GREMLIN Database
GFCB - Uncharacterized lipoprotein GfcB
UniProt: P75884 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13731
Length: 214 (203)
Sequences: 317 (265)
Seq/√Len: 18.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
164_V181_T4.4411.00
52_M207_M4.2691.00
91_L207_M3.8181.00
84_L91_L3.4961.00
90_R110_D2.9430.99
172_T182_F2.8230.98
184_V191_V2.7880.98
15_G78_S2.4050.96
151_E164_V2.2940.94
73_Q87_H2.2290.94
193_Q206_E2.2110.93
76_W193_Q2.2050.93
76_W183_W2.1870.93
167_E183_W2.1030.91
181_T195_R2.0950.91
70_E75_K2.0810.91
143_S169_V2.0420.90
110_D145_F1.9460.88
54_L199_G1.9050.87
90_R124_W1.9010.86
54_L84_L1.8930.86
53_Y61_R1.8920.86
195_R204_P1.8920.86
81_N92_L1.8850.86
91_L208_T1.8490.85
50_S69_I1.8480.85
74_S86_T1.7670.82
153_L162_C1.7630.82
85_V93_K1.7140.80
128_I143_S1.7130.80
144_T177_Q1.7070.80
166_Q179_Q1.6930.79
13_L16_C1.6590.78
68_Y84_L1.6380.77
50_S93_K1.6050.75
42_Q149_G1.5970.75
93_K169_V1.5730.74
104_V130_W1.5700.74
167_E180_N1.5300.72
38_T61_R1.5220.71
94_T182_F1.5120.71
78_S205_V1.5060.70
75_K119_K1.5020.70
194_S207_M1.4940.70
57_N62_I1.4940.70
30_S33_D1.4870.69
57_N99_N1.4850.69
41_D45_Q1.4570.68
111_P145_F1.4230.66
84_L116_L1.4180.66
197_M203_I1.3530.62
27_F31_L1.3520.62
28_R47_L1.3360.61
36_D211_K1.3350.61
44_I156_A1.3250.60
145_F156_A1.3210.60
19_S23_M1.3130.59
95_V98_N1.3110.59
94_T101_L1.2960.58
51_T74_S1.2910.58
92_L182_F1.2890.58
50_S74_S1.2870.58
50_S209_F1.2620.56
94_T97_L1.2450.55
84_L150_L1.2330.55
163_N186_S1.2300.54
128_I141_L1.2230.54
95_V123_R1.2200.54
186_S194_S1.1960.52
91_L194_S1.1830.51
33_D49_Y1.1770.51
20_Q27_F1.1710.51
75_K83_M1.1470.49
6_L11_L1.1460.49
195_R206_E1.1450.49
112_L143_S1.1430.49
129_L199_G1.1360.49
169_V199_G1.1360.49
111_P143_S1.1360.49
64_V191_V1.1350.48
48_P86_T1.1220.48
129_L137_R1.1150.47
26_T36_D1.1140.47
67_G94_T1.1110.47
159_N188_T1.1080.47
185_D192_R1.1040.47
12_F58_E1.1030.46
141_L169_V1.0980.46
58_E103_E1.0980.46
75_K143_S1.0960.46
50_S86_T1.0820.45
51_T63_F1.0710.44
44_I140_T1.0690.44
167_E196_Q1.0600.44
121_G145_F1.0600.44
31_L184_V1.0540.43
80_D207_M1.0530.43
39_V108_G1.0310.42
110_D143_S1.0170.41
9_F146_S1.0070.41
82_A184_V1.0040.40
58_E98_N1.0010.40
25_D133_D0.9810.39
41_D147_F0.9810.39
22_S93_K0.9770.39
104_V126_R0.9740.39
48_P191_V0.9620.38
44_I164_V0.9550.37
65_V92_L0.9540.37
180_N183_W0.9450.37
53_Y75_K0.9420.37
31_L179_Q0.9410.37
17_T162_C0.9330.36
80_D193_Q0.9320.36
198_L205_V0.9270.36
8_I14_A0.9190.35
7_S28_R0.9140.35
93_K143_S0.9140.35
10_A164_V0.9140.35
159_N210_L0.9040.35
84_L126_R0.8980.34
129_L200_A0.8950.34
84_L160_V0.8870.34
51_T130_W0.8870.34
96_K210_L0.8830.33
11_L88_N0.8800.33
106_N124_W0.8780.33
100_N131_S0.8770.33
81_N102_L0.8750.33
75_K93_K0.8750.33
57_N139_A0.8740.33
66_L74_S0.8720.33
57_N203_I0.8720.33
131_S199_G0.8710.33
169_V197_M0.8690.33
53_Y90_R0.8670.32
83_M210_L0.8640.32
126_R182_F0.8640.32
98_N136_F0.8640.32
23_M52_M0.8630.32
97_L101_L0.8600.32
199_G203_I0.8530.32
39_V61_R0.8500.32
51_T65_V0.8450.31
25_D28_R0.8440.31
75_K130_W0.8390.31
183_W193_Q0.8380.31
47_L191_V0.8360.31
150_L186_S0.8340.31
21_Q38_T0.8320.31
37_I194_S0.8300.30
34_N45_Q0.8290.30
7_S12_F0.8280.30
194_S209_F0.8270.30
30_S36_D0.8220.30
59_G103_E0.8200.30
22_S65_V0.8170.30
59_G100_N0.8120.30
54_L207_M0.8070.29
25_D159_N0.8070.29
115_A199_G0.8060.29
136_F191_V0.8060.29
91_L94_T0.7990.29
163_N185_D0.7970.29
29_A87_H0.7950.29
14_A122_S0.7940.29
85_V101_L0.7920.29
50_S63_F0.7890.28
72_E87_H0.7870.28
108_G175_E0.7820.28
155_I158_R0.7770.28
144_T201_G0.7690.27
52_M199_G0.7690.27
161_L176_K0.7660.27
18_H36_D0.7630.27
13_L165_W0.7630.27
25_D150_L0.7560.27
176_K182_F0.7530.27
56_L86_T0.7490.26
33_D48_P0.7460.26
95_V136_F0.7440.26
128_I155_I0.7430.26
97_L146_S0.7400.26
5_I8_I0.7340.26
118_I182_F0.7270.25
117_A206_E0.7270.25
197_M208_T0.7250.25
84_L104_V0.7190.25
87_H121_G0.7150.25
116_L128_I0.7140.25
23_M50_S0.7110.25
5_I13_L0.7110.25
48_P65_V0.7110.25
169_V203_I0.7100.25
12_F34_N0.7100.25
120_D178_W0.7020.24
143_S178_W0.7020.24
159_N177_Q0.7010.24
110_D128_I0.7000.24
154_N159_N0.6910.24
63_F86_T0.6880.24
34_N108_G0.6850.23
46_A151_E0.6840.23
11_L40_A0.6840.23
98_N203_I0.6830.23
15_G122_S0.6800.23
56_L205_V0.6780.23
42_Q47_L0.6740.23
9_F13_L0.6740.23
97_L122_S0.6670.23
147_F165_W0.6670.23
60_Q205_V0.6630.22
25_D186_S0.6580.22
7_S54_L0.6540.22
128_I193_Q0.6460.22
141_L171_S0.6450.22
62_I88_N0.6440.22
91_L95_V0.6440.22
12_F162_C0.6420.22
40_A77_L0.6420.22
68_Y82_A0.6370.21
146_S161_L0.6330.21
139_A197_M0.6320.21
130_W169_V0.6300.21
29_A53_Y0.6290.21
43_Q82_A0.6260.21
47_L179_Q0.6250.21
34_N117_A0.6240.21
13_L98_N0.6230.21
136_F172_T0.6230.21
42_Q159_N0.6200.21
26_T208_T0.6190.21
109_Q121_G0.6170.20
55_R208_T0.6160.20
105_T112_L0.6110.20
65_V134_N0.6100.20
182_F203_I0.6060.20
55_R206_E0.6060.20
97_L210_L0.6060.20
162_C176_K0.6050.20
13_L31_L0.6020.20
182_F204_P0.6020.20
24_V201_G0.6010.20
185_D188_T0.5990.20
190_Q209_F0.5980.20
14_A148_A0.5970.20
101_L211_K0.5960.20
18_H50_S0.5900.19
84_L179_Q0.5890.19
142_S161_L0.5880.19
123_R167_E0.5860.19
78_S168_E0.5830.19
137_R156_A0.5820.19
115_A171_S0.5800.19
30_S192_R0.5780.19
71_Q105_T0.5740.19
23_M191_V0.5730.19
40_A135_H0.5720.19
50_S57_N0.5710.19
53_Y65_V0.5710.19
158_R210_L0.5690.19
76_W180_N0.5650.18
112_L124_W0.5650.18
62_I79_Q0.5650.18
32_F35_Q0.5640.18
154_N204_P0.5610.18
160_V179_Q0.5600.18
54_L91_L0.5550.18
21_Q78_S0.5550.18
95_V194_S0.5540.18
43_Q119_K0.5530.18
153_L183_W0.5510.18
36_D53_Y0.5500.18
26_T191_V0.5480.18
137_R200_A0.5470.18
112_L145_F0.5470.18
90_R112_L0.5460.18
54_L149_G0.5440.18
42_Q147_F0.5440.18
27_F181_T0.5410.18
135_H199_G0.5390.17
57_N137_R0.5370.17
24_V27_F0.5370.17
18_H51_T0.5370.17
30_S81_N0.5340.17
70_E151_E0.5320.17
43_Q92_L0.5310.17
20_Q23_M0.5310.17
133_D207_M0.5310.17
169_V178_W0.5300.17
165_W197_M0.5280.17
114_N210_L0.5280.17
20_Q162_C0.5270.17
170_T177_Q0.5250.17
65_V132_E0.5230.17
10_A88_N0.5210.17
66_L139_A0.5170.17
86_T90_R0.5150.17
54_L205_V0.5110.16
104_V128_I0.5060.16
144_T195_R0.5060.16
89_G191_V0.5040.16
18_H26_T0.5030.16
33_D60_Q0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2in5A 2 0.9019 100 0.168 Contact Map
3zbiC 1 0.1121 75.6 0.93 Contact Map
4fvsA 1 0.8598 52.8 0.94 Contact Map
3pmqA 1 0.5467 29.1 0.948 Contact Map
4jwoA 1 0.8738 18.3 0.953 Contact Map
4av2M 1 0.3598 14.3 0.955 Contact Map
4gioA 1 0.3645 12.6 0.956 Contact Map
4immA 1 0.5888 11.7 0.957 Contact Map
4jg9A 2 0.5 10.6 0.958 Contact Map
1jqgA 1 0.8178 10 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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