GREMLIN Database
NAGZ - Beta-hexosaminidase
UniProt: P75949 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13433
Length: 341 (286)
Sequences: 10739 (7015)
Seq/√Len: 414.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
288_V292_L3.9241.00
98_Q151_D3.5591.00
162_G206_L3.4481.00
121_L146_A3.4201.00
190_R238_E3.1491.00
291_N294_P2.9361.00
185_P188_E2.9261.00
94_G144_A2.7041.00
228_P232_K2.6811.00
233_T237_Q2.6791.00
143_L199_S2.6091.00
161_T208_A2.6021.00
270_D299_R2.5501.00
229_Y233_T2.5471.00
228_P233_T2.4611.00
98_Q155_E2.4171.00
274_D306_K2.3791.00
198_S202_R2.3431.00
97_A145_I2.3181.00
207_D313_E2.2931.00
186_Q190_R2.2591.00
299_R302_R2.1781.00
101_G149_F2.1561.00
44_E48_Q2.1451.00
244_V310_S2.1161.00
211_P225_S2.0891.00
159_K207_D2.0891.00
247_S273_C2.0021.00
287_S291_N1.9941.00
236_R302_R1.9571.00
102_W155_E1.9561.00
154_H207_D1.9331.00
260_S263_E1.9091.00
115_I208_A1.9071.00
50_R53_S1.9051.00
78_L103_L1.9021.00
297_A301_T1.8711.00
84_F97_A1.8591.00
159_K310_S1.8481.00
150_I160_T1.8351.00
231_L245_I1.8101.00
102_W156_A1.8091.00
98_Q152_G1.7901.00
123_V192_K1.7871.00
167_G184_R1.7601.00
98_Q102_W1.7161.00
105_A156_A1.7111.00
98_Q148_R1.7041.00
201_I209_I1.6951.00
299_R303_L1.6891.00
296_K299_R1.6781.00
266_Q270_D1.6681.00
162_G209_I1.6611.00
229_Y234_V1.6611.00
211_P231_L1.6111.00
76_T107_E1.6051.00
154_H160_T1.5831.00
162_G200_L1.5651.00
232_K237_Q1.5391.00
301_T304_Y1.5111.00
144_A199_S1.5061.00
147_S151_D1.4921.00
153_M160_T1.4851.00
102_W106_S1.4591.00
262_A287_S1.4551.00
144_A147_S1.4471.00
116_S153_M1.4431.00
235_L245_I1.4421.00
121_L162_G1.4301.00
95_K99_E1.4251.00
150_I200_L1.4201.00
94_G148_R1.4091.00
195_S199_S1.4071.00
187_A191_A1.4051.00
209_I235_L1.3941.00
198_S239_L1.3931.00
84_F100_A1.3701.00
312_Q317_S1.3441.00
148_R152_G1.3431.00
224_A227_S1.3391.00
43_R47_R1.3271.00
288_V291_N1.3181.00
303_L306_K1.3071.00
266_Q294_P1.3021.00
147_S199_S1.2971.00
270_D296_K1.2951.00
269_L303_L1.2951.00
147_S203_E1.2941.00
267_A270_D1.2901.00
262_A291_N1.2761.00
298_E301_T1.2721.00
236_R306_K1.2541.00
106_S156_A1.2501.00
101_G153_M1.2291.00
99_E102_W1.2271.00
270_D294_P1.2221.00
87_L145_I1.2191.00
148_R151_D1.2181.00
231_L273_C1.1931.00
247_S252_M1.1881.00
184_R188_E1.1861.00
289_L292_L1.1841.00
121_L200_L1.1841.00
195_S198_S1.1801.00
199_S203_E1.1621.00
266_Q288_V1.1591.00
95_K98_Q1.1591.00
222_R267_A1.1521.00
212_A224_A1.1501.00
140_Q144_A1.1481.00
117_F246_F1.1431.00
211_P273_C1.1411.00
143_L147_S1.1351.00
151_D203_E1.1321.00
38_D42_L1.1321.00
263_E267_A1.1321.00
178_E183_P1.1301.00
190_R198_S1.1251.00
149_F153_M1.1251.00
201_I239_L1.1121.00
199_S202_R1.1081.00
234_V238_E1.0991.00
108_M116_S1.0861.00
38_D41_Q1.0851.00
166_P230_W1.0841.00
250_L276_I1.0831.00
31_L46_V1.0801.00
146_A200_L1.0721.00
268_S273_C1.0691.00
115_I246_F1.0681.00
159_K314_L1.0661.00
40_A44_E1.0581.00
186_Q238_E1.0491.00
225_S251_S1.0451.00
37_H41_Q1.0311.00
136_H141_K1.0241.00
78_L107_E1.0191.00
304_Y308_S1.0181.00
305_H309_F1.0161.00
60_A115_I1.0081.00
208_A244_V1.0061.00
144_A203_E1.0021.00
232_K271_A0.9971.00
309_F313_E0.9871.00
88_S141_K0.9841.00
302_R306_K0.9831.00
292_L295_I0.9821.00
104_M153_M0.9761.00
94_G145_I0.9741.00
120_V134_S0.9741.00
82_Q86_A0.9721.00
46_V50_R0.9711.00
138_D141_K0.9681.00
287_S290_D0.9681.00
139_P143_L0.9651.00
140_Q195_S0.9601.00
200_L206_L0.9531.00
150_I154_H0.9521.00
219_V224_A0.9491.00
275_M307_G0.9481.00
59_V113_I0.9481.00
55_N308_S0.9391.00
263_E294_P0.9371.00
167_G189_I0.9321.00
274_D303_L0.9311.00
49_I52_A0.9261.00
118_A153_M0.9211.00
135_Y149_F0.9191.00
80_A132_E0.9131.00
135_Y145_I0.9121.00
47_R50_R0.9121.00
40_A43_R0.9111.00
60_A117_F0.9061.00
29_L49_I0.9041.00
46_V59_V0.9001.00
41_Q45_L0.8961.00
302_R305_H0.8921.00
89_G96_L0.8881.00
87_L96_L0.8881.00
109_I158_M0.8871.00
224_A230_W0.8851.00
108_M113_I0.8811.00
208_A310_S0.8811.00
190_R234_V0.8811.00
96_L99_E0.8801.00
41_Q44_E0.8791.00
232_K302_R0.8781.00
142_A196_V0.8761.00
270_D295_I0.8761.00
39_P43_R0.8731.00
222_R227_S0.8651.00
225_S273_C0.8631.00
165_F194_M0.8591.00
226_G267_A0.8581.00
78_L100_A0.8521.00
45_L48_Q0.8511.00
218_D223_P0.8511.00
48_Q51_A0.8501.00
244_V275_M0.8501.00
160_T207_D0.8491.00
143_L195_S0.8471.00
105_A153_M0.8461.00
49_I53_S0.8411.00
219_V230_W0.8401.00
124_G131_G0.8351.00
226_G255_A0.8321.00
43_R305_H0.8321.00
201_I206_L0.8321.00
186_Q229_Y0.8271.00
194_M234_V0.8251.00
150_I206_L0.8221.00
116_S158_M0.8211.00
123_V142_A0.8121.00
53_S57_L0.8111.00
75_F111_M0.8091.00
188_E192_K0.8091.00
105_A152_G0.8051.00
246_F275_M0.8041.00
249_D277_L0.8011.00
304_Y307_G0.8011.00
168_H171_V0.7991.00
242_D313_E0.7981.00
228_P270_D0.7971.00
85_A141_K0.7971.00
161_T246_F0.7941.00
242_D309_F0.7911.00
308_S312_Q0.7861.00
160_T206_L0.7851.00
166_P194_M0.7801.00
274_D299_R0.7701.00
101_G152_G0.7661.00
83_S86_A0.7651.00
319_R322_A0.7631.00
43_R46_V0.7571.00
253_E257_I0.7541.00
165_F235_L0.7531.00
48_Q52_A0.7521.00
152_G155_E0.7491.00
141_K145_I0.7461.00
58_V114_D0.7401.00
212_A217_S0.7391.00
136_H142_A0.7381.00
147_S150_I0.7351.00
236_R274_D0.7331.00
49_I57_L0.7321.00
97_A101_G0.7291.00
27_G275_M0.7281.00
173_A178_E0.7251.00
230_W234_V0.7221.00
211_P251_S0.7201.00
97_A149_F0.7191.00
212_A216_Y0.7181.00
200_L203_E0.7181.00
42_L46_V0.7171.00
103_L107_E0.7151.00
207_D314_L0.7101.00
269_L300_V0.7091.00
36_Y42_L0.7071.00
115_I159_K0.7071.00
63_Q116_S0.7051.00
169_G196_V0.7051.00
288_V294_P0.7041.00
207_D310_S0.7031.00
265_G276_I0.7031.00
262_A294_P0.7031.00
124_G134_S0.7021.00
46_V49_I0.6981.00
47_R51_A0.6971.00
311_R316_D0.6971.00
263_E266_Q0.6921.00
168_H175_S0.6891.00
39_P74_G0.6891.00
63_Q104_M0.6871.00
153_M158_M0.6861.00
81_A135_Y0.6841.00
140_Q199_S0.6821.00
292_L296_K0.6781.00
130_I134_S0.6731.00
44_E47_R0.6710.99
100_A103_L0.6710.99
88_S144_A0.6710.99
85_A136_H0.6700.99
308_S311_R0.6700.99
117_F275_M0.6690.99
117_F277_L0.6690.99
122_D169_G0.6680.99
45_L49_I0.6660.99
186_Q234_V0.6630.99
281_N285_A0.6610.99
43_R50_R0.6610.99
61_V113_I0.6580.99
190_R194_M0.6570.99
46_V53_S0.6560.99
170_A184_R0.6560.99
244_V307_G0.6550.99
159_K244_V0.6550.99
222_R228_P0.6540.99
85_A135_Y0.6530.99
205_K242_D0.6500.99
289_L295_I0.6460.99
261_Y281_N0.6440.99
88_S94_G0.6410.99
60_A275_M0.6400.99
189_I194_M0.6400.99
220_D229_Y0.6370.99
232_K299_R0.6360.99
168_H212_A0.6330.99
125_H170_A0.6330.99
102_W105_A0.6310.99
226_G268_S0.6290.99
307_G311_R0.6280.99
252_M276_I0.6270.99
256_A261_Y0.6270.99
305_H312_Q0.6260.99
96_L100_A0.6260.99
184_R189_I0.6250.99
65_G80_A0.6240.99
278_V285_A0.6230.99
262_A266_Q0.6200.99
89_G95_K0.6200.99
125_H193_D0.6190.99
143_L196_V0.6180.99
81_A120_V0.6170.99
141_K144_A0.6160.99
49_I54_R0.6140.99
151_D205_K0.6140.99
256_A264_R0.6120.99
209_I241_F0.6120.99
101_G105_A0.6110.99
100_A104_M0.6070.99
125_H192_K0.6060.99
46_V113_I0.6060.99
219_V229_Y0.6060.99
226_G264_R0.6050.99
140_Q143_L0.6010.99
166_P224_A0.6010.99
118_A149_F0.5990.99
237_Q240_G0.5980.99
295_I299_R0.5970.99
24_P28_G0.5970.99
281_N284_G0.5960.99
196_V199_S0.5950.99
82_Q124_G0.5950.99
295_I300_V0.5920.99
267_A271_A0.5910.99
194_M239_L0.5910.99
67_R108_M0.5890.99
289_L296_K0.5870.99
26_V29_L0.5870.99
301_T305_H0.5830.99
254_G258_M0.5820.99
150_I162_G0.5800.99
252_M273_C0.5800.99
50_R57_L0.5790.99
58_V311_R0.5780.99
222_R226_G0.5780.99
85_A145_I0.5760.98
312_Q318_A0.5760.98
139_P195_S0.5740.98
100_A149_F0.5720.98
231_L236_R0.5690.98
139_P192_K0.5660.98
115_I161_T0.5650.98
208_A246_F0.5630.98
232_K236_R0.5630.98
103_L106_S0.5630.98
170_A193_D0.5620.98
175_S179_T0.5620.98
249_D278_V0.5620.98
306_K309_F0.5580.98
58_V115_I0.5580.98
315_M318_A0.5580.98
298_E302_R0.5560.98
176_H252_M0.5560.98
317_S320_W0.5560.98
255_A264_R0.5540.98
67_R111_M0.5520.98
60_A277_L0.5510.98
201_I241_F0.5510.98
124_G136_H0.5510.98
58_V310_S0.5500.98
121_L196_V0.5490.98
233_T238_E0.5480.98
310_S313_E0.5480.98
198_S238_E0.5480.98
171_V174_D0.5470.98
81_A149_F0.5460.98
166_P189_I0.5460.98
249_D279_C0.5440.98
280_N285_A0.5440.98
106_S110_A0.5420.98
294_P297_A0.5420.98
67_R132_E0.5420.98
24_P29_L0.5390.98
192_K195_S0.5370.98
45_L51_A0.5360.98
303_L307_G0.5340.98
27_G30_I0.5330.97
135_Y142_A0.5330.97
152_G156_A0.5310.97
82_Q136_H0.5270.97
45_L50_R0.5260.97
232_K272_G0.5250.97
265_G285_A0.5250.97
43_R49_I0.5240.97
36_Y39_P0.5240.97
269_L276_I0.5220.97
36_Y41_Q0.5220.97
259_G264_R0.5190.97
70_R73_E0.5190.97
168_H174_D0.5170.97
109_I114_D0.5150.97
282_R285_A0.5150.97
31_L59_V0.5140.97
99_E103_L0.5140.97
84_F87_L0.5140.97
117_F249_D0.5130.97
166_P169_G0.5100.97
51_A54_R0.5100.97
231_L271_A0.5090.97
45_L52_A0.5080.97
255_A258_M0.5070.97
63_Q108_M0.5060.97
146_A162_G0.5050.97
105_A109_I0.5050.97
287_S292_L0.5040.96
253_E256_A0.5010.96
274_D302_R0.5010.96
184_R192_K0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tevA 1 0.8739 100 0.117 Contact Map
3bmxA 1 0.9795 100 0.117 Contact Map
3wo8A 2 0.915 100 0.138 Contact Map
3sqlA 2 0.9648 100 0.148 Contact Map
5bu9A 1 0.8974 100 0.153 Contact Map
4gvfA 1 0.9853 100 0.158 Contact Map
4g6cA 2 0.9531 100 0.161 Contact Map
2oxnA 1 0.9296 100 0.168 Contact Map
3wliA 1 0.9413 100 0.181 Contact Map
3rrxA 1 0.9413 100 0.195 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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