GREMLIN Database
RUTE - Probable malonic semialdehyde reductase RutE
UniProt: P75894 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13855
Length: 196 (165)
Sequences: 12622 (9448)
Seq/√Len: 735.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_S32_T3.6821.00
35_E139_L3.5051.00
30_D58_R2.8891.00
26_T174_Y2.6361.00
30_D34_R2.6111.00
54_I128_Q2.5181.00
36_I136_C2.2671.00
16_D137_R2.2521.00
142_D175_G2.1691.00
141_L174_Y2.1381.00
32_T139_L2.0911.00
133_I143_T2.0541.00
38_A41_K2.0361.00
12_T16_D1.9421.00
65_R157_A1.9131.00
39_L135_A1.8921.00
129_A168_L1.8471.00
60_A64_E1.8271.00
67_R79_L1.7711.00
155_D166_S1.7561.00
40_M132_L1.7481.00
55_V88_A1.7291.00
62_G65_R1.7221.00
24_R176_D1.7061.00
22_G176_D1.7021.00
88_A164_L1.6931.00
9_A12_T1.6881.00
32_T141_L1.6871.00
10_L14_F1.6441.00
129_A170_I1.6191.00
133_I145_P1.5461.00
54_I85_A1.5401.00
64_E79_L1.5231.00
36_I132_L1.5011.00
32_T174_Y1.4691.00
10_L13_L1.4661.00
11_S35_E1.4631.00
27_P58_R1.4341.00
69_A153_H1.4311.00
8_G12_T1.4251.00
136_C172_I1.4081.00
60_A63_K1.3921.00
187_L191_E1.3691.00
123_R126_S1.3651.00
69_A157_A1.3581.00
11_S15_T1.3521.00
127_M130_A1.3511.00
141_L172_I1.3431.00
15_T42_W1.3421.00
137_R142_D1.3401.00
153_H156_D1.3241.00
36_I172_I1.3211.00
133_I170_I1.3161.00
66_L154_V1.3051.00
32_T35_E1.2971.00
61_E64_E1.2891.00
85_A132_L1.2771.00
36_I141_L1.2541.00
64_E68_P1.2441.00
53_R164_L1.2271.00
62_G157_A1.1951.00
125_S167_N1.1881.00
61_E65_R1.1871.00
136_C143_T1.1851.00
11_S39_L1.1751.00
59_T62_G1.1651.00
145_P168_L1.1581.00
23_W171_N1.1581.00
46_S120_T1.1571.00
34_R190_E1.1331.00
28_V141_L1.1041.00
39_L139_L1.1001.00
120_T147_S1.0911.00
84_T169_L1.0881.00
15_T38_A1.0871.00
8_G138_A1.0861.00
43_G131_Y1.0801.00
135_A139_L1.0781.00
86_I169_L1.0781.00
19_T144_G1.0761.00
89_W121_A1.0651.00
55_V164_L1.0631.00
11_S139_L1.0461.00
150_D153_H1.0461.00
87_V132_L1.0421.00
153_H157_A1.0381.00
87_V129_A1.0361.00
56_F83_V1.0341.00
12_T15_T1.0271.00
31_E34_R1.0231.00
34_R38_A1.0111.00
143_T172_I1.0021.00
132_L170_I0.9941.00
90_D163_T0.9881.00
143_T170_I0.9831.00
9_A138_A0.9791.00
41_K192_A0.9781.00
65_R68_P0.9711.00
37_Y56_F0.9651.00
122_F167_N0.9561.00
152_Q156_D0.9451.00
135_A138_A0.9371.00
76_Q79_L0.9331.00
126_S145_P0.9311.00
130_A134_V0.9281.00
91_S165_K0.9241.00
37_Y40_M0.9231.00
54_I87_V0.9091.00
29_S174_Y0.9061.00
33_L83_V0.9011.00
129_A145_P0.8941.00
14_F131_Y0.8941.00
87_V125_S0.8931.00
144_G171_N0.8931.00
127_M145_P0.8891.00
10_L134_V0.8851.00
132_L172_I0.8831.00
92_E163_T0.8721.00
131_Y134_V0.8721.00
146_M171_N0.8701.00
8_G13_L0.8661.00
28_V174_Y0.8591.00
24_R174_Y0.8591.00
118_E165_K0.8421.00
53_R90_D0.8411.00
127_M131_Y0.8391.00
34_R189_F0.8371.00
152_Q155_D0.8371.00
22_G177_S0.8351.00
14_F134_V0.8291.00
58_R83_V0.8181.00
45_T52_A0.8181.00
27_P60_A0.8171.00
33_L172_I0.8151.00
123_R147_S0.8141.00
10_L138_A0.8111.00
86_I166_S0.8021.00
88_A160_T0.8011.00
64_E67_R0.7951.00
26_T29_S0.7951.00
161_G164_L0.7881.00
160_T164_L0.7851.00
11_S138_A0.7811.00
85_A172_I0.7681.00
35_E39_L0.7661.00
76_Q80_T0.7631.00
154_V157_A0.7601.00
151_R166_S0.7581.00
155_D165_K0.7571.00
36_I139_L0.7561.00
28_V32_T0.7481.00
35_E38_A0.7441.00
77_K80_T0.7401.00
123_R127_M0.7331.00
55_V158_F0.7311.00
90_D93_F0.7281.00
149_F169_L0.7231.00
11_S135_A0.7231.00
122_F126_S0.7161.00
188_S191_E0.7081.00
124_N147_S0.7071.00
33_L37_Y0.7071.00
38_A189_F0.7031.00
57_T62_G0.6981.00
119_E122_F0.6971.00
84_T171_N0.6891.00
46_S124_N0.6881.00
70_L78_T0.6691.00
46_S147_S0.6681.00
52_A125_S0.6651.00
13_L138_A0.6631.00
155_D160_T0.6621.00
40_M54_I0.6601.00
45_T50_S0.6541.00
86_I158_F0.6531.00
81_A84_T0.6511.00
28_V31_E0.6501.00
187_L192_A0.6461.00
151_R155_D0.6401.00
31_E35_E0.6391.00
13_L134_V0.6341.00
175_G178_S0.6331.00
130_A133_I0.6261.00
23_W144_G0.6251.00
20_H179_K0.6231.00
89_W125_S0.6221.00
36_I40_M0.6211.00
38_A42_W0.6201.00
21_N77_K0.6171.00
70_L169_L0.6151.00
71_S75_L0.6121.00
56_F85_A0.6101.00
177_S180_L0.6061.00
160_T166_S0.6041.00
10_L135_A0.6021.00
78_T81_A0.5981.00
35_E135_A0.5951.00
63_K67_R0.5941.00
52_A128_Q0.5921.00
89_W167_N0.5891.00
20_H175_G0.5841.00
21_N144_G0.5821.00
113_S116_L0.5801.00
81_A85_A0.5781.00
90_D164_L0.5761.00
151_R165_K0.5751.00
75_L79_L0.5741.00
65_R69_A0.5741.00
57_T158_F0.5731.00
17_A44_P0.5721.00
24_R177_S0.5721.00
28_V33_L0.5681.00
128_Q192_A0.5621.00
62_G158_F0.5591.00
28_V82_P0.5581.00
134_V138_A0.5551.00
185_P188_S0.5511.00
68_P157_A0.5441.00
129_A133_I0.5421.00
20_H142_D0.5421.00
87_V170_I0.5421.00
40_M128_Q0.5391.00
123_R145_P0.5391.00
29_S141_L0.5371.00
44_P143_T0.5371.00
42_W184_L0.5361.00
155_D162_S0.5351.00
33_L56_F0.5321.00
15_T35_E0.5321.00
13_L137_R0.5271.00
41_K189_F0.5231.00
119_E123_R0.5231.00
32_T36_I0.5231.00
137_R175_G0.5231.00
44_P130_A0.5221.00
91_S163_T0.5201.00
85_A88_A0.5201.00
66_L169_L0.5191.00
53_R187_L0.5181.00
57_T86_I0.5151.00
22_G80_T0.5151.00
37_Y192_A0.5111.00
114_P117_A0.5101.00
123_R168_L0.5081.00
120_T124_N0.5061.00
62_G66_L0.5041.00
69_A154_V0.5031.00
83_V172_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qlxA 2 0.9898 100 0.152 Contact Map
3gbhA 3 0.9847 100 0.159 Contact Map
1noxA 2 0.9541 100 0.16 Contact Map
3bemA 2 0.9745 100 0.166 Contact Map
3ge6A 2 0.9745 100 0.167 Contact Map
3of4A 3 0.9541 100 0.174 Contact Map
1icrA 2 0.9592 100 0.176 Contact Map
2b67A 2 0.9439 100 0.177 Contact Map
3gagA 4 0.949 100 0.178 Contact Map
2h0uA 2 0.8571 100 0.181 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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