GREMLIN Database
FLGD - Basal-body rod modification protein FlgD
UniProt: P75936 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14268
Length: 231 (209)
Sequences: 1448 (1140)
Seq/√Len: 78.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_L172_S5.5091.00
141_D145_A5.4041.00
132_A135_V4.4101.00
168_L174_A4.2911.00
140_T182_A3.8341.00
53_E56_E3.8051.00
100_V202_V3.4451.00
47_D50_N3.2441.00
140_T146_V3.1731.00
148_R169_T2.8081.00
70_I73_L2.6501.00
138_T146_V2.5791.00
223_T226_E2.5231.00
167_T173_T2.4611.00
49_T57_L2.3491.00
30_D34_S2.2871.00
216_L219_Y2.2681.00
124_F162_F2.2281.00
31_L34_S2.1981.00
73_L77_L2.0461.00
138_T182_A2.0431.00
214_L227_V1.9361.00
66_T70_I1.9241.00
128_L132_A1.9201.00
59_S63_Q1.8481.00
36_L40_V1.8091.00
138_T184_S1.8061.00
147_V174_A1.7881.00
132_A185_A1.7861.00
93_S230_I1.7731.00
200_A216_L1.7351.00
32_Q68_S1.7311.00
137_A183_I1.6551.00
187_N190_T1.6341.00
109_A174_A1.6041.00
33_S37_T1.5691.00
137_A181_V1.5590.99
127_E228_R1.5550.99
107_V122_T1.5490.99
109_A166_G1.5410.99
204_G215_D1.5370.99
59_S62_A1.5120.99
133_D187_N1.4870.99
166_G171_G1.4730.99
164_W171_G1.4580.99
208_G211_G1.4480.99
155_L160_H1.4410.99
139_I181_V1.4390.99
14_G17_T1.4310.99
62_A67_V1.4170.99
69_G74_N1.4150.99
56_E59_S1.3840.99
131_A154_E1.3820.99
65_S68_S1.3550.99
81_S84_I1.3320.98
50_N54_N1.3220.98
89_S207_R1.3120.98
16_S19_S1.3080.98
148_R167_T1.3020.98
43_L57_L1.2900.98
148_R165_D1.2560.98
77_L80_I1.2390.97
126_V160_H1.2360.97
128_L185_A1.2340.97
92_A224_L1.2170.97
45_N61_L1.2130.97
128_L135_V1.2110.97
152_I160_H1.2010.97
185_A194_A1.1860.97
58_T64_I1.1860.97
32_Q40_V1.1820.96
185_A192_L1.1640.96
175_P179_Y1.1490.96
59_S64_I1.1390.96
126_V183_I1.1290.95
102_I222_T1.1220.95
136_T151_D1.1080.95
101_M197_L1.0820.94
64_I215_D1.0820.94
32_Q64_I1.0690.94
67_V74_N1.0660.94
36_L67_V1.0560.93
42_Q62_A1.0420.93
102_I198_Q1.0400.93
30_D58_T1.0360.93
31_L64_I1.0340.93
137_A152_I1.0280.93
92_A205_V1.0260.92
139_I164_W1.0220.92
99_G201_L1.0160.92
93_S98_H1.0040.92
135_V183_I1.0040.92
184_S191_Q1.0030.92
58_T66_T1.0010.92
134_K151_D0.9970.91
109_A112_G0.9930.91
34_S58_T0.9900.91
90_L96_I0.9830.91
166_G179_Y0.9730.90
49_T55_N0.9580.90
41_A44_K0.9580.90
54_N61_L0.9560.90
37_T44_K0.9510.89
140_T180_N0.9440.89
32_Q61_L0.9390.89
80_I84_I0.9360.89
18_T21_S0.9300.88
28_A31_L0.9280.88
34_S68_S0.9270.88
108_L178_S0.9180.88
100_V216_L0.9130.87
14_G19_S0.9030.87
52_M55_N0.9030.87
15_V18_T0.8990.86
66_T69_G0.8970.86
34_S64_I0.8920.86
106_T180_N0.8770.85
138_T149_T0.8770.85
31_L71_E0.8770.85
21_S24_T0.8740.85
183_I196_P0.8690.85
42_Q51_P0.8630.84
102_I200_A0.8550.84
31_L57_L0.8550.84
70_I77_L0.8450.83
134_K186_S0.8340.82
152_I155_L0.8300.82
39_L58_T0.8300.82
127_E197_L0.8280.82
68_S72_K0.8250.81
39_L74_N0.8200.81
147_V179_Y0.8140.80
57_L204_G0.8100.80
57_L66_T0.8090.80
143_N198_Q0.8080.80
126_V152_I0.8070.80
113_S176_N0.8050.80
49_T61_L0.8040.80
17_T20_S0.7990.79
19_S22_S0.7970.79
146_V149_T0.7940.79
89_S96_I0.7920.79
112_G176_N0.7830.78
200_A219_Y0.7810.78
48_P51_P0.7800.78
127_E159_V0.7760.77
128_L194_A0.7750.77
31_L61_L0.7750.77
129_Q194_A0.7740.77
132_A192_L0.7730.77
110_G113_S0.7700.77
66_T73_L0.7660.76
56_E81_S0.7660.76
128_L160_H0.7650.76
41_A45_N0.7640.76
91_Q96_I0.7630.76
200_A218_T0.7520.75
213_T223_T0.7480.75
95_L100_V0.7480.75
75_T78_G0.7460.74
64_I76_T0.7460.74
208_G212_N0.7400.74
96_I152_I0.7390.74
109_A122_T0.7350.73
92_A214_L0.7310.73
34_S37_T0.7310.73
139_I166_G0.7300.73
34_S39_L0.7270.72
128_L158_G0.7260.72
38_L51_P0.7260.72
69_G73_L0.7240.72
73_L88_Q0.7230.72
57_L64_I0.7230.72
110_G176_N0.7230.72
20_S25_G0.7160.71
83_Q192_L0.7160.71
58_T61_L0.7160.71
203_Q215_D0.7150.71
80_I164_W0.7140.71
34_S61_L0.7110.71
62_A66_T0.7100.71
63_Q66_T0.7050.70
139_I148_R0.7040.70
208_G220_G0.7020.70
57_L65_S0.7010.70
43_L207_R0.7000.70
140_T144_G0.7000.70
123_P163_T0.6960.69
31_L63_Q0.6940.69
80_I204_G0.6940.69
54_N69_G0.6920.69
14_G18_T0.6910.69
131_A156_T0.6900.68
28_A32_Q0.6880.68
56_E71_E0.6870.68
50_N58_T0.6810.67
101_M199_F0.6770.67
136_T149_T0.6760.67
90_L224_L0.6730.67
49_T68_S0.6720.66
136_T184_S0.6680.66
58_T74_N0.6670.66
130_Q133_D0.6610.65
31_L62_A0.6610.65
54_N62_A0.6520.64
68_S71_E0.6520.64
40_V44_K0.6520.64
40_V65_S0.6500.64
186_S191_Q0.6490.64
95_L139_I0.6480.64
99_G105_T0.6470.64
71_E75_T0.6460.63
17_T23_L0.6440.63
101_M229_Q0.6420.63
73_L80_I0.6420.63
149_T161_S0.6380.62
32_Q69_G0.6340.62
32_Q36_L0.6320.62
91_Q95_L0.6300.61
58_T62_A0.6230.61
27_N189_G0.6210.60
124_F198_Q0.6210.60
38_L165_D0.6200.60
57_L61_L0.6200.60
165_D171_G0.6190.60
72_K78_G0.6170.60
32_Q73_L0.6150.60
37_T58_T0.6140.59
107_V124_F0.6100.59
82_G147_V0.6090.59
153_G158_G0.6050.58
53_E57_L0.6050.58
148_R168_L0.6020.58
109_A176_N0.6020.58
62_A71_E0.6010.58
136_T191_Q0.5980.57
88_Q214_L0.5980.57
15_V27_N0.5980.57
149_T169_T0.5970.57
135_V191_Q0.5950.57
24_T78_G0.5940.57
207_R212_N0.5940.57
171_G177_G0.5910.57
32_Q52_M0.5900.56
168_L173_T0.5880.56
36_L65_S0.5880.56
62_A65_S0.5870.56
126_V135_V0.5850.56
32_Q72_K0.5840.56
28_A71_E0.5830.56
19_S23_L0.5810.55
217_G229_Q0.5800.55
129_Q189_G0.5780.55
222_T226_E0.5770.55
36_L57_L0.5770.55
67_V70_I0.5750.55
125_G159_V0.5750.55
31_L67_V0.5750.55
146_V182_A0.5720.54
14_G23_L0.5690.54
142_K176_N0.5670.54
64_I95_L0.5650.53
36_L63_Q0.5640.53
125_G206_I0.5640.53
32_Q71_E0.5630.53
28_A34_S0.5610.53
142_K178_S0.5600.53
59_S197_L0.5600.53
149_T153_G0.5590.53
166_G177_G0.5580.52
123_P161_S0.5530.52
44_K76_T0.5520.52
148_R173_T0.5480.51
72_K75_T0.5480.51
141_D147_V0.5460.51
16_S20_S0.5450.51
94_N146_V0.5440.51
82_G110_G0.5430.50
49_T101_M0.5430.50
197_L228_R0.5420.50
15_V22_S0.5410.50
111_T176_N0.5390.50
30_D57_L0.5380.50
42_Q60_Q0.5350.49
47_D57_L0.5340.49
168_L171_G0.5340.49
22_S26_S0.5320.49
56_E197_L0.5270.48
135_V162_F0.5270.48
68_S98_H0.5250.48
22_S142_K0.5240.48
181_V196_P0.5230.48
70_I124_F0.5220.48
39_L201_L0.5220.48
41_A80_I0.5190.47
125_G196_P0.5190.47
40_V52_M0.5170.47
147_V173_T0.5160.47
176_N179_Y0.5160.47
135_V152_I0.5160.47
33_S75_T0.5150.47
87_S92_A0.5150.47
127_E157_A0.5150.47
16_S184_S0.5150.47
61_L68_S0.5140.47
42_Q65_S0.5120.46
40_V67_V0.5090.46
91_Q230_I0.5080.46
43_L55_N0.5070.46
144_G188_G0.5050.46
213_T227_V0.5020.45
80_I171_G0.5010.45
137_A140_T0.5000.45
203_Q212_N0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c12A 2 0.5931 100 0.541 Contact Map
3osvA 2 0.5758 100 0.546 Contact Map
1xf1A 2 0.9437 99.3 0.779 Contact Map
3isyA 1 0.4026 79.5 0.927 Contact Map
2c9rA 1 0.3377 78 0.928 Contact Map
1lyqA 1 0.3377 76.3 0.929 Contact Map
4q1zA 1 0.3983 73.6 0.93 Contact Map
3sd2A 2 0.316 68.5 0.933 Contact Map
3d33A 1 0.3983 59.5 0.937 Contact Map
2p9rA 1 0.4113 52.5 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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