GREMLIN Database
RUTF - FMN reductase (NADH) RutF
UniProt: P75893 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13854
Length: 164 (151)
Sequences: 4751 (3411)
Seq/√Len: 277.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
120_R138_E3.4361.00
122_S136_A2.7311.00
55_R126_S2.7031.00
82_S156_Y2.6631.00
69_L135_C2.6531.00
120_R136_A2.5791.00
101_Q111_E2.4401.00
60_W131_D2.3041.00
18_A37_S1.9751.00
24_T70_C1.9571.00
76_A147_Y1.9221.00
79_E83_N1.8981.00
124_V131_D1.8931.00
64_N124_V1.8721.00
27_G30_G1.8681.00
70_C109_Q1.8261.00
99_R111_E1.7891.00
103_G118_D1.7761.00
7_Q11_D1.7001.00
83_N156_Y1.7001.00
55_R131_D1.6991.00
39_V49_L1.6911.00
33_G85_F1.6761.00
72_N113_A1.6721.00
116_S141_H1.6681.00
16_M19_A1.6631.00
52_C132_I1.6351.00
14_S154_R1.6031.00
35_T82_S1.5751.00
119_C135_C1.5731.00
127_V132_I1.5691.00
93_H96_A1.5621.00
48_T134_F1.5521.00
12_A115_V1.5481.00
105_T118_D1.5201.00
60_W64_N1.5171.00
118_D139_A1.4971.00
107_C118_D1.4681.00
34_F53_L1.4231.00
114_L146_P1.4221.00
125_V134_F1.4081.00
12_A117_F1.3601.00
31_R102_T1.3511.00
84_L97_A1.3471.00
40_C52_C1.3361.00
15_C153_D1.3201.00
67_R121_I1.3181.00
9_F13_M1.2671.00
21_N39_V1.2471.00
48_T127_V1.1991.00
75_S78_Q1.1881.00
126_S131_D1.1721.00
26_D102_T1.1721.00
121_I133_L1.1711.00
14_S153_D1.1711.00
34_F59_V1.1561.00
50_L132_I1.1361.00
26_D31_R1.1341.00
109_Q116_S1.1311.00
143_H146_P1.1281.00
17_G150_V1.1231.00
40_C50_L1.1201.00
42_V127_V1.1181.00
49_L71_V1.1181.00
36_A39_V1.1121.00
24_T72_N1.1111.00
42_V50_L1.0951.00
25_T66_N1.0901.00
8_T11_D1.0861.00
22_I35_T1.0791.00
22_I85_F1.0731.00
68_T120_R1.0711.00
35_T86_G1.0691.00
124_V133_L1.0651.00
48_T122_S1.0481.00
69_L119_C1.0351.00
69_L121_I0.9991.00
75_S146_P0.9881.00
54_N129_T0.9801.00
72_N110_L0.9761.00
84_L98_A0.9671.00
75_S114_L0.9611.00
105_T138_E0.9591.00
26_D29_A0.9561.00
49_L117_F0.9541.00
42_V52_C0.9491.00
114_L152_F0.9471.00
68_T107_C0.9431.00
22_I81_L0.9421.00
103_G107_C0.9401.00
78_Q112_E0.9401.00
60_W133_L0.9291.00
103_G109_Q0.9071.00
127_V134_F0.9071.00
61_P65_E0.8951.00
23_I51_V0.8861.00
68_T138_E0.8851.00
37_S151_W0.8841.00
70_C107_C0.8811.00
72_N116_S0.8741.00
25_T63_F0.8681.00
59_V63_F0.8651.00
13_M41_S0.8651.00
77_G146_P0.8611.00
122_S125_V0.8601.00
147_Y157_H0.8591.00
33_G95_F0.8571.00
6_Q10_R0.8551.00
10_R44_D0.8501.00
31_R100_W0.8461.00
76_A158_A0.8441.00
51_V133_L0.8431.00
73_T117_F0.8391.00
15_C142_R0.8351.00
88_K91_M0.8341.00
38_A51_V0.8291.00
21_N73_T0.8261.00
80_P84_L0.8240.99
59_V94_R0.8210.99
123_Q127_V0.8170.99
121_I124_V0.8170.99
105_T139_A0.8160.99
23_I36_A0.8080.99
104_V139_A0.8050.99
13_M49_L0.8040.99
67_R124_V0.8020.99
48_T136_A0.7970.99
21_N36_A0.7930.99
77_G112_E0.7920.99
61_P64_N0.7900.99
53_L63_F0.7880.99
87_G91_M0.7870.99
19_A37_S0.7870.99
70_C116_S0.7870.99
28_P65_E0.7750.99
27_G66_N0.7710.99
48_T129_T0.7670.99
51_V63_F0.7660.99
83_N87_G0.7660.99
17_G152_F0.7600.99
123_Q126_S0.7500.99
8_T142_R0.7480.99
12_A140_I0.7460.99
80_P83_N0.7450.99
64_N131_D0.7420.99
24_T33_G0.7390.99
13_M117_F0.7380.99
21_N71_V0.7360.99
16_M39_V0.7340.99
42_V134_F0.7340.99
109_Q118_D0.7310.99
68_T105_T0.7230.99
58_S88_K0.7220.99
44_D129_T0.7200.99
70_C118_D0.7170.99
63_F67_R0.7160.99
79_E156_Y0.7120.99
32_A62_A0.7100.99
38_A41_S0.7090.98
151_W154_R0.7030.98
74_L82_S0.6990.98
23_I71_V0.6980.98
32_A94_R0.6950.98
55_R60_W0.6930.98
6_Q45_T0.6790.98
123_Q134_F0.6750.98
48_T128_G0.6750.98
81_L110_L0.6590.98
17_G37_S0.6570.98
36_A71_V0.6570.98
27_G65_E0.6570.98
100_W111_E0.6500.97
40_C51_V0.6500.97
50_L127_V0.6480.97
67_R120_R0.6450.97
32_A59_V0.6420.97
49_L119_C0.6330.97
151_W156_Y0.6310.97
16_M37_S0.6300.97
58_S94_R0.6280.97
54_N57_A0.6280.97
43_T48_T0.6220.97
8_T140_I0.6210.97
7_Q14_S0.6210.97
9_F47_P0.6170.96
36_A51_V0.6150.96
64_N133_L0.6140.96
150_V157_H0.6120.96
73_T115_V0.6120.96
11_D154_R0.6090.96
31_R108_P0.6020.96
25_T107_C0.5980.96
39_V71_V0.5960.96
58_S91_M0.5890.95
53_L60_W0.5870.95
83_N86_G0.5850.95
42_V48_T0.5780.95
152_F157_H0.5780.95
148_G152_F0.5720.95
117_F140_I0.5660.94
87_G92_E0.5630.94
63_F133_L0.5610.94
10_R151_W0.5600.94
15_C152_F0.5520.93
116_S140_I0.5520.93
35_T85_F0.5440.93
37_S40_C0.5430.93
52_C130_H0.5410.93
40_C132_I0.5400.93
147_Y158_A0.5350.92
99_R112_E0.5320.92
76_A148_G0.5310.92
20_V86_G0.5260.92
26_D30_G0.5240.92
153_D157_H0.5230.92
31_R95_F0.5220.91
16_M21_N0.5210.91
25_T68_T0.5200.91
112_E115_V0.5130.91
11_D153_D0.5120.91
63_F121_I0.5110.91
77_G144_T0.5080.90
43_T128_G0.5040.90
154_R157_H0.5020.90
43_T127_V0.5020.90
17_G73_T0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3k86A 2 0.9878 100 0.196 Contact Map
3pftA 2 0.9573 100 0.198 Contact Map
3nfwA 2 0.9878 100 0.204 Contact Map
3cb0A 2 0.9817 100 0.206 Contact Map
2r0xA 2 0.9512 100 0.206 Contact Map
3rh7A 2 0.9817 100 0.208 Contact Map
4l82A 2 0.9634 100 0.212 Contact Map
4r82A 2 0.9817 100 0.213 Contact Map
1rz1A 3 0.9329 100 0.216 Contact Map
1yoaA 2 0.9573 100 0.218 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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