YCEM - ECOLI - GREMLIN Contacts

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YCEM - Putative oxidoreductase YceM

UniProt:	P75931	Sequences: MKKLRIGVVGLGGIAQKAWLPVLAAASDWTLQGAWSPTRAKALPICESWRIPYADSLSSLAASCDAVFVHSSTASHFDVVSTLLNAGVHVCVDKPLAENLRDAERLVELAARKKLTLMVGFNRRFAPLYGELKTQLATAASLRMDKHRSNSVGPHDLYFTLLDDYLHVVDTALWLSGGKASLDGGTLLTNDAGEMLFAEHHFSAGPLQITTCMHRRAGSQRETVQAVTDGALIDITDMREWREERGQGVVHKPIPGWQSTLEQRGFVGCARHFIECVQNQTVPQTAGEQAVLAQRIVDKIWRDAMSE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13879
Length:	307 (295)
Sequences:	25610 (19525)
Seq/√Len:	1136.8

ECOLI - YCEM YCJS YGJR YDGJ YHHX YJHC
BACSU - YRBE IOLX IOLG NTDC YFII IOLW YULF YTET
HALSA - Q9HQT1
SULSO - Q97UK0 Q97UJ6 Q97UJ8 Q97UH0 Q97UK3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
57_L	82_T	3.172	1.00
77_F	105_R	2.908	1.00
124_R	170_D	2.856	1.00
81_S	109_L	2.831	1.00
85_N	109_L	2.728	1.00
5_R	30_T	2.698	1.00
39_R	43_L	2.682	1.00
131_E	134_T	2.661	1.00
104_E	291_V	2.648	1.00
143_R	229_D	2.617	1.00
71_S	79_V	2.501	1.00
77_F	102_D	2.476	1.00
81_S	85_N	2.465	1.00
133_K	137_A	2.416	1.00
7_G	59_S	2.405	1.00
89_H	116_T	2.400	1.00
81_S	105_R	2.395	1.00
198_A	300_I	2.251	1.00
84_L	115_L	2.201	1.00
55_D	58_S	2.169	1.00
75_S	79_V	2.156	1.00
33_G	53_Y	2.138	1.00
275_E	279_N	2.059	1.00
77_F	81_S	2.041	1.00
108_E	112_R	2.016	1.00
134_T	138_T	1.998	1.00
80_V	92_V	1.980	1.00
131_E	135_Q	1.965	1.00
66_A	273_F	1.959	1.00
111_A	288_E	1.955	1.00
16_Q	48_S	1.936	1.00
84_L	110_A	1.903	1.00
78_D	82_T	1.875	1.00
71_S	75_S	1.869	1.00
109_L	113_K	1.848	1.00
85_N	113_K	1.812	1.00
104_E	295_R	1.807	1.00
89_H	115_L	1.799	1.00
104_E	108_E	1.796	1.00
180_A	203_S	1.790	1.00
43_L	47_E	1.785	1.00
38_T	41_K	1.783	1.00
7_G	64_C	1.780	1.00
64_C	88_V	1.740	1.00
67_V	83_L	1.738	1.00
6_I	66_A	1.733	1.00
23_L	68_F	1.714	1.00
100_L	298_D	1.708	1.00
80_V	106_L	1.696	1.00
182_L	201_H	1.682	1.00
99_N	102_D	1.672	1.00
141_S	228_T	1.652	1.00
29_W	274_I	1.645	1.00
26_A	271_R	1.641	1.00
181_S	201_H	1.638	1.00
60_L	83_L	1.631	1.00
28_D	278_Q	1.626	1.00
117_L	287_G	1.620	1.00
120_G	269_C	1.599	1.00
54_A	58_S	1.580	1.00
133_K	174_W	1.575	1.00
56_S	82_T	1.566	1.00
85_N	112_R	1.529	1.00
132_L	233_I	1.508	1.00
292_L	295_R	1.507	1.00
61_A	86_A	1.495	1.00
107_V	291_V	1.488	1.00
98_E	102_D	1.480	1.00
44_P	48_S	1.480	1.00
109_L	112_R	1.478	1.00
107_V	287_G	1.461	1.00
39_R	54_A	1.457	1.00
116_T	280_Q	1.457	1.00
77_F	106_L	1.453	1.00
5_R	32_Q	1.441	1.00
135_Q	140_A	1.437	1.00
58_S	61_A	1.425	1.00
57_L	61_A	1.421	1.00
53_Y	59_S	1.417	1.00
84_L	113_K	1.394	1.00
97_A	103_A	1.381	1.00
145_D	229_D	1.378	1.00
97_A	106_L	1.377	1.00
82_T	85_N	1.375	1.00
225_Q	234_D	1.366	1.00
148_R	225_Q	1.356	1.00
275_E	281_T	1.343	1.00
62_A	88_V	1.335	1.00
103_A	291_V	1.327	1.00
5_R	65_D	1.325	1.00
100_L	104_E	1.323	1.00
100_L	295_R	1.312	1.00
173_L	292_L	1.312	1.00
272_H	276_C	1.296	1.00
11_L	34_A	1.277	1.00
82_T	86_A	1.275	1.00
178_G	203_S	1.256	1.00
173_L	202_F	1.253	1.00
35_W	56_S	1.242	1.00
178_G	204_A	1.229	1.00
141_S	231_A	1.228	1.00
69_V	80_V	1.217	1.00
223_T	234_D	1.211	1.00
87_G	113_K	1.210	1.00
35_W	59_S	1.204	1.00
105_R	108_E	1.195	1.00
272_H	284_Q	1.194	1.00
44_P	47_E	1.193	1.00
69_V	79_V	1.184	1.00
91_C	120_G	1.181	1.00
299_K	303_D	1.180	1.00
83_L	90_V	1.180	1.00
107_V	288_E	1.178	1.00
56_S	79_V	1.178	1.00
40_A	43_L	1.173	1.00
169_V	296_I	1.168	1.00
59_S	64_C	1.166	1.00
274_I	278_Q	1.161	1.00
6_I	29_W	1.158	1.00
84_L	109_L	1.156	1.00
4_L	278_Q	1.144	1.00
96_L	103_A	1.139	1.00
144_M	226_A	1.131	1.00
33_G	64_C	1.127	1.00
135_Q	138_T	1.119	1.00
56_S	60_L	1.113	1.00
25_A	267_V	1.110	1.00
298_D	302_R	1.107	1.00
286_A	289_Q	1.105	1.00
72_S	75_S	1.104	1.00
173_L	289_Q	1.103	1.00
33_G	59_S	1.103	1.00
63_S	88_V	1.096	1.00
299_K	302_R	1.093	1.00
271_R	275_E	1.093	1.00
105_R	109_L	1.090	1.00
107_V	111_A	1.083	1.00
60_L	82_T	1.080	1.00
103_A	294_Q	1.077	1.00
91_C	269_C	1.076	1.00
176_S	206_P	1.075	1.00
4_L	66_A	1.071	1.00
179_K	203_S	1.065	1.00
108_E	111_A	1.062	1.00
173_L	179_K	1.055	1.00
129_Y	174_W	1.054	1.00
92_V	117_L	1.039	1.00
272_H	281_T	1.032	1.00
4_L	277_V	1.032	1.00
9_V	79_V	1.030	1.00
102_D	105_R	1.027	1.00
89_H	280_Q	1.025	1.00
97_A	102_D	1.017	1.00
147_H	176_S	1.006	1.00
81_S	106_L	1.006	1.00
14_I	18_A	1.001	1.00
141_S	144_M	0.998	1.00
125_F	272_H	0.988	1.00
42_A	54_A	0.986	1.00
134_T	137_A	0.980	1.00
89_H	277_V	0.978	1.00
60_L	86_A	0.976	1.00
53_Y	58_S	0.974	1.00
101_R	104_E	0.973	1.00
141_S	233_I	0.965	1.00
124_R	289_Q	0.965	1.00
130_G	284_Q	0.962	1.00
79_V	82_T	0.956	1.00
268_G	271_R	0.950	1.00
21_P	25_A	0.944	1.00
96_L	287_G	0.941	1.00
18_A	21_P	0.941	1.00
42_A	46_C	0.936	1.00
80_V	90_V	0.934	1.00
11_L	36_S	0.931	1.00
272_H	275_E	0.931	1.00
39_R	42_A	0.930	1.00
100_L	291_V	0.919	1.00
41_K	44_P	0.918	1.00
77_F	97_A	0.916	1.00
96_L	117_L	0.915	1.00
181_S	184_G	0.915	1.00
132_L	235_I	0.913	1.00
21_P	48_S	0.911	1.00
101_R	105_R	0.910	1.00
267_V	271_R	0.910	1.00
40_A	44_P	0.906	1.00
106_L	117_L	0.905	1.00
144_M	228_T	0.900	1.00
288_E	292_L	0.899	1.00
210_T	213_M	0.887	1.00
118_M	273_F	0.881	1.00
110_A	113_K	0.875	1.00
5_R	64_C	0.869	1.00
34_A	45_I	0.869	1.00
178_G	292_L	0.869	1.00
275_E	280_Q	0.868	1.00
144_M	176_S	0.868	1.00
122_N	265_G	0.868	1.00
75_S	78_D	0.867	1.00
92_V	96_L	0.864	1.00
43_L	46_C	0.864	1.00
69_V	83_L	0.863	1.00
295_R	299_K	0.858	1.00
104_E	107_V	0.857	1.00
32_Q	63_S	0.855	1.00
73_T	163_D	0.855	1.00
80_V	84_L	0.854	1.00
98_E	157_L	0.844	1.00
36_S	42_A	0.843	1.00
225_Q	232_L	0.842	1.00
68_F	270_A	0.842	1.00
110_A	117_L	0.841	1.00
84_L	90_V	0.840	1.00
28_D	275_E	0.836	1.00
179_K	182_L	0.834	1.00
74_A	156_D	0.830	1.00
149_S	224_V	0.828	1.00
276_C	279_N	0.824	1.00
130_G	134_T	0.822	1.00
16_Q	44_P	0.819	1.00
173_L	293_A	0.819	1.00
7_G	33_G	0.817	1.00
276_C	283_P	0.816	1.00
181_S	203_S	0.815	1.00
169_V	297_V	0.810	1.00
116_T	277_V	0.806	1.00
26_A	29_W	0.806	1.00
46_C	51_I	0.804	1.00
116_T	276_C	0.802	1.00
6_I	23_L	0.801	1.00
209_I	212_C	0.798	1.00
28_D	271_R	0.797	1.00
36_S	41_K	0.797	1.00
110_A	115_L	0.796	1.00
147_H	226_A	0.789	1.00
172_A	202_F	0.787	1.00
118_M	276_C	0.786	1.00
92_V	106_L	0.786	1.00
110_A	287_G	0.785	1.00
7_G	35_W	0.782	1.00
45_I	48_S	0.779	1.00
32_Q	64_C	0.775	1.00
150_N	223_T	0.773	1.00
9_V	71_S	0.770	1.00
8_V	20_L	0.769	1.00
282_V	286_A	0.768	1.00
14_I	70_H	0.767	1.00
23_L	270_A	0.766	1.00
15_A	70_H	0.764	1.00
84_L	117_L	0.764	1.00
121_F	166_L	0.762	1.00
149_S	168_V	0.759	1.00
136_L	228_T	0.759	1.00
223_T	236_T	0.756	1.00
103_A	107_V	0.756	1.00
9_V	56_S	0.756	1.00
158_Y	162_L	0.754	1.00
23_L	29_W	0.752	1.00
96_L	119_V	0.751	1.00
137_A	177_G	0.745	1.00
180_A	201_H	0.744	1.00
182_L	185_G	0.741	1.00
273_F	277_V	0.740	1.00
276_C	281_T	0.740	1.00
147_H	172_A	0.739	1.00
119_V	290_A	0.737	1.00
66_A	89_H	0.734	1.00
266_F	269_C	0.734	1.00
159_F	193_G	0.733	1.00
14_I	266_F	0.732	1.00
7_G	67_V	0.729	1.00
180_A	185_G	0.728	1.00
291_V	295_R	0.727	1.00
142_L	231_A	0.724	1.00
11_L	42_A	0.723	1.00
123_R	126_A	0.722	1.00
166_L	293_A	0.721	1.00
212_C	215_R	0.720	1.00
130_G	268_G	0.717	1.00
148_R	212_C	0.713	1.00
180_A	183_D	0.711	1.00
9_V	35_W	0.711	1.00
210_T	214_H	0.711	1.00
5_R	63_S	0.706	1.00
88_V	115_L	0.704	1.00
77_F	109_L	0.701	1.00
15_A	21_P	0.698	1.00
161_L	297_V	0.691	1.00
30_T	52_P	0.690	1.00
76_H	92_V	0.690	1.00
294_Q	298_D	0.688	1.00
211_T	214_H	0.688	1.00
142_L	228_T	0.686	1.00
289_Q	292_L	0.681	1.00
121_F	170_D	0.680	1.00
257_W	260_T	0.677	1.00
124_R	174_W	0.677	1.00
193_G	301_W	0.675	1.00
176_S	202_F	0.675	1.00
84_L	106_L	0.674	1.00
179_K	292_L	0.672	1.00
45_I	49_W	0.671	1.00
94_K	167_H	0.669	1.00
67_V	88_V	0.667	1.00
81_S	84_L	0.667	1.00
143_R	204_A	0.667	1.00
161_L	196_L	0.666	1.00
121_F	293_A	0.666	1.00
165_Y	168_V	0.664	1.00
202_F	209_I	0.661	1.00
143_R	230_G	0.660	1.00
20_L	31_L	0.659	1.00
28_D	274_I	0.659	1.00
78_D	105_R	0.658	1.00
87_G	115_L	0.658	1.00
6_I	68_F	0.657	1.00
244_E	249_V	0.654	1.00
129_Y	171_T	0.653	1.00
122_N	266_F	0.652	1.00
227_V	232_L	0.652	1.00
6_I	274_I	0.651	1.00
91_C	118_M	0.650	1.00
133_K	175_L	0.650	1.00
287_G	290_A	0.650	1.00
18_A	68_F	0.650	1.00
149_S	172_A	0.649	1.00
136_L	226_A	0.649	1.00
92_V	119_V	0.643	1.00
16_Q	41_K	0.641	1.00
80_V	117_L	0.641	1.00
116_T	282_V	0.639	1.00
66_A	277_V	0.639	1.00
146_K	207_L	0.639	1.00
38_T	43_L	0.638	1.00
241_W	244_E	0.636	1.00
230_G	246_G	0.630	1.00
170_D	293_A	0.630	1.00
175_L	226_A	0.625	1.00
245_R	248_G	0.618	1.00
234_D	242_R	0.616	1.00
214_H	217_A	0.616	1.00
173_L	296_I	0.613	1.00
21_P	24_A	0.613	1.00
183_D	186_T	0.612	1.00
179_K	202_F	0.612	1.00
180_A	202_F	0.611	1.00
170_D	174_W	0.608	1.00
53_Y	62_A	0.607	1.00
151_S	164_D	0.604	1.00
146_K	227_V	0.602	1.00
169_V	300_I	0.602	1.00
272_H	283_P	0.601	1.00
213_M	216_R	0.600	1.00
16_Q	49_W	0.598	1.00
132_L	175_L	0.598	1.00
12_G	15_A	0.596	1.00
118_M	272_H	0.594	1.00
297_V	301_W	0.593	1.00
185_G	201_H	0.592	1.00
13_G	17_K	0.589	1.00
57_L	78_D	0.589	1.00
245_R	249_V	0.587	1.00
139_A	228_T	0.587	1.00
37_P	71_S	0.584	1.00
20_L	45_I	0.581	1.00
214_H	218_G	0.581	1.00
16_Q	21_P	0.580	1.00
56_S	83_L	0.577	1.00
14_I	93_D	0.576	1.00
130_G	174_W	0.575	1.00
275_E	278_Q	0.575	1.00
12_G	70_H	0.574	1.00
29_W	66_A	0.574	1.00
26_A	274_I	0.573	1.00
70_H	93_D	0.570	1.00
116_T	283_P	0.567	1.00
22_V	26_A	0.567	1.00
68_F	91_C	0.564	1.00
293_A	297_V	0.563	1.00
140_A	143_R	0.562	1.00
200_H	296_I	0.561	1.00
69_V	76_H	0.561	1.00
160_T	163_D	0.560	1.00
71_S	76_H	0.560	1.00
161_L	198_A	0.559	1.00
26_A	267_V	0.559	1.00
173_L	178_G	0.558	1.00
179_K	200_H	0.556	1.00
16_Q	45_I	0.554	1.00
136_L	175_L	0.552	1.00
123_R	170_D	0.551	1.00
35_W	53_Y	0.551	1.00
78_D	81_S	0.549	1.00
80_V	110_A	0.547	1.00
55_D	61_A	0.544	1.00
34_A	42_A	0.544	1.00
263_Q	267_V	0.544	1.00
127_P	268_G	0.543	1.00
264_R	267_V	0.539	1.00
139_A	143_R	0.538	1.00
93_D	120_G	0.537	1.00
85_N	105_R	0.535	1.00
160_T	164_D	0.535	1.00
94_K	163_D	0.535	1.00
157_L	192_A	0.534	1.00
107_V	110_A	0.534	1.00
65_D	278_Q	0.532	1.00
74_A	98_E	0.531	1.00
11_L	45_I	0.530	1.00
96_L	106_L	0.529	1.00
237_D	240_E	0.528	1.00
160_T	193_G	0.527	1.00
181_S	185_G	0.527	1.00
181_S	186_T	0.526	1.00
119_V	167_H	0.525	1.00
202_F	206_P	0.523	1.00
146_K	195_M	0.520	1.00
8_V	31_L	0.520	1.00
118_M	269_C	0.519	1.00
121_F	124_R	0.518	1.00
35_W	54_A	0.518	1.00
121_F	167_H	0.518	1.00
153_G	164_D	0.515	1.00
150_N	225_Q	0.515	1.00
162_L	298_D	0.514	1.00
116_T	273_F	0.514	1.00
8_V	68_F	0.514	1.00
15_A	20_L	0.513	1.00
57_L	86_A	0.513	1.00
9_V	69_V	0.512	1.00
167_H	170_D	0.512	1.00
4_L	29_W	0.511	1.00
209_I	214_H	0.505	1.00
150_N	221_R	0.504	1.00
133_K	177_G	0.503	1.00
243_E	246_G	0.503	1.00
199_E	207_L	0.503	1.00
15_A	45_I	0.503	1.00
123_R	237_D	0.501	1.00
168_V	222_E	0.500	1.00
161_L	165_Y	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1h6dA	8	0.9902	100	0.177	Contact Map
1zh8A	2	0.9577	100	0.189	Contact Map
3dtyA	4	0.9805	100	0.197	Contact Map
3ceaA	4	0.9902	100	0.2	Contact Map
2nvwA	3	0.9511	100	0.2	Contact Map
3ec7A	6	0.9837	100	0.202	Contact Map
3euwA	4	0.9902	100	0.203	Contact Map
3uuwA	4	0.9805	100	0.207	Contact Map
4mkxA	4	0.9837	100	0.21	Contact Map
3e9mA	2	0.9739	100	0.21	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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