GREMLIN Database
RUTD - Putative aminoacrylate hydrolase RutD
UniProt: P75895 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13856
Length: 266 (245)
Sequences: 60515 (50619)
Seq/√Len: 3233.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_A107_V4.5771.00
48_R69_E3.9151.00
32_Q248_N3.0841.00
71_H97_L3.0781.00
243_D246_T2.9181.00
207_S233_P2.8931.00
83_A106_T2.8591.00
230_M250_L2.8411.00
202_Q254_G2.7421.00
112_N209_D2.7071.00
81_H106_T2.6311.00
232_M250_L2.5681.00
111_V247_F2.5301.00
9_P41_Q2.4961.00
97_L101_Y2.2751.00
71_H104_S2.2161.00
71_H75_V2.2141.00
71_H101_Y2.2111.00
207_S231_V2.1381.00
74_L82_Y2.1341.00
221_H227_S2.0921.00
75_V104_S2.0881.00
91_A113_G2.0721.00
84_V94_G2.0611.00
35_V248_N1.9101.00
15_V43_V1.9041.00
39_E252_L1.9041.00
96_Q100_D1.8961.00
83_A255_L1.8931.00
214_T231_V1.8901.00
235_G243_D1.8881.00
15_V79_I1.8411.00
68_A100_D1.8401.00
15_V41_Q1.8281.00
98_A108_L1.7541.00
83_A109_I1.7521.00
202_Q230_M1.7421.00
20_S47_Q1.7161.00
201_V224_L1.6951.00
250_L253_N1.6401.00
219_E223_A1.6391.00
24_G28_Y1.6231.00
20_S50_T1.6191.00
47_Q93_V1.6031.00
94_G108_L1.5981.00
40_Y83_A1.5961.00
67_A96_Q1.5851.00
45_Y70_L1.5671.00
64_A100_D1.5651.00
14_P83_A1.5341.00
14_P106_T1.5341.00
97_L105_V1.5281.00
19_I47_Q1.5271.00
101_Y104_S1.5241.00
70_L97_L1.4931.00
19_I70_L1.4681.00
26_G46_D1.4451.00
62_S65_Q1.4381.00
38_Q252_L1.4341.00
249_A253_N1.4171.00
26_G52_N1.4121.00
35_V252_L1.4011.00
97_L104_S1.3871.00
23_G50_T1.3781.00
205_C217_S1.3731.00
95_M110_S1.3541.00
246_T250_L1.3531.00
110_S113_G1.3411.00
87_H240_N1.3371.00
43_V73_A1.3351.00
75_V101_Y1.3251.00
214_T218_S1.3191.00
96_Q99_L1.3151.00
109_I251_L1.3011.00
19_I94_G1.3001.00
35_V38_Q1.2841.00
18_L85_V1.2671.00
193_H196_R1.2661.00
33_L44_C1.2641.00
73_A77_A1.2541.00
18_L42_V1.2451.00
88_A237_H1.2371.00
224_L227_S1.2341.00
246_T249_A1.2221.00
85_V111_V1.2191.00
218_S222_A1.2191.00
109_I202_Q1.2131.00
39_E256_A1.2121.00
221_H229_K1.2051.00
10_Y13_A1.1681.00
16_V40_Y1.1661.00
17_V74_L1.1591.00
79_I82_Y1.1551.00
82_Y105_V1.1531.00
99_L193_H1.1461.00
23_G88_A1.1401.00
232_M235_G1.1341.00
26_G44_C1.1231.00
9_P13_A1.1191.00
183_N186_K1.1181.00
205_C229_K1.1131.00
45_Y73_A1.1051.00
247_F251_L1.0991.00
205_C231_V1.0961.00
46_D51_G1.0961.00
252_L256_A1.0941.00
181_R184_A1.0921.00
185_L188_A1.0771.00
35_V245_E1.0741.00
21_G88_A1.0611.00
19_I84_V1.0521.00
219_E222_A1.0501.00
236_G242_T1.0491.00
204_I232_M1.0491.00
207_S234_Y1.0461.00
195_D223_A1.0331.00
28_Y240_N1.0321.00
40_Y255_L1.0271.00
228_Q250_L1.0271.00
87_H238_A1.0261.00
85_V251_L1.0231.00
74_L97_L1.0221.00
67_A93_V1.0191.00
162_E165_D1.0141.00
205_C214_T1.0051.00
71_H100_D0.9991.00
71_H74_L0.9971.00
111_V240_N0.9971.00
202_Q228_Q0.9951.00
245_E249_A0.9941.00
64_A96_Q0.9791.00
183_N187_R0.9701.00
218_S229_K0.9641.00
232_M246_T0.9621.00
218_S231_V0.9561.00
86_G94_G0.9541.00
82_Y104_S0.9541.00
141_V145_P0.9531.00
47_Q89_L0.9521.00
43_V77_A0.9471.00
14_P81_H0.9411.00
107_V200_P0.9351.00
37_E42_V0.9351.00
162_E166_A0.9351.00
218_S221_H0.9281.00
182_L185_L0.9271.00
230_M253_N0.9261.00
17_V82_Y0.9261.00
74_L79_I0.9251.00
136_G139_A0.9201.00
40_Y256_A0.9181.00
30_L44_C0.9171.00
11_A41_Q0.9041.00
235_G239_C0.8931.00
14_P40_Y0.8911.00
111_V239_C0.8901.00
72_Q75_V0.8861.00
60_D65_Q0.8841.00
67_A100_D0.8701.00
179_L183_N0.8691.00
126_Q130_R0.8651.00
235_G242_T0.8571.00
142_E145_P0.8531.00
68_A71_H0.8511.00
128_R132_L0.8511.00
15_V40_Y0.8511.00
72_Q76_A0.8471.00
107_V254_G0.8471.00
96_Q193_H0.8441.00
180_R184_A0.8441.00
204_I250_L0.8411.00
46_D52_N0.8411.00
65_Q68_A0.8391.00
203_I227_S0.8371.00
16_V85_V0.8331.00
176_N180_R0.8321.00
33_L42_V0.8311.00
34_A37_E0.8261.00
130_R134_S0.8261.00
16_V42_V0.8191.00
181_R185_L0.8181.00
108_L201_V0.8131.00
27_S30_L0.8121.00
230_M246_T0.8111.00
129_E133_Y0.8041.00
217_S229_K0.8021.00
19_I45_Y0.8021.00
26_G45_Y0.8001.00
66_M89_L0.7991.00
98_A105_V0.7981.00
198_R225_P0.7961.00
13_A41_Q0.7931.00
78_G81_H0.7931.00
216_C219_E0.7831.00
159_P163_A0.7821.00
15_V82_Y0.7821.00
180_R183_N0.7811.00
178_L182_L0.7771.00
158_A162_E0.7751.00
122_R126_Q0.7681.00
31_P34_A0.7601.00
22_L89_L0.7571.00
86_G91_A0.7511.00
17_V70_L0.7501.00
14_P107_V0.7491.00
109_I255_L0.7461.00
206_A239_C0.7421.00
47_Q66_M0.7411.00
190_F193_H0.7391.00
173_Q176_N0.7391.00
174_G177_N0.7341.00
184_A188_A0.7301.00
16_V255_L0.7291.00
172_F175_K0.7241.00
215_A218_S0.7241.00
68_A72_Q0.7221.00
109_I254_G0.7191.00
137_A141_V0.7191.00
232_M243_D0.7171.00
165_D168_A0.7171.00
248_N252_L0.7161.00
143_A147_F0.7151.00
67_A97_L0.7141.00
92_L114_W0.7111.00
112_N239_C0.7111.00
112_N205_C0.7091.00
20_S45_Y0.7091.00
23_G89_L0.7051.00
163_A167_L0.7041.00
84_V97_L0.7021.00
127_V130_R0.7001.00
207_S214_T0.6981.00
234_Y243_D0.6971.00
87_H112_N0.6941.00
40_Y252_L0.6921.00
138_Q142_E0.6901.00
84_V105_V0.6901.00
204_I247_F0.6891.00
107_V255_L0.6881.00
182_L186_K0.6881.00
98_A199_C0.6841.00
9_P12_D0.6831.00
192_H195_D0.6821.00
171_H175_K0.6721.00
123_R126_Q0.6711.00
43_V79_I0.6671.00
99_L196_R0.6661.00
41_Q79_I0.6661.00
33_L37_E0.6611.00
171_H174_G0.6581.00
85_V109_I0.6541.00
139_A143_A0.6521.00
151_A154_M0.6491.00
123_R127_V0.6481.00
95_M115_L0.6451.00
112_N206_A0.6451.00
208_D234_Y0.6431.00
16_V83_A0.6431.00
82_Y106_T0.6421.00
18_L29_W0.6391.00
105_V199_C0.6381.00
48_R66_M0.6381.00
64_A68_A0.6381.00
121_T128_R0.6371.00
159_P162_E0.6371.00
47_Q50_T0.6361.00
138_Q141_V0.6331.00
164_E168_A0.6321.00
87_H111_V0.6321.00
126_Q129_E0.6321.00
124_C128_R0.6311.00
32_Q35_V0.6311.00
249_A252_L0.6311.00
131_L135_G0.6301.00
244_P248_N0.6231.00
117_I121_T0.6221.00
177_N180_R0.6221.00
82_Y97_L0.6211.00
141_V144_Q0.6201.00
109_I204_I0.6191.00
128_R131_L0.6181.00
30_L34_A0.6171.00
140_W144_Q0.6161.00
86_G90_G0.6101.00
125_F128_R0.6081.00
165_D169_L0.6061.00
17_V84_V0.5981.00
110_S203_I0.5951.00
127_V131_L0.5951.00
88_A238_A0.5941.00
189_D193_H0.5941.00
17_V45_Y0.5911.00
12_D41_Q0.5901.00
125_F132_L0.5901.00
18_L44_C0.5891.00
145_P149_Y0.5891.00
160_R163_A0.5881.00
66_M93_V0.5871.00
142_E146_L0.5851.00
63_I96_Q0.5761.00
163_A166_A0.5741.00
95_M113_G0.5731.00
164_E167_L0.5711.00
73_A76_A0.5701.00
145_P148_L0.5671.00
209_D237_H0.5651.00
184_A187_R0.5601.00
121_T125_F0.5591.00
80_E104_S0.5581.00
203_I229_K0.5581.00
161_L165_D0.5581.00
173_Q177_N0.5571.00
13_A40_Y0.5541.00
91_A110_S0.5531.00
46_D53_N0.5531.00
178_L181_R0.5511.00
29_W33_L0.5501.00
168_A171_H0.5491.00
148_L154_M0.5481.00
125_F129_E0.5481.00
74_L104_S0.5481.00
217_S221_H0.5451.00
13_A39_E0.5441.00
251_L255_L0.5431.00
67_A71_H0.5431.00
120_H123_R0.5421.00
139_A142_E0.5421.00
204_I230_M0.5401.00
32_Q247_F0.5391.00
36_L251_L0.5391.00
107_V202_Q0.5361.00
203_I221_H0.5361.00
143_A148_L0.5351.00
24_G238_A0.5341.00
130_R133_Y0.5341.00
47_Q70_L0.5321.00
22_L88_A0.5301.00
98_A197_I0.5291.00
125_F131_L0.5281.00
203_I217_S0.5281.00
253_N256_A0.5271.00
117_I120_H0.5261.00
208_D235_G0.5251.00
138_Q144_Q0.5241.00
160_R164_E0.5221.00
178_L185_L0.5221.00
100_D193_H0.5221.00
10_Y41_Q0.5221.00
24_G241_V0.5211.00
197_I201_V0.5191.00
239_C247_F0.5191.00
220_L224_L0.5191.00
179_L184_A0.5181.00
19_I93_V0.5171.00
179_L182_L0.5171.00
157_R160_R0.5161.00
175_K179_L0.5161.00
119_A122_R0.5151.00
111_V204_I0.5121.00
144_Q147_F0.5081.00
120_H125_F0.5061.00
203_I224_L0.5061.00
68_A101_Y0.5021.00
63_I93_V0.5021.00
197_I224_L0.5021.00
49_G61_Y0.5021.00
172_F176_N0.5001.00
28_Y87_H0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3v48A 2 1 100 0.151 Contact Map
3om8A 4 0.9474 100 0.159 Contact Map
2pujA 4 0.9549 100 0.163 Contact Map
2wueA 4 0.9549 100 0.166 Contact Map
4inzA 1 0.9436 100 0.166 Contact Map
3oosA 1 0.9436 100 0.171 Contact Map
1ehyA 1 0.9023 100 0.171 Contact Map
2xuaA 2 0.9436 100 0.173 Contact Map
3bf7A 1 0.9323 100 0.174 Contact Map
4psuA 1 0.9511 100 0.174 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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