GREMLIN Database
CLSC - Cardiolipin synthase C
UniProt: P75919 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13875
Length: 473 (357)
Sequences: 4775 (3290)
Seq/√Len: 174.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_A71_R5.6811.00
39_E67_A4.9571.00
341_E425_Q4.8051.00
37_L142_L4.6351.00
38_A64_A4.2701.00
308_K341_E3.9381.00
34_R134_F3.8021.00
141_T176_V3.5861.00
39_E64_A3.3981.00
377_G412_D3.3521.00
37_L167_M2.9801.00
381_F399_G2.8501.00
20_G169_I2.8361.00
35_Y61_L2.7341.00
281_R377_G2.7311.00
35_Y64_A2.6761.00
30_A34_R2.4471.00
46_D76_R2.3981.00
45_L136_V2.3811.00
380_V411_I2.3801.00
310_A341_E2.3051.00
283_D310_A2.2871.00
374_S408_A2.2001.00
67_A71_R2.1781.00
36_R40_M2.1731.00
22_F33_A2.1721.00
168_A172_V2.1291.00
18_Q171_P2.0941.00
54_D59_R2.0571.00
30_A49_Y2.0271.00
138_G177_A1.9821.00
249_L400_F1.9821.00
282_I375_I1.9481.00
303_V340_V1.9431.00
52_W77_L1.9311.00
281_R412_D1.9261.00
141_T173_V1.9251.00
380_V408_A1.9211.00
402_I407_L1.8941.00
37_L140_V1.8921.00
66_L70_K1.8681.00
38_A45_L1.8241.00
79_L104_L1.8231.00
64_A68_A1.8171.00
33_A167_M1.8171.00
412_D416_I1.7881.00
343_Y425_Q1.7761.00
42_E139_V1.7721.00
74_R101_E1.7661.00
16_P175_D1.7501.00
133_S176_V1.7271.00
24_L33_A1.7211.00
417_Q420_Y1.7041.00
64_A67_A1.7011.00
55_D58_G1.6891.00
87_L91_L1.6831.00
142_L167_M1.6681.00
428_L432_G1.6661.00
62_F66_L1.6421.00
87_L94_L1.6411.00
135_T141_T1.6401.00
22_F167_M1.6311.00
44_T138_G1.6301.00
347_P422_A1.6201.00
33_A37_L1.6111.00
274_I379_T1.6081.00
90_I94_L1.6011.00
95_D100_I1.5741.00
140_V167_M1.5621.00
310_A419_Q1.5611.00
37_L40_M1.5541.00
312_L423_A1.5421.00
62_F94_L1.5361.00
424_W430_R1.5331.00
21_L247_T1.5271.00
281_R308_K1.5131.00
337_R428_L1.5121.00
300_L304_R1.5021.00
168_A400_F1.4921.00
56_M150_D1.4811.00
285_I312_L1.4751.00
275_M282_I1.4671.00
47_V134_F1.4631.00
280_E377_G1.4551.00
172_V247_T1.4521.00
44_T177_A1.4441.00
283_D308_K1.4331.00
162_S418_S1.4311.00
143_V176_V1.4061.00
319_N325_H1.4011.00
346_K424_W1.3861.00
278_P282_I1.3741.00
47_V61_L1.3721.00
274_I375_I1.3691.00
336_L428_L1.3611.00
172_V249_L1.3561.00
46_D177_A1.3511.00
278_P375_I1.3461.00
310_A416_I1.3371.00
87_L92_R1.3291.00
53_Q151_A1.3121.00
332_R342_L1.2911.00
135_T176_V1.2651.00
283_D416_I1.2531.00
55_D59_R1.2521.00
388_D395_N1.2511.00
33_A142_L1.2481.00
28_L32_A1.2421.00
133_S398_M1.2421.00
26_K29_D1.2381.00
335_L340_V1.2331.00
302_M305_K1.2221.00
52_W148_I1.2211.00
419_Q423_A1.2161.00
35_Y60_L1.2161.00
377_G409_Q1.2141.00
270_R401_V1.2121.00
78_L187_K1.2111.00
283_D412_D1.2111.00
76_R101_E1.2101.00
280_E378_K1.2071.00
25_E414_R1.2031.00
63_S67_A1.1821.00
66_L98_P1.1781.00
37_L136_V1.1781.00
247_T400_F1.1611.00
312_L419_Q1.1571.00
81_D104_L1.1531.00
245_A404_S1.1521.00
176_V398_M1.1431.00
32_A60_L1.1391.00
34_R136_V1.1361.00
57_S150_D1.1351.00
179_D251_S1.1251.00
333_K337_R1.1241.00
166_V402_I1.1221.00
427_R430_R1.1191.00
313_T332_R1.1111.00
378_K403_E1.1081.00
139_V169_I1.1081.00
267_L385_F1.1051.00
53_Q149_G1.1031.00
63_S66_L1.0981.00
42_E71_R1.0901.00
32_A36_R1.0901.00
300_L334_K1.0791.00
164_L372_T1.0781.00
39_E60_L1.0721.00
50_Y395_N1.0691.00
129_M183_Y1.0681.00
248_R252_D1.0571.00
27_S31_F1.0460.99
82_N85_P1.0430.99
265_S268_P1.0420.99
87_L95_D1.0400.99
143_V398_M1.0400.99
251_S254_P1.0370.99
416_I419_Q1.0320.99
103_R188_S1.0300.99
317_A346_K1.0300.99
293_R297_A1.0290.99
45_L65_L1.0260.99
88_D91_L1.0250.99
56_M155_A1.0230.99
33_A36_R1.0220.99
285_I372_T1.0220.99
76_R184_W1.0170.99
30_A165_D1.0120.99
93_L97_H1.0120.99
285_I368_L1.0100.99
61_L148_I1.0090.99
289_F311_I1.0070.99
36_R39_E1.0060.99
310_A343_Y1.0050.99
329_A344_E1.0020.99
250_L401_V0.9970.99
166_V382_I0.9960.99
147_N152_Y0.9950.99
91_L94_L0.9940.99
295_G392_T0.9940.99
282_I299_L0.9930.99
415_F419_Q0.9890.99
48_Q129_M0.9880.99
317_A424_W0.9870.99
87_L90_I0.9870.99
62_F91_L0.9830.99
373_F381_F0.9820.99
168_A176_V0.9810.99
281_R374_S0.9710.99
245_A402_I0.9650.99
29_D32_A0.9650.99
410_L414_R0.9640.99
385_F399_G0.9600.99
101_E190_S0.9510.99
38_A134_F0.9400.99
91_L95_D0.9380.99
301_R305_K0.9370.99
333_K428_L0.9340.99
30_A146_R0.9320.99
16_P19_C0.9280.99
24_L142_L0.9270.99
70_K97_H0.9270.99
271_L286_S0.9260.99
189_V192_L0.9240.99
35_Y39_E0.9210.99
126_N390_R0.9170.99
92_R95_D0.9150.99
246_K403_E0.9130.99
410_L413_K0.9120.99
332_R336_L0.9120.99
39_E71_R0.9120.99
329_A438_D0.9100.99
384_S395_N0.9090.99
312_L415_F0.9090.99
344_E426_L0.9070.99
273_D277_S0.8980.98
62_F100_I0.8930.98
276_G298_Q0.8900.98
312_L368_L0.8900.98
143_V166_V0.8890.98
275_M302_M0.8860.98
303_V338_Y0.8860.98
431_W434_I0.8860.98
416_I420_Y0.8820.98
378_K405_E0.8820.98
268_P292_T0.8810.98
328_Y332_R0.8800.98
46_D74_R0.8800.98
90_I95_D0.8770.98
374_S412_D0.8750.98
19_C171_P0.8710.98
21_L245_A0.8690.98
384_S398_M0.8680.98
59_R63_S0.8680.98
233_N236_V0.8660.98
382_I411_I0.8610.98
285_I415_F0.8570.98
145_G152_Y0.8560.98
276_G301_R0.8530.98
133_S143_V0.8530.98
23_P407_L0.8510.98
380_V407_L0.8490.98
145_G163_D0.8430.98
298_Q302_M0.8390.98
140_V169_I0.8360.98
281_R310_A0.8360.98
339_G344_E0.8340.98
272_F298_Q0.8340.98
417_Q422_A0.8240.97
387_F392_T0.8240.97
284_I373_F0.8220.97
15_H246_K0.8170.97
135_T173_V0.8160.97
390_R395_N0.8140.97
56_M59_R0.8130.97
22_F410_L0.8120.97
413_K417_Q0.8070.97
415_F418_S0.8060.97
279_S378_K0.8040.97
381_F401_V0.8040.97
66_L100_I0.8040.97
249_L398_M0.8030.97
26_K160_L0.7980.97
332_R344_E0.7970.97
68_A72_G0.7960.97
45_L68_A0.7930.97
69_A98_P0.7920.97
249_L252_D0.7920.97
194_Q198_V0.7900.97
64_A71_R0.7890.97
278_P307_V0.7860.96
88_D92_R0.7810.96
282_I302_M0.7780.96
377_G408_A0.7750.96
339_G342_L0.7750.96
265_S393_L0.7740.96
52_W79_L0.7690.96
21_L402_I0.7670.96
426_L434_I0.7670.96
422_A425_Q0.7640.96
274_I381_F0.7640.96
333_K431_W0.7630.96
320_D324_V0.7600.96
46_D138_G0.7590.96
40_M139_V0.7580.96
69_A100_I0.7570.96
46_D181_A0.7550.96
343_Y419_Q0.7540.96
176_V249_L0.7540.96
49_Y147_N0.7530.95
90_I93_L0.7510.95
24_L167_M0.7500.95
52_W62_F0.7500.95
409_Q416_I0.7500.95
425_Q428_L0.7490.95
300_L338_Y0.7480.95
60_L63_S0.7460.95
309_I340_V0.7460.95
146_R165_D0.7460.95
177_A181_A0.7430.95
48_Q131_N0.7300.95
19_C168_A0.7290.95
331_W334_K0.7280.95
66_L69_A0.7280.95
179_D398_M0.7240.94
86_G90_I0.7230.94
192_L195_V0.7190.94
181_A185_Y0.7180.94
271_L381_F0.7150.94
272_F295_G0.7140.94
34_R61_L0.7120.94
47_V148_I0.7110.94
88_D94_L0.7110.94
55_D150_D0.7110.94
409_Q413_K0.7110.94
272_F276_G0.7100.94
75_V100_I0.7100.94
313_T328_Y0.7080.94
297_A301_R0.7080.94
245_A407_L0.7060.94
413_K416_I0.7040.94
70_K98_P0.7010.93
283_D374_S0.7000.93
346_K422_A0.7000.93
197_D200_E0.6990.93
372_T382_I0.6970.93
434_I438_D0.6960.93
302_M307_V0.6920.93
174_E178_D0.6910.93
329_A332_R0.6900.93
287_S388_D0.6870.93
299_L340_V0.6870.93
372_T411_I0.6820.92
280_E308_K0.6800.92
253_D261_A0.6800.92
250_L270_R0.6750.92
424_W428_L0.6740.92
66_L94_L0.6740.92
267_L399_G0.6740.92
17_G246_K0.6730.92
80_D128_R0.6730.92
23_P414_R0.6720.92
121_D124_R0.6710.92
426_L430_R0.6700.92
264_H338_Y0.6700.92
51_I151_A0.6660.92
52_W58_G0.6650.92
39_E68_A0.6650.92
136_V142_L0.6630.91
379_T401_V0.6600.91
35_Y57_S0.6580.91
434_I439_R0.6580.91
22_F29_D0.6580.91
414_R417_Q0.6580.91
435_N440_H0.6580.91
170_G173_V0.6580.91
49_Y165_D0.6560.91
275_M299_L0.6500.91
267_L271_L0.6500.91
166_V400_F0.6500.91
427_R431_W0.6490.91
335_L342_L0.6460.90
156_G159_P0.6460.90
374_S377_G0.6440.90
58_G148_I0.6420.90
300_L303_V0.6420.90
20_G244_W0.6410.90
170_G184_W0.6400.90
163_D314_N0.6400.90
333_K434_I0.6400.90
67_A70_K0.6380.90
193_Q201_G0.6350.90
244_W404_S0.6340.89
193_Q198_V0.6310.89
60_L64_A0.6300.89
52_W61_L0.6300.89
135_T181_A0.6280.89
179_D182_R0.6260.89
168_A247_T0.6250.89
245_A406_T0.6250.89
32_A35_Y0.6250.89
308_K416_I0.6250.89
234_H239_T0.6250.89
94_L98_P0.6230.89
244_W406_T0.6220.89
142_L165_D0.6190.88
149_G152_Y0.6180.88
340_V344_E0.6170.88
275_M295_G0.6170.88
283_D415_F0.6170.88
303_V309_I0.6160.88
278_P302_M0.6130.88
336_L342_L0.6120.88
195_V199_P0.6120.88
42_E169_I0.6110.88
50_Y80_D0.6100.88
65_L77_L0.6090.88
46_D135_T0.6070.87
318_A322_A0.6060.87
180_F184_W0.6060.87
391_S397_E0.6020.87
44_T76_R0.6020.87
38_A65_L0.6010.87
409_Q412_D0.6000.87
143_V400_F0.5980.87
405_E409_Q0.5970.86
95_D99_R0.5960.86
406_T409_Q0.5950.86
294_A298_Q0.5950.86
94_L100_I0.5940.86
43_H139_V0.5940.86
105_F396_T0.5930.86
420_Y424_W0.5930.86
374_S380_V0.5930.86
248_R403_E0.5930.86
271_L399_G0.5920.86
314_N396_T0.5890.86
95_D193_Q0.5890.86
159_P366_A0.5880.86
161_F164_L0.5880.86
295_G387_F0.5870.86
333_K432_G0.5870.86
324_V327_G0.5850.85
314_N321_V0.5840.85
131_N179_D0.5820.85
308_K425_Q0.5800.85
47_V77_L0.5800.85
192_L198_V0.5790.85
105_F145_G0.5790.85
325_H329_A0.5790.85
39_E43_H0.5780.85
147_N388_D0.5770.85
322_A325_H0.5760.84
236_V239_T0.5760.84
323_V326_A0.5730.84
95_D98_P0.5730.84
70_K99_R0.5710.84
294_A297_A0.5710.84
374_S419_Q0.5700.84
31_F61_L0.5690.84
429_D433_R0.5690.84
385_F392_T0.5680.84
286_S366_A0.5660.83
166_V407_L0.5650.83
197_D201_G0.5650.83
38_A68_A0.5620.83
98_P101_E0.5620.83
267_L270_R0.5610.83
389_P393_L0.5600.83
337_R432_G0.5600.83
340_V343_Y0.5590.83
61_L64_A0.5590.83
402_I408_A0.5580.83
127_R394_L0.5570.82
80_D131_N0.5570.82
298_Q301_R0.5560.82
56_M60_L0.5550.82
19_C404_S0.5540.82
76_R180_F0.5530.82
414_R418_S0.5520.82
57_S148_I0.5510.82
248_R251_S0.5510.82
101_E105_F0.5510.82
317_A347_P0.5510.82
433_R437_V0.5500.82
291_P327_G0.5500.82
194_Q197_D0.5470.81
372_T415_F0.5450.81
336_L425_Q0.5440.81
50_Y128_R0.5430.81
245_A250_L0.5430.81
328_Y331_W0.5420.81
276_G280_E0.5410.81
269_Q301_R0.5410.81
45_L73_V0.5400.81
436_W440_H0.5390.80
377_G416_I0.5380.80
293_R300_L0.5370.80
322_A326_A0.5360.80
44_T74_R0.5350.80
149_G153_F0.5330.80
266_L270_R0.5320.80
185_Y188_S0.5320.80
327_G331_W0.5310.79
287_S367_S0.5310.79
43_H197_D0.5310.79
268_P392_T0.5310.79
314_N367_S0.5300.79
281_R375_I0.5280.79
22_F169_I0.5280.79
247_T402_I0.5280.79
404_S407_L0.5270.79
271_L385_F0.5270.79
171_P174_E0.5270.79
283_D419_Q0.5260.79
427_R435_N0.5260.79
81_D107_P0.5260.79
411_I414_R0.5260.79
245_A405_E0.5250.79
249_L254_P0.5240.79
128_R144_G0.5240.79
265_S269_Q0.5230.78
17_G171_P0.5220.78
275_M373_F0.5210.78
18_Q243_I0.5200.78
97_H100_I0.5180.78
145_G165_D0.5170.78
39_E42_E0.5170.78
161_F165_D0.5160.77
254_P390_R0.5150.77
264_H304_R0.5150.77
98_P106_N0.5150.77
407_L411_I0.5150.77
144_G390_R0.5140.77
296_V303_V0.5130.77
19_C172_V0.5120.77
127_R253_D0.5110.77
381_F385_F0.5110.77
191_P195_V0.5100.77
312_L418_S0.5100.77
74_R198_V0.5090.77
405_E413_K0.5090.77
425_Q430_R0.5080.76
191_P198_V0.5060.76
98_P107_P0.5060.76
317_A344_E0.5050.76
314_N390_R0.5050.76
51_I128_R0.5050.76
301_R337_R0.5040.76
88_D93_L0.5030.76
430_R434_I0.5030.76
432_G436_W0.5020.76
424_W427_R0.5010.75
83_N87_L0.5010.75
430_R433_R0.5000.75
102_V105_F0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v0wA 1 0.8372 100 0.436 Contact Map
3hsiA 2 0.8478 100 0.457 Contact Map
1xdpA 4 0.7146 100 0.573 Contact Map
2o8rA 2 0.7082 100 0.578 Contact Map
4urjA 1 0.3721 99.9 0.777 Contact Map
1byrA 2 0.3192 99.9 0.784 Contact Map
4gelA 2 0.3869 99.9 0.798 Contact Map
4ggjA 2 0.3192 99.9 0.802 Contact Map
2c1lA 2 0.4144 99.8 0.819 Contact Map
4rctA 2 0.4249 99.4 0.869 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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