GREMLIN Database
OPGC - Glucans biosynthesis protein C
UniProt: P75920 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13876
Length: 385 (322)
Sequences: 14621 (12893)
Seq/√Len: 718.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_R13_D4.2121.00
307_Y311_A3.7381.00
353_I357_E3.7281.00
318_V355_L3.5121.00
24_I315_I3.4581.00
19_L62_V3.3621.00
88_V92_G3.1501.00
84_W154_V3.1491.00
72_Y228_A3.0601.00
357_E361_R2.9131.00
142_F146_L2.7901.00
17_A309_V2.7591.00
311_A353_I2.7551.00
307_Y353_I2.7311.00
80_L84_W2.5921.00
13_D310_N2.5821.00
81_K85_K2.4451.00
348_V352_A2.4361.00
95_M140_L2.2901.00
28_I323_T2.2901.00
307_Y357_E2.2871.00
61_Q223_F2.2451.00
98_A318_V2.1831.00
80_L154_V2.1831.00
354_I358_I2.1421.00
92_G96_L2.1301.00
17_A312_S2.1251.00
56_H59_R2.0891.00
64_F145_V1.9841.00
70_F73_M1.9331.00
361_R365_L1.9071.00
73_M77_R1.8841.00
17_A308_F1.8751.00
187_G191_A1.8681.00
191_A195_R1.8631.00
14_S301_Q1.8581.00
220_Y223_F1.8291.00
314_F356_Y1.8281.00
13_D306_T1.8161.00
284_L287_V1.8111.00
79_P82_K1.8061.00
20_M315_I1.8001.00
26_F56_H1.7991.00
98_A317_L1.7751.00
73_M231_F1.7741.00
85_K89_E1.7541.00
65_V230_A1.7351.00
138_S320_H1.7311.00
12_L66_I1.6881.00
311_A352_A1.6641.00
72_Y153_C1.6571.00
314_F355_L1.6481.00
315_I348_V1.6481.00
315_I352_A1.6461.00
117_A120_W1.6141.00
75_F153_C1.6001.00
94_P317_L1.5951.00
12_L70_F1.5901.00
15_I62_V1.5601.00
193_I197_I1.5551.00
285_W289_V1.5451.00
71_S153_C1.5191.00
307_Y310_N1.5071.00
23_G60_M1.5031.00
302_S305_V1.4901.00
70_F74_L1.4551.00
119_S122_G1.4221.00
218_L222_P1.4141.00
97_T359_H1.4041.00
287_V291_F1.3941.00
287_V290_V1.3921.00
146_L150_T1.3771.00
280_M283_G1.3741.00
295_H298_L1.3661.00
356_Y360_L1.3581.00
72_Y76_L1.3581.00
101_L318_V1.3521.00
102_L321_P1.3461.00
306_T310_N1.3451.00
126_Y129_Y1.3381.00
9_E69_Y1.3361.00
258_Y261_N1.3321.00
311_A314_F1.3291.00
282_L285_W1.3231.00
356_Y361_R1.3081.00
322_L351_I1.3071.00
87_R150_T1.2951.00
19_L59_R1.2891.00
130_N133_A1.2871.00
304_R308_F1.2781.00
187_G195_R1.2761.00
144_L148_V1.2641.00
82_K86_V1.2581.00
71_S150_T1.2571.00
283_G287_V1.2561.00
311_A315_I1.2521.00
338_W342_L1.2491.00
64_F146_L1.2391.00
69_Y231_F1.2361.00
279_T282_L1.2351.00
92_G147_V1.2311.00
326_F344_G1.2271.00
94_P355_L1.2271.00
303_A307_Y1.2241.00
258_Y262_Q1.2221.00
149_M224_F1.2191.00
67_S146_L1.2181.00
153_C224_F1.2081.00
319_H323_T1.2081.00
139_H320_H1.2051.00
361_R366_K1.2041.00
190_Y194_R1.1971.00
17_A21_L1.1871.00
346_I350_G1.1851.00
344_G348_V1.1811.00
127_D131_T1.1781.00
17_A305_V1.1741.00
194_R198_F1.1721.00
72_Y232_I1.1691.00
141_W145_V1.1631.00
22_L59_R1.1601.00
75_F78_Y1.1581.00
342_L346_I1.1571.00
151_T154_V1.1561.00
61_Q220_Y1.1491.00
250_A254_A1.1461.00
158_K162_N1.1451.00
98_A140_L1.1441.00
247_C251_A1.1401.00
241_T244_S1.1391.00
98_A102_L1.1341.00
14_S305_V1.1321.00
72_Y231_F1.1031.00
84_W147_V1.0981.00
88_V147_V1.0931.00
318_V321_P1.0881.00
351_I355_L1.0881.00
313_L317_L1.0881.00
277_V280_M1.0871.00
93_I97_T1.0851.00
285_W288_N1.0761.00
121_P124_S1.0751.00
94_P314_F1.0731.00
69_Y234_P1.0711.00
118_E121_P1.0651.00
314_F360_L1.0651.00
238_A241_T1.0541.00
323_T344_G1.0501.00
71_S74_L1.0491.00
83_W150_T1.0481.00
355_L359_H1.0451.00
82_K85_K1.0411.00
134_W137_I1.0411.00
286_M289_V1.0331.00
100_P104_L1.0261.00
249_L253_L1.0261.00
178_K182_I1.0241.00
288_N292_S1.0211.00
177_V180_S1.0211.00
336_S339_L1.0201.00
9_E73_M1.0191.00
364_L367_F1.0161.00
328_A332_P1.0071.00
153_C228_A1.0061.00
20_M142_F0.9951.00
91_V150_T0.9951.00
251_A254_A0.9951.00
23_G59_R0.9911.00
20_M63_F0.9891.00
350_G354_I0.9871.00
191_A194_R0.9861.00
56_H60_M0.9811.00
145_V220_Y0.9771.00
180_S183_F0.9761.00
315_I349_V0.9701.00
192_V196_T0.9691.00
214_V220_Y0.9681.00
339_L342_L0.9681.00
186_L190_Y0.9651.00
293_F296_R0.9591.00
296_R299_N0.9541.00
119_S124_S0.9531.00
276_S279_T0.9511.00
254_A258_Y0.9491.00
242_T245_R0.9481.00
95_M313_L0.9471.00
303_A306_T0.9431.00
104_L108_I0.9351.00
24_I345_L0.9331.00
118_E122_G0.9321.00
140_L317_L0.9321.00
22_L58_F0.9311.00
24_I319_H0.9291.00
257_A261_N0.9271.00
352_A356_Y0.9231.00
239_L242_T0.9221.00
284_L288_N0.9181.00
14_S302_S0.9171.00
275_E280_M0.9171.00
139_H316_Y0.9151.00
297_L300_F0.9121.00
181_V184_L0.9111.00
179_L183_F0.9101.00
13_D309_V0.9071.00
363_P367_F0.9061.00
226_L284_L0.9061.00
83_W87_R0.9031.00
245_R249_L0.8981.00
248_T252_A0.8951.00
224_F228_A0.8951.00
355_L358_I0.8951.00
251_A255_F0.8881.00
26_F57_S0.8871.00
216_Q220_Y0.8841.00
26_F59_R0.8831.00
306_T309_V0.8821.00
318_V351_I0.8781.00
143_L317_L0.8771.00
322_L326_F0.8751.00
216_Q219_F0.8731.00
311_A357_E0.8671.00
16_R66_I0.8651.00
11_F14_S0.8631.00
132_L136_L0.8591.00
195_R199_I0.8581.00
222_P225_I0.8581.00
83_W154_V0.8571.00
119_S123_L0.8491.00
296_R300_F0.8471.00
243_P246_G0.8471.00
46_L49_T0.8461.00
89_E92_G0.8431.00
240_F243_P0.8431.00
311_A356_Y0.8401.00
139_H321_P0.8351.00
22_L26_F0.8351.00
282_L286_M0.8321.00
286_M290_V0.8311.00
276_S280_M0.8291.00
128_K131_T0.8281.00
236_L239_L0.8271.00
281_V285_W0.8251.00
74_L77_R0.8231.00
225_I228_A0.8181.00
128_K133_A0.8181.00
61_Q219_F0.8141.00
17_A20_M0.8141.00
292_S295_H0.8121.00
180_S184_L0.8091.00
318_V352_A0.8061.00
303_A310_N0.8051.00
190_Y193_I0.8051.00
273_E280_M0.8041.00
104_L107_F0.8001.00
183_F187_G0.7981.00
308_F349_V0.7961.00
276_S283_G0.7951.00
319_H348_V0.7951.00
90_R146_L0.7891.00
13_D16_R0.7871.00
217_T220_Y0.7871.00
155_W159_R0.7841.00
145_V149_M0.7821.00
283_G286_M0.7811.00
161_R165_E0.7811.00
275_E282_L0.7811.00
68_G228_A0.7791.00
10_Y13_D0.7771.00
87_R146_L0.7711.00
270_W273_E0.7701.00
46_L50_L0.7681.00
301_Q304_R0.7611.00
139_H319_H0.7611.00
301_Q306_T0.7601.00
16_R142_F0.7531.00
275_E279_T0.7521.00
99_I103_T0.7511.00
177_V181_V0.7471.00
21_L25_P0.7421.00
272_Y277_V0.7401.00
279_T283_G0.7381.00
8_R306_T0.7381.00
358_I363_P0.7381.00
178_K181_V0.7381.00
357_E363_P0.7361.00
65_V223_F0.7351.00
23_G142_F0.7311.00
28_I344_G0.7291.00
190_Y195_R0.7211.00
102_L139_H0.7171.00
194_R197_I0.7161.00
284_L292_S0.7151.00
59_R149_M0.7141.00
273_E276_S0.7121.00
272_Y276_S0.7121.00
248_T251_A0.7121.00
302_S306_T0.7101.00
71_S83_W0.7101.00
272_Y275_E0.7101.00
64_F141_W0.7091.00
274_T277_V0.7091.00
64_F142_F0.7041.00
105_P109_M0.6981.00
75_F157_F0.6961.00
28_I341_F0.6951.00
76_L232_I0.6931.00
14_S17_A0.6921.00
111_Q114_K0.6921.00
214_V217_T0.6921.00
64_F220_Y0.6911.00
60_M63_F0.6911.00
154_V158_K0.6911.00
326_F330_I0.6911.00
326_F340_G0.6871.00
149_M154_V0.6841.00
310_N361_R0.6841.00
238_A242_T0.6831.00
102_L106_Q0.6821.00
161_R164_L0.6811.00
28_I348_V0.6761.00
15_I66_I0.6761.00
67_S71_S0.6761.00
326_F329_Y0.6761.00
91_V146_L0.6761.00
67_S224_F0.6751.00
147_V224_F0.6731.00
159_R163_N0.6731.00
278_I282_L0.6731.00
254_A257_A0.6701.00
20_M59_R0.6691.00
89_E364_L0.6671.00
24_I348_V0.6661.00
232_I236_L0.6661.00
181_V185_C0.6641.00
318_V348_V0.6641.00
125_L128_K0.6641.00
193_I196_T0.6631.00
234_P237_K0.6631.00
87_R142_F0.6631.00
187_G190_Y0.6601.00
120_W124_S0.6571.00
235_H238_A0.6541.00
304_R307_Y0.6511.00
127_D132_L0.6501.00
18_W22_L0.6491.00
20_M308_F0.6481.00
26_F61_Q0.6471.00
248_T255_F0.6451.00
16_R146_L0.6431.00
45_S49_T0.6431.00
259_L262_Q0.6431.00
71_S224_F0.6421.00
305_V309_V0.6401.00
246_G250_A0.6401.00
149_M220_Y0.6401.00
146_L313_L0.6391.00
216_Q223_F0.6381.00
255_F258_Y0.6381.00
324_L328_A0.6371.00
188_I192_V0.6361.00
14_S306_T0.6331.00
228_A232_I0.6331.00
101_L105_P0.6321.00
289_V293_F0.6311.00
95_M99_I0.6281.00
340_G344_G0.6281.00
97_T101_L0.6261.00
131_T137_I0.6241.00
339_L343_C0.6231.00
253_L257_A0.6211.00
57_S61_Q0.6211.00
182_I186_L0.6211.00
71_S147_V0.6201.00
159_R162_N0.6171.00
185_C189_G0.6151.00
20_M24_I0.6121.00
239_L243_P0.6121.00
246_G249_L0.6111.00
213_I217_T0.6071.00
276_S287_V0.6061.00
87_R90_R0.6051.00
195_R198_F0.6051.00
179_L182_I0.6041.00
107_F111_Q0.6031.00
225_I229_L0.6031.00
320_H323_T0.6011.00
78_Y82_K0.6001.00
325_F329_Y0.5991.00
343_C347_F0.5971.00
157_F161_R0.5941.00
336_S340_G0.5941.00
340_G343_C0.5931.00
145_V148_V0.5931.00
279_T291_F0.5891.00
103_T106_Q0.5881.00
287_V294_G0.5861.00
249_L252_A0.5861.00
341_F344_G0.5851.00
149_M153_C0.5851.00
280_M291_F0.5841.00
64_F149_M0.5831.00
363_P366_K0.5811.00
322_L325_F0.5811.00
131_T134_W0.5811.00
49_T53_D0.5801.00
295_H299_N0.5791.00
92_G95_M0.5781.00
83_W153_C0.5751.00
325_F328_A0.5741.00
125_L131_T0.5731.00
91_V147_V0.5731.00
98_A355_L0.5731.00
20_M309_V0.5711.00
292_S296_R0.5701.00
19_L60_M0.5681.00
277_V281_V0.5651.00
10_Y306_T0.5651.00
142_F313_L0.5641.00
145_V217_T0.5641.00
115_G119_S0.5621.00
322_L347_F0.5611.00
294_G298_L0.5601.00
187_G193_I0.5581.00
308_F315_I0.5581.00
162_N165_E0.5571.00
67_S142_F0.5561.00
20_M23_G0.5541.00
23_G146_L0.5541.00
91_V313_L0.5541.00
23_G56_H0.5511.00
8_R310_N0.5511.00
140_L143_L0.5511.00
73_M234_P0.5501.00
280_M284_L0.5491.00
271_M276_S0.5471.00
20_M312_S0.5461.00
76_L231_F0.5461.00
247_C250_A0.5451.00
229_L233_F0.5451.00
338_W341_F0.5451.00
143_L313_L0.5431.00
47_W50_L0.5431.00
90_R93_I0.5421.00
249_L260_L0.5421.00
71_S146_L0.5381.00
108_I111_Q0.5351.00
354_I357_E0.5341.00
129_Y133_A0.5341.00
147_V151_T0.5341.00
345_L348_V0.5341.00
219_F223_F0.5321.00
256_V261_N0.5321.00
68_G141_W0.5311.00
245_R248_T0.5271.00
55_I59_R0.5261.00
12_L69_Y0.5261.00
233_F237_K0.5251.00
330_I333_H0.5231.00
231_F234_P0.5221.00
223_F228_A0.5191.00
62_V66_I0.5171.00
14_S300_F0.5171.00
23_G27_H0.5131.00
137_I140_L0.5131.00
196_T199_I0.5131.00
17_A311_A0.5131.00
124_S127_D0.5111.00
58_F62_V0.5101.00
359_H364_L0.5101.00
248_T259_L0.5070.99
342_L345_L0.5070.99
341_F345_L0.5070.99
89_E365_L0.5060.99
142_F316_Y0.5040.99
343_C346_I0.5040.99
103_T107_F0.5040.99
293_F297_L0.5030.99
272_Y279_T0.5020.99
20_M146_L0.5020.99
117_A122_G0.5020.99
7_Q10_Y0.5010.99
310_N320_H0.5010.99
322_L344_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4j72A 2 0.0987 9.4 0.954 Contact Map
3udcA 3 0.1299 5.9 0.958 Contact Map
4ldsA 2 0.4987 5.4 0.959 Contact Map
3j1zP 8 0.3766 4.9 0.96 Contact Map
2kluA 1 0.1221 4.7 0.96 Contact Map
4czbA 2 0.8597 3.9 0.962 Contact Map
2cfqA 1 0.5403 3.5 0.963 Contact Map
2ad6B 1 0.0597 3.3 0.963 Contact Map
2kv5A 1 0.0857 2.6 0.965 Contact Map
4px7A 1 0.5013 2.4 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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