GREMLIN Database
FLGE - Flagellar hook protein FlgE
UniProt: P75937 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14269
Length: 402 (387)
Sequences: 2025 (1551)
Seq/√Len: 78.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
231_N235_T5.2091.00
326_A336_T4.4231.00
117_T136_N4.3491.00
122_T126_P4.1611.00
321_N324_G4.0641.00
150_T281_N3.9011.00
137_I312_G3.8851.00
328_E334_S3.7621.00
107_N138_S3.6321.00
345_G352_F3.2971.00
94_Y319_F3.2071.00
85_L95_S3.1771.00
115_Q136_N2.9171.00
12_A52_V2.8831.00
301_G311_L2.8221.00
122_T125_P2.7881.00
288_L301_G2.7571.00
201_V211_Y2.7391.00
75_V355_L2.6621.00
84_R317_A2.6171.00
110_N114_L2.6031.00
289_V304_S2.6031.00
228_L236_L2.5861.00
75_V314_I2.5601.00
24_I367_L2.5561.00
6_A387_T2.5521.00
66_T359_A2.5251.00
75_V293_I2.4971.00
317_A344_L2.4891.00
313_Q346_T2.4121.00
108_L116_L2.4001.00
356_T359_A2.3951.00
298_T310_L2.3261.00
87_D91_S2.2911.00
151_T281_N2.2591.00
107_N115_Q2.2371.00
103_D107_N2.1931.00
77_I316_L2.1741.00
94_Y342_A2.1531.00
75_V357_N2.0931.00
84_R117_T2.0921.00
16_N377_A2.0701.00
286_G304_S2.0651.00
149_T258_F2.0351.00
66_T76_A2.0271.00
77_I353_G2.0231.00
231_N237_V1.9991.00
335_A341_V1.9901.00
157_N267_Q1.9721.00
386_Q389_K1.9571.00
300_V310_L1.9491.00
283_Y307_Q1.9371.00
286_G305_N1.9231.00
21_G387_T1.8971.00
93_F332_V1.8641.00
294_N298_T1.8521.00
147_K283_Y1.8431.00
69_T74_D1.8311.00
198_V210_V1.8281.00
209_Q227_T1.8051.00
165_P179_N1.8031.00
178_Y199_Y1.7751.00
147_K150_T1.7651.00
181_K197_S1.7521.00
20_I377_A1.7411.00
85_L93_F1.7391.00
185_T193_A1.7311.00
207_N229_E1.7131.00
198_V212_T1.6621.00
84_R344_L1.6591.00
82_F322_N1.6471.00
122_T127_T1.6461.00
386_Q397_T1.6281.00
203_T209_Q1.6191.00
67_T362_A1.6171.00
27_S367_L1.6161.00
328_E332_V1.6161.00
120_P135_T1.6101.00
13_A380_N1.5971.00
318_N352_F1.5630.99
326_A334_S1.5490.99
118_G137_I1.5350.99
61_F82_F1.5350.99
86_V136_N1.5330.99
36_T60_D1.5110.99
76_A359_A1.4930.99
32_F35_G1.4860.99
162_D179_N1.4850.99
157_N269_N1.4850.99
16_N373_N1.4730.99
75_V116_L1.4680.99
86_V117_T1.4630.99
316_L352_F1.4620.99
85_L332_V1.4520.99
336_T339_S1.4360.99
165_P177_S1.4310.99
15_T54_V1.4280.99
97_N331_N1.4220.99
108_L118_G1.3810.99
210_V226_T1.3750.99
393_Q396_N1.3670.99
160_S190_Q1.3640.99
71_R74_D1.3560.99
207_N227_T1.3550.99
149_T280_Q1.3460.98
30_Y360_L1.3450.98
319_F342_A1.3230.98
83_F100_F1.3200.98
389_K392_D1.3180.98
17_L374_M1.3140.98
160_S192_N1.2820.98
392_D395_L1.2810.98
28_A380_N1.2800.98
203_T207_N1.2470.97
110_N332_V1.2450.97
10_L394_I1.2350.97
377_A394_I1.2340.97
48_V57_I1.2320.97
41_D44_A1.2280.97
119_Y315_V1.2280.97
348_G354_T1.2230.97
124_T127_T1.2100.97
388_I401_L1.2080.97
112_Q330_D1.2070.97
366_D369_K1.2030.97
180_K273_N1.2010.97
80_N322_N1.1910.97
30_Y97_N1.1900.97
153_S261_S1.1790.96
186_V196_M1.1740.96
188_D194_H1.1710.96
293_I299_V1.1700.96
379_R392_D1.1630.96
190_Q268_Q1.1590.96
47_K50_L1.1570.96
36_T58_T1.1510.96
294_N300_V1.1510.96
17_L377_A1.1460.96
156_I266_M1.1450.96
41_D329_G1.1440.96
20_I374_M1.1410.96
300_V308_T1.1360.96
186_V214_D1.1320.95
18_D50_L1.1320.95
93_F334_S1.1270.95
35_G59_Q1.1240.95
17_L27_S1.1220.95
229_E237_V1.1140.95
371_L397_T1.1020.95
209_Q225_A1.0960.95
347_A352_F1.0900.94
116_L314_I1.0900.94
103_D109_V1.0850.94
19_V37_A1.0760.94
38_S58_T1.0730.94
97_N111_M1.0730.94
9_G384_N1.0720.94
388_I392_D1.0660.94
152_A184_V1.0640.94
239_G242_A1.0570.93
120_P312_G1.0560.93
134_P315_V1.0560.93
190_Q253_A1.0510.93
123_G126_P1.0490.93
49_G61_F1.0460.93
174_N177_S1.0450.93
91_S334_S1.0440.93
194_H215_S1.0420.93
2_A391_Q1.0410.93
206_N268_Q1.0360.93
123_G127_T1.0300.93
228_L262_F1.0290.93
249_A255_P1.0290.93
159_N162_D1.0260.92
395_L399_V1.0230.92
293_I314_I1.0200.92
93_F328_E1.0140.92
152_A196_M1.0090.92
5_Q395_L1.0080.92
84_R134_P1.0070.92
373_N376_V1.0040.92
319_F335_A0.9840.91
327_S333_W0.9810.91
42_M301_G0.9800.91
188_D192_N0.9790.91
187_F284_K0.9710.90
30_Y99_Q0.9690.90
87_D114_L0.9660.90
196_M258_F0.9650.90
114_L332_V0.9640.90
121_A127_T0.9630.90
3_F7_V0.9610.90
58_T323_E0.9560.90
17_L394_I0.9500.89
3_F6_A0.9500.89
178_Y181_K0.9490.89
19_V49_G0.9480.89
208_W268_Q0.9450.89
51_G74_D0.9440.89
339_S342_A0.9430.89
131_G134_P0.9400.89
230_F282_G0.9340.88
110_N116_L0.9340.88
19_V57_I0.9310.88
371_L389_K0.9300.88
7_V13_A0.9300.88
22_N49_G0.9290.88
47_K327_S0.9270.88
14_A381_Y0.9190.88
87_D93_F0.9160.87
61_F323_E0.9130.87
202_K268_Q0.9120.87
318_N322_N0.9110.87
41_D49_G0.8990.86
99_Q360_L0.8990.86
85_L110_N0.8950.86
28_A367_L0.8930.86
282_G286_G0.8920.86
370_E373_N0.8870.86
13_A16_N0.8840.86
83_F97_N0.8810.85
369_K373_N0.8770.85
287_D304_S0.8760.85
292_Q302_N0.8630.84
298_T313_Q0.8620.84
190_Q206_N0.8580.84
48_V336_T0.8570.84
81_G348_G0.8560.84
68_N359_A0.8550.84
164_L203_T0.8480.83
379_R382_Q0.8440.83
155_Q276_V0.8430.83
381_Y385_A0.8380.82
87_D139_I0.8340.82
4_S7_V0.8340.82
49_G329_G0.8330.82
250_I253_A0.8330.82
391_Q394_I0.8320.82
280_Q283_Y0.8290.82
200_F228_L0.8280.82
282_G305_N0.8240.81
6_A388_I0.8230.81
294_N310_L0.8220.81
72_G292_Q0.8210.81
202_K206_N0.8150.81
71_R323_E0.8100.80
187_F193_A0.8070.80
174_N178_Y0.8070.80
245_I252_G0.8070.80
10_L401_L0.8050.80
335_A342_A0.8010.79
22_N368_S0.7990.79
201_V209_Q0.7980.79
158_L208_W0.7960.79
374_M394_I0.7950.79
387_T397_T0.7950.79
146_A158_L0.7950.79
191_G282_G0.7910.79
149_T186_V0.7910.79
68_N358_G0.7880.78
66_T269_N0.7860.78
318_N351_N0.7840.78
368_S387_T0.7830.78
78_S356_T0.7820.78
125_P128_I0.7800.78
22_N324_G0.7790.77
374_M386_Q0.7770.77
147_K280_Q0.7770.77
162_D202_K0.7760.77
41_D61_F0.7740.77
202_K208_W0.7740.77
290_S302_N0.7710.77
371_L383_S0.7690.77
392_D397_T0.7690.77
121_A125_P0.7680.76
149_T152_A0.7680.76
41_D185_T0.7670.76
16_N20_I0.7670.76
19_V32_F0.7640.76
94_Y335_A0.7610.76
80_N318_N0.7600.76
101_K111_M0.7590.76
237_V241_M0.7590.76
370_E379_R0.7590.76
280_Q385_A0.7580.76
73_L102_L0.7550.75
41_D48_V0.7500.75
228_L266_M0.7500.75
38_S371_L0.7480.75
251_N254_E0.7480.75
296_D337_Q0.7420.74
296_D355_L0.7400.74
74_D99_Q0.7390.74
28_A140_P0.7340.73
16_N380_N0.7330.73
53_K330_D0.7320.73
22_N44_A0.7320.73
139_I374_M0.7290.73
294_N338_S0.7280.73
4_S376_V0.7270.72
13_A17_L0.7250.72
368_S391_Q0.7240.72
234_G237_V0.7240.72
385_A394_I0.7230.72
194_H253_A0.7210.72
27_S371_L0.7210.72
99_Q386_Q0.7210.72
394_I397_T0.7200.72
161_S270_T0.7200.72
252_G256_A0.7200.72
184_V198_V0.7170.71
10_L388_I0.7150.71
388_I398_L0.7140.71
282_G303_Y0.7140.71
102_L116_L0.7130.71
314_I355_L0.7130.71
18_D49_G0.7090.71
233_N237_V0.7080.70
226_T239_G0.7060.70
183_S250_I0.7050.70
367_L398_L0.7050.70
204_G207_N0.7050.70
5_Q25_A0.7030.70
54_V57_I0.7010.70
229_E239_G0.7000.70
232_A237_V0.7000.70
386_Q391_Q0.7000.70
210_V260_L0.7000.70
73_L108_L0.6990.69
42_M46_S0.6990.69
34_S60_D0.6980.69
86_V92_V0.6980.69
228_L239_G0.6970.69
311_L314_I0.6970.69
109_V157_N0.6970.69
59_Q333_W0.6970.69
158_L200_F0.6940.69
61_F280_Q0.6930.69
22_N321_N0.6920.69
386_Q390_T0.6920.69
376_V388_I0.6910.69
374_M391_Q0.6890.68
85_L100_F0.6880.68
320_A335_A0.6870.68
319_F325_L0.6870.68
152_A260_L0.6860.68
12_A54_V0.6840.68
236_L239_G0.6830.68
259_S263_L0.6830.68
44_A50_L0.6810.67
371_L384_N0.6800.67
324_G338_S0.6800.67
27_S380_N0.6790.67
37_A54_V0.6780.67
15_T48_V0.6780.67
121_A310_L0.6780.67
49_G57_I0.6780.67
83_F96_R0.6780.67
5_Q391_Q0.6750.67
393_Q399_V0.6750.67
164_L204_G0.6750.67
116_L299_V0.6740.67
278_T385_A0.6740.67
324_G340_G0.6710.66
40_A55_A0.6680.66
196_M214_D0.6670.66
372_V401_L0.6660.66
16_N21_G0.6660.66
203_T206_N0.6640.66
367_L383_S0.6630.65
238_D241_M0.6630.65
185_T195_D0.6600.65
164_L179_N0.6600.65
165_P174_N0.6580.65
312_G315_V0.6560.65
93_F114_L0.6550.64
166_T238_D0.6540.64
6_A9_G0.6530.64
374_M377_A0.6520.64
184_V278_T0.6510.64
142_T303_Y0.6500.64
39_F43_F0.6500.64
303_Y389_K0.6490.64
230_F234_G0.6480.64
6_A392_D0.6480.64
371_L380_N0.6450.63
157_N268_Q0.6450.63
21_G368_S0.6430.63
59_Q327_S0.6410.63
229_E232_A0.6410.63
75_V290_S0.6370.62
381_Y398_L0.6370.62
181_K199_Y0.6360.62
236_L311_L0.6360.62
65_T384_N0.6360.62
21_G377_A0.6360.62
252_G257_T0.6340.62
6_A386_Q0.6330.62
345_G394_I0.6320.62
317_A342_A0.6310.62
196_M212_T0.6300.61
183_S195_D0.6300.61
192_N316_L0.6280.61
70_G358_G0.6270.61
382_Q394_I0.6270.61
250_I254_E0.6270.61
11_N369_K0.6240.61
198_V351_N0.6210.60
123_G281_N0.6200.60
157_N160_S0.6180.60
145_A269_N0.6180.60
17_L69_T0.6150.60
7_V16_N0.6150.60
58_T333_W0.6150.60
209_Q226_T0.6150.60
96_R361_E0.6140.59
49_G382_Q0.6130.59
392_D396_N0.6130.59
200_F266_M0.6100.59
344_L352_F0.6100.59
85_L116_L0.6100.59
38_S56_G0.6090.59
6_A183_S0.6060.58
111_M301_G0.6050.58
69_T360_L0.6010.58
60_D71_R0.6010.58
5_Q18_D0.5990.58
48_V54_V0.5990.58
377_A380_N0.5990.58
161_S192_N0.5980.57
226_T260_L0.5980.57
289_V308_T0.5980.57
160_S268_Q0.5940.57
218_P223_K0.5940.57
371_L386_Q0.5920.57
7_V20_I0.5910.57
137_I326_A0.5910.57
196_M306_E0.5900.56
144_M283_Y0.5890.56
374_M398_L0.5890.56
7_V377_A0.5880.56
26_N29_T0.5860.56
35_G371_L0.5860.56
211_Y225_A0.5850.56
102_L139_I0.5840.56
3_F333_W0.5830.56
19_V54_V0.5820.55
41_D327_S0.5820.55
18_D22_N0.5810.55
10_L21_G0.5810.55
154_M198_V0.5810.55
186_V194_H0.5800.55
18_D48_V0.5790.55
274_N277_A0.5780.55
38_S99_Q0.5780.55
78_S354_T0.5780.55
326_A338_S0.5760.55
19_V55_A0.5760.55
20_I370_E0.5760.55
162_D377_A0.5750.55
21_G391_Q0.5740.54
77_I355_L0.5740.54
244_N261_S0.5720.54
302_N308_T0.5710.54
34_S370_E0.5710.54
316_L355_L0.5690.54
84_R92_V0.5680.54
208_W230_F0.5670.54
365_V370_E0.5670.54
151_T259_S0.5670.54
11_N15_T0.5660.53
159_N273_N0.5660.53
31_G97_N0.5660.53
200_F262_F0.5650.53
290_S332_V0.5640.53
379_R401_L0.5620.53
52_V99_Q0.5610.53
154_M336_T0.5600.53
67_T338_S0.5600.53
53_K75_V0.5590.53
49_G74_D0.5590.53
100_F116_L0.5580.52
199_Y211_Y0.5570.52
77_I400_N0.5560.52
3_F387_T0.5560.52
208_W282_G0.5560.52
200_F208_W0.5550.52
152_A278_T0.5550.52
3_F43_F0.5530.52
3_F395_L0.5530.52
367_L391_Q0.5520.52
154_M278_T0.5520.52
247_T250_I0.5490.51
2_A5_Q0.5470.51
288_L311_L0.5470.51
13_A372_V0.5470.51
22_N73_L0.5460.51
32_F131_G0.5450.51
116_L375_I0.5440.51
108_L376_V0.5430.50
237_V255_P0.5420.50
189_S194_H0.5420.50
189_S206_N0.5400.50
389_K393_Q0.5390.50
368_S376_V0.5380.50
18_D55_A0.5370.50
32_F41_D0.5360.50
286_G303_Y0.5360.50
27_S386_Q0.5360.50
275_I278_T0.5360.50
107_N136_N0.5360.50
15_T24_I0.5350.49
164_L202_K0.5350.49
314_I346_T0.5340.49
183_S197_S0.5330.49
333_W372_V0.5330.49
50_L381_Y0.5330.49
372_V376_V0.5330.49
210_V214_D0.5320.49
135_T312_G0.5320.49
316_L347_A0.5320.49
200_F379_R0.5320.49
63_D96_R0.5310.49
179_N199_Y0.5310.49
208_W281_N0.5310.49
22_N41_D0.5290.49
4_S371_L0.5280.49
18_D391_Q0.5270.48
48_V52_V0.5260.48
85_L114_L0.5260.48
163_P202_K0.5250.48
320_A323_E0.5250.48
238_D242_A0.5250.48
296_D313_Q0.5240.48
92_V117_T0.5230.48
38_S301_G0.5230.48
108_L137_I0.5230.48
19_V35_G0.5220.48
173_S177_S0.5220.48
148_T163_P0.5220.48
218_P244_N0.5210.48
304_S351_N0.5200.48
299_V314_I0.5200.48
86_V115_Q0.5190.47
212_T226_T0.5160.47
59_Q372_V0.5160.47
253_A256_A0.5160.47
63_D383_S0.5150.47
244_N257_T0.5140.47
215_S270_T0.5140.47
16_N395_L0.5140.47
370_E378_Q0.5130.47
45_G50_L0.5120.46
86_V90_G0.5120.46
2_A16_N0.5110.46
19_V47_K0.5110.46
163_P166_T0.5110.46
63_D76_A0.5100.46
284_K304_S0.5090.46
5_Q10_L0.5090.46
59_Q364_N0.5090.46
377_A392_D0.5080.46
71_R101_K0.5080.46
119_Y134_P0.5060.46
149_T286_G0.5060.46
350_G400_N0.5060.46
311_L375_I0.5060.46
43_F47_K0.5060.46
108_L139_I0.5050.46
215_S218_P0.5050.46
348_G351_N0.5040.45
47_K371_L0.5030.45
188_D230_F0.5020.45
233_N254_E0.5010.45
236_L263_L0.5010.45
146_A164_L0.5010.45
191_G230_F0.5010.45
188_D191_G0.5010.45
318_N350_G0.5000.45
54_V74_D0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a69A 3 0.8557 100 0.177 Contact Map
1wlgA 2 0.7214 100 0.439 Contact Map
4ut1A 1 0.6741 99.9 0.797 Contact Map
1oryB 2 0.097 6.7 0.98 Contact Map
2yh9A 5 0.1692 6.1 0.98 Contact Map
2grgA 1 0.2363 5.2 0.981 Contact Map
4xpmB 1 0.1592 4.8 0.981 Contact Map
2km7A 1 0.2537 3.1 0.983 Contact Map
3c12A 2 0.3333 3 0.983 Contact Map
1d2dA 1 0.0821 2.6 0.983 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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