GREMLIN Database
RUTB - Peroxyureidoacrylate/ureidoacrylate amidohydrolase RutB
UniProt: P75897 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13858
Length: 230 (180)
Sequences: 7008 (4917)
Seq/√Len: 366.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
145_D179_Y3.1241.00
145_D149_R3.0471.00
137_S173_D2.7071.00
71_Q132_P2.5831.00
60_A65_M2.4141.00
25_M53_I2.4021.00
155_H180_F2.3971.00
17_Q154_R2.3571.00
204_I209_G2.3241.00
158_F171_L2.2671.00
53_I159_T2.2651.00
145_D177_L2.2621.00
184_L217_F2.2351.00
193_P198_K2.1461.00
28_A115_D2.0881.00
18_S155_H1.9531.00
143_P147_I1.9531.00
174_G181_G1.9421.00
52_N214_V1.9221.00
155_H182_V1.9191.00
59_A63_A1.9131.00
213_D216_T1.9061.00
19_A153_I1.9041.00
138_G170_T1.8801.00
185_E211_V1.8611.00
27_N120_D1.8471.00
56_A184_L1.8431.00
163_T197_Q1.7891.00
27_N114_W1.7441.00
168_E172_R1.7281.00
55_T215_E1.7281.00
30_A119_V1.7211.00
186_D214_V1.7161.00
52_N55_T1.6951.00
185_E213_D1.6931.00
190_Q197_Q1.6891.00
18_S157_V1.6841.00
59_A218_C1.6461.00
131_L147_I1.5621.00
22_V159_T1.5461.00
187_A214_V1.5231.00
158_F170_T1.4921.00
156_L174_G1.4881.00
70_F138_G1.4601.00
129_I147_I1.4161.00
66_L151_R1.4141.00
163_T188_T1.4081.00
68_I147_I1.3811.00
167_V183_V1.3801.00
54_Q58_T1.3781.00
22_V57_V1.3771.00
45_T48_P1.3721.00
60_A157_V1.3561.00
61_R128_D1.3531.00
52_N187_A1.3451.00
163_T201_L1.3391.00
168_E203_N1.3391.00
149_R179_Y1.3301.00
23_V166_C1.3281.00
168_E200_A1.3161.00
183_V188_T1.2821.00
21_I158_F1.2811.00
194_K198_K1.2571.00
49_V53_I1.2551.00
146_S150_S1.2331.00
20_L60_A1.2311.00
147_I151_R1.2301.00
22_V25_M1.2241.00
22_V53_I1.2231.00
157_V184_L1.2091.00
71_Q118_L1.2021.00
198_K202_F1.2001.00
185_E201_L1.1911.00
164_N190_Q1.1861.00
140_F177_L1.1811.00
73_G116_Y1.1401.00
54_Q121_E1.1361.00
215_E219_D1.1291.00
171_L204_I1.1131.00
171_L183_V1.1101.00
192_G195_F1.1061.00
59_A62_A1.1041.00
135_R178_E1.1001.00
173_D177_L1.0861.00
71_Q130_V1.0721.00
118_L130_V1.0681.00
184_L212_S1.0561.00
114_W117_Q1.0501.00
24_D133_K1.0411.00
27_N117_Q1.0381.00
138_G144_L1.0311.00
57_V61_R1.0301.00
21_I144_L1.0251.00
73_G132_P1.0221.00
77_Q80_E1.0091.00
169_S172_R1.0081.00
19_A68_I1.0071.00
56_A217_F0.9941.00
156_L181_G0.9891.00
58_T62_A0.9861.00
56_A187_A0.9821.00
19_A148_L0.9681.00
163_T190_Q0.9601.00
157_V182_V0.9551.00
157_V217_F0.9551.00
54_Q124_P0.9541.00
188_T197_Q0.9501.00
23_V158_F0.9501.00
125_Q128_D0.9471.00
182_V212_S0.9451.00
201_L211_V0.9381.00
31_T47_R0.9291.00
57_V69_W0.9141.00
143_P146_S0.9101.00
117_Q123_V0.9091.00
73_G111_K0.9091.00
56_A214_V0.8941.00
212_S216_T0.8831.00
212_S217_F0.8781.00
139_F174_G0.8741.00
175_F209_G0.8721.00
17_Q155_H0.8581.00
69_W124_P0.8501.00
113_S116_Y0.8451.00
68_I151_R0.8421.00
69_W118_L0.8401.00
53_I187_A0.8391.00
199_A202_F0.8371.00
55_T214_V0.8351.00
216_T219_D0.8321.00
25_M161_I0.8291.00
110_A113_S0.8211.00
51_A121_E0.8181.00
56_A159_T0.8171.00
69_W128_D0.8141.00
173_D176_F0.8131.00
180_F210_W0.8021.00
158_F167_V0.7931.00
182_V210_W0.7891.00
154_R180_F0.7871.00
55_T218_C0.7861.00
58_T125_Q0.7831.00
20_L56_A0.7831.00
69_W127_G0.7821.00
202_F205_E0.7821.00
214_V218_C0.7801.00
48_P51_A0.7801.00
171_L209_G0.7781.00
184_L187_A0.7741.00
20_L57_V0.7671.00
194_K202_F0.7651.00
51_A54_Q0.7581.00
55_T58_T0.7541.00
52_N186_D0.7521.00
159_T187_A0.7521.00
124_P128_D0.7521.00
29_Y166_C0.7381.00
58_T123_V0.7381.00
27_N31_T0.7361.00
47_R121_E0.7341.00
195_F199_A0.7331.00
55_T59_A0.7271.00
202_F206_T0.7130.99
25_M49_V0.7130.99
68_I144_L0.7100.99
50_I119_V0.7070.99
57_V67_I0.7050.99
28_A34_G0.7030.99
30_A50_I0.6960.99
111_K132_P0.6940.99
124_P130_V0.6940.99
25_M122_L0.6930.99
112_G117_Q0.6930.99
75_D80_E0.6930.99
147_I150_S0.6890.99
114_W120_D0.6880.99
164_N203_N0.6840.99
201_L205_E0.6830.99
22_V69_W0.6820.99
99_R102_P0.6820.99
164_N191_A0.6750.99
44_S48_P0.6680.99
61_R125_Q0.6620.99
161_I189_H0.6620.99
129_I151_R0.6600.99
29_Y162_A0.6580.99
158_F181_G0.6510.99
51_A55_T0.6500.99
199_A203_N0.6470.99
61_R127_G0.6470.99
105_Q108_L0.6450.99
20_L159_T0.6420.99
54_Q123_V0.6400.99
68_I129_I0.6400.99
200_A204_I0.6400.99
49_V161_I0.6390.99
107_K110_A0.6380.99
101_Q104_L0.6380.99
148_L179_Y0.6360.99
120_D123_V0.6360.99
66_L153_I0.6250.99
27_N119_V0.6240.99
183_V201_L0.6220.99
43_V46_T0.6220.99
100_K104_L0.6190.99
66_L147_I0.6140.98
140_F176_F0.6130.98
69_W130_V0.6120.98
28_A109_L0.6100.98
49_V189_H0.6040.98
57_V128_D0.6030.98
72_N162_A0.5980.98
102_P106_G0.5950.98
119_V122_L0.5920.98
75_D78_Y0.5900.98
164_N195_F0.5870.98
75_D111_K0.5860.98
30_A161_I0.5830.98
185_E205_E0.5810.98
137_S177_L0.5800.98
183_V204_I0.5720.98
131_L143_P0.5710.98
21_I156_L0.5690.98
18_S65_M0.5640.97
50_I122_L0.5630.97
99_R103_Q0.5630.97
50_I54_Q0.5580.97
135_R141_N0.5550.97
194_K199_A0.5540.97
136_Y175_F0.5540.97
57_V60_A0.5540.97
100_K103_Q0.5520.97
103_Q107_K0.5510.97
75_D81_A0.5450.97
172_R207_F0.5430.97
68_I131_L0.5410.97
162_A165_V0.5380.97
56_A60_A0.5350.96
172_R176_F0.5340.96
185_E197_Q0.5330.96
188_T201_L0.5330.96
124_P127_G0.5330.96
144_L170_T0.5320.96
34_G42_D0.5310.96
141_N146_S0.5310.96
27_N115_D0.5280.96
74_W80_E0.5270.96
61_R69_W0.5260.96
46_T49_V0.5260.96
215_E218_C0.5240.96
159_T184_L0.5230.96
172_R208_F0.5220.96
65_M157_V0.5210.96
186_D213_D0.5190.96
17_Q152_G0.5190.96
123_V127_G0.5160.96
30_A46_T0.5150.96
71_Q116_Y0.5140.95
171_L181_G0.5090.95
166_C208_F0.5090.95
136_Y176_F0.5090.95
169_S176_F0.5060.95
191_A195_F0.5060.95
99_R104_L0.5040.95
118_L124_P0.5040.95
66_L128_D0.5040.95
25_M69_W0.5040.95
137_S169_S0.5030.95
134_P143_P0.5010.95
163_T200_A0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kl2A 4 0.8913 100 0.237 Contact Map
2fq1A 2 0.8957 100 0.248 Contact Map
3irvA 2 0.8652 100 0.252 Contact Map
3hb7A 3 0.8043 100 0.253 Contact Map
3hu5A 3 0.8261 100 0.257 Contact Map
1nbaA 4 0.913 100 0.262 Contact Map
4l07A 4 0.8826 100 0.271 Contact Map
1nf9A 2 0.8391 100 0.271 Contact Map
3r2jA 2 0.8217 100 0.271 Contact Map
3ot4A 4 0.8652 100 0.278 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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