GREMLIN Database
YCDT - Probable diguanylate cyclase YcdT
UniProt: P75908 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13866
Length: 452 (384)
Sequences: 7733 (7175)
Seq/√Len: 366.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
350_R353_D5.8121.00
280_N284_R4.8501.00
315_M406_I4.4781.00
300_L418_P4.0381.00
315_M379_A4.0111.00
313_C410_V4.0021.00
321_H437_R3.9411.00
296_F364_G3.5631.00
271_I275_L3.3961.00
432_A441_V3.3421.00
291_F295_Y3.3161.00
380_E383_R3.2551.00
290_I342_V2.9071.00
358_V364_G2.8541.00
290_I355_L2.7691.00
336_Q339_K2.7021.00
387_E438_N2.7001.00
296_F356_A2.6811.00
319_I341_V2.6591.00
313_C375_A2.5961.00
371_D374_R2.5071.00
417_N420_E2.5041.00
367_L378_L2.4871.00
345_I355_L2.3561.00
383_R440_V2.2851.00
435_T441_V2.2721.00
325_V337_V2.2621.00
316_I429_L2.2341.00
349_I355_L2.2251.00
275_L278_T2.1881.00
299_E302_V2.1811.00
386_V404_I2.1801.00
431_E435_T2.1781.00
332_P423_R2.1731.00
403_T438_N2.1721.00
295_Y299_E2.1311.00
337_V402_V2.1001.00
320_D405_S2.0951.00
260_K267_F2.0521.00
415_A424_L2.0521.00
380_E384_E2.0281.00
288_T338_I2.0211.00
299_E354_L2.0081.00
291_F354_L2.0071.00
340_T343_N1.9771.00
317_M404_I1.9351.00
432_A439_K1.9301.00
426_D430_Y1.9151.00
409_V421_I1.9141.00
344_I390_T1.9121.00
319_I404_I1.8951.00
340_T391_G1.8921.00
431_E434_E1.8671.00
317_M406_I1.8661.00
341_V386_V1.8511.00
412_Q415_A1.8401.00
325_V400_Q1.8001.00
405_S432_A1.8001.00
279_K283_H1.7981.00
383_R387_E1.7911.00
340_T344_I1.7451.00
271_I274_A1.7311.00
264_M267_F1.7161.00
272_F275_L1.6901.00
435_T439_K1.6811.00
295_Y354_L1.6741.00
431_E441_V1.6671.00
331_H426_D1.6641.00
312_Y411_T1.6591.00
321_H361_E1.6501.00
358_V422_Y1.6451.00
343_N346_G1.6441.00
336_Q340_T1.6381.00
315_M367_L1.6271.00
393_N396_Y1.6231.00
348_S385_N1.6201.00
408_A440_V1.6111.00
333_V336_Q1.5981.00
411_T421_I1.5831.00
283_H298_N1.5771.00
323_K430_Y1.5601.00
257_V267_F1.5211.00
424_L443_R1.5211.00
281_I294_N1.5191.00
286_P294_N1.5011.00
327_D430_Y1.5011.00
337_V391_G1.4931.00
333_V393_N1.4901.00
316_I358_V1.4901.00
378_L381_R1.4801.00
299_E303_Q1.4651.00
300_L366_L1.4631.00
361_E403_T1.4571.00
341_V345_I1.4491.00
423_R427_N1.4481.00
331_H430_Y1.4261.00
323_K327_D1.4181.00
349_I353_D1.3871.00
293_R335_D1.3851.00
359_G430_Y1.3791.00
303_Q368_T1.3751.00
348_S381_R1.3731.00
267_F271_I1.3721.00
326_N334_G1.3521.00
322_F338_I1.3521.00
360_G430_Y1.3511.00
316_I422_Y1.3511.00
296_F366_L1.3491.00
312_Y421_I1.3491.00
297_F419_N1.3421.00
342_V355_L1.3331.00
376_K380_E1.3311.00
319_I403_T1.3241.00
416_L424_L1.3231.00
364_G422_Y1.3221.00
355_L365_V1.3131.00
375_A408_A1.3061.00
320_D437_R1.3061.00
315_M365_V1.3011.00
353_D381_R1.2871.00
298_N302_V1.2821.00
257_V260_K1.2801.00
359_G362_E1.2701.00
321_H324_K1.2691.00
261_L267_F1.2651.00
318_D430_Y1.2601.00
375_A379_A1.2591.00
337_V361_E1.2531.00
376_K440_V1.2501.00
318_D433_K1.2501.00
327_D426_D1.2491.00
263_V267_F1.2441.00
379_A406_I1.2341.00
324_K328_T1.2271.00
432_A436_G1.2231.00
261_L264_M1.2171.00
385_N388_R1.2041.00
376_K442_V1.1941.00
383_R406_I1.1931.00
299_E356_A1.1851.00
356_A364_G1.1611.00
379_A408_A1.1601.00
296_F300_L1.1591.00
383_R438_N1.1591.00
301_T418_P1.1561.00
283_H295_Y1.1411.00
317_M345_I1.1391.00
277_V280_N1.1331.00
316_I364_G1.1261.00
295_Y298_N1.1191.00
260_K264_M1.1171.00
260_K269_C1.1131.00
408_A442_V1.1061.00
359_G426_D1.1021.00
291_F356_A1.0911.00
341_V402_V1.0871.00
119_R122_S1.0851.00
427_N443_R1.0801.00
403_T436_G1.0791.00
263_V269_C1.0781.00
264_M268_M1.0761.00
323_K426_D1.0741.00
362_E430_Y1.0611.00
313_C408_A1.0591.00
393_N400_Q1.0591.00
409_V424_L1.0591.00
274_A277_V1.0511.00
384_E388_R1.0481.00
367_L375_A1.0441.00
310_T369_D1.0381.00
263_V268_M1.0371.00
299_E366_L1.0361.00
317_M365_V1.0311.00
277_V281_I1.0301.00
260_K263_V1.0281.00
303_Q312_Y1.0241.00
347_K385_N1.0211.00
323_K331_H1.0191.00
265_V269_C1.0181.00
392_D399_P1.0151.00
331_H362_E1.0141.00
256_E260_K1.0031.00
420_E423_R0.9981.00
268_M271_I0.9961.00
284_R291_F0.9961.00
262_T265_V0.9951.00
287_L293_R0.9941.00
339_K343_N0.9941.00
275_L279_K0.9841.00
362_E426_D0.9801.00
297_F301_T0.9701.00
323_K433_K0.9671.00
429_L437_R0.9651.00
318_D331_H0.9651.00
333_V400_Q0.9631.00
314_V422_Y0.9581.00
283_H291_F0.9511.00
293_R297_F0.9501.00
361_E439_K0.9461.00
311_P413_E0.9311.00
428_A432_A0.9261.00
360_G426_D0.9221.00
339_K342_V0.9201.00
343_N347_K0.9131.00
315_M408_A0.9111.00
78_S85_L0.9081.00
344_I391_G0.9071.00
237_S241_M0.9041.00
323_K362_E0.9031.00
57_A60_F0.8991.00
392_D395_E0.8981.00
257_V263_V0.8941.00
307_A350_R0.8931.00
327_D362_E0.8911.00
320_D436_G0.8901.00
418_P422_Y0.8891.00
349_I365_V0.8881.00
261_L268_M0.8871.00
379_A440_V0.8841.00
344_I385_N0.8831.00
257_V261_L0.8791.00
323_K360_G0.8761.00
336_Q394_P0.8701.00
243_R247_S0.8661.00
350_R381_R0.8651.00
265_V271_I0.8641.00
327_D360_G0.8641.00
270_H273_S0.8621.00
353_D378_L0.8601.00
323_K326_N0.8591.00
349_I382_I0.8581.00
361_E437_R0.8551.00
256_E259_S0.8551.00
386_V402_V0.8511.00
260_K268_M0.8511.00
342_V345_I0.8491.00
303_Q307_A0.8491.00
276_R279_K0.8461.00
341_V404_I0.8441.00
325_V393_N0.8421.00
284_R290_I0.8401.00
75_C80_A0.8351.00
76_V79_L0.8351.00
384_E387_E0.8271.00
326_N361_E0.8261.00
153_I156_F0.8261.00
370_I374_R0.8251.00
203_W207_L0.8201.00
375_A410_V0.8191.00
430_Y433_K0.8171.00
326_N433_K0.8151.00
256_E267_F0.8131.00
345_I349_I0.8121.00
331_H433_K0.8121.00
312_Y366_L0.8101.00
322_F432_A0.8061.00
349_I378_L0.7981.00
331_H360_G0.7971.00
147_K150_T0.7971.00
144_L148_K0.7871.00
353_D367_L0.7851.00
361_E433_K0.7841.00
146_S150_T0.7771.00
147_K160_G0.7771.00
374_R377_A0.7761.00
109_Q113_A0.7751.00
143_N147_K0.7721.00
56_V61_M0.7691.00
130_A134_K0.7681.00
113_A116_Y0.7651.00
189_V193_A0.7651.00
259_S263_V0.7631.00
332_P419_N0.7621.00
125_I129_L0.7611.00
257_V269_C0.7601.00
361_E438_N0.7591.00
361_E432_A0.7581.00
290_I345_I0.7571.00
365_V382_I0.7541.00
183_T186_N0.7531.00
297_F300_L0.7521.00
221_W224_V0.7511.00
295_Y356_A0.7511.00
64_Y68_D0.7501.00
289_N339_K0.7491.00
297_F356_A0.7491.00
327_D359_G0.7481.00
409_V425_A0.7481.00
178_H181_E0.7461.00
267_F272_F0.7461.00
95_I99_I0.7421.00
145_F149_M0.7421.00
329_W400_Q0.7411.00
286_P297_F0.7381.00
350_R370_I0.7381.00
424_L428_A0.7351.00
361_E436_G0.7341.00
318_D362_E0.7311.00
197_T200_I0.7301.00
262_T268_M0.7281.00
327_D331_H0.7271.00
390_T401_K0.7271.00
161_G165_A0.7241.00
314_V421_I0.7241.00
78_S82_L0.7231.00
346_G355_L0.7211.00
279_K298_N0.7211.00
198_I201_F0.7211.00
320_D438_N0.7181.00
127_I131_L0.7181.00
378_L382_I0.7171.00
322_F337_V0.7161.00
61_M65_F0.7150.99
334_G361_E0.7140.99
93_I97_Q0.7100.99
258_V262_T0.7080.99
263_V271_I0.7070.99
372_T442_V0.7070.99
278_T281_I0.7050.99
116_Y127_I0.7000.99
354_L366_L0.7000.99
261_L265_V0.6980.99
340_T390_T0.6980.99
318_D326_N0.6960.99
154_S158_V0.6960.99
296_F314_V0.6950.99
144_L147_K0.6940.99
258_V261_L0.6930.99
326_N360_G0.6900.99
56_V62_Q0.6860.99
331_H361_E0.6860.99
345_I382_I0.6860.99
405_S437_R0.6850.99
263_V266_I0.6810.99
272_F276_R0.6800.99
256_E264_M0.6800.99
383_R403_T0.6780.99
390_T400_Q0.6770.99
265_V268_M0.6760.99
320_D429_L0.6750.99
190_V193_A0.6750.99
370_I375_A0.6740.99
179_I183_T0.6740.99
268_M272_F0.6740.99
386_V391_G0.6730.99
409_V428_A0.6730.99
320_D433_K0.6730.99
126_L129_L0.6720.99
128_F133_N0.6720.99
337_V393_N0.6710.99
405_S436_G0.6710.99
56_V63_L0.6700.99
76_V80_A0.6700.99
163_I167_I0.6680.99
286_P358_V0.6670.99
424_L427_N0.6660.99
429_L436_G0.6660.99
411_T415_A0.6650.99
264_M269_C0.6640.99
154_S157_F0.6640.99
255_I260_K0.6630.99
234_Y238_L0.6620.99
123_L127_I0.6620.99
319_I338_I0.6620.99
326_N362_E0.6610.99
404_I429_L0.6600.99
318_D334_G0.6580.99
56_V59_I0.6580.99
362_E433_K0.6570.99
256_E261_L0.6510.99
209_V213_F0.6500.99
187_G191_W0.6500.99
188_Q192_K0.6490.99
377_A381_R0.6460.99
92_V96_Q0.6400.99
325_V329_W0.6390.99
80_A83_S0.6390.99
222_N225_T0.6380.99
62_Q65_F0.6380.99
416_L420_E0.6370.99
361_E443_R0.6360.99
267_F270_H0.6360.99
334_G433_K0.6350.99
296_F422_Y0.6350.99
415_A420_E0.6340.99
324_K361_E0.6330.99
234_Y237_S0.6330.99
261_L266_I0.6330.99
87_Y93_I0.6330.99
361_E404_I0.6310.99
331_H359_G0.6310.99
372_T410_V0.6300.99
194_S198_I0.6300.99
74_N77_L0.6280.99
60_F63_L0.6280.99
372_T376_K0.6260.99
319_I322_F0.6250.99
85_L91_T0.6250.99
350_R378_L0.6240.99
59_I63_L0.6220.99
128_F131_L0.6210.99
194_S197_T0.6200.99
274_A278_T0.6200.99
256_E269_C0.6190.99
62_Q66_I0.6190.99
224_V227_I0.6160.98
318_D361_E0.6150.98
222_N230_C0.6150.98
58_F65_F0.6140.98
322_F433_K0.6120.98
185_E192_K0.6120.98
142_R146_S0.6110.98
284_R295_Y0.6110.98
162_P166_H0.6110.98
116_Y120_Q0.6100.98
185_E189_V0.6100.98
82_L85_L0.6090.98
143_N146_S0.6090.98
148_K152_C0.6080.98
278_T282_A0.6080.98
125_I128_F0.6070.98
323_K359_G0.6060.98
59_I62_Q0.6050.98
373_E376_K0.6050.98
93_I96_Q0.6040.98
313_C367_L0.6040.98
361_E430_Y0.6040.98
348_S353_D0.6020.98
92_V95_I0.5990.98
63_L67_Y0.5980.98
322_F326_N0.5980.98
83_S87_Y0.5980.98
334_G362_E0.5980.98
274_A281_I0.5970.98
345_I365_V0.5970.98
61_M68_D0.5970.98
199_M202_M0.5950.98
222_N226_V0.5950.98
186_N191_W0.5940.98
323_K334_G0.5920.98
238_L241_M0.5910.98
379_A383_R0.5910.98
116_Y122_S0.5900.98
254_T261_L0.5890.98
199_M203_W0.5890.98
362_E405_S0.5890.98
180_A188_Q0.5880.98
300_L422_Y0.5870.98
247_S251_I0.5870.98
405_S430_Y0.5860.98
414_N442_V0.5850.98
282_A323_K0.5850.98
258_V265_V0.5840.98
286_P291_F0.5830.98
353_D370_I0.5830.98
94_I98_I0.5810.98
235_N238_L0.5800.98
282_A292_N0.5800.98
344_I393_N0.5790.98
428_A443_R0.5780.98
304_S411_T0.5780.98
361_E383_R0.5780.98
237_S245_S0.5770.98
86_I93_I0.5770.98
318_D327_D0.5730.98
141_Q148_K0.5720.98
146_S153_I0.5720.98
195_Y201_F0.5720.98
411_T414_N0.5710.98
71_Q74_N0.5710.98
196_V200_I0.5700.98
218_Y222_N0.5690.97
66_I70_R0.5670.97
117_L120_Q0.5650.97
358_V361_E0.5640.97
281_I286_P0.5640.97
325_V361_E0.5620.97
88_F91_T0.5620.97
414_N424_L0.5600.97
143_N153_I0.5600.97
380_E440_V0.5590.97
55_T60_F0.5580.97
124_C128_F0.5570.97
332_P358_V0.5560.97
59_I64_Y0.5560.97
258_V266_I0.5560.97
153_I157_F0.5540.97
218_Y223_G0.5530.97
278_T283_H0.5520.97
194_S200_I0.5510.97
61_M64_Y0.5500.97
236_I239_L0.5500.97
268_M275_L0.5500.97
85_L89_V0.5490.97
381_R385_N0.5490.97
165_A168_L0.5480.97
64_Y67_Y0.5470.97
157_F160_G0.5450.97
262_T267_F0.5450.97
257_V268_M0.5450.97
55_T63_L0.5410.97
383_R436_G0.5410.97
412_Q424_L0.5400.97
266_I269_C0.5400.97
156_F159_F0.5400.97
156_F160_G0.5400.97
137_E140_K0.5390.97
348_S382_I0.5370.96
76_V83_S0.5370.96
259_S262_T0.5370.96
209_V212_Y0.5360.96
95_I98_I0.5360.96
75_C79_L0.5350.96
121_M124_C0.5350.96
412_Q416_L0.5340.96
291_F355_L0.5330.96
283_H294_N0.5330.96
254_T260_K0.5320.96
56_V60_F0.5320.96
269_C273_S0.5320.96
321_H429_L0.5310.96
374_R378_L0.5300.96
198_I203_W0.5300.96
286_P292_N0.5300.96
296_F358_V0.5300.96
57_A64_Y0.5290.96
231_A235_N0.5290.96
131_L135_V0.5290.96
60_F67_Y0.5290.96
323_K429_L0.5270.96
62_Q70_R0.5260.96
286_P295_Y0.5260.96
280_N289_N0.5260.96
396_Y400_Q0.5240.96
203_W208_S0.5230.96
178_H192_K0.5230.96
391_G401_K0.5220.96
243_R246_V0.5220.96
195_Y198_I0.5210.96
58_F66_I0.5210.96
260_K265_V0.5200.96
83_S86_I0.5200.96
119_R126_L0.5190.96
148_K151_L0.5180.96
315_M378_L0.5180.96
126_L134_K0.5180.96
145_F148_K0.5180.96
361_E429_L0.5170.96
225_T229_F0.5160.96
150_T153_I0.5150.96
195_Y200_I0.5150.96
320_D430_Y0.5150.96
390_T393_N0.5150.96
329_W396_Y0.5150.96
141_Q146_S0.5130.95
405_S433_K0.5110.95
57_A61_M0.5100.95
321_H403_T0.5090.95
311_P371_D0.5090.95
57_A62_Q0.5090.95
142_R145_F0.5090.95
246_V249_W0.5090.95
370_I410_V0.5080.95
300_L314_V0.5060.95
146_S154_S0.5060.95
114_I117_L0.5060.95
187_G193_A0.5060.95
332_P336_Q0.5050.95
300_L312_Y0.5050.95
147_K151_L0.5030.95
313_C368_T0.5020.95
383_R432_A0.5010.95
153_I162_P0.5010.95
329_W333_V0.5010.95
372_T375_A0.5010.95
230_C233_L0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4j40A 2 0.0044 100 0.48 Contact Map
1w25A 2 0.7389 100 0.484 Contact Map
3pjxA 1 0.3916 100 0.492 Contact Map
4rnhA 2 0.3606 100 0.493 Contact Map
3mtkA 2 0.3606 100 0.502 Contact Map
4h54A 2 0.604 100 0.508 Contact Map
3i5cA 2 0.427 100 0.512 Contact Map
3tvkA 1 0.3783 100 0.513 Contact Map
3ignA 1 0.3628 100 0.515 Contact Map
3ezuA 2 0.7235 100 0.516 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0112 seconds.