GREMLIN Database
PGAC - Poly-beta-1,6-N-acetyl-D-glucosamine synthase
UniProt: P75905 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13863
Length: 441 (385)
Sequences: 10178 (7573)
Seq/√Len: 385.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_R174_A4.9471.00
87_E117_K4.7571.00
239_R243_A4.5031.00
158_Y177_V3.5061.00
78_S156_S3.4281.00
106_E133_R3.3451.00
160_V236_A3.2821.00
111_N136_H3.2791.00
80_I110_V3.1151.00
110_V150_G2.9961.00
241_A268_W2.9741.00
119_R123_D2.9701.00
78_S106_E2.9391.00
175_Y275_R2.9101.00
158_Y180_M2.8991.00
117_K120_A2.8251.00
244_E266_N2.8001.00
120_A124_R2.6921.00
106_E156_S2.6791.00
77_I177_V2.5321.00
186_V271_F2.4941.00
179_P273_E2.4651.00
285_T288_G2.4551.00
200_T203_G2.4031.00
171_D175_Y2.3351.00
158_Y236_A2.2981.00
91_E124_R2.2891.00
81_I97_A2.2481.00
180_M236_A2.2481.00
330_T333_A2.1961.00
101_R171_D2.1781.00
76_S157_E2.1531.00
316_N320_W2.1301.00
122_L134_V2.1121.00
77_I173_A2.1031.00
185_R269_T2.1011.00
111_N114_S2.0961.00
76_S156_S2.0801.00
183_N269_T2.0311.00
78_S154_A2.0041.00
176_I236_A1.9981.00
91_E95_H1.9701.00
187_G268_W1.9701.00
240_S244_E1.9501.00
78_S108_I1.9381.00
244_E268_W1.8831.00
241_A263_L1.8541.00
315_E319_M1.8431.00
230_V235_A1.8351.00
76_S155_K1.8311.00
399_I402_P1.8241.00
160_V173_A1.8211.00
329_T333_A1.8001.00
38_P42_S1.7841.00
292_Q296_W1.7621.00
91_E121_I1.7321.00
42_S45_W1.7301.00
76_S104_N1.6821.00
369_L373_C1.6561.00
106_E155_K1.6391.00
409_S412_T1.6341.00
48_G51_Y1.6031.00
158_Y238_R1.6001.00
416_S419_R1.5991.00
76_S106_E1.5931.00
75_P177_V1.5711.00
74_N103_E1.5631.00
209_E293_R1.5611.00
188_A270_I1.5521.00
95_H125_M1.5281.00
75_P102_Y1.5241.00
101_R170_R1.5151.00
151_A159_L1.5081.00
45_W48_G1.5071.00
48_G52_F1.4931.00
45_W49_G1.4861.00
379_V383_I1.4621.00
258_D262_K1.4601.00
96_A168_L1.4541.00
154_A239_R1.4411.00
123_D126_A1.4351.00
367_I370_C1.4301.00
120_A123_D1.4101.00
122_L126_A1.4031.00
109_A122_L1.3981.00
42_S46_I1.3931.00
150_G154_A1.3771.00
254_T299_G1.3741.00
317_F321_P1.3661.00
108_I133_R1.3641.00
323_F326_Y1.3451.00
159_L239_R1.3421.00
369_L372_L1.3401.00
376_Q383_I1.3391.00
322_L325_E1.3251.00
315_E320_W1.3051.00
110_V146_A1.2991.00
315_E321_P1.2971.00
166_A278_C1.2951.00
44_M48_G1.2941.00
316_N319_M1.2931.00
365_A369_L1.2921.00
85_N114_S1.2921.00
143_K147_L1.2871.00
415_V418_T1.2851.00
86_E164_G1.2821.00
159_L242_L1.2781.00
330_T334_F1.2751.00
52_F55_Y1.2701.00
96_A167_L1.2681.00
318_R321_P1.2651.00
123_D136_H1.2641.00
372_L376_Q1.2641.00
100_Q173_A1.2601.00
394_S401_F1.2571.00
94_I125_M1.2551.00
408_L411_A1.2451.00
79_I160_V1.2451.00
121_I124_R1.2421.00
343_Y346_Q1.2341.00
350_V353_N1.2221.00
373_C376_Q1.2141.00
412_T416_S1.2091.00
102_Y177_V1.2001.00
172_A234_I1.1991.00
51_Y55_Y1.1971.00
34_V38_P1.1971.00
317_F320_W1.1951.00
329_T332_W1.1931.00
83_C118_T1.1931.00
292_Q295_R1.1851.00
97_A107_V1.1761.00
339_G343_Y1.1741.00
370_C373_C1.1731.00
119_R136_H1.1661.00
47_V55_Y1.1601.00
99_A170_R1.1591.00
39_F42_S1.1551.00
175_Y178_E1.1531.00
45_W52_F1.1501.00
149_T153_A1.1441.00
315_E318_R1.1431.00
369_L376_Q1.1401.00
32_R36_F1.1351.00
168_L172_A1.1331.00
135_I149_T1.1321.00
36_F40_F1.1261.00
51_Y54_V1.1221.00
42_S52_F1.1211.00
280_I283_P1.1151.00
416_S420_V1.1101.00
322_L326_Y1.1051.00
380_S385_N1.0971.00
397_W401_F1.0941.00
45_W56_R1.0931.00
188_A263_L1.0871.00
111_N119_R1.0841.00
197_T203_G1.0811.00
83_C90_V1.0781.00
299_G302_E1.0741.00
78_S239_R1.0741.00
32_R39_F1.0731.00
407_M411_A1.0701.00
190_T193_P1.0671.00
380_S383_I1.0671.00
187_G238_R1.0661.00
135_I153_A1.0661.00
195_I282_M1.0651.00
105_I173_A1.0601.00
49_G52_F1.0571.00
40_F44_M1.0571.00
33_F37_W1.0521.00
383_I386_R1.0511.00
97_A168_L1.0481.00
41_M45_W1.0431.00
342_I346_Q1.0431.00
46_I50_V1.0421.00
193_P233_V1.0421.00
410_L416_S1.0401.00
95_H99_A1.0401.00
245_V263_L1.0401.00
45_W53_W1.0391.00
112_D140_N1.0381.00
346_Q350_V1.0371.00
98_L129_I1.0361.00
162_I168_L1.0361.00
406_W410_L1.0291.00
149_T152_A1.0281.00
376_Q379_V1.0271.00
48_G55_Y1.0251.00
74_N174_A1.0231.00
345_V349_G1.0171.00
320_W323_F1.0161.00
333_A337_L1.0151.00
106_E154_A1.0141.00
147_L161_C1.0131.00
90_V109_A1.0111.00
35_F39_F1.0041.00
394_S397_W1.0011.00
117_K121_I0.9981.00
381_L384_E0.9971.00
156_S239_R0.9971.00
147_L248_W0.9971.00
319_M323_F0.9961.00
376_Q380_S0.9941.00
188_A230_V0.9841.00
121_I125_M0.9791.00
293_R296_W0.9791.00
48_G58_R0.9781.00
248_W251_D0.9751.00
122_L125_M0.9741.00
200_T204_K0.9741.00
42_S49_G0.9721.00
218_K221_Q0.9711.00
303_V307_N0.9691.00
400_W404_I0.9691.00
247_Y251_D0.9641.00
114_S118_T0.9631.00
47_V50_V0.9621.00
71_L74_N0.9531.00
412_T419_R0.9511.00
396_F399_I0.9491.00
52_F56_R0.9461.00
90_V94_I0.9461.00
336_C339_G0.9441.00
169_D279_W0.9431.00
55_Y58_R0.9431.00
43_I47_V0.9411.00
85_N115_T0.9391.00
402_P406_W0.9361.00
415_V419_R0.9351.00
49_G53_W0.9311.00
411_A414_L0.9281.00
399_I403_V0.9271.00
393_S396_F0.9241.00
157_E240_S0.9221.00
148_K152_A0.9191.00
366_G369_L0.9131.00
32_R38_P0.9121.00
176_I191_G0.9111.00
326_Y330_T0.9111.00
408_L412_T0.9091.00
98_L131_H0.9051.00
346_Q349_G0.9001.00
299_G303_V0.8981.00
48_G56_R0.8981.00
406_W409_S0.8951.00
201_L204_K0.8951.00
49_G56_R0.8941.00
176_I189_V0.8931.00
151_A154_A0.8921.00
381_L385_N0.8901.00
37_W41_M0.8871.00
126_A129_I0.8861.00
92_E95_H0.8861.00
325_E329_T0.8831.00
131_H136_H0.8821.00
102_Y105_I0.8821.00
372_L375_L0.8811.00
38_P45_W0.8771.00
133_R136_H0.8701.00
379_V382_M0.8691.00
397_W402_P0.8651.00
343_Y350_V0.8601.00
211_S214_I0.8591.00
84_F140_N0.8581.00
35_F42_S0.8571.00
32_R35_F0.8571.00
38_P48_G0.8561.00
392_T396_F0.8561.00
93_T97_A0.8551.00
219_R274_P0.8531.00
372_L380_S0.8511.00
380_S384_E0.8501.00
409_S413_T0.8491.00
398_I402_P0.8471.00
137_L149_T0.8461.00
90_V118_T0.8441.00
166_A280_I0.8331.00
52_F59_H0.8311.00
79_I105_I0.8301.00
80_I150_G0.8261.00
179_P271_F0.8191.00
41_M48_G0.8181.00
108_I154_A0.8181.00
44_M52_F0.8121.00
316_N321_P0.8121.00
333_A336_C0.8121.00
289_L293_R0.8081.00
289_L292_Q0.8071.00
332_W336_C0.8071.00
395_L399_I0.8051.00
125_M129_I0.8011.00
410_L413_T0.8011.00
38_P47_V0.8001.00
412_T415_V0.7971.00
187_G241_A0.7971.00
407_M410_L0.7931.00
134_V137_L0.7931.00
74_N104_N0.7921.00
413_T416_S0.7911.00
39_F43_I0.7891.00
408_L419_R0.7851.00
42_S53_W0.7831.00
36_F39_F0.7821.00
340_F343_Y0.7821.00
43_I53_W0.7821.00
54_V57_E0.7811.00
234_I278_C0.7801.00
189_V273_E0.7801.00
238_R268_W0.7781.00
70_Q73_D0.7731.00
347_L350_V0.7731.00
260_S270_I0.7731.00
240_S243_A0.7711.00
368_L376_Q0.7701.00
392_T398_I0.7701.00
52_F57_E0.7681.00
309_T313_R0.7611.00
206_Q209_E0.7591.00
135_I150_G0.7591.00
35_F38_P0.7581.00
187_G263_L0.7551.00
401_F404_I0.7551.00
43_I54_V0.7521.00
326_Y329_T0.7501.00
35_F41_M0.7491.00
116_D120_A0.7481.00
144_A147_L0.7471.00
56_R59_H0.7471.00
53_W57_E0.7451.00
373_C377_F0.7431.00
406_W412_T0.7431.00
249_S253_I0.7421.00
46_I49_G0.7401.00
206_Q210_Y0.7391.00
336_C340_F0.7361.00
144_A148_K0.7351.00
409_S416_S0.7351.00
53_W56_R0.7321.00
45_W55_Y0.7321.00
414_L418_T0.7321.00
383_I387_Y0.7311.00
38_P41_M0.7311.00
167_L196_R0.7291.00
119_R134_V0.7281.00
47_V52_F0.7281.00
393_S401_F0.7251.00
132_L137_L0.7231.00
160_V172_A0.7221.00
38_P55_Y0.7221.00
34_V45_W0.7221.00
131_H137_L0.7221.00
391_L395_L0.7211.00
35_F46_I0.7161.00
373_C380_S0.7161.00
298_Q302_E0.7091.00
79_I100_Q0.7081.00
43_I48_G0.7071.00
376_Q381_L0.7041.00
37_W52_F0.7041.00
202_V205_I0.7031.00
377_F380_S0.7031.00
151_A161_C0.7021.00
43_I51_Y0.7001.00
42_S48_G0.6940.99
343_Y349_G0.6940.99
73_D104_N0.6930.99
408_L416_S0.6910.99
250_D253_I0.6890.99
119_R122_L0.6890.99
44_M55_Y0.6880.99
49_G55_Y0.6820.99
394_S400_W0.6780.99
37_W40_F0.6780.99
143_K232_G0.6780.99
38_P49_G0.6760.99
43_I49_G0.6760.99
374_L378_I0.6740.99
397_W400_W0.6730.99
310_R313_R0.6720.99
41_M51_Y0.6720.99
180_M186_V0.6720.99
368_L371_T0.6720.99
375_L382_M0.6710.99
38_P52_F0.6710.99
311_L314_K0.6690.99
247_Y250_D0.6680.99
160_V176_I0.6660.99
319_M322_L0.6650.99
319_M325_E0.6640.99
108_I150_G0.6620.99
380_S387_Y0.6610.99
34_V42_S0.6600.99
249_S252_M0.6590.99
44_M51_Y0.6580.99
330_T337_L0.6570.99
263_L268_W0.6570.99
54_V58_R0.6540.99
39_F50_V0.6530.99
148_K151_A0.6510.99
328_L332_W0.6450.99
115_T118_T0.6440.99
375_L384_E0.6420.99
83_C164_G0.6400.99
364_T369_L0.6390.99
192_N195_I0.6380.99
417_F420_V0.6360.99
329_T340_F0.6350.99
93_T96_A0.6330.99
410_L419_R0.6330.99
411_A416_S0.6310.99
47_V51_Y0.6290.99
49_G57_E0.6270.99
96_A100_Q0.6270.99
415_V420_V0.6260.99
390_N393_S0.6240.99
107_V132_L0.6230.99
35_F48_G0.6210.99
45_W51_Y0.6200.99
320_W324_F0.6190.99
74_N102_Y0.6180.99
406_W416_S0.6170.99
38_P46_I0.6160.99
34_V44_M0.6140.99
171_D174_A0.6100.99
43_I46_I0.6100.99
75_P157_E0.6080.99
47_V56_R0.6080.99
255_E299_G0.6060.99
283_P292_Q0.6060.99
289_L296_W0.6050.99
409_S419_R0.6030.99
407_M412_T0.5990.98
317_F323_F0.5990.98
100_Q168_L0.5990.98
191_G276_A0.5980.98
118_T122_L0.5980.98
354_I358_H0.5970.98
38_P53_W0.5970.98
377_F383_I0.5960.98
413_T418_T0.5950.98
394_S403_V0.5940.98
255_E258_D0.5930.98
248_W252_M0.5900.98
141_Q145_I0.5900.98
213_I218_K0.5900.98
131_H134_V0.5890.98
238_R241_A0.5870.98
376_Q384_E0.5860.98
371_T375_L0.5850.98
133_R137_L0.5850.98
348_A351_P0.5840.98
326_Y333_A0.5820.98
365_A368_L0.5820.98
365_A372_L0.5820.98
390_N401_F0.5810.98
32_R40_F0.5810.98
403_V407_M0.5810.98
186_V189_V0.5810.98
34_V41_M0.5800.98
173_A236_A0.5790.98
364_T367_I0.5790.98
35_F49_G0.5790.98
94_I122_L0.5760.98
32_R56_R0.5740.98
97_A162_I0.5730.98
133_R138_A0.5730.98
169_D277_L0.5710.98
44_M56_R0.5700.98
90_V122_L0.5700.98
248_W253_I0.5690.98
381_L386_R0.5690.98
38_P44_M0.5680.98
237_F263_L0.5680.98
190_T230_V0.5670.98
323_F327_C0.5670.98
215_G219_R0.5670.98
136_H139_Q0.5660.98
217_I220_T0.5660.98
214_I217_I0.5650.98
232_G256_D0.5640.98
253_I302_E0.5640.98
43_I58_R0.5640.98
175_Y273_E0.5630.98
50_V54_V0.5580.98
87_E118_T0.5580.98
249_S306_K0.5570.98
329_T335_T0.5570.98
132_L135_I0.5560.98
179_P189_V0.5550.98
294_L298_Q0.5550.98
166_A233_V0.5550.98
191_G234_I0.5540.98
343_Y347_L0.5530.97
328_L334_F0.5530.97
97_A100_Q0.5530.97
85_N111_N0.5530.97
393_S397_W0.5520.97
93_T98_L0.5510.97
121_I126_A0.5510.97
32_R43_I0.5500.97
253_I299_G0.5490.97
392_T395_L0.5480.97
390_N394_S0.5480.97
352_L355_E0.5460.97
280_I292_Q0.5450.97
330_T335_T0.5450.97
411_A418_T0.5440.97
40_F55_Y0.5430.97
329_T336_C0.5420.97
328_L336_C0.5400.97
42_S51_Y0.5390.97
45_W50_V0.5390.97
85_N116_D0.5380.97
77_I158_Y0.5380.97
143_K255_E0.5380.97
42_S55_Y0.5380.97
44_M50_V0.5380.97
111_N165_D0.5380.97
396_F400_W0.5370.97
365_A376_Q0.5370.97
38_P54_V0.5360.97
378_I384_E0.5340.97
395_L402_P0.5330.97
192_N272_Y0.5320.97
46_I54_V0.5310.97
283_P296_W0.5300.97
43_I50_V0.5300.97
392_T397_W0.5280.97
409_S418_T0.5260.97
190_T195_I0.5250.97
332_W340_F0.5250.97
40_F43_I0.5250.97
241_A244_E0.5250.97
112_D137_L0.5250.97
210_Y231_S0.5230.96
400_W403_V0.5220.96
345_V348_A0.5210.96
371_T376_Q0.5200.96
328_L333_A0.5200.96
382_M387_Y0.5200.96
193_P210_Y0.5200.96
118_T121_I0.5200.96
41_M52_F0.5190.96
98_L132_L0.5180.96
337_L340_F0.5180.96
396_F401_F0.5170.96
378_I381_L0.5170.96
249_S262_K0.5160.96
247_Y253_I0.5160.96
176_I234_I0.5160.96
398_I401_F0.5150.96
40_F51_Y0.5150.96
161_C230_V0.5140.96
210_Y214_I0.5140.96
80_I151_A0.5130.96
346_Q353_N0.5130.96
296_W299_G0.5120.96
410_L415_V0.5110.96
44_M53_W0.5090.96
245_V262_K0.5090.96
34_V43_I0.5080.96
372_L379_V0.5080.96
264_Q270_I0.5080.96
229_T257_I0.5080.96
210_Y221_Q0.5070.96
93_T162_I0.5070.96
316_N322_L0.5050.96
394_S398_I0.5040.96
329_T334_F0.5040.96
79_I173_A0.5030.96
373_C383_I0.5030.96
38_P56_R0.5020.96
348_A352_L0.5020.96
222_R271_F0.5020.96
87_E121_I0.5010.96
36_F48_G0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p02A 1 0.9478 100 0.343 Contact Map
2z86A 2 0.6916 100 0.555 Contact Map
1qg8A 1 0.4898 100 0.571 Contact Map
1xhbA 1 0.8163 100 0.572 Contact Map
3bcvA 2 0.4104 100 0.575 Contact Map
2bo4A 4 0.7619 100 0.595 Contact Map
5ajoA 1 0.8073 100 0.596 Contact Map
2d7iA 1 0.9116 100 0.598 Contact Map
3ckjA 2 0.6372 100 0.6 Contact Map
3l7iA 4 0.1451 100 0.602 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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