FLGJ - ECOLI - GREMLIN Contacts

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FLGJ - Peptidoglycan hydrolase FlgJ

UniProt:	P75942	Sequences: MISDSKLLASAAWDAQSLNELKAKAGEDPAANIRPVARQVEGMFVQMMLKSMRDALPKDGLFSSEHTRLYTSMYDQQIAQQMTAGKGLGLAEMMVKQMTPEQPLPEESTPAAPMKFPLETVVRYQNQALSQLVQKAVPRNYDDSLPGDSKAFLAQLSLPAQLASQQSGVPHHLILAQAALESGWGQRQIRRENGEPSYNLFGVKASGNWKGPVTEITTTEYENGEAKKVKAKFRVYSSYLEALSDYVGLLTRNPRYAAVTTAASAEQGAQALQDAGYATDPHYARKLTNMIQQMKSISDKVSKTYSMNIDNLF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG14272
Length:	313 (283)
Sequences:	816 (651)
Seq/√Len:	38.7

ECOLI - FLGJ
BACSU - LYTG

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
237_S	241_E	5.529	1.00
206_S	249_L	3.816	1.00
163_A	247_V	3.712	1.00
269_A	287_L	3.682	1.00
222_E	229_V	3.595	1.00
28_D	31_A	3.448	1.00
153_L	175_L	3.318	1.00
270_Q	288_T	3.296	1.00
280_D	286_K	3.132	1.00
221_Y	281_P	2.927	1.00
212_P	237_S	2.819	1.00
218_T	231_A	2.735	1.00
219_T	226_A	2.667	1.00
214_T	235_V	2.620	1.00
250_L	268_G	2.537	1.00
19_N	22_K	2.461	1.00
198_Y	239_Y	2.421	1.00
156_L	175_L	2.412	1.00
238_S	241_E	2.411	1.00
221_Y	226_A	2.371	1.00
188_Q	196_P	2.367	1.00
182_S	187_R	2.295	1.00
272_L	276_G	2.265	1.00
15_A	19_N	2.263	1.00
60_G	63_S	2.248	0.99
162_L	240_L	2.139	0.99
169_V	174_I	2.118	0.99
191_R	195_E	2.111	0.99
92_E	95_V	2.089	0.99
18_L	22_K	2.041	0.99
17_S	291_I	2.040	0.99
147_G	151_A	2.033	0.99
222_E	227_K	1.972	0.99
268_G	271_A	1.971	0.99
202_G	218_T	1.960	0.99
215_E	230_K	1.915	0.98
215_E	232_K	1.877	0.98
172_H	291_I	1.835	0.98
28_D	36_V	1.782	0.97
255_R	276_G	1.714	0.97
33_I	95_V	1.714	0.97
234_R	245_D	1.700	0.96
25_A	32_N	1.700	0.96
45_V	83_T	1.691	0.96
287_L	291_I	1.686	0.96
23_A	27_E	1.633	0.95
262_A	265_A	1.633	0.95
166_Q	251_T	1.624	0.95
217_T	228_K	1.565	0.94
288_T	291_I	1.564	0.94
219_T	228_K	1.545	0.94
248_G	252_R	1.540	0.94
35_P	38_R	1.531	0.94
65_E	68_R	1.520	0.93
274_D	284_A	1.494	0.93
200_L	242_A	1.474	0.92
170_P	291_I	1.453	0.92
174_I	269_A	1.431	0.91
167_S	174_I	1.414	0.91
131_Q	134_Q	1.397	0.90
44_F	47_M	1.393	0.90
202_G	269_A	1.387	0.90
205_A	209_W	1.382	0.90
34_R	38_R	1.379	0.89
180_L	290_M	1.367	0.89
128_A	131_Q	1.357	0.89
191_R	235_V	1.347	0.88
13_W	17_S	1.340	0.88
12_A	15_A	1.335	0.88
43_M	198_Y	1.325	0.87
104_L	107_E	1.296	0.86
159_P	240_L	1.290	0.86
213_V	232_K	1.282	0.86
173_L	268_G	1.275	0.85
197_S	235_V	1.269	0.85
173_L	269_A	1.268	0.85
53_R	75_D	1.268	0.85
191_R	214_T	1.266	0.85
93_M	96_K	1.244	0.84
164_S	169_V	1.239	0.84
75_D	97_Q	1.236	0.84
127_Q	130_S	1.233	0.83
157_S	161_Q	1.233	0.83
282_H	285_R	1.227	0.83
269_A	288_T	1.219	0.83
249_L	269_A	1.206	0.82
89_G	98_M	1.205	0.82
255_R	272_L	1.204	0.82
250_L	259_V	1.200	0.82
75_D	89_G	1.196	0.81
167_S	247_V	1.188	0.81
125_Q	133_V	1.173	0.80
21_L	25_A	1.171	0.80
55_A	78_I	1.158	0.79
174_I	243_L	1.155	0.79
267_Q	284_A	1.152	0.79
236_Y	245_D	1.150	0.79
170_P	287_L	1.148	0.79
10_S	18_L	1.141	0.78
169_V	275_A	1.141	0.78
255_R	281_P	1.131	0.78
17_S	20_E	1.116	0.77
60_G	66_H	1.114	0.77
24_K	29_P	1.103	0.76
12_A	80_Q	1.102	0.76
247_V	275_A	1.091	0.75
52_M	55_A	1.089	0.75
189_I	202_G	1.085	0.75
123_R	133_V	1.079	0.74
17_S	172_H	1.078	0.74
212_P	241_E	1.071	0.74
9_A	17_S	1.061	0.73
13_W	291_I	1.059	0.73
241_E	244_S	1.051	0.72
253_N	259_V	1.049	0.72
173_L	266_E	1.047	0.72
180_L	286_K	1.044	0.72
250_L	289_N	1.044	0.72
38_R	228_K	1.044	0.72
16_Q	19_N	1.041	0.71
267_Q	271_A	1.039	0.71
110_P	114_M	1.032	0.71
19_N	23_A	1.018	0.70
131_Q	136_A	1.016	0.70
13_W	80_Q	1.011	0.69
11_A	15_A	1.001	0.68
74_Y	85_G	1.000	0.68
240_L	244_S	0.997	0.68
163_A	169_V	0.992	0.68
45_V	82_M	0.987	0.67
189_I	214_T	0.986	0.67
224_G	239_Y	0.978	0.67
45_V	48_M	0.976	0.66
54_D	57_P	0.974	0.66
134_Q	137_V	0.968	0.66
131_Q	137_V	0.967	0.66
177_Q	242_A	0.965	0.66
163_A	167_S	0.964	0.65
259_V	262_A	0.964	0.65
78_I	82_M	0.962	0.65
150_K	154_A	0.961	0.65
194_G	214_T	0.958	0.65
182_S	188_Q	0.957	0.65
174_I	291_I	0.952	0.64
175_L	243_L	0.951	0.64
174_I	242_A	0.950	0.64
70_Y	156_L	0.949	0.64
33_I	36_V	0.942	0.64
130_S	135_K	0.940	0.63
41_E	90_L	0.937	0.63
109_T	112_A	0.926	0.62
170_P	247_V	0.924	0.62
170_P	265_A	0.924	0.62
189_I	218_T	0.923	0.62
53_R	77_Q	0.923	0.62
200_L	239_Y	0.922	0.62
112_A	117_P	0.920	0.62
110_P	117_P	0.918	0.62
74_Y	78_I	0.917	0.62
174_I	247_V	0.916	0.61
156_L	173_L	0.909	0.61
164_S	170_P	0.909	0.61
159_P	243_L	0.905	0.61
247_V	287_L	0.903	0.60
112_A	115_K	0.902	0.60
107_E	113_P	0.901	0.60
33_I	98_M	0.899	0.60
265_A	268_G	0.897	0.60
154_A	182_S	0.896	0.60
174_I	288_T	0.890	0.59
249_L	289_N	0.890	0.59
183_G	255_R	0.886	0.59
158_L	161_Q	0.885	0.59
77_Q	97_Q	0.884	0.59
169_V	291_I	0.884	0.59
176_A	272_L	0.882	0.59
163_A	243_L	0.871	0.58
133_V	136_A	0.871	0.58
260_T	267_Q	0.869	0.57
149_S	250_L	0.868	0.57
90_L	98_M	0.860	0.57
53_R	89_G	0.859	0.56
125_Q	134_Q	0.857	0.56
10_S	13_W	0.857	0.56
87_G	180_L	0.850	0.56
167_S	259_V	0.849	0.56
216_I	226_A	0.848	0.56
169_V	260_T	0.847	0.55
148_D	274_D	0.841	0.55
66_H	69_L	0.841	0.55
92_E	97_Q	0.835	0.54
22_K	71_T	0.834	0.54
124_Y	128_A	0.833	0.54
10_S	26_G	0.833	0.54
71_T	221_Y	0.829	0.54
179_A	290_M	0.828	0.54
186_Q	237_S	0.826	0.54
12_A	16_Q	0.823	0.53
182_S	202_G	0.822	0.53
107_E	290_M	0.822	0.53
80_Q	214_T	0.818	0.53
106_E	109_T	0.817	0.53
31_A	108_S	0.814	0.52
213_V	241_E	0.814	0.52
122_V	125_Q	0.812	0.52
209_W	237_S	0.811	0.52
51_S	55_A	0.811	0.52
111_A	115_K	0.810	0.52
159_P	163_A	0.808	0.52
169_V	265_A	0.801	0.51
88_L	187_R	0.799	0.51
126_N	136_A	0.799	0.51
173_L	291_I	0.798	0.51
273_Q	284_A	0.796	0.51
178_A	269_A	0.796	0.51
205_A	245_D	0.795	0.51
30_A	34_R	0.795	0.51
38_R	43_M	0.794	0.51
234_R	256_Y	0.793	0.51
188_Q	202_G	0.793	0.51
129_L	133_V	0.792	0.50
152_F	178_A	0.792	0.50
110_P	113_P	0.791	0.50
163_A	271_A	0.791	0.50
124_Y	135_K	0.790	0.50
249_L	253_N	0.789	0.50
113_P	116_F	0.783	0.50
91_A	98_M	0.781	0.50
9_A	23_A	0.781	0.50
255_R	275_A	0.781	0.50
47_M	187_R	0.780	0.49
262_A	268_G	0.774	0.49
139_R	142_D	0.773	0.49
172_H	290_M	0.771	0.49
87_G	94_M	0.771	0.49
83_T	91_A	0.769	0.48
169_V	249_L	0.767	0.48
206_S	213_V	0.766	0.48
125_Q	128_A	0.765	0.48
173_L	288_T	0.765	0.48
127_Q	135_K	0.765	0.48
27_E	192_E	0.765	0.48
161_Q	165_Q	0.764	0.48
12_A	287_L	0.762	0.48
57_P	60_G	0.757	0.47
174_I	178_A	0.756	0.47
111_A	114_M	0.755	0.47
130_S	137_V	0.753	0.47
269_A	291_I	0.751	0.47
33_I	99_T	0.747	0.46
157_S	171_H	0.746	0.46
104_L	108_S	0.745	0.46
259_V	268_G	0.743	0.46
56_L	76_Q	0.743	0.46
81_Q	85_G	0.741	0.46
11_A	16_Q	0.741	0.46
66_H	113_P	0.740	0.46
79_A	85_G	0.737	0.46
217_T	230_K	0.735	0.45
12_A	76_Q	0.732	0.45
125_Q	130_S	0.729	0.45
167_S	171_H	0.728	0.45
132_L	135_K	0.728	0.45
41_E	77_Q	0.726	0.45
35_P	72_S	0.719	0.44
10_S	187_R	0.719	0.44
289_N	293_Q	0.711	0.43
167_S	269_A	0.710	0.43
184_W	255_R	0.709	0.43
37_A	92_E	0.709	0.43
258_A	262_A	0.708	0.43
25_A	182_S	0.705	0.43
23_A	31_A	0.704	0.43
167_S	170_P	0.697	0.42
10_S	17_S	0.697	0.42
245_D	256_Y	0.696	0.42
188_Q	239_Y	0.693	0.42
124_Y	133_V	0.692	0.42
202_G	291_I	0.691	0.41
228_K	239_Y	0.691	0.41
123_R	127_Q	0.690	0.41
91_A	253_N	0.688	0.41
27_E	38_R	0.688	0.41
45_V	92_E	0.688	0.41
184_W	272_L	0.688	0.41
251_T	259_V	0.687	0.41
74_Y	79_A	0.687	0.41
166_Q	244_S	0.685	0.41
156_L	291_I	0.680	0.41
18_L	32_N	0.679	0.40
53_R	255_R	0.678	0.40
169_V	173_L	0.678	0.40
160_A	243_L	0.678	0.40
35_P	156_L	0.674	0.40
70_Y	86_K	0.665	0.39
138_P	142_D	0.665	0.39
13_W	172_H	0.664	0.39
130_S	133_V	0.662	0.39
204_K	277_Y	0.662	0.39
176_A	212_P	0.656	0.38
79_A	83_T	0.651	0.38
220_E	233_F	0.647	0.38
123_R	126_N	0.647	0.38
196_P	291_I	0.647	0.38
126_N	135_K	0.644	0.37
198_Y	246_Y	0.644	0.37
75_D	83_T	0.642	0.37
9_A	15_A	0.642	0.37
168_G	255_R	0.640	0.37
20_E	270_Q	0.639	0.37
49_L	79_A	0.637	0.37
173_L	178_A	0.636	0.37
90_L	94_M	0.636	0.37
197_S	213_V	0.634	0.37
194_G	216_I	0.633	0.36
76_Q	80_Q	0.633	0.36
22_K	29_P	0.631	0.36
10_S	19_N	0.629	0.36
149_S	240_L	0.628	0.36
27_E	31_A	0.624	0.36
183_G	186_Q	0.621	0.35
168_G	280_D	0.620	0.35
157_S	175_L	0.620	0.35
167_S	217_T	0.619	0.35
251_T	260_T	0.618	0.35
127_Q	132_L	0.616	0.35
106_E	113_P	0.616	0.35
195_E	198_Y	0.613	0.35
249_L	262_A	0.611	0.35
204_K	233_F	0.610	0.35
114_M	117_P	0.609	0.35
16_Q	22_K	0.609	0.35
16_Q	178_A	0.608	0.34
107_E	110_P	0.608	0.34
58_K	67_T	0.606	0.34
247_V	269_A	0.605	0.34
76_Q	272_L	0.603	0.34
89_G	209_W	0.602	0.34
101_E	138_P	0.602	0.34
262_A	267_Q	0.600	0.34
162_L	264_S	0.599	0.34
107_E	139_R	0.597	0.34
268_G	276_G	0.595	0.33
24_K	27_E	0.593	0.33
129_L	137_V	0.592	0.33
153_L	294_M	0.591	0.33
71_T	182_S	0.589	0.33
105_P	117_P	0.588	0.33
108_S	114_M	0.587	0.33
157_S	257_A	0.586	0.33
217_T	231_A	0.584	0.33
173_L	262_A	0.584	0.33
23_A	28_D	0.583	0.32
80_Q	202_G	0.582	0.32
69_L	73_M	0.580	0.32
18_L	172_H	0.579	0.32
26_G	193_N	0.579	0.32
225_E	240_L	0.578	0.32
128_A	208_N	0.577	0.32
45_V	157_S	0.577	0.32
183_G	276_G	0.576	0.32
20_E	23_A	0.575	0.32
26_G	34_R	0.573	0.32
58_K	164_S	0.570	0.31
42_G	46_Q	0.570	0.31
106_E	134_Q	0.567	0.31
116_F	140_N	0.566	0.31
108_S	128_A	0.566	0.31
139_R	154_A	0.565	0.31
22_K	228_K	0.565	0.31
90_L	262_A	0.559	0.31
246_Y	272_L	0.559	0.31
26_G	208_N	0.557	0.30
30_A	102_Q	0.552	0.30
115_K	137_V	0.551	0.30
20_E	261_T	0.550	0.30
221_Y	224_G	0.548	0.30
52_M	73_M	0.548	0.30
247_V	253_N	0.547	0.30
258_A	267_Q	0.546	0.30
164_S	167_S	0.540	0.29
15_A	18_L	0.539	0.29
105_P	109_T	0.537	0.29
287_L	290_M	0.536	0.29
173_L	287_L	0.534	0.29
32_N	242_A	0.534	0.29
75_D	197_S	0.534	0.29
125_Q	129_L	0.533	0.29
198_Y	242_A	0.531	0.28
19_N	24_K	0.531	0.28
260_T	265_A	0.530	0.28
88_L	230_K	0.530	0.28
37_A	40_V	0.529	0.28
258_A	261_T	0.526	0.28
203_V	256_Y	0.525	0.28
109_T	114_M	0.525	0.28
129_L	132_L	0.524	0.28
10_S	172_H	0.524	0.28
153_L	260_T	0.523	0.28
11_A	17_S	0.523	0.28
258_A	268_G	0.521	0.28
138_P	141_Y	0.520	0.28
16_Q	153_L	0.519	0.28
77_Q	89_G	0.518	0.28
205_A	234_R	0.517	0.27
126_N	134_Q	0.517	0.27
67_T	106_E	0.516	0.27
174_I	246_Y	0.515	0.27
63_S	176_A	0.514	0.27
51_S	54_D	0.514	0.27
130_S	136_A	0.512	0.27
63_S	92_E	0.512	0.27
27_E	208_N	0.510	0.27
202_G	285_R	0.507	0.27
126_N	133_V	0.507	0.27
148_D	229_V	0.507	0.27
246_Y	290_M	0.506	0.27
26_G	186_Q	0.505	0.27
149_S	184_W	0.505	0.27
173_L	219_T	0.504	0.27
198_Y	241_E	0.504	0.27
159_P	174_I	0.502	0.26
122_V	128_A	0.501	0.26
163_A	244_S	0.500	0.26

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2zycA	1	0.4984	100	0.463	Contact Map
3fi7A	4	0.5431	100	0.493	Contact Map
4qdnA	2	0.3738	100	0.55	Contact Map
4kt3A	1	0.4377	100	0.597	Contact Map
4q2wA	1	0.5719	100	0.679	Contact Map
3gxrA	1	0.5304	90.8	0.943	Contact Map
1gbsA	1	0.5463	87.7	0.946	Contact Map
3w6bA	1	0.476	87.1	0.947	Contact Map
4g9sA	1	0.5399	78.4	0.952	Contact Map
4xp8A	1	0.2716	76.4	0.953	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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