CLSC - ECOLI - GREMLIN Contacts

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CLSC - Cardiolipin synthase C

UniProt:	P75919	Sequences: MPRLASAVLPLCSQHPGQCGLFPLEKSLDAFAARYRLAEMAEHTLDVQYYIWQDDMSGRLLFSALLAAAKRGVRVRLLLDDNNTPGLDDILRLLDSHPRIEVRLFNPFSFRLLRPLGYITDFSRLNRRMHNKSFTVDGVVTLVGGRNIGDAYFGAGEEPLFSDLDVMAIGPVVEDVADDFARYWYCKSVSPLQQVLDVPEGEMADRIELPASWHNDAMTHRYLRKMESSPFINHLVDGTLPLIWAKTRLLSDDPAKGEGKAKRHSLLPQRLFDIMGSPSERIDIISSYFVPTRAGVAQLLRMVRKGVKIAILTNSLAANDVAVVHAGYARWRKKLLRYGVELYELKPTREQSSTLHDRGITGNSGASLHAKTFSIDGKTVFIGSFNFDPRSTLLNTEMGFVIESETLAQLIDKRFIQSQYDAAWQLRLDRWGRINWVDRHAKKEIILKKEPATSFWKRVMVRLASILPVEWLL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13875
Length:	473 (357)
Sequences:	4775 (3290)
Seq/√Len:	174.1

ECOLI - CLSC CLSA CLSB
BACSU - CLSA CLS1 CLSB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
68_A	71_R	5.681	1.00
39_E	67_A	4.957	1.00
341_E	425_Q	4.805	1.00
37_L	142_L	4.635	1.00
38_A	64_A	4.270	1.00
308_K	341_E	3.938	1.00
34_R	134_F	3.802	1.00
141_T	176_V	3.586	1.00
39_E	64_A	3.398	1.00
377_G	412_D	3.352	1.00
37_L	167_M	2.980	1.00
381_F	399_G	2.850	1.00
20_G	169_I	2.836	1.00
35_Y	61_L	2.734	1.00
281_R	377_G	2.731	1.00
35_Y	64_A	2.676	1.00
30_A	34_R	2.447	1.00
46_D	76_R	2.398	1.00
45_L	136_V	2.381	1.00
380_V	411_I	2.380	1.00
310_A	341_E	2.305	1.00
283_D	310_A	2.287	1.00
374_S	408_A	2.200	1.00
67_A	71_R	2.178	1.00
36_R	40_M	2.173	1.00
22_F	33_A	2.172	1.00
168_A	172_V	2.129	1.00
18_Q	171_P	2.094	1.00
54_D	59_R	2.057	1.00
30_A	49_Y	2.027	1.00
138_G	177_A	1.982	1.00
249_L	400_F	1.982	1.00
282_I	375_I	1.948	1.00
303_V	340_V	1.943	1.00
52_W	77_L	1.931	1.00
281_R	412_D	1.926	1.00
141_T	173_V	1.925	1.00
380_V	408_A	1.921	1.00
402_I	407_L	1.894	1.00
37_L	140_V	1.892	1.00
66_L	70_K	1.868	1.00
38_A	45_L	1.824	1.00
79_L	104_L	1.823	1.00
64_A	68_A	1.817	1.00
33_A	167_M	1.817	1.00
412_D	416_I	1.788	1.00
343_Y	425_Q	1.776	1.00
42_E	139_V	1.772	1.00
74_R	101_E	1.766	1.00
16_P	175_D	1.750	1.00
133_S	176_V	1.727	1.00
24_L	33_A	1.721	1.00
417_Q	420_Y	1.704	1.00
64_A	67_A	1.701	1.00
55_D	58_G	1.689	1.00
87_L	91_L	1.683	1.00
142_L	167_M	1.668	1.00
428_L	432_G	1.666	1.00
62_F	66_L	1.642	1.00
87_L	94_L	1.641	1.00
135_T	141_T	1.640	1.00
22_F	167_M	1.631	1.00
44_T	138_G	1.630	1.00
347_P	422_A	1.620	1.00
33_A	37_L	1.611	1.00
274_I	379_T	1.608	1.00
90_I	94_L	1.601	1.00
95_D	100_I	1.574	1.00
140_V	167_M	1.562	1.00
310_A	419_Q	1.561	1.00
37_L	40_M	1.554	1.00
312_L	423_A	1.542	1.00
62_F	94_L	1.536	1.00
424_W	430_R	1.533	1.00
21_L	247_T	1.527	1.00
281_R	308_K	1.513	1.00
337_R	428_L	1.512	1.00
300_L	304_R	1.502	1.00
168_A	400_F	1.492	1.00
56_M	150_D	1.481	1.00
285_I	312_L	1.475	1.00
275_M	282_I	1.467	1.00
47_V	134_F	1.463	1.00
280_E	377_G	1.455	1.00
172_V	247_T	1.452	1.00
44_T	177_A	1.444	1.00
283_D	308_K	1.433	1.00
162_S	418_S	1.431	1.00
143_V	176_V	1.406	1.00
319_N	325_H	1.401	1.00
346_K	424_W	1.386	1.00
278_P	282_I	1.374	1.00
47_V	61_L	1.372	1.00
274_I	375_I	1.369	1.00
336_L	428_L	1.361	1.00
172_V	249_L	1.356	1.00
46_D	177_A	1.351	1.00
278_P	375_I	1.346	1.00
310_A	416_I	1.337	1.00
87_L	92_R	1.329	1.00
53_Q	151_A	1.312	1.00
332_R	342_L	1.291	1.00
135_T	176_V	1.265	1.00
283_D	416_I	1.253	1.00
55_D	59_R	1.252	1.00
388_D	395_N	1.251	1.00
33_A	142_L	1.248	1.00
28_L	32_A	1.242	1.00
133_S	398_M	1.242	1.00
26_K	29_D	1.238	1.00
335_L	340_V	1.233	1.00
302_M	305_K	1.222	1.00
52_W	148_I	1.221	1.00
419_Q	423_A	1.216	1.00
35_Y	60_L	1.216	1.00
377_G	409_Q	1.214	1.00
270_R	401_V	1.212	1.00
78_L	187_K	1.211	1.00
283_D	412_D	1.211	1.00
76_R	101_E	1.210	1.00
280_E	378_K	1.207	1.00
25_E	414_R	1.203	1.00
63_S	67_A	1.182	1.00
66_L	98_P	1.178	1.00
37_L	136_V	1.178	1.00
247_T	400_F	1.161	1.00
312_L	419_Q	1.157	1.00
81_D	104_L	1.153	1.00
245_A	404_S	1.152	1.00
176_V	398_M	1.143	1.00
32_A	60_L	1.139	1.00
34_R	136_V	1.136	1.00
57_S	150_D	1.135	1.00
179_D	251_S	1.125	1.00
333_K	337_R	1.124	1.00
166_V	402_I	1.122	1.00
427_R	430_R	1.119	1.00
313_T	332_R	1.111	1.00
378_K	403_E	1.108	1.00
139_V	169_I	1.108	1.00
267_L	385_F	1.105	1.00
53_Q	149_G	1.103	1.00
63_S	66_L	1.098	1.00
42_E	71_R	1.090	1.00
32_A	36_R	1.090	1.00
300_L	334_K	1.079	1.00
164_L	372_T	1.078	1.00
39_E	60_L	1.072	1.00
50_Y	395_N	1.069	1.00
129_M	183_Y	1.068	1.00
248_R	252_D	1.057	1.00
27_S	31_F	1.046	0.99
82_N	85_P	1.043	0.99
265_S	268_P	1.042	0.99
87_L	95_D	1.040	0.99
143_V	398_M	1.040	0.99
251_S	254_P	1.037	0.99
416_I	419_Q	1.032	0.99
103_R	188_S	1.030	0.99
317_A	346_K	1.030	0.99
293_R	297_A	1.029	0.99
45_L	65_L	1.026	0.99
88_D	91_L	1.025	0.99
56_M	155_A	1.023	0.99
33_A	36_R	1.022	0.99
285_I	372_T	1.022	0.99
76_R	184_W	1.017	0.99
30_A	165_D	1.012	0.99
93_L	97_H	1.012	0.99
285_I	368_L	1.010	0.99
61_L	148_I	1.009	0.99
289_F	311_I	1.007	0.99
36_R	39_E	1.006	0.99
310_A	343_Y	1.005	0.99
329_A	344_E	1.002	0.99
250_L	401_V	0.997	0.99
166_V	382_I	0.996	0.99
147_N	152_Y	0.995	0.99
91_L	94_L	0.994	0.99
295_G	392_T	0.994	0.99
282_I	299_L	0.993	0.99
415_F	419_Q	0.989	0.99
48_Q	129_M	0.988	0.99
317_A	424_W	0.987	0.99
87_L	90_I	0.987	0.99
62_F	91_L	0.983	0.99
373_F	381_F	0.982	0.99
168_A	176_V	0.981	0.99
281_R	374_S	0.971	0.99
245_A	402_I	0.965	0.99
29_D	32_A	0.965	0.99
410_L	414_R	0.964	0.99
385_F	399_G	0.960	0.99
101_E	190_S	0.951	0.99
38_A	134_F	0.940	0.99
91_L	95_D	0.938	0.99
301_R	305_K	0.937	0.99
333_K	428_L	0.934	0.99
30_A	146_R	0.932	0.99
16_P	19_C	0.928	0.99
24_L	142_L	0.927	0.99
70_K	97_H	0.927	0.99
271_L	286_S	0.926	0.99
189_V	192_L	0.924	0.99
35_Y	39_E	0.921	0.99
126_N	390_R	0.917	0.99
92_R	95_D	0.915	0.99
246_K	403_E	0.913	0.99
410_L	413_K	0.912	0.99
332_R	336_L	0.912	0.99
39_E	71_R	0.912	0.99
329_A	438_D	0.910	0.99
384_S	395_N	0.909	0.99
312_L	415_F	0.909	0.99
344_E	426_L	0.907	0.99
273_D	277_S	0.898	0.98
62_F	100_I	0.893	0.98
276_G	298_Q	0.890	0.98
312_L	368_L	0.890	0.98
143_V	166_V	0.889	0.98
275_M	302_M	0.886	0.98
303_V	338_Y	0.886	0.98
431_W	434_I	0.886	0.98
416_I	420_Y	0.882	0.98
378_K	405_E	0.882	0.98
268_P	292_T	0.881	0.98
328_Y	332_R	0.880	0.98
46_D	74_R	0.880	0.98
90_I	95_D	0.877	0.98
374_S	412_D	0.875	0.98
19_C	171_P	0.871	0.98
21_L	245_A	0.869	0.98
384_S	398_M	0.868	0.98
59_R	63_S	0.868	0.98
233_N	236_V	0.866	0.98
382_I	411_I	0.861	0.98
285_I	415_F	0.857	0.98
145_G	152_Y	0.856	0.98
276_G	301_R	0.853	0.98
133_S	143_V	0.853	0.98
23_P	407_L	0.851	0.98
380_V	407_L	0.849	0.98
145_G	163_D	0.843	0.98
298_Q	302_M	0.839	0.98
140_V	169_I	0.836	0.98
281_R	310_A	0.836	0.98
339_G	344_E	0.834	0.98
272_F	298_Q	0.834	0.98
417_Q	422_A	0.824	0.97
387_F	392_T	0.824	0.97
284_I	373_F	0.822	0.97
15_H	246_K	0.817	0.97
135_T	173_V	0.816	0.97
390_R	395_N	0.814	0.97
56_M	59_R	0.813	0.97
22_F	410_L	0.812	0.97
413_K	417_Q	0.807	0.97
415_F	418_S	0.806	0.97
279_S	378_K	0.804	0.97
381_F	401_V	0.804	0.97
66_L	100_I	0.804	0.97
249_L	398_M	0.803	0.97
26_K	160_L	0.798	0.97
332_R	344_E	0.797	0.97
68_A	72_G	0.796	0.97
45_L	68_A	0.793	0.97
69_A	98_P	0.792	0.97
249_L	252_D	0.792	0.97
194_Q	198_V	0.790	0.97
64_A	71_R	0.789	0.97
278_P	307_V	0.786	0.96
88_D	92_R	0.781	0.96
282_I	302_M	0.778	0.96
377_G	408_A	0.775	0.96
339_G	342_L	0.775	0.96
265_S	393_L	0.774	0.96
52_W	79_L	0.769	0.96
21_L	402_I	0.767	0.96
426_L	434_I	0.767	0.96
422_A	425_Q	0.764	0.96
274_I	381_F	0.764	0.96
333_K	431_W	0.763	0.96
320_D	324_V	0.760	0.96
46_D	138_G	0.759	0.96
40_M	139_V	0.758	0.96
69_A	100_I	0.757	0.96
46_D	181_A	0.755	0.96
343_Y	419_Q	0.754	0.96
176_V	249_L	0.754	0.96
49_Y	147_N	0.753	0.95
90_I	93_L	0.751	0.95
24_L	167_M	0.750	0.95
52_W	62_F	0.750	0.95
409_Q	416_I	0.750	0.95
425_Q	428_L	0.749	0.95
300_L	338_Y	0.748	0.95
60_L	63_S	0.746	0.95
309_I	340_V	0.746	0.95
146_R	165_D	0.746	0.95
177_A	181_A	0.743	0.95
48_Q	131_N	0.730	0.95
19_C	168_A	0.729	0.95
331_W	334_K	0.728	0.95
66_L	69_A	0.728	0.95
179_D	398_M	0.724	0.94
86_G	90_I	0.723	0.94
192_L	195_V	0.719	0.94
181_A	185_Y	0.718	0.94
271_L	381_F	0.715	0.94
272_F	295_G	0.714	0.94
34_R	61_L	0.712	0.94
47_V	148_I	0.711	0.94
88_D	94_L	0.711	0.94
55_D	150_D	0.711	0.94
409_Q	413_K	0.711	0.94
272_F	276_G	0.710	0.94
75_V	100_I	0.710	0.94
313_T	328_Y	0.708	0.94
297_A	301_R	0.708	0.94
245_A	407_L	0.706	0.94
413_K	416_I	0.704	0.94
70_K	98_P	0.701	0.93
283_D	374_S	0.700	0.93
346_K	422_A	0.700	0.93
197_D	200_E	0.699	0.93
372_T	382_I	0.697	0.93
434_I	438_D	0.696	0.93
302_M	307_V	0.692	0.93
174_E	178_D	0.691	0.93
329_A	332_R	0.690	0.93
287_S	388_D	0.687	0.93
299_L	340_V	0.687	0.93
372_T	411_I	0.682	0.92
280_E	308_K	0.680	0.92
253_D	261_A	0.680	0.92
250_L	270_R	0.675	0.92
424_W	428_L	0.674	0.92
66_L	94_L	0.674	0.92
267_L	399_G	0.674	0.92
17_G	246_K	0.673	0.92
80_D	128_R	0.673	0.92
23_P	414_R	0.672	0.92
121_D	124_R	0.671	0.92
426_L	430_R	0.670	0.92
264_H	338_Y	0.670	0.92
51_I	151_A	0.666	0.92
52_W	58_G	0.665	0.92
39_E	68_A	0.665	0.92
136_V	142_L	0.663	0.91
379_T	401_V	0.660	0.91
35_Y	57_S	0.658	0.91
434_I	439_R	0.658	0.91
22_F	29_D	0.658	0.91
414_R	417_Q	0.658	0.91
435_N	440_H	0.658	0.91
170_G	173_V	0.658	0.91
49_Y	165_D	0.656	0.91
275_M	299_L	0.650	0.91
267_L	271_L	0.650	0.91
166_V	400_F	0.650	0.91
427_R	431_W	0.649	0.91
335_L	342_L	0.646	0.90
156_G	159_P	0.646	0.90
374_S	377_G	0.644	0.90
58_G	148_I	0.642	0.90
300_L	303_V	0.642	0.90
20_G	244_W	0.641	0.90
170_G	184_W	0.640	0.90
163_D	314_N	0.640	0.90
333_K	434_I	0.640	0.90
67_A	70_K	0.638	0.90
193_Q	201_G	0.635	0.90
244_W	404_S	0.634	0.89
193_Q	198_V	0.631	0.89
60_L	64_A	0.630	0.89
52_W	61_L	0.630	0.89
135_T	181_A	0.628	0.89
179_D	182_R	0.626	0.89
168_A	247_T	0.625	0.89
245_A	406_T	0.625	0.89
32_A	35_Y	0.625	0.89
308_K	416_I	0.625	0.89
234_H	239_T	0.625	0.89
94_L	98_P	0.623	0.89
244_W	406_T	0.622	0.89
142_L	165_D	0.619	0.88
149_G	152_Y	0.618	0.88
340_V	344_E	0.617	0.88
275_M	295_G	0.617	0.88
283_D	415_F	0.617	0.88
303_V	309_I	0.616	0.88
278_P	302_M	0.613	0.88
336_L	342_L	0.612	0.88
195_V	199_P	0.612	0.88
42_E	169_I	0.611	0.88
50_Y	80_D	0.610	0.88
65_L	77_L	0.609	0.88
46_D	135_T	0.607	0.87
318_A	322_A	0.606	0.87
180_F	184_W	0.606	0.87
391_S	397_E	0.602	0.87
44_T	76_R	0.602	0.87
38_A	65_L	0.601	0.87
409_Q	412_D	0.600	0.87
143_V	400_F	0.598	0.87
405_E	409_Q	0.597	0.86
95_D	99_R	0.596	0.86
406_T	409_Q	0.595	0.86
294_A	298_Q	0.595	0.86
94_L	100_I	0.594	0.86
43_H	139_V	0.594	0.86
105_F	396_T	0.593	0.86
420_Y	424_W	0.593	0.86
374_S	380_V	0.593	0.86
248_R	403_E	0.593	0.86
271_L	399_G	0.592	0.86
314_N	396_T	0.589	0.86
95_D	193_Q	0.589	0.86
159_P	366_A	0.588	0.86
161_F	164_L	0.588	0.86
295_G	387_F	0.587	0.86
333_K	432_G	0.587	0.86
324_V	327_G	0.585	0.85
314_N	321_V	0.584	0.85
131_N	179_D	0.582	0.85
308_K	425_Q	0.580	0.85
47_V	77_L	0.580	0.85
192_L	198_V	0.579	0.85
105_F	145_G	0.579	0.85
325_H	329_A	0.579	0.85
39_E	43_H	0.578	0.85
147_N	388_D	0.577	0.85
322_A	325_H	0.576	0.84
236_V	239_T	0.576	0.84
323_V	326_A	0.573	0.84
95_D	98_P	0.573	0.84
70_K	99_R	0.571	0.84
294_A	297_A	0.571	0.84
374_S	419_Q	0.570	0.84
31_F	61_L	0.569	0.84
429_D	433_R	0.569	0.84
385_F	392_T	0.568	0.84
286_S	366_A	0.566	0.83
166_V	407_L	0.565	0.83
197_D	201_G	0.565	0.83
38_A	68_A	0.562	0.83
98_P	101_E	0.562	0.83
267_L	270_R	0.561	0.83
389_P	393_L	0.560	0.83
337_R	432_G	0.560	0.83
340_V	343_Y	0.559	0.83
61_L	64_A	0.559	0.83
402_I	408_A	0.558	0.83
127_R	394_L	0.557	0.82
80_D	131_N	0.557	0.82
298_Q	301_R	0.556	0.82
56_M	60_L	0.555	0.82
19_C	404_S	0.554	0.82
76_R	180_F	0.553	0.82
414_R	418_S	0.552	0.82
57_S	148_I	0.551	0.82
248_R	251_S	0.551	0.82
101_E	105_F	0.551	0.82
317_A	347_P	0.551	0.82
433_R	437_V	0.550	0.82
291_P	327_G	0.550	0.82
194_Q	197_D	0.547	0.81
372_T	415_F	0.545	0.81
336_L	425_Q	0.544	0.81
50_Y	128_R	0.543	0.81
245_A	250_L	0.543	0.81
328_Y	331_W	0.542	0.81
276_G	280_E	0.541	0.81
269_Q	301_R	0.541	0.81
45_L	73_V	0.540	0.81
436_W	440_H	0.539	0.80
377_G	416_I	0.538	0.80
293_R	300_L	0.537	0.80
322_A	326_A	0.536	0.80
44_T	74_R	0.535	0.80
149_G	153_F	0.533	0.80
266_L	270_R	0.532	0.80
185_Y	188_S	0.532	0.80
327_G	331_W	0.531	0.79
287_S	367_S	0.531	0.79
43_H	197_D	0.531	0.79
268_P	392_T	0.531	0.79
314_N	367_S	0.530	0.79
281_R	375_I	0.528	0.79
22_F	169_I	0.528	0.79
247_T	402_I	0.528	0.79
404_S	407_L	0.527	0.79
271_L	385_F	0.527	0.79
171_P	174_E	0.527	0.79
283_D	419_Q	0.526	0.79
427_R	435_N	0.526	0.79
81_D	107_P	0.526	0.79
411_I	414_R	0.526	0.79
245_A	405_E	0.525	0.79
249_L	254_P	0.524	0.79
128_R	144_G	0.524	0.79
265_S	269_Q	0.523	0.78
17_G	171_P	0.522	0.78
275_M	373_F	0.521	0.78
18_Q	243_I	0.520	0.78
97_H	100_I	0.518	0.78
145_G	165_D	0.517	0.78
39_E	42_E	0.517	0.78
161_F	165_D	0.516	0.77
254_P	390_R	0.515	0.77
264_H	304_R	0.515	0.77
98_P	106_N	0.515	0.77
407_L	411_I	0.515	0.77
144_G	390_R	0.514	0.77
296_V	303_V	0.513	0.77
19_C	172_V	0.512	0.77
127_R	253_D	0.511	0.77
381_F	385_F	0.511	0.77
191_P	195_V	0.510	0.77
312_L	418_S	0.510	0.77
74_R	198_V	0.509	0.77
405_E	413_K	0.509	0.77
425_Q	430_R	0.508	0.76
191_P	198_V	0.506	0.76
98_P	107_P	0.506	0.76
317_A	344_E	0.505	0.76
314_N	390_R	0.505	0.76
51_I	128_R	0.505	0.76
301_R	337_R	0.504	0.76
88_D	93_L	0.503	0.76
430_R	434_I	0.503	0.76
432_G	436_W	0.502	0.76
424_W	427_R	0.501	0.75
83_N	87_L	0.501	0.75
430_R	433_R	0.500	0.75
102_V	105_F	0.500	0.75

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1v0wA	1	0.8372	100	0.436	Contact Map
3hsiA	2	0.8478	100	0.457	Contact Map
1xdpA	4	0.7146	100	0.573	Contact Map
2o8rA	2	0.7082	100	0.578	Contact Map
4urjA	1	0.3721	99.9	0.777	Contact Map
1byrA	2	0.3192	99.9	0.784	Contact Map
4gelA	2	0.3869	99.9	0.798	Contact Map
4ggjA	2	0.3192	99.9	0.802	Contact Map
2c1lA	2	0.4144	99.8	0.819	Contact Map
4rctA	2	0.4249	99.4	0.869	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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