GREMLIN Database
RUTG - Putative pyrimidine permease RutG
UniProt: P75892 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13853
Length: 442 (390)
Sequences: 4337 (2256)
Seq/√Len: 114.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
178_M209_L5.3021.00
182_C205_V5.2211.00
117_I297_G4.8261.00
166_V176_A4.4141.00
153_A414_A4.1201.00
233_W340_K3.8301.00
183_I202_G3.8261.00
63_L336_G3.6701.00
122_V253_A3.4671.00
208_L216_V3.2891.00
110_S243_A3.1791.00
226_T230_H3.1031.00
186_V201_V3.0641.00
394_L417_G3.0621.00
175_M210_Y3.0391.00
175_M222_A2.9361.00
225_F228_V2.8061.00
66_G333_M2.7791.00
391_T418_A2.7211.00
114_G244_F2.6801.00
118_A249_M2.6641.00
111_I243_A2.6601.00
178_M205_V2.6211.00
211_G216_V2.5781.00
231_A340_K2.5101.00
383_G426_S2.4521.00
108_N111_I2.4181.00
267_L285_A2.4031.00
68_G292_A2.3961.00
180_V359_V2.3731.00
36_G327_A2.3551.00
40_A331_I2.3481.00
207_C223_V2.2681.00
174_W178_M2.2161.00
178_M182_C2.2071.00
33_A331_I2.2071.00
117_I294_M2.1891.00
64_M299_V2.1511.00
121_L125_V2.1261.00
204_I208_L2.1171.00
79_R279_D2.0911.00
70_L329_A2.0681.00
175_M217_L2.0611.00
228_V344_L2.0561.00
229_S232_A2.0541.00
32_T327_A2.0441.00
420_L424_L2.0261.00
141_L423_A2.0221.00
70_L326_V2.0071.00
182_C209_L1.9961.00
117_I242_P1.9841.00
208_L211_G1.9751.00
182_C186_V1.9721.00
73_F326_V1.9721.00
319_V324_V1.9721.00
124_T287_V1.9681.00
183_I356_A1.9401.00
54_M94_V1.8661.00
127_G287_V1.8361.00
227_L347_T1.8131.00
63_L333_M1.8131.00
207_C347_T1.7951.00
156_L365_A1.7811.00
24_D276_R1.7661.00
124_T294_M1.7451.00
185_L189_F1.7411.00
94_V112_A1.7321.00
165_S350_A1.7301.00
231_A343_A1.7181.00
116_I297_G1.7011.00
143_P422_N1.6981.00
121_L294_M1.6941.00
226_T229_S1.6931.00
228_V231_A1.6691.00
186_V190_T1.6521.00
126_I260_V1.6361.00
193_M197_L1.6301.00
40_A328_A1.5941.00
65_S83_Y1.5491.00
281_Y284_R1.5391.00
387_M421_L1.5391.00
26_R323_L1.5331.00
330_V334_L1.5301.00
180_V390_V1.5291.00
190_T194_I1.5221.00
174_W177_V1.5181.00
120_G294_M1.5071.00
391_T417_G1.5041.00
245_N248_A1.4991.00
206_A352_V1.4671.00
394_L413_T1.4571.00
22_A276_R1.4471.00
401_L404_G1.4351.00
276_R281_Y1.4021.00
124_T291_L1.3991.00
209_L216_V1.3951.00
177_V181_L1.3901.00
95_I98_T1.3861.00
70_L73_F1.3811.00
190_T195_Q1.3811.00
39_H310_N1.3601.00
194_I201_V1.3561.00
111_I245_N1.3461.00
416_F420_L1.3401.00
145_V388_V1.3301.00
120_G293_T1.3191.00
209_L217_L1.3161.00
181_L185_L1.3101.00
244_F249_M1.2991.00
404_G408_L1.2960.99
390_V417_G1.2920.99
227_L230_H1.2910.99
120_G290_G1.2860.99
114_G118_A1.2860.99
21_V25_E1.2860.99
340_K343_A1.2830.99
74_F326_V1.2770.99
22_A25_E1.2710.99
30_A34_V1.2660.99
314_M320_Y1.2630.99
97_A248_A1.2590.99
216_V222_A1.2570.99
91_V95_I1.2540.99
101_N245_N1.2510.99
69_T83_Y1.2490.99
67_I333_M1.2450.99
124_T290_G1.2300.99
211_G225_F1.2270.99
73_F325_F1.2260.99
70_L333_M1.2250.99
270_V314_M1.2240.99
98_T112_A1.2150.99
377_V384_N1.2090.99
205_V209_L1.2040.99
43_M47_T1.2020.99
201_V205_V1.1890.99
238_H300_G1.1830.99
63_L299_V1.1820.99
197_L201_V1.1730.99
217_L222_A1.1710.99
153_A395_G1.1630.99
379_L388_V1.1580.99
266_H308_A1.1570.99
82_S270_V1.1540.99
403_L407_T1.1460.99
271_A278_M1.1450.99
76_T291_L1.1200.99
123_Y259_L1.1180.98
174_W217_L1.1170.98
97_A252_I1.1170.98
131_M283_G1.1150.98
263_N267_L1.1100.98
87_S259_L1.1090.98
77_G284_R1.1020.98
338_S342_G1.1000.98
145_V149_A1.0960.98
85_G307_Y1.0910.98
163_V397_G1.0910.98
403_L406_F1.0900.98
398_D401_L1.0850.98
235_G339_P1.0750.98
27_L32_T1.0690.98
89_A259_L1.0690.98
21_V27_L1.0660.98
84_L306_T1.0590.98
267_L289_D1.0580.98
27_L321_S1.0510.98
93_V255_V1.0460.98
117_I298_S1.0440.98
266_H311_I1.0430.98
272_G376_R1.0200.97
178_M217_L1.0180.97
262_E305_T1.0160.97
162_A176_A1.0110.97
334_L338_S1.0070.97
175_M209_L0.9940.97
42_A313_V0.9900.97
386_I390_V0.9870.97
119_C256_A0.9830.97
29_F33_A0.9770.96
296_S304_V0.9700.96
83_Y328_A0.9620.96
125_V129_V0.9620.96
224_D227_L0.9620.96
180_V184_G0.9590.96
82_S306_T0.9590.96
67_I295_L0.9590.96
159_A393_V0.9570.96
27_L324_V0.9570.96
152_M392_L0.9530.96
211_G223_V0.9520.96
45_G51_P0.9480.96
101_N111_I0.9480.96
186_V202_G0.9460.96
96_A100_F0.9430.96
323_L326_V0.9420.96
392_L396_A0.9410.96
246_G249_M0.9410.96
182_C202_G0.9400.96
115_G119_C0.9320.95
263_N285_A0.9300.95
170_A173_S0.9270.95
191_R195_Q0.9250.95
380_S384_N0.9250.95
75_I291_L0.9240.95
33_A37_V0.9220.95
55_G58_P0.9090.95
207_C225_F0.9010.94
67_I71_L0.9000.94
39_H43_M0.8910.94
39_H42_A0.8900.94
157_N411_I0.8890.94
152_M369_A0.8870.94
295_L299_V0.8850.94
210_Y216_V0.8820.94
274_T320_Y0.8800.94
37_V331_I0.8780.94
341_F344_L0.8780.94
66_G329_A0.8760.94
28_P31_Q0.8760.94
83_Y325_F0.8560.93
96_A99_G0.8550.93
291_L295_L0.8540.93
236_L337_F0.8530.93
72_F80_V0.8520.93
50_M88_A0.8500.93
46_A361_F0.8470.92
23_P26_R0.8440.92
365_A392_L0.8420.92
200_L204_I0.8410.92
127_G283_G0.8410.92
82_S267_L0.8390.92
247_Q251_L0.8380.92
185_L424_L0.8360.92
70_L330_V0.8330.92
187_A316_V0.8300.92
26_R32_T0.8300.92
21_V28_P0.8270.92
228_V340_K0.8270.92
142_M415_T0.8260.91
277_N280_P0.8220.91
326_V329_A0.8220.91
383_G387_M0.8220.91
87_S305_T0.8210.91
246_G250_M0.8190.91
57_D238_H0.8170.91
274_T277_N0.8150.91
225_F347_T0.8130.91
263_N289_D0.8100.91
187_A386_I0.8100.91
110_S113_L0.8070.91
210_Y217_L0.8060.90
52_I353_I0.8020.90
128_L287_V0.8020.90
202_G205_V0.8010.90
366_V385_L0.8000.90
73_F322_T0.8000.90
207_C348_I0.7930.90
46_A309_E0.7920.90
228_V347_T0.7920.90
33_A327_A0.7890.90
40_A335_L0.7880.89
117_I121_L0.7840.89
82_S313_V0.7830.89
263_N305_T0.7820.89
335_L341_F0.7810.89
58_P98_T0.7810.89
61_S302_S0.7780.89
64_M296_S0.7780.89
149_A391_T0.7780.89
232_A235_G0.7760.89
233_W338_S0.7710.88
399_F403_L0.7670.88
186_V205_V0.7660.88
71_L75_I0.7650.88
217_L223_V0.7640.88
165_S361_F0.7630.88
257_V261_A0.7610.88
259_L305_T0.7590.88
390_V421_L0.7550.87
123_Y290_G0.7550.87
114_G242_P0.7530.87
387_M391_T0.7530.87
402_T405_G0.7520.87
264_L282_M0.7520.87
111_I248_A0.7510.87
387_M426_S0.7510.87
174_W209_L0.7480.87
165_S353_I0.7480.87
280_P284_R0.7480.87
115_G248_A0.7470.87
151_V266_H0.7450.87
317_T331_I0.7440.87
89_A360_V0.7400.86
311_I314_M0.7400.86
169_S173_S0.7390.86
97_A115_G0.7390.86
81_P325_F0.7360.86
47_T65_S0.7350.86
101_N108_N0.7330.86
49_L165_S0.7320.86
92_G95_I0.7310.86
151_V154_I0.7280.85
199_I313_V0.7270.85
64_M295_L0.7270.85
141_L419_I0.7270.85
359_V386_I0.7260.85
400_A403_L0.7250.85
35_M39_H0.7240.85
111_I115_G0.7240.85
175_M351_A0.7230.85
60_L63_L0.7220.85
166_V358_I0.7210.85
86_S90_F0.7150.84
210_Y222_A0.7140.84
185_L190_T0.7120.84
36_G328_A0.7100.84
43_M83_Y0.7100.84
400_A404_G0.7070.84
223_V347_T0.7070.84
257_V269_A0.7060.84
343_A346_H0.7060.84
121_L124_T0.7030.83
50_M86_S0.7020.83
196_R426_S0.7010.83
94_V116_I0.7000.83
43_M310_N0.6970.83
159_A396_A0.6960.83
164_K167_S0.6950.83
59_N342_G0.6950.83
228_V343_A0.6950.83
63_L337_F0.6950.83
326_V330_V0.6940.83
203_L261_A0.6920.82
61_S65_S0.6910.82
208_L334_L0.6900.82
91_V257_V0.6890.82
127_G290_G0.6880.82
372_W377_V0.6860.82
188_V366_V0.6820.81
362_G366_V0.6810.81
137_W141_L0.6810.81
190_T193_M0.6790.81
293_T304_V0.6780.81
395_G414_A0.6770.81
47_T61_S0.6760.81
124_T128_L0.6760.81
389_A393_V0.6760.81
273_M315_A0.6750.81
183_I186_V0.6740.81
110_S240_S0.6710.80
199_I275_G0.6700.80
45_G309_E0.6700.80
89_A154_I0.6680.80
203_L356_A0.6670.80
179_T206_A0.6660.80
64_M301_G0.6640.80
366_V388_V0.6640.80
113_L117_I0.6620.80
194_I198_L0.6610.79
270_V306_T0.6590.79
294_M298_S0.6580.79
61_S86_S0.6570.79
39_H313_V0.6540.79
315_A370_R0.6540.79
33_A229_S0.6530.79
152_M372_W0.6520.78
164_K170_A0.6510.78
143_P312_G0.6510.78
159_A389_A0.6490.78
253_A256_A0.6490.78
125_V181_L0.6480.78
395_G410_G0.6470.78
362_G385_L0.6450.78
130_V286_F0.6450.78
80_V285_A0.6450.78
188_V364_I0.6450.78
71_L288_G0.6430.78
331_I335_L0.6430.78
183_I359_V0.6430.78
84_L263_N0.6410.77
23_P27_L0.6410.77
225_F344_L0.6380.77
60_L64_M0.6360.77
162_A179_T0.6360.77
109_I113_L0.6330.76
64_M292_A0.6330.76
388_V392_L0.6310.76
343_A347_T0.6300.76
175_M203_L0.6300.76
259_L262_E0.6270.76
49_L52_I0.6260.76
262_E289_D0.6230.75
239_F242_P0.6220.75
123_Y260_V0.6200.75
236_L336_G0.6190.75
87_S90_F0.6190.75
293_T296_S0.6190.75
123_Y256_A0.6170.75
169_S172_D0.6170.75
78_G281_Y0.6160.74
398_D402_T0.6150.74
169_S336_G0.6120.74
157_N409_G0.6120.74
164_K171_F0.6110.74
147_T339_P0.6110.74
92_G96_A0.6110.74
208_L234_F0.6110.74
67_I299_V0.6090.74
204_I344_L0.6080.74
419_I423_A0.6060.73
205_V208_L0.6060.73
75_I280_P0.6050.73
266_H367_A0.6040.73
223_V227_L0.6040.73
110_S241_T0.6030.73
309_E361_F0.6030.73
270_V311_I0.6010.73
100_F108_N0.6010.73
29_F331_I0.6010.73
149_A418_A0.6000.73
145_V384_N0.5990.72
94_V98_T0.5970.72
63_L408_L0.5960.72
203_L353_I0.5950.72
137_W142_M0.5940.72
150_V180_V0.5940.72
154_I307_Y0.5930.72
145_V387_M0.5930.72
370_R376_R0.5930.72
257_V419_I0.5930.72
208_L229_S0.5930.72
181_L184_G0.5930.72
252_I351_A0.5920.72
399_F402_T0.5920.72
140_R423_A0.5900.71
43_M370_R0.5900.71
231_A339_P0.5900.71
186_V194_I0.5890.71
379_L385_L0.5890.71
289_D389_A0.5890.71
68_G288_G0.5890.71
266_H306_T0.5890.71
98_T108_N0.5880.71
410_G414_A0.5850.71
117_I244_F0.5850.71
383_G421_L0.5820.70
65_S82_S0.5820.70
269_A367_A0.5820.70
54_M203_L0.5810.70
152_M365_A0.5810.70
108_N243_A0.5810.70
334_L406_F0.5800.70
186_V198_L0.5790.70
278_M281_Y0.5790.70
236_L257_V0.5780.70
115_G253_A0.5750.69
164_K172_D0.5750.69
237_P359_V0.5740.69
47_T50_M0.5740.69
26_R29_F0.5730.69
127_G131_M0.5730.69
393_V396_A0.5710.69
308_A367_A0.5700.69
49_L53_L0.5700.69
84_L293_T0.5700.69
81_P115_G0.5700.69
130_V143_P0.5680.68
187_A195_Q0.5670.68
66_G70_L0.5670.68
161_I165_S0.5660.68
89_A305_T0.5660.68
165_S357_S0.5650.68
207_C211_G0.5640.68
101_N248_A0.5640.68
25_E321_S0.5640.68
72_F322_T0.5640.68
113_L119_C0.5630.68
264_L268_K0.5630.68
201_V204_I0.5620.68
336_G342_G0.5620.68
291_L294_M0.5620.68
414_A418_A0.5620.68
81_P120_G0.5610.67
118_A253_A0.5610.67
97_A101_N0.5590.67
148_G368_G0.5590.67
319_V353_I0.5580.67
379_L384_N0.5580.67
88_A154_I0.5560.67
285_A289_D0.5560.67
289_D305_T0.5560.67
23_P321_S0.5560.67
73_F329_A0.5560.67
33_A334_L0.5550.67
95_I99_G0.5540.67
142_M192_G0.5530.66
256_A293_T0.5530.66
392_L398_D0.5500.66
268_K318_K0.5500.66
211_G424_L0.5490.66
294_M297_G0.5480.66
227_L231_A0.5470.66
47_T51_P0.5460.65
263_N306_T0.5450.65
69_T305_T0.5450.65
70_L74_F0.5450.65
322_T326_V0.5440.65
123_Y127_G0.5430.65
93_V96_A0.5430.65
185_L246_G0.5420.65
327_A330_V0.5420.65
90_F293_T0.5410.65
110_S114_G0.5400.65
259_L267_L0.5400.65
37_V167_S0.5390.64
62_I342_G0.5360.64
81_P274_T0.5360.64
186_V189_F0.5360.64
69_T329_A0.5360.64
425_L428_K0.5350.64
259_L266_H0.5350.64
310_N313_V0.5340.64
29_F32_T0.5330.64
94_V252_I0.5330.64
53_L95_I0.5320.63
383_G427_R0.5320.63
370_R379_L0.5310.63
155_G162_A0.5270.63
54_M57_D0.5260.63
184_G188_V0.5260.63
308_A311_I0.5260.63
241_T298_S0.5250.62
398_D404_G0.5240.62
115_G123_Y0.5230.62
86_S305_T0.5230.62
181_L230_H0.5230.62
36_G74_F0.5220.62
97_A112_A0.5220.62
170_A204_I0.5210.62
97_A114_G0.5210.62
277_N427_R0.5210.62
36_G316_V0.5210.62
195_Q379_L0.5200.62
337_F341_F0.5200.62
41_V387_M0.5200.62
60_L300_G0.5190.62
84_L267_L0.5180.61
21_V24_D0.5180.61
218_G223_V0.5180.61
394_L399_F0.5170.61
124_T127_G0.5170.61
390_V396_A0.5170.61
268_K271_A0.5170.61
68_G82_S0.5150.61
315_A358_I0.5150.61
52_I55_G0.5130.61
412_G416_F0.5130.61
308_A412_G0.5120.61
122_V256_A0.5120.61
35_M308_A0.5120.61
234_F338_S0.5110.60
370_R380_S0.5100.60
93_V410_G0.5100.60
387_M397_G0.5100.60
309_E363_L0.5090.60
266_H289_D0.5090.60
226_T231_A0.5090.60
204_I424_L0.5080.60
40_A251_L0.5080.60
366_V389_A0.5080.60
182_C201_V0.5070.60
372_W385_L0.5060.60
182_C185_L0.5060.60
372_W379_L0.5050.59
381_Q429_L0.5050.59
137_W279_D0.5030.59
265_G395_G0.5030.59
47_T332_A0.5030.59
353_I356_A0.5010.59
129_V291_L0.5010.59
199_I361_F0.5010.59
98_T339_P0.5000.59
166_V169_S0.5000.59
143_P148_G0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qe7A 2 0.8982 100 0.392 Contact Map
1pw4A 1 0.862 77.2 0.962 Contact Map
2jlnA 1 0.8597 63.9 0.966 Contact Map
3o7qA 1 0.4186 40.6 0.97 Contact Map
4lz6A 1 0.9163 36.6 0.971 Contact Map
2nwlA 3 0.3824 32.7 0.972 Contact Map
3w4tA 1 0.9027 28 0.973 Contact Map
4humA 1 0.9299 25.6 0.973 Contact Map
3mktA 1 0.9367 22 0.974 Contact Map
4j05A 3 0.819 18 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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