GREMLIN Database
C56I - Cytochrome b561 homolog 2
UniProt: P75925 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12659
Length: 188 (174)
Sequences: 2691 (1995)
Seq/√Len: 151.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
165_K170_D5.5011.00
164_L168_F3.4651.00
109_Y113_T3.1901.00
21_S63_L3.0071.00
25_V101_L2.7711.00
14_S69_W2.7181.00
83_S86_T2.4991.00
11_G73_S2.4621.00
54_S122_F2.4051.00
167_H176_K2.3441.00
88_L91_R2.2351.00
13_I69_W2.2081.00
167_H174_T2.2031.00
21_S101_L2.1751.00
15_A180_G2.1721.00
95_L99_L2.1671.00
93_G158_M2.1551.00
11_G69_W2.0931.00
21_S62_G2.0711.00
16_A20_L1.8681.00
32_G35_M1.8571.00
167_H175_L1.7951.00
58_L121_V1.7901.00
11_G14_S1.7571.00
63_L101_L1.7391.00
157_V161_F1.7121.00
63_L102_F1.6621.00
92_A95_L1.6581.00
110_L141_A1.6371.00
14_S73_S1.6141.00
17_F65_I1.6111.00
143_A146_F1.6081.00
53_K112_S1.5881.00
84_P88_L1.5661.00
156_S160_G1.5651.00
28_M59_L1.5481.00
103_A148_L1.5421.00
167_H173_D1.5311.00
144_L148_L1.4811.00
150_W154_V1.4711.00
173_D176_K1.4621.00
40_Y45_Y1.4561.00
9_R15_A1.4511.00
154_V158_M1.4151.00
60_M105_G1.4091.00
88_L92_A1.4001.00
121_V125_F1.3881.00
26_Y30_A1.3831.00
137_Q140_F1.3591.00
69_W73_S1.3201.00
93_G162_M1.3031.00
86_T165_K1.2931.00
29_F156_S1.2811.00
84_P87_R1.2581.00
104_I149_A1.2571.00
104_I148_L1.2501.00
35_M49_P1.2411.00
49_P53_K1.2181.00
111_I142_G1.2101.00
114_A131_L1.2091.00
134_A137_Q1.1971.00
9_R180_G1.1901.00
51_L55_I1.1851.00
34_W38_L1.1711.00
158_M161_F1.1701.00
174_T177_R1.1671.00
92_A96_A1.1611.00
60_M64_V1.1561.00
120_S126_D1.1511.00
57_I121_V1.1501.00
13_I16_A1.1491.00
104_I107_S1.1381.00
87_R91_R1.1371.00
113_T130_T1.1301.00
51_L54_S1.1240.99
107_S141_A1.1210.99
107_S144_L1.1190.99
107_S149_A1.1140.99
79_L174_T1.1090.99
99_L103_A1.0990.99
96_A155_L1.0960.99
109_Y114_A1.0950.99
158_M162_M1.0930.99
12_V15_A1.0690.99
44_W48_A1.0490.99
98_Y101_L1.0410.99
101_L105_G1.0240.99
114_A138_A1.0230.99
113_T129_A1.0230.99
163_A167_H1.0200.99
17_F69_W1.0170.99
152_V156_S1.0160.99
32_G149_A1.0110.99
67_V102_F1.0070.99
46_H49_P1.0060.99
169_I172_D1.0030.99
30_A34_W0.9940.99
147_W151_S0.9830.99
60_M109_Y0.9760.99
160_G163_A0.9750.99
79_L173_D0.9710.99
112_S119_I0.9710.99
147_W150_W0.9500.98
79_L82_Y0.9480.98
139_D143_A0.9370.98
78_P82_Y0.9340.98
78_P91_R0.9310.98
85_M88_L0.9290.98
148_L151_S0.9230.98
46_H50_E0.9220.98
12_V16_A0.9180.98
146_F150_W0.9160.98
70_R75_P0.8930.97
121_V124_W0.8860.97
63_L105_G0.8850.97
22_A26_Y0.8820.97
27_G55_I0.8800.97
38_L48_A0.8710.97
25_V152_V0.8710.97
67_V95_L0.8620.97
59_L63_L0.8560.97
47_K51_L0.8490.97
68_L72_I0.8470.97
57_I61_M0.8420.96
136_A140_F0.8330.96
25_V63_L0.8320.96
109_Y128_P0.8300.96
97_L156_S0.8260.96
119_I127_V0.8130.96
52_H56_G0.8120.96
106_I110_L0.8090.95
91_R95_L0.8030.95
32_G153_V0.7930.95
24_I59_L0.7820.95
109_Y130_T0.7770.94
14_S17_F0.7710.94
131_L134_A0.7700.94
144_L147_W0.7700.94
64_V68_L0.7670.94
106_I109_Y0.7650.94
31_L48_A0.7610.94
175_L178_M0.7600.94
39_S42_D0.7530.93
28_M55_I0.7510.93
161_F165_K0.7420.93
154_V157_V0.7410.93
57_I119_I0.7360.93
102_F106_I0.7310.92
24_I55_I0.7290.92
61_M68_L0.7260.92
15_A179_L0.7230.92
29_F33_L0.7220.92
90_A93_G0.7220.92
114_A141_A0.7180.92
14_S75_P0.7160.92
50_E123_G0.6970.90
107_S110_L0.6970.90
153_V157_V0.6950.90
39_S45_Y0.6920.90
10_Y14_S0.6810.89
50_E112_S0.6800.89
46_H117_K0.6710.89
135_G139_D0.6630.88
168_F171_K0.6530.87
79_L177_R0.6490.87
110_L132_A0.6460.87
49_P142_G0.6460.87
164_L172_D0.6340.86
116_G129_A0.6330.86
115_D138_A0.6330.86
151_S155_L0.6320.86
78_P174_T0.6310.86
58_L122_F0.6290.85
45_Y49_P0.6290.85
13_I65_I0.6280.85
89_A92_A0.6280.85
139_D142_G0.6260.85
13_I73_S0.6260.85
64_V102_F0.6240.85
100_L151_S0.6220.85
89_A93_G0.6190.84
33_L37_T0.6180.84
89_A162_M0.6170.84
33_L153_V0.6150.84
66_R98_Y0.6110.84
176_K179_L0.6110.84
50_E119_I0.6090.83
60_M63_L0.6040.83
27_G31_L0.6030.83
68_L71_V0.6000.83
118_P126_D0.6000.83
110_L114_A0.5990.82
119_I129_A0.5970.82
88_L171_K0.5940.82
85_M89_A0.5940.82
81_S87_R0.5930.82
82_Y86_T0.5920.82
34_W37_T0.5880.81
100_L152_V0.5870.81
110_L131_L0.5850.81
11_G74_P0.5840.81
12_V180_G0.5830.81
50_E54_S0.5810.81
93_G155_L0.5800.80
32_G49_P0.5790.80
104_I152_V0.5780.80
21_S28_M0.5750.80
78_P81_S0.5750.80
42_D45_Y0.5720.80
153_V156_S0.5710.79
22_A29_F0.5680.79
137_Q141_A0.5640.79
96_A100_L0.5640.79
167_H171_K0.5590.78
120_S123_G0.5580.78
97_L101_L0.5540.77
61_M65_I0.5540.77
156_S161_F0.5530.77
21_S98_Y0.5490.77
38_L153_V0.5460.76
75_P91_R0.5440.76
107_S111_I0.5440.76
100_L148_L0.5430.76
14_S72_I0.5400.76
163_A178_M0.5390.75
100_L155_L0.5390.75
29_F153_V0.5380.75
36_V150_W0.5360.75
36_V39_S0.5350.75
13_I72_I0.5350.75
34_W48_A0.5350.75
24_I28_M0.5350.75
94_H162_M0.5340.75
150_W157_V0.5320.74
82_Y174_T0.5310.74
175_L179_L0.5290.74
29_F35_M0.5290.74
117_K129_A0.5290.74
165_K169_I0.5260.74
109_Y118_P0.5240.73
107_S148_L0.5240.73
126_D129_A0.5220.73
103_A151_S0.5210.73
31_L37_T0.5210.73
30_A33_L0.5200.73
31_L55_I0.5170.72
78_P87_R0.5160.72
111_I115_D0.5160.72
134_A138_A0.5150.72
110_L149_A0.5110.72
54_S120_S0.5110.72
171_K176_K0.5100.71
37_T42_D0.5100.71
162_M172_D0.5090.71
81_S170_D0.5080.71
14_S74_P0.5060.71
38_L45_Y0.5050.71
45_Y112_S0.5030.70
52_H145_H0.5000.70
150_W153_V0.5000.70
68_L106_I0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kqfC 3 0.8936 100 0.498 Contact Map
4gd3A 2 0.8032 100 0.5 Contact Map
4o6yA 2 0.7819 69.1 0.923 Contact Map
3cx5C 2 0.6277 18.6 0.945 Contact Map
1pp9C 2 0.8777 18.4 0.945 Contact Map
1q16C 2 0.8936 15.3 0.947 Contact Map
1qleD 1 0.1915 14.7 0.948 Contact Map
1m56D 1 0.1915 13.5 0.948 Contact Map
2qjyA 2 0.6862 9.8 0.952 Contact Map
4i0uA 4 0.383 6.3 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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