OPGC - ECOLI - GREMLIN Contacts

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OPGC - Glucans biosynthesis protein C

UniProt:	P75920	Sequences: MNPVPAQREYFLDSIRAWLMLLGIPFHISLIYSSHTWHVNSAESSLWLTLFNDFIHSFRMQVFFVISGYFSYMLFLRYPLKKWWKVRVERVGIPMLTAIPLLTLPQFIMLQYVKGKAESWPGLSLYDKYNTLAWELISHLWFLLVLVVMTTLCVWIFKRIRNNLENSDKTNKKFSMVKLSVIFLCLGIGYAVIRRTIFIVYPPILSNGMFNFIVMQTLFYLPFFILGALAFIFPHLKALFTTPSRGCTLAAALAFVAYLLNQRYGSGDAWMYETESVITMVLGLWMVNVVFSFGHRLLNFQSARVTYFVNASLFIYLVHHPLTLFFGAYITPHITSNWLGFLCGLIFVVGIAIILYEIHLRIPLLKFLFSGKPVVKRENDKAPAR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13876
Length:	385 (322)
Sequences:	14621 (12893)
Seq/√Len:	718.5

ECOLI - OPGC YCFT YIAH
BACSU - YFIQ YRHL YKRP

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
8_R	13_D	4.212	1.00
307_Y	311_A	3.738	1.00
353_I	357_E	3.728	1.00
318_V	355_L	3.512	1.00
24_I	315_I	3.458	1.00
19_L	62_V	3.362	1.00
88_V	92_G	3.150	1.00
84_W	154_V	3.149	1.00
72_Y	228_A	3.060	1.00
357_E	361_R	2.913	1.00
142_F	146_L	2.790	1.00
17_A	309_V	2.759	1.00
311_A	353_I	2.755	1.00
307_Y	353_I	2.731	1.00
80_L	84_W	2.592	1.00
13_D	310_N	2.582	1.00
81_K	85_K	2.445	1.00
348_V	352_A	2.436	1.00
95_M	140_L	2.290	1.00
28_I	323_T	2.290	1.00
307_Y	357_E	2.287	1.00
61_Q	223_F	2.245	1.00
98_A	318_V	2.183	1.00
80_L	154_V	2.183	1.00
354_I	358_I	2.142	1.00
92_G	96_L	2.130	1.00
17_A	312_S	2.125	1.00
56_H	59_R	2.089	1.00
64_F	145_V	1.984	1.00
70_F	73_M	1.933	1.00
361_R	365_L	1.907	1.00
73_M	77_R	1.884	1.00
17_A	308_F	1.875	1.00
187_G	191_A	1.868	1.00
191_A	195_R	1.863	1.00
14_S	301_Q	1.858	1.00
220_Y	223_F	1.829	1.00
314_F	356_Y	1.828	1.00
13_D	306_T	1.816	1.00
284_L	287_V	1.811	1.00
79_P	82_K	1.806	1.00
20_M	315_I	1.800	1.00
26_F	56_H	1.799	1.00
98_A	317_L	1.775	1.00
73_M	231_F	1.774	1.00
85_K	89_E	1.754	1.00
65_V	230_A	1.735	1.00
138_S	320_H	1.731	1.00
12_L	66_I	1.688	1.00
311_A	352_A	1.664	1.00
72_Y	153_C	1.657	1.00
314_F	355_L	1.648	1.00
315_I	348_V	1.648	1.00
315_I	352_A	1.646	1.00
117_A	120_W	1.614	1.00
75_F	153_C	1.600	1.00
94_P	317_L	1.595	1.00
12_L	70_F	1.590	1.00
15_I	62_V	1.560	1.00
193_I	197_I	1.555	1.00
285_W	289_V	1.545	1.00
71_S	153_C	1.519	1.00
307_Y	310_N	1.507	1.00
23_G	60_M	1.503	1.00
302_S	305_V	1.490	1.00
70_F	74_L	1.455	1.00
119_S	122_G	1.422	1.00
218_L	222_P	1.414	1.00
97_T	359_H	1.404	1.00
287_V	291_F	1.394	1.00
287_V	290_V	1.392	1.00
146_L	150_T	1.377	1.00
280_M	283_G	1.374	1.00
295_H	298_L	1.366	1.00
356_Y	360_L	1.358	1.00
72_Y	76_L	1.358	1.00
101_L	318_V	1.352	1.00
102_L	321_P	1.346	1.00
306_T	310_N	1.345	1.00
126_Y	129_Y	1.338	1.00
9_E	69_Y	1.336	1.00
258_Y	261_N	1.332	1.00
311_A	314_F	1.329	1.00
282_L	285_W	1.323	1.00
356_Y	361_R	1.308	1.00
322_L	351_I	1.307	1.00
87_R	150_T	1.295	1.00
19_L	59_R	1.289	1.00
130_N	133_A	1.287	1.00
304_R	308_F	1.278	1.00
187_G	195_R	1.276	1.00
144_L	148_V	1.264	1.00
82_K	86_V	1.258	1.00
71_S	150_T	1.257	1.00
283_G	287_V	1.256	1.00
311_A	315_I	1.252	1.00
338_W	342_L	1.249	1.00
64_F	146_L	1.239	1.00
69_Y	231_F	1.236	1.00
279_T	282_L	1.235	1.00
92_G	147_V	1.231	1.00
326_F	344_G	1.227	1.00
94_P	355_L	1.227	1.00
303_A	307_Y	1.224	1.00
258_Y	262_Q	1.222	1.00
149_M	224_F	1.219	1.00
67_S	146_L	1.218	1.00
153_C	224_F	1.208	1.00
319_H	323_T	1.208	1.00
139_H	320_H	1.205	1.00
361_R	366_K	1.204	1.00
190_Y	194_R	1.197	1.00
17_A	21_L	1.187	1.00
346_I	350_G	1.185	1.00
344_G	348_V	1.181	1.00
127_D	131_T	1.178	1.00
17_A	305_V	1.174	1.00
194_R	198_F	1.172	1.00
72_Y	232_I	1.169	1.00
141_W	145_V	1.163	1.00
22_L	59_R	1.160	1.00
75_F	78_Y	1.158	1.00
342_L	346_I	1.157	1.00
151_T	154_V	1.156	1.00
61_Q	220_Y	1.149	1.00
250_A	254_A	1.146	1.00
158_K	162_N	1.145	1.00
98_A	140_L	1.144	1.00
247_C	251_A	1.140	1.00
241_T	244_S	1.139	1.00
98_A	102_L	1.134	1.00
14_S	305_V	1.132	1.00
72_Y	231_F	1.103	1.00
84_W	147_V	1.098	1.00
88_V	147_V	1.093	1.00
318_V	321_P	1.088	1.00
351_I	355_L	1.088	1.00
313_L	317_L	1.088	1.00
277_V	280_M	1.087	1.00
93_I	97_T	1.085	1.00
285_W	288_N	1.076	1.00
121_P	124_S	1.075	1.00
94_P	314_F	1.073	1.00
69_Y	234_P	1.071	1.00
118_E	121_P	1.065	1.00
314_F	360_L	1.065	1.00
238_A	241_T	1.054	1.00
323_T	344_G	1.050	1.00
71_S	74_L	1.049	1.00
83_W	150_T	1.048	1.00
355_L	359_H	1.045	1.00
82_K	85_K	1.041	1.00
134_W	137_I	1.041	1.00
286_M	289_V	1.033	1.00
100_P	104_L	1.026	1.00
249_L	253_L	1.026	1.00
178_K	182_I	1.024	1.00
288_N	292_S	1.021	1.00
177_V	180_S	1.021	1.00
336_S	339_L	1.020	1.00
9_E	73_M	1.019	1.00
364_L	367_F	1.016	1.00
328_A	332_P	1.007	1.00
153_C	228_A	1.006	1.00
20_M	142_F	0.995	1.00
91_V	150_T	0.995	1.00
251_A	254_A	0.995	1.00
23_G	59_R	0.991	1.00
20_M	63_F	0.989	1.00
350_G	354_I	0.987	1.00
191_A	194_R	0.986	1.00
56_H	60_M	0.981	1.00
145_V	220_Y	0.977	1.00
180_S	183_F	0.976	1.00
315_I	349_V	0.970	1.00
192_V	196_T	0.969	1.00
214_V	220_Y	0.968	1.00
339_L	342_L	0.968	1.00
186_L	190_Y	0.965	1.00
293_F	296_R	0.959	1.00
296_R	299_N	0.954	1.00
119_S	124_S	0.953	1.00
276_S	279_T	0.951	1.00
254_A	258_Y	0.949	1.00
242_T	245_R	0.948	1.00
95_M	313_L	0.947	1.00
303_A	306_T	0.943	1.00
104_L	108_I	0.935	1.00
24_I	345_L	0.933	1.00
118_E	122_G	0.932	1.00
140_L	317_L	0.932	1.00
22_L	58_F	0.931	1.00
24_I	319_H	0.929	1.00
257_A	261_N	0.927	1.00
352_A	356_Y	0.923	1.00
239_L	242_T	0.922	1.00
284_L	288_N	0.918	1.00
14_S	302_S	0.917	1.00
275_E	280_M	0.917	1.00
139_H	316_Y	0.915	1.00
297_L	300_F	0.912	1.00
181_V	184_L	0.911	1.00
179_L	183_F	0.910	1.00
13_D	309_V	0.907	1.00
363_P	367_F	0.906	1.00
226_L	284_L	0.906	1.00
83_W	87_R	0.903	1.00
245_R	249_L	0.898	1.00
248_T	252_A	0.895	1.00
224_F	228_A	0.895	1.00
355_L	358_I	0.895	1.00
251_A	255_F	0.888	1.00
26_F	57_S	0.887	1.00
216_Q	220_Y	0.884	1.00
26_F	59_R	0.883	1.00
306_T	309_V	0.882	1.00
318_V	351_I	0.878	1.00
143_L	317_L	0.877	1.00
322_L	326_F	0.875	1.00
216_Q	219_F	0.873	1.00
311_A	357_E	0.867	1.00
16_R	66_I	0.865	1.00
11_F	14_S	0.863	1.00
132_L	136_L	0.859	1.00
195_R	199_I	0.858	1.00
222_P	225_I	0.858	1.00
83_W	154_V	0.857	1.00
119_S	123_L	0.849	1.00
296_R	300_F	0.847	1.00
243_P	246_G	0.847	1.00
46_L	49_T	0.846	1.00
89_E	92_G	0.843	1.00
240_F	243_P	0.843	1.00
311_A	356_Y	0.840	1.00
139_H	321_P	0.835	1.00
22_L	26_F	0.835	1.00
282_L	286_M	0.832	1.00
286_M	290_V	0.831	1.00
276_S	280_M	0.829	1.00
128_K	131_T	0.828	1.00
236_L	239_L	0.827	1.00
281_V	285_W	0.825	1.00
74_L	77_R	0.823	1.00
225_I	228_A	0.818	1.00
128_K	133_A	0.818	1.00
61_Q	219_F	0.814	1.00
17_A	20_M	0.814	1.00
292_S	295_H	0.812	1.00
180_S	184_L	0.809	1.00
318_V	352_A	0.806	1.00
303_A	310_N	0.805	1.00
190_Y	193_I	0.805	1.00
273_E	280_M	0.804	1.00
104_L	107_F	0.800	1.00
183_F	187_G	0.798	1.00
308_F	349_V	0.796	1.00
276_S	283_G	0.795	1.00
319_H	348_V	0.795	1.00
90_R	146_L	0.789	1.00
13_D	16_R	0.787	1.00
217_T	220_Y	0.787	1.00
155_W	159_R	0.784	1.00
145_V	149_M	0.782	1.00
283_G	286_M	0.781	1.00
161_R	165_E	0.781	1.00
275_E	282_L	0.781	1.00
68_G	228_A	0.779	1.00
10_Y	13_D	0.777	1.00
87_R	146_L	0.771	1.00
270_W	273_E	0.770	1.00
46_L	50_L	0.768	1.00
301_Q	304_R	0.761	1.00
139_H	319_H	0.761	1.00
301_Q	306_T	0.760	1.00
16_R	142_F	0.753	1.00
275_E	279_T	0.752	1.00
99_I	103_T	0.751	1.00
177_V	181_V	0.747	1.00
21_L	25_P	0.742	1.00
272_Y	277_V	0.740	1.00
279_T	283_G	0.738	1.00
8_R	306_T	0.738	1.00
358_I	363_P	0.738	1.00
178_K	181_V	0.738	1.00
357_E	363_P	0.736	1.00
65_V	223_F	0.735	1.00
23_G	142_F	0.731	1.00
28_I	344_G	0.729	1.00
190_Y	195_R	0.721	1.00
102_L	139_H	0.717	1.00
194_R	197_I	0.716	1.00
284_L	292_S	0.715	1.00
59_R	149_M	0.714	1.00
273_E	276_S	0.712	1.00
272_Y	276_S	0.712	1.00
248_T	251_A	0.712	1.00
302_S	306_T	0.710	1.00
71_S	83_W	0.710	1.00
272_Y	275_E	0.710	1.00
64_F	141_W	0.709	1.00
274_T	277_V	0.709	1.00
64_F	142_F	0.704	1.00
105_P	109_M	0.698	1.00
75_F	157_F	0.696	1.00
28_I	341_F	0.695	1.00
76_L	232_I	0.693	1.00
14_S	17_A	0.692	1.00
111_Q	114_K	0.692	1.00
214_V	217_T	0.692	1.00
64_F	220_Y	0.691	1.00
60_M	63_F	0.691	1.00
154_V	158_K	0.691	1.00
326_F	330_I	0.691	1.00
326_F	340_G	0.687	1.00
149_M	154_V	0.684	1.00
310_N	361_R	0.684	1.00
238_A	242_T	0.683	1.00
102_L	106_Q	0.682	1.00
161_R	164_L	0.681	1.00
28_I	348_V	0.676	1.00
15_I	66_I	0.676	1.00
67_S	71_S	0.676	1.00
326_F	329_Y	0.676	1.00
91_V	146_L	0.676	1.00
67_S	224_F	0.675	1.00
147_V	224_F	0.673	1.00
159_R	163_N	0.673	1.00
278_I	282_L	0.673	1.00
254_A	257_A	0.670	1.00
20_M	59_R	0.669	1.00
89_E	364_L	0.667	1.00
24_I	348_V	0.666	1.00
232_I	236_L	0.666	1.00
181_V	185_C	0.664	1.00
318_V	348_V	0.664	1.00
125_L	128_K	0.664	1.00
193_I	196_T	0.663	1.00
234_P	237_K	0.663	1.00
87_R	142_F	0.663	1.00
187_G	190_Y	0.660	1.00
120_W	124_S	0.657	1.00
235_H	238_A	0.654	1.00
304_R	307_Y	0.651	1.00
127_D	132_L	0.650	1.00
18_W	22_L	0.649	1.00
20_M	308_F	0.648	1.00
26_F	61_Q	0.647	1.00
248_T	255_F	0.645	1.00
16_R	146_L	0.643	1.00
45_S	49_T	0.643	1.00
259_L	262_Q	0.643	1.00
71_S	224_F	0.642	1.00
305_V	309_V	0.640	1.00
246_G	250_A	0.640	1.00
149_M	220_Y	0.640	1.00
146_L	313_L	0.639	1.00
216_Q	223_F	0.638	1.00
255_F	258_Y	0.638	1.00
324_L	328_A	0.637	1.00
188_I	192_V	0.636	1.00
14_S	306_T	0.633	1.00
228_A	232_I	0.633	1.00
101_L	105_P	0.632	1.00
289_V	293_F	0.631	1.00
95_M	99_I	0.628	1.00
340_G	344_G	0.628	1.00
97_T	101_L	0.626	1.00
131_T	137_I	0.624	1.00
339_L	343_C	0.623	1.00
253_L	257_A	0.621	1.00
57_S	61_Q	0.621	1.00
182_I	186_L	0.621	1.00
71_S	147_V	0.620	1.00
159_R	162_N	0.617	1.00
185_C	189_G	0.615	1.00
20_M	24_I	0.612	1.00
239_L	243_P	0.612	1.00
246_G	249_L	0.611	1.00
213_I	217_T	0.607	1.00
276_S	287_V	0.606	1.00
87_R	90_R	0.605	1.00
195_R	198_F	0.605	1.00
179_L	182_I	0.604	1.00
107_F	111_Q	0.603	1.00
225_I	229_L	0.603	1.00
320_H	323_T	0.601	1.00
78_Y	82_K	0.600	1.00
325_F	329_Y	0.599	1.00
343_C	347_F	0.597	1.00
157_F	161_R	0.594	1.00
336_S	340_G	0.594	1.00
340_G	343_C	0.593	1.00
145_V	148_V	0.593	1.00
279_T	291_F	0.589	1.00
103_T	106_Q	0.588	1.00
287_V	294_G	0.586	1.00
249_L	252_A	0.586	1.00
341_F	344_G	0.585	1.00
149_M	153_C	0.585	1.00
280_M	291_F	0.584	1.00
64_F	149_M	0.583	1.00
363_P	366_K	0.581	1.00
322_L	325_F	0.581	1.00
131_T	134_W	0.581	1.00
49_T	53_D	0.580	1.00
295_H	299_N	0.579	1.00
92_G	95_M	0.578	1.00
83_W	153_C	0.575	1.00
325_F	328_A	0.574	1.00
125_L	131_T	0.573	1.00
91_V	147_V	0.573	1.00
98_A	355_L	0.573	1.00
20_M	309_V	0.571	1.00
292_S	296_R	0.570	1.00
19_L	60_M	0.568	1.00
277_V	281_V	0.565	1.00
10_Y	306_T	0.565	1.00
142_F	313_L	0.564	1.00
145_V	217_T	0.564	1.00
115_G	119_S	0.562	1.00
322_L	347_F	0.561	1.00
294_G	298_L	0.560	1.00
187_G	193_I	0.558	1.00
308_F	315_I	0.558	1.00
162_N	165_E	0.557	1.00
67_S	142_F	0.556	1.00
20_M	23_G	0.554	1.00
23_G	146_L	0.554	1.00
91_V	313_L	0.554	1.00
23_G	56_H	0.551	1.00
8_R	310_N	0.551	1.00
140_L	143_L	0.551	1.00
73_M	234_P	0.550	1.00
280_M	284_L	0.549	1.00
271_M	276_S	0.547	1.00
20_M	312_S	0.546	1.00
76_L	231_F	0.546	1.00
247_C	250_A	0.545	1.00
229_L	233_F	0.545	1.00
338_W	341_F	0.545	1.00
143_L	313_L	0.543	1.00
47_W	50_L	0.543	1.00
90_R	93_I	0.542	1.00
249_L	260_L	0.542	1.00
71_S	146_L	0.538	1.00
108_I	111_Q	0.535	1.00
354_I	357_E	0.534	1.00
129_Y	133_A	0.534	1.00
147_V	151_T	0.534	1.00
345_L	348_V	0.534	1.00
219_F	223_F	0.532	1.00
256_V	261_N	0.532	1.00
68_G	141_W	0.531	1.00
245_R	248_T	0.527	1.00
55_I	59_R	0.526	1.00
12_L	69_Y	0.526	1.00
233_F	237_K	0.525	1.00
330_I	333_H	0.523	1.00
231_F	234_P	0.522	1.00
223_F	228_A	0.519	1.00
62_V	66_I	0.517	1.00
14_S	300_F	0.517	1.00
23_G	27_H	0.513	1.00
137_I	140_L	0.513	1.00
196_T	199_I	0.513	1.00
17_A	311_A	0.513	1.00
124_S	127_D	0.511	1.00
58_F	62_V	0.510	1.00
359_H	364_L	0.510	1.00
248_T	259_L	0.507	0.99
342_L	345_L	0.507	0.99
341_F	345_L	0.507	0.99
89_E	365_L	0.506	0.99
142_F	316_Y	0.504	0.99
343_C	346_I	0.504	0.99
103_T	107_F	0.504	0.99
293_F	297_L	0.503	0.99
272_Y	279_T	0.502	0.99
20_M	146_L	0.502	0.99
117_A	122_G	0.502	0.99
7_Q	10_Y	0.501	0.99
310_N	320_H	0.501	0.99
322_L	344_G	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4j72A	2	0.0987	9.4	0.954	Contact Map
3udcA	3	0.1299	5.9	0.958	Contact Map
4ldsA	2	0.4987	5.4	0.959	Contact Map
3j1zP	8	0.3766	4.9	0.96	Contact Map
2kluA	1	0.1221	4.7	0.96	Contact Map
4czbA	2	0.8597	3.9	0.962	Contact Map
2cfqA	1	0.5403	3.5	0.963	Contact Map
2ad6B	1	0.0597	3.3	0.963	Contact Map
2kv5A	1	0.0857	2.6	0.965	Contact Map
4px7A	1	0.5013	2.4	0.965	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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