GREMLIN Database
YCDX - Probable phosphatase YcdX
UniProt: P75914 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13870
Length: 245 (211)
Sequences: 3733 (2824)
Seq/√Len: 194.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_S62_V3.8911.00
146_E183_A3.6021.00
142_K179_A3.4461.00
26_Q30_K3.2781.00
26_Q29_Q2.9481.00
99_G130_S2.8101.00
97_I130_S2.7391.00
36_A95_L2.6011.00
174_R211_A2.4271.00
8_M35_F2.3851.00
122_A147_A2.1991.00
35_F68_I2.1861.00
18_S196_A2.1851.00
21_S25_A2.0311.00
118_I143_A1.9631.00
95_L128_I1.9601.00
198_T201_E1.9391.00
56_M70_R1.9071.00
24_I66_V1.9021.00
34_L69_L1.8961.00
118_I147_A1.8921.00
57_R70_R1.8801.00
3_P33_K1.8671.00
53_F70_R1.8541.00
179_A182_D1.8271.00
18_S22_D1.8161.00
57_R60_P1.8121.00
55_N58_I1.7431.00
145_A183_A1.7191.00
28_K66_V1.7071.00
118_I144_V1.7041.00
122_A151_H1.6881.00
147_A150_K1.6861.00
12_A55_N1.6661.00
127_H223_S1.6571.00
195_T198_T1.6431.00
6_L34_L1.6381.00
141_V176_V1.5931.00
20_L59_W1.5901.00
181_R214_F1.5891.00
157_I209_L1.5881.00
187_V214_F1.5831.00
115_Q140_D1.5631.00
145_A179_A1.5591.00
6_L36_A1.5361.00
180_V185_G1.5281.00
5_D191_S1.5181.00
38_T95_L1.5001.00
34_L67_G1.4751.00
155_L180_V1.4701.00
179_A183_A1.4501.00
98_A126_V1.4211.00
25_A29_Q1.3901.00
19_T22_D1.3821.00
122_A150_K1.3621.00
149_A185_G1.3601.00
174_R178_A1.3551.00
147_A151_H1.3421.00
20_L37_I1.3421.00
121_I148_A1.3311.00
157_I177_A1.3291.00
189_L209_L1.3161.00
50_H92_S1.3111.00
8_M23_Y1.2951.00
128_I154_A1.2911.00
145_A185_G1.2691.00
145_A176_V1.2651.00
174_R212_V1.2601.00
67_G221_N1.2551.00
142_K182_D1.2471.00
51_W54_I1.2371.00
159_N205_C1.2321.00
109_D112_T1.2251.00
28_K63_V1.2231.00
110_K138_E1.2181.00
193_S198_T1.2041.00
38_T71_G1.2031.00
10_T23_Y1.2011.00
149_A183_A1.1871.00
145_A180_V1.1611.00
28_K65_G1.1581.00
154_A220_L1.1381.00
72_I96_I1.1321.00
207_K211_A1.1321.00
112_T115_Q1.1291.00
149_A180_V1.1271.00
152_Q186_W1.1141.00
11_V19_T1.1071.00
163_L198_T1.0981.00
49_H72_I1.0951.00
58_I62_V1.0861.00
121_I147_A1.0841.00
4_V34_L1.0771.00
181_R212_V1.0741.00
87_G91_D1.0651.00
118_I122_A1.0611.00
119_A122_A1.0611.00
111_A140_D1.0551.00
25_A28_K1.0441.00
32_I202_F1.0411.00
24_I63_V1.0251.00
142_K183_A1.0171.00
177_A214_F1.0121.00
72_I93_L1.0091.00
206_L210_D1.0081.00
78_N119_A1.0041.00
111_A115_Q1.0031.00
121_I151_H1.0001.00
32_I200_G0.9961.00
53_F57_R0.9951.00
59_W63_V0.9921.00
117_M144_V0.9840.99
22_D25_A0.9770.99
104_V109_D0.9730.99
161_S171_D0.9640.99
28_K64_D0.9580.99
128_I190_G0.9530.99
140_D143_A0.9490.99
48_P51_W0.9490.99
24_I59_W0.9330.99
132_P155_L0.9260.99
25_A63_V0.9230.99
51_W55_N0.9200.99
53_F93_L0.9190.99
30_K199_M0.9170.99
204_E207_K0.9170.99
148_A155_L0.9130.99
121_I144_V0.9080.99
27_A35_F0.9070.99
149_A184_G0.9020.99
115_Q143_A0.9010.99
78_N82_E0.8970.99
181_R218_R0.8960.99
18_S23_Y0.8960.99
117_M139_I0.8930.99
41_G74_A0.8920.99
85_C89_M0.8840.99
5_D8_M0.8730.99
61_R64_D0.8720.99
21_S59_W0.8680.99
159_N191_S0.8680.99
23_Y193_S0.8670.99
6_L69_L0.8630.99
146_E150_K0.8570.99
42_P46_D0.8540.99
81_G90_F0.8520.99
100_F117_M0.8490.98
97_I128_I0.8480.98
128_I188_A0.8470.98
115_Q119_A0.8450.98
143_A146_E0.8450.98
177_A187_V0.8450.98
124_G153_V0.8440.98
181_R215_P0.8410.98
46_D86_S0.8400.98
38_T97_I0.8390.98
13_S39_D0.8260.98
55_N59_W0.8260.98
21_S63_V0.8240.98
126_V153_V0.8230.98
8_M38_T0.8230.98
208_I212_V0.8210.98
120_T129_I0.8200.98
113_N117_M0.8170.98
74_A96_I0.8150.98
60_P66_V0.8140.98
24_I68_I0.8110.98
54_I58_I0.8020.98
163_L201_E0.8000.98
209_L214_F0.7990.98
42_P75_N0.7990.98
30_K200_G0.7980.98
13_S42_P0.7960.98
215_P218_R0.7960.98
83_I90_F0.7860.97
178_A212_V0.7820.97
117_M132_P0.7820.97
143_A147_A0.7810.97
186_W218_R0.7800.97
41_G75_N0.7770.97
76_I98_A0.7740.97
53_F56_M0.7640.97
23_Y26_Q0.7600.97
20_L55_N0.7570.97
32_I35_F0.7560.97
186_W216_P0.7560.97
6_L38_T0.7530.97
26_Q196_A0.7510.97
160_S171_D0.7480.97
154_A188_A0.7440.96
83_I87_G0.7440.96
59_W68_I0.7430.96
124_G151_H0.7400.96
114_T144_V0.7380.96
54_I92_S0.7360.96
177_A212_V0.7310.96
118_I140_D0.7310.96
126_V148_A0.7260.96
129_I148_A0.7180.96
69_L94_D0.7170.96
50_H54_I0.7170.96
82_E85_C0.7160.96
63_V66_V0.7150.96
10_T20_L0.7140.96
60_P70_R0.7140.96
209_L212_V0.7090.95
86_S90_F0.7050.95
40_H194_H0.7040.95
69_L221_N0.6980.95
189_L206_L0.6970.95
24_I35_F0.6970.95
10_T37_I0.6970.95
117_M129_I0.6910.95
14_T45_E0.6900.95
8_M37_I0.6870.95
23_Y196_A0.6840.94
178_A182_D0.6820.94
23_Y37_I0.6810.94
6_L188_A0.6810.94
98_A120_T0.6800.94
132_P176_V0.6800.94
56_M68_I0.6790.94
85_C90_F0.6740.94
10_T13_S0.6730.94
220_L223_S0.6730.94
148_A153_V0.6700.94
45_E48_P0.6660.94
11_V55_N0.6560.93
84_D88_K0.6560.93
13_S16_A0.6530.93
114_T118_I0.6530.93
24_I28_K0.6520.93
95_L127_H0.6470.93
100_F113_N0.6470.93
174_R208_I0.6470.93
161_S172_N0.6450.93
52_H56_M0.6430.92
141_V145_A0.6420.92
100_F116_A0.6420.92
5_D200_G0.6370.92
203_E207_K0.6320.92
21_S58_I0.6290.92
100_F129_I0.6250.91
148_A185_G0.6240.91
132_P145_A0.6210.91
189_L205_C0.6170.91
37_I56_M0.6140.91
82_E88_K0.6140.91
186_W223_S0.6130.90
36_A128_I0.6130.90
81_G85_C0.6120.90
53_F92_S0.6080.90
177_A208_I0.6060.90
101_H194_H0.6040.90
206_L209_L0.6030.90
82_E86_S0.6020.90
121_I129_I0.6010.90
34_L219_I0.5990.89
57_R92_S0.5980.89
175_E178_A0.5980.89
81_G88_K0.5910.89
133_G173_C0.5860.88
110_K140_D0.5860.88
56_M60_P0.5860.88
39_D156_E0.5850.88
81_G84_D0.5830.88
162_F170_E0.5820.88
58_I61_R0.5780.88
25_A64_D0.5780.88
74_A85_C0.5770.88
120_T123_S0.5760.88
75_N100_F0.5730.87
208_I211_A0.5690.87
142_K146_E0.5670.87
18_S195_T0.5640.87
12_A20_L0.5640.87
86_S89_M0.5630.86
112_T119_A0.5610.86
90_F96_I0.5600.86
25_A62_V0.5600.86
112_T116_A0.5590.86
146_E149_A0.5580.86
85_C88_K0.5580.86
160_S163_L0.5520.85
6_L128_I0.5520.85
121_I153_V0.5500.85
145_A187_V0.5470.85
144_V147_A0.5460.85
78_N103_P0.5400.84
130_S156_E0.5390.84
11_V20_L0.5380.84
180_V187_V0.5350.84
173_C176_V0.5350.84
132_P172_N0.5320.83
76_I120_T0.5290.83
3_P32_I0.5290.83
91_D111_A0.5240.82
220_L224_P0.5230.82
40_H101_H0.5200.82
56_M59_W0.5200.82
205_C209_L0.5190.82
204_E208_I0.5180.82
178_A181_R0.5180.82
83_I86_S0.5160.81
42_P180_V0.5160.81
91_D125_N0.5160.81
157_I214_F0.5160.81
189_L221_N0.5100.81
49_H93_L0.5090.80
76_I116_A0.5090.80
78_N116_A0.5060.80
218_R225_R0.5050.80
92_S222_V0.5030.80
42_P45_E0.5010.79
23_Y199_M0.5010.79
202_F205_C0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gc3A 1 0.9061 100 0.345 Contact Map
1m65A 3 0.951 100 0.359 Contact Map
3b0xA 1 0.9265 100 0.383 Contact Map
2w9mA 1 0.9224 100 0.387 Contact Map
2yxoA 3 0.9265 100 0.388 Contact Map
3dcpA 1 0.8408 100 0.421 Contact Map
2wjeA 1 0.9184 100 0.479 Contact Map
3qy7A 1 0.9469 100 0.49 Contact Map
1v77A 1 0.7918 100 0.516 Contact Map
2anuA 5 0.7959 100 0.561 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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