GREMLIN Database
GFCC - Uncharacterized protein GfcC
UniProt: P75883 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13730
Length: 248 (219)
Sequences: 789 (659)
Seq/√Len: 44.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_E51_Q4.1001.00
59_W62_G3.4431.00
46_V132_N2.9301.00
192_T216_S2.8071.00
192_T213_P2.8061.00
61_P213_P2.7981.00
230_K233_D2.7421.00
233_D237_Q2.5951.00
191_I219_W2.5201.00
63_A141_L2.4601.00
174_L179_R2.3651.00
54_L60_W2.3411.00
29_Y140_T2.2781.00
168_R172_D2.2461.00
150_I212_P2.2301.00
232_A237_Q2.2091.00
75_L111_N2.1971.00
228_P233_D2.1201.00
44_N47_Q2.0950.99
26_V48_L2.0900.99
229_E237_Q2.0790.99
188_V220_L2.0760.99
155_A180_L2.0710.99
229_E236_D2.0330.99
75_L112_I2.0200.99
233_D236_D2.0020.99
228_P237_Q1.9980.99
63_A120_L1.9840.99
49_V141_L1.9340.99
232_A235_N1.9030.99
193_P216_S1.8840.99
77_D80_H1.8200.99
228_P232_A1.8020.98
72_A76_K1.7980.98
228_P231_Y1.7830.98
170_V200_A1.7730.98
232_A236_D1.7490.98
122_P125_V1.7480.98
229_E233_D1.7360.98
229_E232_A1.7240.98
80_H84_Q1.7220.98
119_K122_P1.6640.97
39_V43_E1.6460.97
30_L67_D1.6460.97
165_Q172_D1.6290.97
79_Q83_A1.6150.97
97_A106_Q1.5730.96
190_V218_L1.5550.96
170_V212_P1.5260.96
28_I32_G1.4420.94
86_A108_L1.4410.94
234_L237_Q1.4350.94
168_R176_D1.4230.94
179_R183_A1.4210.94
230_K234_L1.4120.93
96_V99_T1.4100.93
151_T161_Q1.4090.93
173_Y195_G1.4040.93
76_K80_H1.3940.93
48_L52_P1.3930.93
70_A74_A1.3820.93
230_K237_Q1.3720.92
230_K236_D1.3720.92
139_Y144_V1.3710.92
156_V220_L1.3440.92
73_K76_K1.3430.91
48_L141_L1.3390.91
32_G221_G1.3330.91
52_P221_G1.3320.91
231_Y234_L1.2940.90
28_I87_S1.2920.90
67_D139_Y1.2870.90
152_L156_V1.2800.89
139_Y178_P1.2220.87
30_L144_V1.2210.87
21_F190_V1.2090.86
82_M85_L1.2050.86
228_P236_D1.2020.86
105_Q109_N1.1910.86
58_L144_V1.1900.86
30_L139_Y1.1770.85
229_E235_N1.1720.85
31_P55_R1.1670.84
34_Q219_W1.1640.84
191_I194_E1.1560.84
119_K125_V1.1490.84
78_Y81_V1.1400.83
114_G122_P1.1390.83
93_D96_V1.1310.83
190_V212_P1.1300.82
95_D98_A1.1290.82
190_V198_V1.1050.81
155_A222_F1.1000.81
38_S56_D1.0960.80
30_L58_L1.0900.80
189_M221_G1.0820.80
43_E47_Q1.0810.80
80_H111_N1.0770.79
65_L223_S1.0630.78
75_L78_Y1.0550.78
107_L112_I1.0540.78
48_L135_L1.0460.77
99_T102_S1.0460.77
28_I55_R1.0410.77
162_L177_H1.0370.77
164_W218_L1.0320.76
63_A221_G1.0240.76
128_D132_N1.0140.75
180_L183_A1.0120.75
151_T217_Q1.0060.74
28_I49_V1.0050.74
86_A106_Q0.9990.74
75_L79_Q0.9960.74
111_N114_G0.9950.74
97_A110_L0.9920.73
152_L169_S0.9910.73
118_V141_L0.9800.72
30_L35_Q0.9780.72
213_P216_S0.9730.72
64_L142_Y0.9700.72
195_G215_G0.9590.71
20_A23_Q0.9570.71
28_I72_A0.9500.70
228_P235_N0.9460.70
79_Q207_K0.9340.69
193_P197_T0.9300.68
122_P126_R0.9240.68
114_G117_P0.9180.67
91_E164_W0.9140.67
101_K105_Q0.9130.67
123_D126_R0.9030.66
23_Q175_Q0.9010.66
148_V163_P0.8930.65
45_V133_P0.8900.65
117_P124_F0.8740.64
36_T99_T0.8690.63
37_L46_V0.8650.63
32_G53_Q0.8630.63
184_D187_N0.8620.62
120_L141_L0.8490.61
164_W208_R0.8460.61
69_A141_L0.8430.61
39_V51_Q0.8400.60
47_Q51_Q0.8400.60
176_D212_P0.8390.60
67_D144_V0.8390.60
28_I52_P0.8380.60
161_Q172_D0.8300.60
63_A173_Y0.8260.59
68_S71_K0.8120.58
118_V128_D0.8110.58
84_Q191_I0.8100.58
191_I195_G0.8060.57
150_I153_L0.8060.57
99_T103_V0.8040.57
30_L156_V0.8030.57
78_Y82_M0.7990.57
202_V206_N0.7950.56
95_D218_L0.7950.56
165_Q168_R0.7910.56
133_P165_Q0.7890.56
53_Q58_L0.7890.56
27_T181_A0.7860.55
107_L115_R0.7850.55
155_A206_N0.7840.55
202_V205_W0.7770.55
80_H143_T0.7760.54
143_T178_P0.7750.54
66_T142_Y0.7740.54
32_G149_T0.7740.54
173_Y215_G0.7630.53
139_Y177_H0.7580.53
156_V178_P0.7550.52
51_Q189_M0.7550.52
117_P122_P0.7500.52
170_V216_S0.7500.52
165_Q176_D0.7480.52
186_N199_V0.7430.51
57_R98_A0.7400.51
227_L233_D0.7360.51
30_L37_L0.7360.51
219_W223_S0.7340.50
58_L67_D0.7340.50
227_L232_A0.7330.50
146_R166_A0.7310.50
51_Q54_L0.7300.50
27_T140_T0.7250.50
27_T48_L0.7250.50
112_I115_R0.7240.49
30_L220_L0.7210.49
101_K104_R0.7180.49
200_A214_P0.7180.49
231_Y235_N0.7160.49
22_A27_T0.7160.49
47_Q220_L0.7150.49
59_W221_G0.7150.49
31_P42_V0.7120.48
116_L124_F0.7120.48
27_T166_A0.7110.48
17_T170_V0.7100.48
58_L139_Y0.7060.48
116_L125_V0.7040.47
173_Y191_I0.6990.47
26_V183_A0.6920.46
118_V124_F0.6900.46
231_Y237_Q0.6880.46
170_V188_V0.6880.46
115_R205_W0.6860.46
120_L126_R0.6830.45
82_M112_I0.6830.45
138_D156_V0.6810.45
102_S105_Q0.6790.45
164_W185_K0.6750.45
27_T36_T0.6730.44
155_A182_G0.6730.44
139_Y156_V0.6700.44
212_P218_L0.6680.44
143_T199_V0.6670.44
49_V185_K0.6630.44
200_A209_H0.6630.44
72_A75_L0.6630.44
114_G184_D0.6620.43
31_P53_Q0.6590.43
81_V143_T0.6530.43
74_A155_A0.6510.42
68_S146_R0.6510.42
212_P216_S0.6510.42
201_P209_H0.6500.42
85_L188_V0.6480.42
107_L114_G0.6460.42
25_T164_W0.6450.42
76_K79_Q0.6430.42
179_R188_V0.6430.42
44_N132_N0.6420.42
59_W147_P0.6370.41
61_P146_R0.6370.41
70_A114_G0.6360.41
190_V208_R0.6320.41
119_K123_D0.6310.41
31_P58_L0.6310.41
157_S199_V0.6280.40
73_K99_T0.6270.40
67_D178_P0.6260.40
117_P120_L0.6240.40
31_P145_Q0.6220.40
17_T136_V0.6210.40
227_L230_K0.6170.39
69_A74_A0.6130.39
79_Q109_N0.6110.39
153_L217_Q0.6110.39
194_E231_Y0.6110.39
192_T212_P0.6110.39
30_L178_P0.6100.39
32_G58_L0.6070.38
152_L216_S0.6060.38
61_P150_I0.6010.38
96_V108_L0.5990.38
167_G212_P0.5970.37
33_E56_D0.5940.37
144_V215_G0.5940.37
62_G149_T0.5920.37
52_P58_L0.5900.37
40_G142_Y0.5880.37
34_Q37_L0.5880.37
227_L234_L0.5870.36
87_S185_K0.5860.36
82_M106_Q0.5840.36
182_G222_F0.5840.36
37_L48_L0.5830.36
38_S48_L0.5820.36
88_W91_E0.5800.36
133_P169_S0.5790.36
29_Y142_Y0.5790.36
105_Q108_L0.5780.36
20_A162_L0.5780.36
116_L122_P0.5770.36
180_L218_L0.5770.36
133_P189_M0.5760.36
94_D99_T0.5760.36
167_G172_D0.5670.35
48_L164_W0.5650.35
157_S179_R0.5620.34
56_D109_N0.5620.34
174_L212_P0.5610.34
167_G211_E0.5580.34
65_L162_L0.5540.34
32_G161_Q0.5540.34
224_A229_E0.5530.34
53_Q221_G0.5530.34
31_P48_L0.5500.33
38_S183_A0.5500.33
77_D103_V0.5490.33
70_A73_K0.5460.33
224_A228_P0.5440.33
26_V74_A0.5440.33
185_K211_E0.5440.33
67_D74_A0.5430.33
30_L42_V0.5410.32
223_S231_Y0.5400.32
67_D156_V0.5400.32
37_L53_Q0.5380.32
228_P234_L0.5380.32
188_V192_T0.5370.32
118_V189_M0.5360.32
88_W92_A0.5330.32
35_Q193_P0.5320.32
35_Q42_V0.5320.32
197_T219_W0.5280.31
143_T150_I0.5270.31
77_D81_V0.5240.31
106_Q181_A0.5230.31
55_R65_L0.5210.31
227_L235_N0.5190.31
107_L111_N0.5180.31
118_V121_D0.5180.31
31_P67_D0.5170.30
185_K209_H0.5170.30
59_W145_Q0.5150.30
99_T182_G0.5140.30
25_T36_T0.5130.30
155_A178_P0.5120.30
152_L162_L0.5100.30
25_T140_T0.5070.30
87_S90_A0.5030.29
75_L82_M0.5020.29
40_G109_N0.5010.29
65_L217_Q0.5000.29
78_Y85_L0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3p42A 2 0.9113 100 0.341 Contact Map
2j58A 5 0.7823 99.7 0.728 Contact Map
4b8vA 2 0.7097 76.2 0.933 Contact Map
4uz3A 1 0.3992 54.5 0.942 Contact Map
1e0gA 1 0.1935 27.7 0.951 Contact Map
2f0cA 3 0.5363 25.1 0.952 Contact Map
2l32A 1 0.2661 24.3 0.952 Contact Map
1ryjA 1 0.2782 19.1 0.954 Contact Map
4hrsA 2 0.2661 19.1 0.954 Contact Map
2q5wD 1 0.2903 16.9 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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