GREMLIN Database
GHRA - Glyoxylate/hydroxypyruvate reductase A
UniProt: P75913 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13869
Length: 312 (271)
Sequences: 19597 (13395)
Seq/√Len: 813.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
209_N212_L4.4001.00
210_Q238_A3.2391.00
232_V235_D3.0691.00
139_I155_L2.7441.00
241_D267_H2.4881.00
138_T161_P2.4691.00
200_N229_V2.4411.00
40_D58_K2.4141.00
185_S215_K2.3371.00
138_T163_R2.2641.00
218_D244_K2.2291.00
188_L212_L2.1961.00
140_G187_F2.1931.00
144_A164_C2.0831.00
163_R190_Q2.0681.00
189_S215_K2.0541.00
118_R122_N2.0441.00
206_G254_N2.0241.00
183_E186_A1.9971.00
104_V155_L1.9751.00
49_V82_N1.9321.00
295_Q300_E1.9241.00
113_R116_D1.9041.00
214_E244_K1.9021.00
111_F193_V1.8951.00
38_S56_D1.8831.00
238_A242_S1.8661.00
59_A88_F1.8631.00
140_G191_C1.8511.00
150_K153_Q1.8211.00
206_G232_V1.7851.00
105_S114_F1.7761.00
220_A245_V1.7731.00
208_I213_L1.7721.00
49_V53_A1.7671.00
221_Y247_G1.7491.00
222_L231_V1.7311.00
241_D263_P1.7221.00
185_S212_L1.7111.00
107_V193_V1.7091.00
237_L267_H1.6891.00
104_V158_W1.6791.00
86_P305_Q1.6751.00
79_E82_N1.6741.00
210_Q214_E1.6621.00
213_L239_A1.6191.00
141_I148_G1.6141.00
106_Q249_M1.6131.00
186_A190_Q1.5901.00
139_I160_F1.5811.00
267_H270_V1.5771.00
109_H115_D1.5631.00
192_R217_P1.5621.00
102_Y277_A1.5591.00
202_P205_V1.5471.00
236_L248_A1.5341.00
233_E254_N1.5291.00
208_I212_L1.5291.00
200_N205_V1.5101.00
132_Y137_F1.5091.00
97_E135_E1.4921.00
137_F282_P1.4801.00
216_L220_A1.4741.00
53_A83_P1.4701.00
211_Q215_K1.4671.00
155_L160_F1.4621.00
188_L208_I1.4531.00
294_A298_K1.4521.00
237_L241_D1.4341.00
151_V197_L1.4271.00
110_W247_G1.4261.00
101_E154_S1.4211.00
80_M87_L1.4141.00
210_Q235_D1.4031.00
196_N230_H1.3881.00
221_Y246_K1.3771.00
133_H284_E1.3711.00
150_K154_S1.3651.00
295_Q303_C1.3621.00
212_L215_K1.3611.00
103_A151_V1.3561.00
141_I195_I1.3491.00
119_I122_N1.3481.00
197_L225_L1.3451.00
40_D56_D1.3331.00
205_V229_V1.3301.00
226_A230_H1.3011.00
97_E150_K1.2931.00
161_P190_Q1.2851.00
198_L230_H1.2631.00
196_N222_L1.2521.00
291_R295_Q1.2391.00
141_I152_A1.2311.00
119_I123_S1.2231.00
187_F191_C1.2231.00
52_L83_P1.2221.00
95_M278_A1.2181.00
79_E83_P1.2171.00
287_E291_R1.2121.00
161_P180_G1.2071.00
41_Y59_A1.2011.00
103_A225_L1.2001.00
110_W221_Y1.1861.00
102_Y106_Q1.1851.00
120_Q125_H1.1831.00
253_F272_I1.1811.00
142_L198_L1.1721.00
49_V79_E1.1651.00
296_L302_V1.1491.00
144_A149_S1.1491.00
153_Q159_R1.1481.00
108_L158_W1.1471.00
217_P220_A1.1441.00
115_D118_R1.1411.00
151_V195_I1.1371.00
185_S211_Q1.1341.00
100_Q154_S1.1311.00
163_R182_E1.1311.00
124_S266_Q1.1311.00
234_D263_P1.1251.00
211_Q214_E1.1241.00
48_P51_M1.1241.00
142_L207_I1.1181.00
70_I80_M1.1141.00
110_W249_M1.1121.00
62_A70_I1.1091.00
59_A296_L1.1081.00
207_I230_H1.1021.00
97_E154_S1.0961.00
291_R303_C1.0961.00
142_L208_I1.0961.00
288_Y304_G1.0941.00
194_L216_L1.0941.00
105_S108_L1.0931.00
110_W271_T1.0861.00
73_K82_N1.0851.00
195_I225_L1.0711.00
163_R191_C1.0701.00
193_V221_Y1.0641.00
184_L212_L1.0611.00
258_L262_S1.0601.00
213_L222_L1.0451.00
53_A79_E1.0391.00
138_T190_Q1.0391.00
52_L80_M1.0271.00
233_E255_R1.0251.00
102_Y273_T1.0221.00
240_L270_V1.0191.00
166_S170_K1.0181.00
142_L194_L1.0041.00
107_V139_I1.0011.00
61_F292_T0.9991.00
241_D266_Q0.9981.00
219_G244_K0.9981.00
209_N235_D0.9971.00
107_V155_L0.9871.00
102_Y249_M0.9851.00
142_L184_L0.9841.00
233_E262_S0.9791.00
239_A244_K0.9741.00
29_R33_S0.9711.00
61_F289_I0.9651.00
237_L263_P0.9641.00
86_P302_V0.9571.00
167_R203_E0.9521.00
283_A287_E0.9491.00
73_K81_L0.9481.00
184_L188_L0.9451.00
153_Q156_Q0.9431.00
70_I87_L0.9411.00
255_R259_P0.9401.00
182_E186_A0.9311.00
180_G190_Q0.9221.00
208_I222_L0.9211.00
111_F132_Y0.9211.00
106_Q271_T0.9161.00
29_R50_E0.9141.00
62_A69_S0.9101.00
72_S81_L0.9091.00
239_A245_V0.9091.00
41_Y293_I0.9071.00
199_P204_T0.8951.00
191_C194_L0.8911.00
209_N232_V0.8911.00
151_V155_L0.8911.00
149_S170_K0.8781.00
61_F88_F0.8761.00
198_L207_I0.8761.00
104_V154_S0.8751.00
34_G37_D0.8731.00
33_S54_G0.8681.00
179_A182_E0.8681.00
98_Q133_H0.8671.00
64_G69_S0.8661.00
111_F137_F0.8641.00
142_L196_N0.8631.00
29_R48_P0.8611.00
109_H114_F0.8461.00
213_L244_K0.8461.00
96_G150_K0.8431.00
133_H280_T0.8421.00
141_I151_V0.8371.00
135_E159_R0.8331.00
139_I195_I0.8321.00
213_L216_L0.8291.00
119_I268_P0.8261.00
41_Y297_E0.8251.00
60_V80_M0.8251.00
30_A33_S0.8241.00
231_V236_L0.8231.00
111_F221_Y0.8231.00
219_G246_K0.8161.00
134_R160_F0.8161.00
71_L79_E0.8121.00
196_N208_I0.8101.00
109_H271_T0.8091.00
50_E53_A0.8071.00
292_T295_Q0.8051.00
52_L60_V0.8041.00
247_G271_T0.8021.00
255_R258_L0.7941.00
152_A162_L0.7861.00
115_D119_I0.7851.00
238_A241_D0.7841.00
99_M277_A0.7841.00
144_A152_A0.7821.00
188_L194_L0.7801.00
236_L245_V0.7751.00
97_E101_E0.7721.00
43_L289_I0.7681.00
178_F182_E0.7681.00
104_V151_V0.7681.00
234_D238_A0.7671.00
182_E187_F0.7651.00
185_S189_S0.7641.00
194_L220_A0.7601.00
200_N204_T0.7571.00
59_A293_I0.7561.00
214_E242_S0.7541.00
233_E264_L0.7521.00
132_Y282_P0.7491.00
132_Y281_R0.7471.00
29_R32_K0.7441.00
96_G146_V0.7431.00
250_L270_V0.7391.00
103_A197_L0.7381.00
284_E287_E0.7371.00
37_D54_G0.7341.00
149_S173_P0.7291.00
105_S109_H0.7271.00
97_E133_H0.7271.00
42_A47_P0.7251.00
253_F258_L0.7231.00
234_D254_N0.7211.00
165_W184_L0.7201.00
111_F115_D0.7181.00
101_E112_R0.7161.00
104_V107_V0.7151.00
170_K173_P0.7141.00
117_Y276_V0.7131.00
36_N42_A0.7091.00
90_L288_Y0.7081.00
240_L269_R0.7051.00
160_F193_V0.7031.00
37_D55_R0.7011.00
188_L215_K0.6991.00
219_G245_V0.6991.00
248_A270_V0.6971.00
156_Q178_F0.6961.00
103_A195_I0.6951.00
132_Y219_G0.6901.00
154_S158_W0.6901.00
92_D146_V0.6891.00
210_Q244_K0.6891.00
221_Y249_M0.6871.00
107_V151_V0.6871.00
138_T191_C0.6861.00
186_A189_S0.6831.00
38_S55_R0.6831.00
290_S294_A0.6831.00
121_Q265_W0.6791.00
169_R181_R0.6791.00
67_V72_S0.6781.00
62_A67_V0.6761.00
258_L261_E0.6761.00
196_N226_A0.6751.00
98_Q101_E0.6721.00
184_L207_I0.6721.00
164_C181_R0.6711.00
92_D288_Y0.6631.00
236_L250_L0.6621.00
90_L94_G0.6581.00
231_V248_A0.6571.00
166_S169_R0.6561.00
49_V71_L0.6551.00
103_A106_Q0.6521.00
49_V83_P0.6511.00
295_Q301_R0.6501.00
100_Q150_K0.6501.00
118_R121_Q0.6491.00
194_L217_P0.6461.00
301_R305_Q0.6431.00
61_F293_I0.6401.00
295_Q302_V0.6391.00
262_S266_Q0.6371.00
107_V134_R0.6371.00
149_S153_Q0.6351.00
291_R294_A0.6321.00
67_V89_R0.6311.00
249_M271_T0.6301.00
137_F193_V0.6301.00
135_E284_E0.6301.00
198_L226_A0.6291.00
36_N55_R0.6261.00
188_L216_L0.6241.00
238_A244_K0.6231.00
138_T217_P0.6221.00
138_T192_R0.6191.00
90_L285_A0.6191.00
164_C179_A0.6181.00
201_T204_T0.6131.00
205_V254_N0.6121.00
98_Q280_T0.6111.00
140_G165_W0.6081.00
210_Q242_S0.6061.00
182_E190_Q0.6051.00
265_W272_I0.6041.00
206_G229_V0.6011.00
120_Q123_S0.6001.00
58_K296_L0.6001.00
35_D39_A0.5991.00
61_F90_L0.5921.00
94_G285_A0.5911.00
139_I151_V0.5911.00
117_Y274_P0.5891.00
68_D200_N0.5881.00
102_Y105_S0.5871.00
50_E54_G0.5861.00
107_V223_L0.5861.00
94_G278_A0.5851.00
258_L265_W0.5841.00
102_Y112_R0.5791.00
106_Q109_H0.5771.00
229_V254_N0.5771.00
240_L248_A0.5771.00
107_V195_I0.5771.00
259_P262_S0.5751.00
92_D96_G0.5731.00
206_G209_N0.5691.00
241_D268_P0.5691.00
210_Q239_A0.5681.00
63_L285_A0.5651.00
41_Y61_F0.5651.00
118_R272_I0.5651.00
97_E159_R0.5641.00
72_S87_L0.5641.00
137_F160_F0.5611.00
111_F160_F0.5601.00
156_Q176_Q0.5571.00
156_Q162_L0.5551.00
163_R187_F0.5551.00
134_R158_W0.5521.00
198_L204_T0.5521.00
94_G288_Y0.5501.00
233_E237_L0.5501.00
287_E290_S0.5491.00
154_S157_T0.5481.00
161_P179_A0.5471.00
163_R181_R0.5471.00
178_F181_R0.5471.00
106_Q110_W0.5461.00
89_R306_V0.5411.00
121_Q253_F0.5391.00
41_Y44_V0.5371.00
239_A242_S0.5351.00
115_D271_T0.5351.00
31_W34_G0.5321.00
52_L85_V0.5321.00
302_V305_Q0.5321.00
194_L208_I0.5311.00
120_Q127_Q0.5311.00
116_D120_Q0.5301.00
99_M103_A0.5301.00
120_Q129_L0.5271.00
95_M98_Q0.5241.00
255_R262_S0.5241.00
144_A166_S0.5241.00
47_P52_L0.5231.00
117_Y129_L0.5211.00
73_K79_E0.5201.00
153_Q157_T0.5161.00
263_P267_H0.5161.00
219_G242_S0.5141.00
55_R83_P0.5131.00
227_R275_H0.5101.00
188_L207_I0.5101.00
156_Q177_S0.5091.00
194_L222_L0.5071.00
175_V178_F0.5071.00
167_R170_K0.5071.00
111_F134_R0.5071.00
234_D262_S0.5071.00
33_S51_M0.5041.00
262_S265_W0.5021.00
152_A164_C0.5001.00
172_W176_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n18A 2 0.9712 100 0.201 Contact Map
4xa8A 2 0.9359 100 0.21 Contact Map
3pp8A 2 0.9647 100 0.21 Contact Map
3hg7A 2 0.9615 100 0.218 Contact Map
4z0pA 2 0.9744 100 0.226 Contact Map
4zqbA 2 0.9808 100 0.228 Contact Map
4xcvA 2 0.9744 100 0.229 Contact Map
3kb6A 4 0.9776 100 0.235 Contact Map
1dxyA 5 0.9615 100 0.238 Contact Map
3evtA 2 0.9583 100 0.243 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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