GREMLIN Database
RUTA - Pyrimidine monooxygenase RutA
UniProt: P75898 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13859
Length: 382 (317)
Sequences: 14310 (9012)
Seq/√Len: 506.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
268_D329_S5.5951.00
182_K187_T3.3761.00
54_Q96_V3.2751.00
268_D326_S3.0761.00
55_K58_H2.6901.00
55_K358_E2.6751.00
267_T270_A2.6101.00
268_D272_R2.5801.00
164_T218_R2.5261.00
241_A245_Q2.4711.00
161_D184_D2.4611.00
101_Q132_G2.4561.00
214_A246_A2.4511.00
90_M102_I2.3881.00
328_A367_L2.3871.00
57_E99_R2.3711.00
333_M336_E2.3391.00
360_F364_I2.2991.00
331_A367_L2.2921.00
265_D270_A2.2881.00
213_M242_R2.2371.00
335_D339_S2.2311.00
240_A256_S2.2211.00
94_A127_S2.2201.00
358_E362_E2.1711.00
326_S329_S2.1691.00
245_Q249_Q2.0981.00
266_E363_R2.0701.00
269_D273_A2.0561.00
50_K54_Q2.0511.00
47_E128_G2.0501.00
237_A241_A2.0491.00
240_A244_K2.0491.00
54_Q58_H2.0421.00
168_Q219_Y2.0111.00
59_Y361_G1.9981.00
53_V93_L1.9911.00
237_A340_V1.9341.00
247_A254_V1.9301.00
51_A54_Q1.9011.00
242_R246_A1.8971.00
124_D129_G1.8811.00
217_A246_A1.8611.00
276_E280_A1.8591.00
60_H369_Q1.8561.00
50_K96_V1.8271.00
94_A102_I1.7671.00
158_R184_D1.7491.00
323_L330_V1.7111.00
355_S358_E1.7071.00
120_A131_F1.6971.00
336_E340_V1.6661.00
175_G200_P1.6481.00
64_A100_I1.6351.00
124_D199_V1.6341.00
85_E119_M1.6241.00
93_L102_I1.6221.00
55_K59_Y1.5931.00
53_V64_A1.5831.00
242_R245_Q1.5611.00
161_D185_F1.5391.00
328_A332_R1.5351.00
168_Q172_D1.5331.00
246_A249_Q1.5311.00
264_A330_V1.5311.00
238_P241_A1.5201.00
270_A274_K1.5101.00
214_A249_Q1.4951.00
50_K92_G1.4721.00
41_Q44_P1.4691.00
171_R219_Y1.4571.00
180_D190_D1.4551.00
65_L103_Y1.4551.00
214_A218_R1.4341.00
266_E355_S1.4331.00
172_D176_T1.4231.00
258_V343_A1.4141.00
355_S359_T1.4131.00
331_A335_D1.4061.00
47_E51_A1.4041.00
207_G223_N1.3871.00
363_R367_L1.3811.00
58_H98_S1.3751.00
141_K145_E1.3741.00
359_T363_R1.3731.00
308_Q311_D1.3521.00
158_R161_D1.3441.00
171_R203_V1.3321.00
111_L119_M1.3151.00
51_A55_K1.3131.00
120_A133_V1.3101.00
44_P48_L1.3051.00
336_E339_S1.2991.00
329_S332_R1.2971.00
247_A252_R1.2931.00
168_Q181_F1.2861.00
53_V97_T1.2691.00
335_D338_A1.2681.00
217_A250_T1.2511.00
92_G95_A1.2511.00
270_A273_A1.2451.00
327_Y359_T1.2381.00
103_Y132_G1.2351.00
263_I274_K1.2341.00
164_T219_Y1.2291.00
158_R185_F1.2101.00
266_E270_A1.2101.00
128_G198_S1.2051.00
329_S333_M1.2041.00
264_A327_Y1.2001.00
53_V100_I1.1991.00
182_K189_N1.1961.00
273_A276_E1.1941.00
365_Q369_Q1.1891.00
162_Y165_E1.1841.00
66_S90_M1.1791.00
66_S93_L1.1731.00
92_G126_I1.1661.00
265_D271_A1.1641.00
85_E88_T1.1631.00
332_R336_E1.1541.00
88_T91_A1.1501.00
214_A250_T1.1491.00
133_V170_L1.1471.00
210_D242_R1.1431.00
172_D181_F1.1371.00
169_V181_F1.1361.00
255_G344_E1.1341.00
218_R250_T1.1311.00
57_E98_S1.1291.00
59_Y357_I1.1281.00
123_I131_F1.1201.00
171_R221_D1.1171.00
178_K190_D1.1151.00
84_L122_T1.1151.00
172_D177_G1.1061.00
275_W279_K1.1031.00
135_L167_V1.0991.00
54_Q98_S1.0921.00
164_T168_Q1.0761.00
204_I222_F1.0751.00
233_P336_E1.0721.00
303_D307_R1.0691.00
58_H358_E1.0651.00
214_A242_R1.0641.00
165_E183_G1.0611.00
90_M104_A1.0591.00
92_G96_V1.0571.00
306_V310_A1.0521.00
272_R276_E1.0461.00
57_E97_T1.0431.00
171_R201_M1.0401.00
145_E189_N1.0361.00
188_M191_C1.0331.00
115_I119_M1.0221.00
325_G330_V1.0211.00
139_W143_E1.0201.00
273_A277_H1.0141.00
262_V348_L1.0141.00
356_G359_T1.0131.00
264_A359_T1.0101.00
204_I257_Y1.0071.00
169_V188_M1.0001.00
40_P48_L0.9971.00
237_A341_P0.9951.00
246_A250_T0.9941.00
61_F361_G0.9941.00
87_F119_M0.9851.00
39_A42_Y0.9751.00
158_R162_Y0.9721.00
215_F219_Y0.9691.00
275_W324_V0.9651.00
260_F323_L0.9611.00
313_T316_V0.9581.00
348_L360_F0.9561.00
63_F103_Y0.9531.00
43_M47_E0.9521.00
170_L174_W0.9501.00
265_D274_K0.9481.00
260_F334_L0.9461.00
56_A357_I0.9451.00
238_P242_R0.9421.00
295_Q298_T0.9381.00
167_V219_Y0.9361.00
235_A238_P0.9341.00
303_D306_V0.9321.00
264_A364_I0.9301.00
169_V186_F0.9281.00
332_R335_D0.9261.00
267_T271_A0.9231.00
211_A214_A0.9171.00
232_T235_A0.9161.00
274_K359_T0.9101.00
169_V172_D0.9101.00
62_D369_Q0.9081.00
125_S198_S0.9081.00
304_T307_R0.9061.00
286_A289_W0.9051.00
305_N308_Q0.9031.00
161_D211_A0.9031.00
47_E50_K0.9021.00
331_A364_I0.8991.00
94_A131_F0.8931.00
354_L358_E0.8921.00
269_D272_R0.8881.00
166_Y170_L0.8881.00
266_E359_T0.8871.00
46_F126_I0.8831.00
357_I361_G0.8751.00
247_A250_T0.8681.00
125_S199_V0.8671.00
95_A127_S0.8611.00
216_S223_N0.8601.00
165_E184_D0.8601.00
116_V166_Y0.8601.00
361_G365_Q0.8581.00
213_M246_A0.8561.00
323_L333_M0.8551.00
300_S303_D0.8541.00
51_A58_H0.8501.00
162_Y166_Y0.8491.00
224_F257_Y0.8431.00
213_M217_A0.8401.00
48_L51_A0.8391.00
247_A253_D0.8381.00
171_R200_P0.8361.00
223_N243_M0.8351.00
277_H280_A0.8331.00
277_H281_G0.8321.00
171_R175_G0.8271.00
121_A197_P0.8241.00
88_T123_I0.8201.00
233_P340_V0.8191.00
241_A342_G0.8181.00
243_M254_V0.8181.00
244_K256_S0.8181.00
58_H362_E0.8151.00
276_E279_K0.8121.00
137_T159_R0.8111.00
51_A354_L0.8111.00
205_C212_G0.8091.00
300_S304_T0.8081.00
138_G143_E0.8071.00
255_G345_G0.8051.00
124_D201_M0.8031.00
140_Q143_E0.8001.00
233_P237_A0.7991.00
109_L116_V0.7941.00
46_F92_G0.7941.00
352_D355_S0.7931.00
37_T355_S0.7881.00
240_A243_M0.7851.00
173_L179_S0.7851.00
262_V360_F0.7831.00
191_C195_P0.7801.00
113_P169_V0.7791.00
304_T310_A0.7771.00
272_R319_N0.7721.00
314_S317_N0.7721.00
172_D179_S0.7721.00
272_R275_W0.7711.00
314_S318_I0.7711.00
42_Y45_T0.7691.00
106_A116_V0.7671.00
294_S297_D0.7641.00
335_D367_L0.7641.00
287_L290_L0.7631.00
172_D175_G0.7631.00
225_C239_T0.7601.00
164_T215_F0.7581.00
66_S89_L0.7581.00
90_M123_I0.7581.00
181_F184_D0.7581.00
157_S211_A0.7571.00
168_Q218_R0.7541.00
350_F360_F0.7521.00
106_A206_A0.7511.00
293_Q296_K0.7481.00
50_K93_L0.7471.00
180_D189_N0.7461.00
234_T237_A0.7461.00
192_R197_P0.7451.00
135_L203_V0.7451.00
199_V202_K0.7431.00
109_L166_Y0.7401.00
142_P145_E0.7391.00
210_D214_A0.7351.00
168_Q171_R0.7291.00
312_P316_V0.7281.00
52_I357_I0.7281.00
243_M247_A0.7261.00
91_A95_A0.7221.00
205_C216_S0.7201.00
210_D246_A0.7181.00
178_K192_R0.7171.00
102_I127_S0.7141.00
265_D359_T0.7121.00
240_A341_P0.7111.00
65_L105_T0.7101.00
111_L115_I0.7071.00
94_A123_I0.7061.00
90_M94_A0.7051.00
205_C215_F0.7031.00
280_A284_E0.7021.00
192_R196_Q0.7011.00
335_D368_M0.6951.00
55_K361_G0.6951.00
334_L346_V0.6941.00
112_P115_I0.6921.00
90_M131_F0.6921.00
47_E98_S0.6881.00
116_V170_L0.6871.00
124_D197_P0.6871.00
46_F50_K0.6861.00
274_K277_H0.6861.00
307_R311_D0.6861.00
103_Y204_I0.6861.00
63_F345_G0.6851.00
150_W158_R0.6851.00
61_F365_Q0.6831.00
167_V205_C0.6821.00
48_L52_I0.6811.00
263_I275_W0.6801.00
196_Q199_V0.6781.00
272_R324_V0.6771.00
164_T211_A0.6771.00
62_D99_R0.6751.00
300_S306_V0.6731.00
250_T253_D0.6691.00
289_W293_Q0.6691.00
305_N309_M0.6661.00
150_W187_T0.6641.00
70_L118_R0.6621.00
193_V196_Q0.6621.00
106_A136_V0.6611.00
350_F357_I0.6581.00
307_R310_A0.6561.00
312_P315_A0.6561.00
165_E169_V0.6561.00
213_M223_N0.6541.00
266_E327_Y0.6541.00
257_Y345_G0.6531.00
141_K151_P0.6521.00
91_A123_I0.6521.00
107_A138_G0.6521.00
259_L347_L0.6521.00
160_Y211_A0.6501.00
137_T163_L0.6481.00
120_A174_W0.6471.00
327_Y363_R0.6461.00
213_M243_M0.6431.00
271_A275_W0.6421.00
181_F186_F0.6391.00
87_F120_A0.6391.00
286_A290_L0.6381.00
101_Q199_V0.6381.00
132_G204_I0.6361.00
291_T294_S0.6351.00
50_K95_A0.6341.00
292_E295_Q0.6331.00
45_T48_L0.6321.00
303_D308_Q0.6291.00
294_S298_T0.6241.00
303_D310_A0.6231.00
279_K282_A0.6211.00
244_K247_A0.6191.00
182_K185_F0.6181.00
244_K248_E0.6151.00
262_V323_L0.6111.00
218_R246_A0.6111.00
169_V173_L0.6091.00
328_A363_R0.6071.00
149_I162_Y0.6040.99
47_E95_A0.6030.99
293_Q297_D0.6010.99
306_V309_M0.6000.99
124_D127_S0.5990.99
291_T295_Q0.5970.99
256_S343_A0.5960.99
303_D309_M0.5940.99
208_Q226_F0.5940.99
54_Q57_E0.5940.99
87_F107_A0.5930.99
114_A191_C0.5920.99
208_Q227_G0.5900.99
244_K342_G0.5890.99
124_D198_S0.5880.99
244_K344_E0.5880.99
114_A173_L0.5860.99
150_W157_S0.5840.99
91_A127_S0.5840.99
104_A131_F0.5840.99
56_A100_I0.5830.99
49_N52_I0.5830.99
176_T196_Q0.5830.99
331_A368_M0.5800.99
197_P201_M0.5780.99
286_A291_T0.5770.99
110_T144_Y0.5760.99
338_A343_A0.5760.99
262_V330_V0.5760.99
165_E168_Q0.5750.99
333_M337_V0.5750.99
162_Y186_F0.5740.99
71_R140_Q0.5720.99
64_A93_L0.5720.99
265_D268_D0.5720.99
210_D238_P0.5710.99
113_P166_Y0.5690.99
264_A326_S0.5660.99
316_V320_M0.5640.99
111_L116_V0.5630.99
205_C220_A0.5630.99
204_I345_G0.5610.99
304_T309_M0.5600.99
323_L337_V0.5590.99
121_A125_S0.5580.99
134_N206_A0.5570.99
88_T92_G0.5560.99
121_A174_W0.5560.99
268_D271_A0.5560.99
50_K53_V0.5550.99
177_G180_D0.5540.99
217_A247_A0.5530.99
356_G360_F0.5530.99
271_A326_S0.5520.99
267_T326_S0.5520.99
211_A215_F0.5510.99
68_I111_L0.5500.99
317_N320_M0.5460.99
62_D101_Q0.5460.99
63_F347_L0.5450.99
89_L122_T0.5440.99
235_A239_T0.5440.99
243_M256_S0.5430.99
40_P44_P0.5430.99
121_A196_Q0.5420.99
288_S291_T0.5400.99
92_G127_S0.5400.99
343_A346_V0.5390.99
304_T308_Q0.5380.99
271_A324_V0.5380.99
88_T122_T0.5360.99
208_Q239_T0.5330.99
97_T130_R0.5320.99
90_M127_S0.5320.99
330_V333_M0.5310.99
135_L170_L0.5300.99
334_L348_L0.5300.99
174_W203_V0.5290.99
327_Y331_A0.5260.99
59_Y358_E0.5250.99
257_Y347_L0.5250.99
169_V183_G0.5230.99
267_T273_A0.5210.98
274_K355_S0.5200.98
116_V120_A0.5200.98
175_G179_S0.5200.98
264_A360_F0.5180.98
58_H99_R0.5170.98
51_A358_E0.5170.98
167_V171_R0.5160.98
241_A244_K0.5150.98
289_W292_E0.5140.98
227_G236_F0.5130.98
176_T200_P0.5120.98
321_G333_M0.5100.98
261_M322_T0.5080.98
296_K299_R0.5060.98
44_P47_E0.5060.98
240_A343_A0.5060.98
214_A245_Q0.5050.98
222_F255_G0.5030.98
300_S305_N0.5010.98
65_L134_N0.5000.98
294_S299_R0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b9oA 2 0.9424 100 0.241 Contact Map
1tvlA 2 0.9084 100 0.244 Contact Map
3sdoA 2 0.9555 100 0.245 Contact Map
1nqkA 4 0.8848 100 0.265 Contact Map
3raoA 2 0.9058 100 0.268 Contact Map
2i7gA 2 0.8613 100 0.276 Contact Map
1lucA 1 0.8141 100 0.277 Contact Map
2wgkA 2 0.8822 100 0.283 Contact Map
3c8nA 2 0.8717 100 0.291 Contact Map
1ezwA 3 0.8403 100 0.297 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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