
143_M146_R0.7171.00
79_A147_T0.7161.00
26_D29_M0.7141.00
49_T52_K0.7131.00
193_K197_I0.7081.00
35_H40_T0.7041.00
53_A58_A0.7031.00
90_E95_S0.6991.00
200_T203_R0.6981.00
167_V171_A0.6971.00
196_Q200_T0.6951.00
117_C120_I0.6931.00
143_M147_T0.6891.00
15_R18_V0.6881.00
121_N125_T0.6871.00
34_Q44_D0.6861.00
72_D139_S0.6791.00
152_L167_V0.6781.00
43_A57_Y0.6741.00
138_K142_A0.6721.00
131_G134_A0.6661.00
116_G119_M0.6561.00
106_N194_L0.6541.00
92_S96_A0.6531.00
25_L29_M0.6491.00
129_D133_I0.6451.00
152_L156_Q0.6431.00
184_S188_G0.6261.00
20_D55_T0.6231.00
32_F67_F0.6191.00
80_A83_E0.6151.00
106_N110_S0.6101.00
102_A199_G0.6101.00
37_Y64_E0.6071.00
163_P166_D0.5991.00
90_E99_D0.5971.00
173_F176_C0.5941.00
98_A101_F0.5931.00
37_Y40_T0.5891.00
104_I108_F0.5881.00
84_A103_A0.5851.00
42_L63_K0.5841.00
170_L173_F0.5731.00
193_K198_A0.5711.00
18_V21_R0.5711.00
29_M77_R0.5701.00
198_A201_T0.5651.00
24_A59_E0.5631.00
75_I140_R0.5601.00
156_Q162_P0.5601.00
197_I200_T0.5581.00
125_T129_D0.5551.00
179_Q183_I0.5551.00
116_G121_N0.5541.00
75_I143_M0.5531.00
118_F121_N0.5511.00
68_R132_D0.5501.00
121_N124_T0.5451.00
107_C110_S0.5441.00
184_S187_E0.5431.00
166_D170_L0.5421.00
132_D136_T0.5411.00
94_E160_E0.5401.00
49_T53_A0.5401.00
180_G183_I0.5381.00
103_A107_C0.5351.00
17_K59_E0.5331.00
179_Q184_S0.5321.00
152_L170_L0.5321.00
91_K96_A0.5271.00
76_D140_R0.5271.00
96_A155_R0.5251.00
147_T151_F0.5231.00
81_K107_C0.5221.00
138_K141_H0.5211.00
176_C184_S0.5191.00
28_A45_L0.5181.00
195_M198_A0.5181.00
33_W116_G0.5181.00
46_V51_A0.5151.00
142_A145_E0.5141.00
20_D52_K0.5131.00
167_V170_L0.5111.00
93_V160_E0.5071.00
155_R159_G0.5051.00
135_N138_K0.5041.00
185_A189_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bruA 2 0.9048 100 0.21 Contact Map
2hyjA 2 0.919 100 0.231 Contact Map
4udsA 2 0.8905 100 0.232 Contact Map
3g1oA 2 0.8952 100 0.233 Contact Map
2ibdA 2 0.9048 100 0.235 Contact Map
3kz9A 2 0.9619 100 0.236 Contact Map
3knwA 2 0.8667 100 0.238 Contact Map
2i10A 2 0.881 100 0.239 Contact Map
3eupA 2 0.9571 100 0.241 Contact Map
2xdnA 2 0.9381 100 0.244 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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