GREMLIN Database
YCEM - Putative oxidoreductase YceM
UniProt: P75931 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13879
Length: 307 (295)
Sequences: 25610 (19525)
Seq/√Len: 1136.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_L82_T3.1721.00
77_F105_R2.9081.00
124_R170_D2.8561.00
81_S109_L2.8311.00
85_N109_L2.7281.00
5_R30_T2.6981.00
39_R43_L2.6821.00
131_E134_T2.6611.00
104_E291_V2.6481.00
143_R229_D2.6171.00
71_S79_V2.5011.00
77_F102_D2.4761.00
81_S85_N2.4651.00
133_K137_A2.4161.00
7_G59_S2.4051.00
89_H116_T2.4001.00
81_S105_R2.3951.00
198_A300_I2.2511.00
84_L115_L2.2011.00
55_D58_S2.1691.00
75_S79_V2.1561.00
33_G53_Y2.1381.00
275_E279_N2.0591.00
77_F81_S2.0411.00
108_E112_R2.0161.00
134_T138_T1.9981.00
80_V92_V1.9801.00
131_E135_Q1.9651.00
66_A273_F1.9591.00
111_A288_E1.9551.00
16_Q48_S1.9361.00
84_L110_A1.9031.00
78_D82_T1.8751.00
71_S75_S1.8691.00
109_L113_K1.8481.00
85_N113_K1.8121.00
104_E295_R1.8071.00
89_H115_L1.7991.00
104_E108_E1.7961.00
180_A203_S1.7901.00
43_L47_E1.7851.00
38_T41_K1.7831.00
7_G64_C1.7801.00
64_C88_V1.7401.00
67_V83_L1.7381.00
6_I66_A1.7331.00
23_L68_F1.7141.00
100_L298_D1.7081.00
80_V106_L1.6961.00
182_L201_H1.6821.00
99_N102_D1.6721.00
141_S228_T1.6521.00
29_W274_I1.6451.00
26_A271_R1.6411.00
181_S201_H1.6381.00
60_L83_L1.6311.00
28_D278_Q1.6261.00
117_L287_G1.6201.00
120_G269_C1.5991.00
54_A58_S1.5801.00
133_K174_W1.5751.00
56_S82_T1.5661.00
85_N112_R1.5291.00
132_L233_I1.5081.00
292_L295_R1.5071.00
61_A86_A1.4951.00
107_V291_V1.4881.00
98_E102_D1.4801.00
44_P48_S1.4801.00
109_L112_R1.4781.00
107_V287_G1.4611.00
39_R54_A1.4571.00
116_T280_Q1.4571.00
77_F106_L1.4531.00
5_R32_Q1.4411.00
135_Q140_A1.4371.00
58_S61_A1.4251.00
57_L61_A1.4211.00
53_Y59_S1.4171.00
84_L113_K1.3941.00
97_A103_A1.3811.00
145_D229_D1.3781.00
97_A106_L1.3771.00
82_T85_N1.3751.00
225_Q234_D1.3661.00
148_R225_Q1.3561.00
275_E281_T1.3431.00
62_A88_V1.3351.00
103_A291_V1.3271.00
5_R65_D1.3251.00
100_L104_E1.3231.00
100_L295_R1.3121.00
173_L292_L1.3121.00
272_H276_C1.2961.00
11_L34_A1.2771.00
82_T86_A1.2751.00
178_G203_S1.2561.00
173_L202_F1.2531.00
35_W56_S1.2421.00
178_G204_A1.2291.00
141_S231_A1.2281.00
69_V80_V1.2171.00
223_T234_D1.2111.00
87_G113_K1.2101.00
35_W59_S1.2041.00
105_R108_E1.1951.00
272_H284_Q1.1941.00
44_P47_E1.1931.00
69_V79_V1.1841.00
91_C120_G1.1811.00
299_K303_D1.1801.00
83_L90_V1.1801.00
107_V288_E1.1781.00
56_S79_V1.1781.00
40_A43_L1.1731.00
169_V296_I1.1681.00
59_S64_C1.1661.00
274_I278_Q1.1611.00
6_I29_W1.1581.00
84_L109_L1.1561.00
4_L278_Q1.1441.00
96_L103_A1.1391.00
144_M226_A1.1311.00
33_G64_C1.1271.00
135_Q138_T1.1191.00
56_S60_L1.1131.00
25_A267_V1.1101.00
298_D302_R1.1071.00
286_A289_Q1.1051.00
72_S75_S1.1041.00
173_L289_Q1.1031.00
33_G59_S1.1031.00
63_S88_V1.0961.00
299_K302_R1.0931.00
271_R275_E1.0931.00
105_R109_L1.0901.00
107_V111_A1.0831.00
60_L82_T1.0801.00
103_A294_Q1.0771.00
91_C269_C1.0761.00
176_S206_P1.0751.00
4_L66_A1.0711.00
179_K203_S1.0651.00
108_E111_A1.0621.00
173_L179_K1.0551.00
129_Y174_W1.0541.00
92_V117_L1.0391.00
272_H281_T1.0321.00
4_L277_V1.0321.00
9_V79_V1.0301.00
102_D105_R1.0271.00
89_H280_Q1.0251.00
97_A102_D1.0171.00
147_H176_S1.0061.00
81_S106_L1.0061.00
14_I18_A1.0011.00
141_S144_M0.9981.00
125_F272_H0.9881.00
42_A54_A0.9861.00
134_T137_A0.9801.00
89_H277_V0.9781.00
60_L86_A0.9761.00
53_Y58_S0.9741.00
101_R104_E0.9731.00
141_S233_I0.9651.00
124_R289_Q0.9651.00
130_G284_Q0.9621.00
79_V82_T0.9561.00
268_G271_R0.9501.00
21_P25_A0.9441.00
96_L287_G0.9411.00
18_A21_P0.9411.00
42_A46_C0.9361.00
80_V90_V0.9341.00
11_L36_S0.9311.00
272_H275_E0.9311.00
39_R42_A0.9301.00
100_L291_V0.9191.00
41_K44_P0.9181.00
77_F97_A0.9161.00
96_L117_L0.9151.00
181_S184_G0.9151.00
132_L235_I0.9131.00
21_P48_S0.9111.00
101_R105_R0.9101.00
267_V271_R0.9101.00
40_A44_P0.9061.00
106_L117_L0.9051.00
144_M228_T0.9001.00
288_E292_L0.8991.00
210_T213_M0.8871.00
118_M273_F0.8811.00
110_A113_K0.8751.00
5_R64_C0.8691.00
34_A45_I0.8691.00
178_G292_L0.8691.00
275_E280_Q0.8681.00
144_M176_S0.8681.00
122_N265_G0.8681.00
75_S78_D0.8671.00
92_V96_L0.8641.00
43_L46_C0.8641.00
69_V83_L0.8631.00
295_R299_K0.8581.00
104_E107_V0.8571.00
32_Q63_S0.8551.00
73_T163_D0.8551.00
80_V84_L0.8541.00
98_E157_L0.8441.00
36_S42_A0.8431.00
225_Q232_L0.8421.00
68_F270_A0.8421.00
110_A117_L0.8411.00
84_L90_V0.8401.00
28_D275_E0.8361.00
179_K182_L0.8341.00
74_A156_D0.8301.00
149_S224_V0.8281.00
276_C279_N0.8241.00
130_G134_T0.8221.00
16_Q44_P0.8191.00
173_L293_A0.8191.00
7_G33_G0.8171.00
276_C283_P0.8161.00
181_S203_S0.8151.00
169_V297_V0.8101.00
116_T277_V0.8061.00
26_A29_W0.8061.00
46_C51_I0.8041.00
116_T276_C0.8021.00
6_I23_L0.8011.00
209_I212_C0.7981.00
28_D271_R0.7971.00
36_S41_K0.7971.00
110_A115_L0.7961.00
147_H226_A0.7891.00
172_A202_F0.7871.00
118_M276_C0.7861.00
92_V106_L0.7861.00
110_A287_G0.7851.00
7_G35_W0.7821.00
45_I48_S0.7791.00
32_Q64_C0.7751.00
150_N223_T0.7731.00
9_V71_S0.7701.00
8_V20_L0.7691.00
282_V286_A0.7681.00
14_I70_H0.7671.00
23_L270_A0.7661.00
15_A70_H0.7641.00
84_L117_L0.7641.00
121_F166_L0.7621.00
149_S168_V0.7591.00
136_L228_T0.7591.00
223_T236_T0.7561.00
103_A107_V0.7561.00
9_V56_S0.7561.00
158_Y162_L0.7541.00
23_L29_W0.7521.00
96_L119_V0.7511.00
137_A177_G0.7451.00
180_A201_H0.7441.00
182_L185_G0.7411.00
273_F277_V0.7401.00
276_C281_T0.7401.00
147_H172_A0.7391.00
119_V290_A0.7371.00
66_A89_H0.7341.00
266_F269_C0.7341.00
159_F193_G0.7331.00
14_I266_F0.7321.00
7_G67_V0.7291.00
180_A185_G0.7281.00
291_V295_R0.7271.00
142_L231_A0.7241.00
11_L42_A0.7231.00
123_R126_A0.7221.00
166_L293_A0.7211.00
212_C215_R0.7201.00
130_G268_G0.7171.00
148_R212_C0.7131.00
180_A183_D0.7111.00
9_V35_W0.7111.00
210_T214_H0.7111.00
5_R63_S0.7061.00
88_V115_L0.7041.00
77_F109_L0.7011.00
15_A21_P0.6981.00
161_L297_V0.6911.00
30_T52_P0.6901.00
76_H92_V0.6901.00
294_Q298_D0.6881.00
211_T214_H0.6881.00
142_L228_T0.6861.00
289_Q292_L0.6811.00
121_F170_D0.6801.00
257_W260_T0.6771.00
124_R174_W0.6771.00
193_G301_W0.6751.00
176_S202_F0.6751.00
84_L106_L0.6741.00
179_K292_L0.6721.00
45_I49_W0.6711.00
94_K167_H0.6691.00
67_V88_V0.6671.00
81_S84_L0.6671.00
143_R204_A0.6671.00
161_L196_L0.6661.00
121_F293_A0.6661.00
165_Y168_V0.6641.00
202_F209_I0.6611.00
143_R230_G0.6601.00
20_L31_L0.6591.00
28_D274_I0.6591.00
78_D105_R0.6581.00
87_G115_L0.6581.00
6_I68_F0.6571.00
244_E249_V0.6541.00
129_Y171_T0.6531.00
122_N266_F0.6521.00
227_V232_L0.6521.00
6_I274_I0.6511.00
91_C118_M0.6501.00
133_K175_L0.6501.00
287_G290_A0.6501.00
18_A68_F0.6501.00
149_S172_A0.6491.00
136_L226_A0.6491.00
92_V119_V0.6431.00
16_Q41_K0.6411.00
80_V117_L0.6411.00
116_T282_V0.6391.00
66_A277_V0.6391.00
146_K207_L0.6391.00
38_T43_L0.6381.00
241_W244_E0.6361.00
230_G246_G0.6301.00
170_D293_A0.6301.00
175_L226_A0.6251.00
245_R248_G0.6181.00
234_D242_R0.6161.00
214_H217_A0.6161.00
173_L296_I0.6131.00
21_P24_A0.6131.00
183_D186_T0.6121.00
179_K202_F0.6121.00
180_A202_F0.6111.00
170_D174_W0.6081.00
53_Y62_A0.6071.00
151_S164_D0.6041.00
146_K227_V0.6021.00
169_V300_I0.6021.00
272_H283_P0.6011.00
213_M216_R0.6001.00
16_Q49_W0.5981.00
132_L175_L0.5981.00
12_G15_A0.5961.00
118_M272_H0.5941.00
297_V301_W0.5931.00
185_G201_H0.5921.00
13_G17_K0.5891.00
57_L78_D0.5891.00
245_R249_V0.5871.00
139_A228_T0.5871.00
37_P71_S0.5841.00
20_L45_I0.5811.00
214_H218_G0.5811.00
16_Q21_P0.5801.00
56_S83_L0.5771.00
14_I93_D0.5761.00
130_G174_W0.5751.00
275_E278_Q0.5751.00
12_G70_H0.5741.00
29_W66_A0.5741.00
26_A274_I0.5731.00
70_H93_D0.5701.00
116_T283_P0.5671.00
22_V26_A0.5671.00
68_F91_C0.5641.00
293_A297_V0.5631.00
140_A143_R0.5621.00
200_H296_I0.5611.00
69_V76_H0.5611.00
160_T163_D0.5601.00
71_S76_H0.5601.00
161_L198_A0.5591.00
26_A267_V0.5591.00
173_L178_G0.5581.00
179_K200_H0.5561.00
16_Q45_I0.5541.00
136_L175_L0.5521.00
123_R170_D0.5511.00
35_W53_Y0.5511.00
78_D81_S0.5491.00
80_V110_A0.5471.00
55_D61_A0.5441.00
34_A42_A0.5441.00
263_Q267_V0.5441.00
127_P268_G0.5431.00
264_R267_V0.5391.00
139_A143_R0.5381.00
93_D120_G0.5371.00
85_N105_R0.5351.00
160_T164_D0.5351.00
94_K163_D0.5351.00
157_L192_A0.5341.00
107_V110_A0.5341.00
65_D278_Q0.5321.00
74_A98_E0.5311.00
11_L45_I0.5301.00
96_L106_L0.5291.00
237_D240_E0.5281.00
160_T193_G0.5271.00
181_S185_G0.5271.00
181_S186_T0.5261.00
119_V167_H0.5251.00
202_F206_P0.5231.00
146_K195_M0.5201.00
8_V31_L0.5201.00
118_M269_C0.5191.00
121_F124_R0.5181.00
35_W54_A0.5181.00
121_F167_H0.5181.00
153_G164_D0.5151.00
150_N225_Q0.5151.00
162_L298_D0.5141.00
116_T273_F0.5141.00
8_V68_F0.5141.00
15_A20_L0.5131.00
57_L86_A0.5131.00
9_V69_V0.5121.00
167_H170_D0.5121.00
4_L29_W0.5111.00
209_I214_H0.5051.00
150_N221_R0.5041.00
133_K177_G0.5031.00
243_E246_G0.5031.00
199_E207_L0.5031.00
15_A45_I0.5031.00
123_R237_D0.5011.00
168_V222_E0.5001.00
161_L165_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1h6dA 8 0.9902 100 0.177 Contact Map
1zh8A 2 0.9577 100 0.189 Contact Map
3dtyA 4 0.9805 100 0.197 Contact Map
3ceaA 4 0.9902 100 0.2 Contact Map
2nvwA 3 0.9511 100 0.2 Contact Map
3ec7A 6 0.9837 100 0.202 Contact Map
3euwA 4 0.9902 100 0.203 Contact Map
3uuwA 4 0.9805 100 0.207 Contact Map
4mkxA 4 0.9837 100 0.21 Contact Map
3e9mA 2 0.9739 100 0.21 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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