YCCS - ECOLI - GREMLIN Contacts

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YCCS - Inner membrane protein YccS

UniProt:	P75870	Sequences: MLSPLLKRYTWNSAWLYYARIFIALCGTTAFPWWLGDVKLTIPLTLGMVAAALTDLDDRLAGRLRNLIITLFCFFIASASVELLFPWPWLFAIGLTLSTSGFILLGGLGQRYATIAFGALLIAIYTMLGTSLYEHWYQQPMYLLAGAVWYNVLTLIGHLLFPVRPLQDNLARCYEQLARYLELKSRMFDPDIEDQSQAPLYDLALANGLLMATLNQTKLSLLTRLRGDRGQRGTRRTLHYYFVAQDIHERASSSHIQYQTLREHFRHSDVLFRFQRLMSMQGQACQQLSRCILLRQPYQHDPHFERAFTHIDAALERMRDNGAPADLLKTLGFLLNNLRAIDAQLATIESEQAQALPHNNDENELADDSPHGLSDIWLRLSRHFTPESALFRHAVRMSLVLCFGYAIIQITGMHHGYWILLTSLFVCQPNYNATRHRLKLRIIGTLVGIAIGIPVLWFVPSLEGQLVLLVITGVLFFAFRNVQYAHATMFITLLVLLCFNLLGEGFEVALPRVIDTLIGCAIAWAAVSYIWPDWQFRNLPRMLERATEANCRYLDAILEQYHQGRDNRLAYRIARRDAHNRDAELASVVSNMSSEPNVTPQIREAAFRLLCLNHTFTSYISALGAHREQLTNPEILAFLDDAVCYVDDALHHQPADEERVNEALASLKQRMQQLEPRADSKEPLVVQQVGLLIALLPEIGRLQRQITQVPQETPVSA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13721
Length:	717 (628)
Sequences:	2264 (1795)
Seq/√Len:	71.6

ECOLI - YCCS YHFK MDTO
BACSU - YVAC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
254_S	257_Q	4.866	1.00
639_L	643_V	4.272	1.00
215_N	218_K	4.183	1.00
404_G	423_S	3.856	1.00
96_T	398_S	3.712	1.00
288_L	292_I	3.665	1.00
182_E	286_Q	3.555	1.00
24_A	153_L	3.358	1.00
400_V	522_I	3.296	1.00
93_I	97_L	3.206	1.00
247_I	255_H	3.162	1.00
245_Q	249_E	3.140	1.00
400_V	423_S	3.138	1.00
467_V	471_I	3.007	1.00
211_M	215_N	2.935	1.00
535_Q	591_N	2.910	1.00
248_H	254_S	2.903	1.00
400_V	526_A	2.815	1.00
137_Y	140_P	2.798	1.00
311_I	315_L	2.777	1.00
334_L	342_D	2.755	1.00
96_T	402_C	2.734	1.00
174_Y	177_L	2.659	1.00
289_S	292_I	2.651	1.00
141_M	145_A	2.501	1.00
100_S	391_F	2.500	1.00
248_H	255_H	2.495	1.00
419_I	518_I	2.471	1.00
152_V	156_I	2.395	1.00
422_T	516_T	2.375	1.00
418_W	445_T	2.348	1.00
207_N	218_K	2.308	1.00
204_A	207_N	2.301	1.00
109_G	112_Y	2.282	1.00
100_S	398_S	2.276	1.00
316_E	319_R	2.261	1.00
657_E	660_V	2.256	1.00
407_I	522_I	2.256	1.00
314_A	319_R	2.253	1.00
418_W	519_G	2.206	1.00
252_S	257_Q	2.183	1.00
230_G	233_G	2.136	1.00
210_L	218_K	2.136	1.00
244_A	252_S	2.091	1.00
575_R	579_H	2.087	1.00
28_T	149_W	2.078	1.00
330_T	333_F	2.067	1.00
419_I	515_D	2.057	1.00
363_N	366_A	2.048	1.00
364_E	368_D	2.029	1.00
519_G	523_A	2.026	1.00
248_H	253_S	2.023	1.00
550_N	613_N	2.016	1.00
246_D	250_R	2.009	1.00
249_E	254_S	1.992	1.00
404_G	522_I	1.957	1.00
327_L	338_L	1.954	1.00
244_A	256_I	1.953	1.00
248_H	257_Q	1.951	1.00
241_Y	255_H	1.944	1.00
329_K	337_N	1.940	1.00
335_L	342_D	1.935	1.00
472_T	493_L	1.929	1.00
95_L	123_A	1.917	1.00
639_L	642_A	1.900	1.00
309_T	313_A	1.898	1.00
95_L	103_I	1.884	1.00
636_L	639_L	1.879	1.00
286_Q	289_S	1.871	1.00
249_E	258_Y	1.859	1.00
269_D	273_R	1.856	1.00
446_L	450_A	1.853	1.00
250_R	257_Q	1.850	1.00
368_D	372_G	1.838	1.00
328_L	335_L	1.822	1.00
333_F	344_Q	1.818	1.00
645_Y	654_P	1.796	1.00
178_A	282_G	1.792	1.00
407_I	518_I	1.769	1.00
252_S	255_H	1.760	1.00
237_T	244_A	1.758	1.00
447_V	489_M	1.758	1.00
643_V	653_Q	1.746	1.00
92_A	402_C	1.742	1.00
437_R	484_Y	1.730	1.00
495_V	499_F	1.727	1.00
329_K	333_F	1.723	1.00
642_A	649_A	1.710	1.00
216_Q	219_L	1.702	1.00
260_T	263_E	1.700	1.00
245_Q	250_R	1.695	1.00
28_T	41_T	1.688	1.00
469_L	497_L	1.676	1.00
551_C	640_D	1.670	1.00
318_M	326_D	1.668	1.00
444_G	512_R	1.661	1.00
362_E	366_A	1.654	1.00
463_E	466_L	1.652	1.00
337_N	342_D	1.643	0.99
415_H	418_W	1.638	0.99
251_A	255_H	1.631	0.99
270_V	273_R	1.631	0.99
365_L	370_P	1.626	0.99
261_L	264_H	1.624	0.99
364_E	367_D	1.622	0.99
257_Q	260_T	1.593	0.99
643_V	646_V	1.582	0.99
67_L	151_N	1.580	0.99
178_A	517_L	1.576	0.99
100_S	104_L	1.568	0.99
586_A	614_H	1.557	0.99
48_M	146_G	1.554	0.99
99_T	401_L	1.551	0.99
329_K	332_G	1.542	0.99
242_F	245_Q	1.525	0.99
405_Y	420_L	1.500	0.99
318_M	322_G	1.497	0.99
393_H	429_P	1.496	0.99
640_D	643_V	1.492	0.99
58_D	62_G	1.492	0.99
232_R	235_R	1.491	0.99
250_R	253_S	1.481	0.99
317_R	321_N	1.475	0.99
250_R	254_S	1.469	0.99
94_G	98_S	1.469	0.99
641_D	645_Y	1.463	0.99
206_A	211_M	1.454	0.99
175_E	289_S	1.452	0.99
466_L	470_V	1.451	0.99
241_Y	244_A	1.445	0.99
176_Q	179_R	1.441	0.99
458_F	464_G	1.441	0.99
44_L	47_G	1.439	0.99
431_Y	596_P	1.439	0.99
289_S	293_L	1.438	0.99
248_H	252_S	1.433	0.99
401_L	424_L	1.422	0.99
335_L	341_I	1.421	0.99
406_A	410_I	1.421	0.99
245_Q	248_H	1.415	0.98
175_E	290_R	1.411	0.98
315_L	319_R	1.411	0.98
638_F	650_L	1.406	0.98
646_V	649_A	1.405	0.98
209_L	213_T	1.402	0.98
487_A	491_I	1.399	0.98
223_T	227_G	1.398	0.98
556_A	559_E	1.397	0.98
367_D	373_L	1.397	0.98
636_L	643_V	1.391	0.98
279_S	283_Q	1.381	0.98
241_Y	245_Q	1.379	0.98
419_I	422_T	1.378	0.98
246_D	251_A	1.378	0.98
218_K	222_L	1.376	0.98
446_L	513_V	1.374	0.98
327_L	335_L	1.368	0.98
152_V	155_L	1.361	0.98
477_F	490_F	1.361	0.98
244_A	254_S	1.360	0.98
337_N	341_I	1.359	0.98
103_I	397_M	1.358	0.98
319_R	323_A	1.356	0.98
383_H	388_S	1.351	0.98
241_Y	247_I	1.350	0.98
464_G	467_V	1.346	0.98
642_A	645_Y	1.345	0.98
211_M	218_K	1.345	0.98
394_A	398_S	1.344	0.98
18_Y	474_V	1.343	0.98
302_P	316_E	1.337	0.98
557_I	561_Y	1.335	0.98
337_N	348_I	1.331	0.98
445_T	516_T	1.328	0.98
89_W	93_I	1.326	0.98
548_E	651_H	1.324	0.98
334_L	338_L	1.320	0.98
642_A	650_L	1.316	0.98
244_A	247_I	1.313	0.97
83_L	87_W	1.312	0.97
318_M	321_N	1.311	0.97
660_V	663_A	1.310	0.97
301_D	304_F	1.308	0.97
246_D	254_S	1.307	0.97
518_I	521_A	1.298	0.97
461_S	464_G	1.296	0.97
492_T	499_F	1.289	0.97
214_L	217_T	1.289	0.97
253_S	257_Q	1.288	0.97
212_A	218_K	1.287	0.97
247_I	254_S	1.285	0.97
643_V	647_D	1.280	0.97
22_F	26_C	1.279	0.97
175_E	293_L	1.275	0.97
319_R	322_G	1.274	0.97
378_L	381_S	1.262	0.97
644_C	653_Q	1.254	0.97
261_L	265_F	1.254	0.97
333_F	338_L	1.251	0.97
182_E	282_G	1.249	0.97
291_C	296_Q	1.248	0.97
249_E	253_S	1.247	0.97
207_N	211_M	1.247	0.97
333_F	342_D	1.244	0.97
234_T	238_L	1.244	0.97
643_V	650_L	1.241	0.96
334_L	341_I	1.240	0.96
210_L	215_N	1.239	0.96
93_I	361_D	1.234	0.96
243_V	254_S	1.234	0.96
549_A	581_R	1.232	0.96
327_L	333_F	1.230	0.96
249_E	257_Q	1.230	0.96
311_I	314_A	1.226	0.96
251_A	258_Y	1.224	0.96
338_L	348_I	1.221	0.96
28_T	32_P	1.221	0.96
329_K	334_L	1.217	0.96
313_A	317_R	1.216	0.96
489_M	492_T	1.212	0.96
243_V	257_Q	1.212	0.96
341_I	344_Q	1.211	0.96
512_R	519_G	1.210	0.96
370_P	402_C	1.208	0.96
246_D	249_E	1.200	0.96
235_R	238_L	1.200	0.96
226_R	230_G	1.199	0.96
259_Q	262_R	1.196	0.96
648_D	652_H	1.196	0.96
210_L	219_L	1.196	0.96
652_H	660_V	1.196	0.96
327_L	330_T	1.193	0.96
175_E	517_L	1.193	0.96
339_R	342_D	1.192	0.96
534_W	596_P	1.191	0.96
70_T	115_I	1.189	0.95
342_D	345_L	1.186	0.95
635_I	648_D	1.182	0.95
559_E	638_F	1.179	0.95
245_Q	254_S	1.176	0.95
364_E	450_A	1.174	0.95
506_F	510_L	1.173	0.95
258_Y	262_R	1.173	0.95
241_Y	248_H	1.171	0.95
320_D	323_A	1.169	0.95
84_L	92_A	1.168	0.95
92_A	95_L	1.167	0.95
233_G	237_T	1.165	0.95
333_F	337_N	1.160	0.95
83_L	136_W	1.159	0.95
322_G	326_D	1.157	0.95
60_L	158_H	1.150	0.95
46_L	49_V	1.150	0.95
602_I	606_A	1.149	0.95
212_A	215_N	1.147	0.95
499_F	508_V	1.147	0.95
438_L	524_W	1.144	0.94
451_I	489_M	1.141	0.94
18_Y	22_F	1.140	0.94
312_D	316_E	1.139	0.94
22_F	470_V	1.133	0.94
646_V	650_L	1.132	0.94
418_W	492_T	1.129	0.94
580_N	584_E	1.128	0.94
328_L	331_L	1.127	0.94
635_I	642_A	1.127	0.94
335_L	347_T	1.117	0.94
228_D	231_Q	1.115	0.94
327_L	332_G	1.115	0.94
243_V	253_S	1.113	0.94
336_N	342_D	1.108	0.93
75_F	144_L	1.106	0.93
211_M	219_L	1.105	0.93
281_Q	285_C	1.102	0.93
449_I	509_A	1.098	0.93
241_Y	254_S	1.098	0.93
480_R	487_A	1.097	0.93
132_L	442_I	1.095	0.93
445_T	492_T	1.090	0.93
644_C	655_A	1.090	0.93
649_A	654_P	1.090	0.93
241_Y	250_R	1.083	0.93
479_F	486_H	1.081	0.93
488_T	491_I	1.081	0.93
179_R	183_L	1.078	0.92
317_R	320_D	1.076	0.92
277_L	281_Q	1.073	0.92
315_L	318_M	1.072	0.92
517_L	521_A	1.071	0.92
644_C	647_D	1.069	0.92
178_A	289_S	1.068	0.92
334_L	340_A	1.067	0.92
334_L	337_N	1.064	0.92
392_R	531_W	1.062	0.92
640_D	644_C	1.059	0.92
223_T	226_R	1.059	0.92
380_L	610_L	1.058	0.92
217_T	221_L	1.056	0.92
299_Q	303_H	1.056	0.92
644_C	648_D	1.052	0.92
344_Q	347_T	1.050	0.91
303_H	323_A	1.050	0.91
71_L	147_A	1.049	0.91
398_S	402_C	1.048	0.91
207_N	214_L	1.047	0.91
314_A	318_M	1.045	0.91
136_W	140_P	1.041	0.91
642_A	653_Q	1.041	0.91
211_M	217_T	1.040	0.91
643_V	655_A	1.039	0.91
641_D	646_V	1.036	0.91
244_A	250_R	1.034	0.91
288_L	291_C	1.033	0.91
211_M	214_L	1.031	0.91
384_F	388_S	1.031	0.91
242_F	246_D	1.030	0.91
179_R	286_Q	1.030	0.91
426_V	484_Y	1.029	0.91
284_A	287_Q	1.029	0.91
330_T	335_L	1.026	0.90
240_Y	255_H	1.024	0.90
396_R	520_C	1.024	0.90
294_L	297_P	1.018	0.90
396_R	418_W	1.016	0.90
328_L	337_N	1.015	0.90
241_Y	252_S	1.014	0.90
637_A	656_D	1.006	0.90
261_L	271_L	1.003	0.89
365_L	369_S	1.003	0.89
318_M	324_P	1.002	0.89
242_F	249_E	1.001	0.89
328_L	332_G	0.999	0.89
231_Q	239_H	0.998	0.89
190_P	341_I	0.998	0.89
419_I	522_I	0.997	0.89
159_L	162_P	0.997	0.89
362_E	367_D	0.995	0.89
23_I	320_D	0.994	0.89
231_Q	235_R	0.994	0.89
209_L	215_N	0.992	0.89
644_C	651_H	0.991	0.89
429_P	553_Y	0.991	0.89
252_S	258_Y	0.990	0.89
262_R	265_F	0.988	0.89
241_Y	258_Y	0.986	0.89
621_S	624_G	0.983	0.88
385_T	394_A	0.980	0.88
637_A	640_D	0.979	0.88
429_P	535_Q	0.979	0.88
366_A	373_L	0.978	0.88
254_S	260_T	0.977	0.88
23_I	223_T	0.973	0.88
426_V	519_G	0.973	0.88
260_T	264_H	0.973	0.88
310_H	313_A	0.973	0.88
657_E	662_E	0.968	0.88
214_L	218_K	0.966	0.88
342_D	348_I	0.964	0.88
208_G	219_L	0.964	0.88
286_Q	292_I	0.962	0.87
327_L	342_D	0.962	0.87
244_A	255_H	0.961	0.87
17_Y	20_R	0.959	0.87
80_S	93_I	0.959	0.87
305_E	308_F	0.954	0.87
94_G	99_T	0.954	0.87
250_R	256_I	0.952	0.87
331_L	344_Q	0.950	0.87
253_S	256_I	0.946	0.87
334_L	345_L	0.946	0.87
407_I	637_A	0.944	0.86
331_L	339_R	0.944	0.86
210_L	213_T	0.943	0.86
336_N	347_T	0.941	0.86
443_I	655_A	0.941	0.86
638_F	648_D	0.941	0.86
549_A	574_A	0.940	0.86
396_R	579_H	0.939	0.86
618_S	621_S	0.938	0.86
76_I	412_G	0.938	0.86
330_T	340_A	0.936	0.86
332_G	337_N	0.934	0.86
253_S	261_L	0.933	0.86
510_L	514_I	0.932	0.86
26_C	470_V	0.931	0.86
178_A	399_L	0.928	0.85
638_F	642_A	0.927	0.85
26_C	467_V	0.926	0.85
636_L	644_C	0.925	0.85
363_N	367_D	0.924	0.85
207_N	215_N	0.922	0.85
525_A	590_S	0.921	0.85
106_G	113_A	0.921	0.85
302_P	307_A	0.920	0.85
340_A	346_A	0.920	0.85
657_E	661_N	0.918	0.85
91_F	127_M	0.917	0.85
417_Y	515_D	0.912	0.84
269_D	272_F	0.910	0.84
113_A	452_G	0.908	0.84
610_L	614_H	0.906	0.84
146_G	150_Y	0.905	0.84
240_Y	244_A	0.904	0.84
240_Y	247_I	0.904	0.84
35_L	38_V	0.903	0.84
329_K	336_N	0.902	0.84
400_V	438_L	0.902	0.84
349_E	364_E	0.897	0.83
138_Q	141_M	0.896	0.83
327_L	331_L	0.895	0.83
518_I	584_E	0.895	0.83
207_N	222_L	0.895	0.83
484_Y	519_G	0.892	0.83
643_V	649_A	0.886	0.83
208_G	211_M	0.885	0.83
454_P	521_A	0.885	0.83
259_Q	265_F	0.884	0.83
342_D	347_T	0.880	0.82
285_C	454_P	0.879	0.82
404_G	419_I	0.875	0.82
418_W	516_T	0.874	0.82
207_N	210_L	0.870	0.82
337_N	344_Q	0.869	0.81
367_D	370_P	0.869	0.81
244_A	251_A	0.868	0.81
574_A	577_D	0.867	0.81
608_R	613_N	0.865	0.81
40_L	44_L	0.865	0.81
394_A	408_I	0.861	0.81
614_H	617_T	0.860	0.81
640_D	648_D	0.859	0.81
332_G	341_I	0.857	0.81
454_P	518_I	0.857	0.81
431_Y	534_W	0.856	0.80
89_W	394_A	0.855	0.80
153_L	156_I	0.855	0.80
635_I	638_F	0.855	0.80
210_L	221_L	0.854	0.80
57_D	499_F	0.853	0.80
649_A	656_D	0.851	0.80
130_T	139_Q	0.850	0.80
46_L	50_A	0.850	0.80
643_V	652_H	0.850	0.80
249_E	252_S	0.850	0.80
636_L	642_A	0.849	0.80
306_R	521_A	0.849	0.80
278_M	282_G	0.846	0.80
290_R	331_L	0.846	0.80
441_R	484_Y	0.845	0.80
240_Y	243_V	0.843	0.79
446_L	517_L	0.842	0.79
511_P	515_D	0.842	0.79
336_N	345_L	0.841	0.79
19_A	263_E	0.837	0.79
24_A	28_T	0.837	0.79
98_S	123_A	0.833	0.79
303_H	308_F	0.831	0.78
20_R	31_F	0.831	0.78
431_Y	516_T	0.830	0.78
640_D	654_P	0.828	0.78
20_R	159_L	0.827	0.78
643_V	648_D	0.823	0.78
316_E	323_A	0.820	0.78
299_Q	314_A	0.820	0.78
647_D	652_H	0.820	0.78
82_E	139_Q	0.820	0.78
565_R	570_A	0.819	0.77
211_M	216_Q	0.818	0.77
422_T	431_Y	0.818	0.77
502_L	505_G	0.817	0.77
548_E	647_D	0.817	0.77
241_Y	253_S	0.815	0.77
214_L	222_L	0.815	0.77
276_R	280_M	0.815	0.77
243_V	248_H	0.815	0.77
377_W	381_S	0.814	0.77
635_I	645_Y	0.811	0.77
49_V	452_G	0.811	0.77
552_R	559_E	0.810	0.77
134_E	137_Y	0.810	0.77
592_M	612_L	0.809	0.77
210_L	214_L	0.808	0.77
12_N	15_W	0.808	0.77
167_Q	178_A	0.806	0.76
90_L	94_G	0.804	0.76
639_L	653_Q	0.801	0.76
246_D	261_L	0.801	0.76
106_G	432_N	0.799	0.76
266_R	443_I	0.798	0.76
301_D	308_F	0.797	0.76
111_R	114_T	0.796	0.75
483_Q	489_M	0.796	0.75
416_G	420_L	0.795	0.75
339_R	343_A	0.794	0.75
637_A	655_A	0.794	0.75
436_H	440_L	0.789	0.75
245_Q	253_S	0.788	0.75
52_A	57_D	0.787	0.75
328_L	333_F	0.786	0.75
649_A	655_A	0.784	0.74
246_D	257_Q	0.783	0.74
418_W	512_R	0.783	0.74
427_C	445_T	0.782	0.74
343_A	346_A	0.782	0.74
638_F	643_V	0.781	0.74
430_N	477_F	0.781	0.74
244_A	265_F	0.779	0.74
84_L	90_L	0.777	0.74
614_H	624_G	0.777	0.74
327_L	337_N	0.775	0.73
428_Q	437_R	0.774	0.73
609_L	616_F	0.773	0.73
225_L	229_R	0.772	0.73
438_L	591_N	0.770	0.73
336_N	341_I	0.770	0.73
330_T	334_L	0.770	0.73
283_Q	287_Q	0.770	0.73
144_L	468_L	0.769	0.73
534_W	592_M	0.769	0.73
570_A	587_S	0.769	0.73
23_I	525_A	0.768	0.73
103_I	107_G	0.766	0.73
547_T	647_D	0.766	0.73
93_I	296_Q	0.765	0.72
284_A	291_C	0.765	0.72
635_I	639_L	0.765	0.72
650_L	657_E	0.765	0.72
327_L	341_I	0.764	0.72
257_Q	261_L	0.763	0.72
47_G	396_R	0.760	0.72
99_T	103_I	0.760	0.72
46_L	453_I	0.760	0.72
153_L	468_L	0.759	0.72
305_E	450_A	0.759	0.72
327_L	348_I	0.754	0.71
54_T	67_L	0.754	0.71
477_F	480_R	0.753	0.71
135_H	139_Q	0.752	0.71
452_G	496_L	0.752	0.71
464_G	468_L	0.752	0.71
173_C	177_L	0.751	0.71
193_E	232_R	0.751	0.71
252_S	256_I	0.749	0.71
627_R	630_L	0.748	0.71
117_F	121_L	0.745	0.70
278_M	304_F	0.744	0.70
278_M	292_I	0.743	0.70
102_F	106_G	0.743	0.70
452_G	519_G	0.742	0.70
484_Y	488_T	0.742	0.70
455_V	459_V	0.740	0.70
300_H	306_R	0.739	0.70
454_P	458_F	0.737	0.70
642_A	651_H	0.734	0.69
331_L	337_N	0.734	0.69
259_Q	263_E	0.729	0.69
516_T	534_W	0.729	0.69
236_R	239_H	0.729	0.69
147_A	245_Q	0.729	0.69
302_P	306_R	0.728	0.69
97_L	101_G	0.727	0.69
395_V	471_I	0.727	0.69
638_F	649_A	0.727	0.69
430_N	433_A	0.726	0.69
637_A	643_V	0.725	0.68
333_F	340_A	0.724	0.68
130_T	134_E	0.724	0.68
20_R	97_L	0.722	0.68
330_T	344_Q	0.719	0.68
630_L	633_P	0.719	0.68
393_H	523_A	0.718	0.68
291_C	295_R	0.717	0.68
636_L	640_D	0.717	0.68
55_D	58_D	0.716	0.67
152_V	462_L	0.716	0.67
244_A	257_Q	0.715	0.67
210_L	216_Q	0.715	0.67
473_G	476_F	0.715	0.67
142_Y	496_L	0.714	0.67
335_L	339_R	0.713	0.67
80_S	94_G	0.712	0.67
246_D	255_H	0.712	0.67
636_L	649_A	0.712	0.67
141_M	633_P	0.711	0.67
329_K	345_L	0.710	0.67
337_N	340_A	0.710	0.67
83_L	86_P	0.710	0.67
102_F	119_A	0.710	0.67
18_Y	26_C	0.709	0.67
639_L	651_H	0.709	0.67
292_I	296_Q	0.707	0.66
278_M	288_L	0.705	0.66
641_D	649_A	0.704	0.66
619_Y	624_G	0.704	0.66
245_Q	257_Q	0.704	0.66
100_S	111_R	0.703	0.66
156_I	217_T	0.703	0.66
361_D	366_A	0.703	0.66
243_V	250_R	0.702	0.66
439_K	443_I	0.702	0.66
657_E	663_A	0.702	0.66
239_H	250_R	0.701	0.66
375_D	378_L	0.701	0.66
555_D	640_D	0.700	0.66
210_L	253_S	0.699	0.66
472_T	513_V	0.697	0.65
393_H	432_N	0.696	0.65
84_L	94_G	0.696	0.65
456_L	515_D	0.694	0.65
181_L	281_Q	0.693	0.65
254_S	258_Y	0.692	0.65
651_H	654_P	0.691	0.65
179_R	186_R	0.690	0.65
278_M	293_L	0.689	0.64
215_N	222_L	0.689	0.64
75_F	140_P	0.687	0.64
499_F	516_T	0.687	0.64
374_S	395_V	0.687	0.64
180_Y	184_K	0.687	0.64
207_N	217_T	0.686	0.64
47_G	81_V	0.686	0.64
93_I	101_G	0.686	0.64
645_Y	649_A	0.686	0.64
234_T	239_H	0.686	0.64
648_D	651_H	0.685	0.64
615_T	619_Y	0.685	0.64
525_A	558_L	0.684	0.64
485_A	490_F	0.684	0.64
330_T	336_N	0.683	0.64
139_Q	142_Y	0.681	0.64
247_I	252_S	0.681	0.64
136_W	458_F	0.680	0.63
95_L	99_T	0.679	0.63
112_Y	425_F	0.678	0.63
292_I	295_R	0.678	0.63
107_G	112_Y	0.676	0.63
423_S	526_A	0.675	0.63
240_Y	246_D	0.675	0.63
393_H	516_T	0.673	0.63
105_L	608_R	0.673	0.63
36_G	39_K	0.673	0.63
313_A	320_D	0.672	0.63
340_A	344_Q	0.671	0.62
64_L	239_H	0.671	0.62
120_L	124_I	0.670	0.62
116_A	392_R	0.670	0.62
472_T	490_F	0.670	0.62
313_A	316_E	0.670	0.62
608_R	612_L	0.669	0.62
385_T	517_L	0.667	0.62
603_R	607_F	0.667	0.62
96_T	237_T	0.665	0.62
384_F	403_F	0.664	0.62
641_D	644_C	0.664	0.62
613_N	617_T	0.662	0.61
375_D	379_R	0.660	0.61
246_D	253_S	0.660	0.61
285_C	290_R	0.658	0.61
72_F	76_I	0.658	0.61
54_T	57_D	0.658	0.61
636_L	641_D	0.657	0.61
571_Y	575_R	0.656	0.61
100_S	103_I	0.656	0.61
105_L	412_G	0.656	0.61
259_Q	264_H	0.655	0.61
260_T	265_F	0.654	0.60
304_F	307_A	0.654	0.60
576_R	579_H	0.653	0.60
124_I	127_M	0.652	0.60
470_V	474_V	0.651	0.60
19_A	469_L	0.650	0.60
280_M	311_I	0.650	0.60
380_L	586_A	0.650	0.60
337_N	346_A	0.649	0.60
258_Y	261_L	0.648	0.60
651_H	655_A	0.648	0.60
241_Y	256_I	0.648	0.60
393_H	425_F	0.647	0.60
407_I	468_L	0.646	0.60
245_Q	256_I	0.645	0.59
101_G	104_L	0.645	0.59
642_A	648_D	0.642	0.59
366_A	371_H	0.641	0.59
328_L	340_A	0.641	0.59
400_V	531_W	0.640	0.59
626_H	631_T	0.640	0.59
366_A	369_S	0.640	0.59
312_D	334_L	0.639	0.59
488_T	515_D	0.637	0.58
18_Y	616_F	0.635	0.58
653_Q	657_E	0.634	0.58
243_V	249_E	0.634	0.58
637_A	642_A	0.633	0.58
396_R	530_I	0.633	0.58
30_A	263_E	0.633	0.58
101_G	529_Y	0.632	0.58
187_M	454_P	0.632	0.58
209_L	216_Q	0.631	0.58
413_M	456_L	0.629	0.57
247_I	257_Q	0.628	0.57
141_M	652_H	0.628	0.57
636_L	650_L	0.628	0.57
309_T	323_A	0.628	0.57
221_L	224_R	0.626	0.57
306_R	349_E	0.626	0.57
37_D	40_L	0.626	0.57
103_I	110_Q	0.626	0.57
520_C	621_S	0.626	0.57
143_L	423_S	0.626	0.57
240_Y	250_R	0.625	0.57
141_M	289_S	0.625	0.57
21_I	52_A	0.624	0.57
440_L	483_Q	0.624	0.57
422_T	426_V	0.624	0.57
442_I	520_C	0.624	0.57
306_R	309_T	0.623	0.57
329_K	335_L	0.623	0.57
332_G	336_N	0.622	0.57
367_D	372_G	0.622	0.57
396_R	416_G	0.622	0.57
146_G	575_R	0.621	0.57
118_G	452_G	0.621	0.57
276_R	306_R	0.620	0.56
315_L	569_L	0.620	0.56
99_T	104_L	0.619	0.56
504_E	617_T	0.618	0.56
506_F	509_A	0.618	0.56
206_A	443_I	0.617	0.56
27_G	149_W	0.616	0.56
170_L	522_I	0.615	0.56
189_D	214_L	0.615	0.56
497_L	556_A	0.614	0.56
547_T	654_P	0.614	0.56
46_L	506_F	0.613	0.56
636_L	648_D	0.612	0.55
245_Q	255_H	0.611	0.55
311_I	318_M	0.611	0.55
368_D	373_L	0.611	0.55
228_D	233_G	0.611	0.55
333_F	336_N	0.611	0.55
549_A	553_Y	0.610	0.55
334_L	339_R	0.609	0.55
641_D	660_V	0.608	0.55
397_M	553_Y	0.608	0.55
54_T	118_G	0.606	0.55
152_V	641_D	0.604	0.54
407_I	462_L	0.604	0.54
63_R	426_V	0.602	0.54
305_E	447_V	0.601	0.54
408_I	515_D	0.600	0.54
589_V	597_N	0.599	0.54
272_F	275_Q	0.598	0.54
387_E	395_V	0.597	0.54
278_M	294_L	0.595	0.53
23_I	399_L	0.595	0.53
229_R	235_R	0.595	0.53
392_R	424_L	0.594	0.53
645_Y	652_H	0.594	0.53
21_I	56_L	0.593	0.53
380_L	648_D	0.593	0.53
361_D	395_V	0.592	0.53
323_A	326_D	0.592	0.53
236_R	241_Y	0.591	0.53
641_D	654_P	0.591	0.53
149_W	153_L	0.591	0.53
329_K	338_L	0.591	0.53
468_L	497_L	0.589	0.53
246_D	252_S	0.589	0.53
422_T	441_R	0.589	0.53
67_L	377_W	0.589	0.53
632_N	640_D	0.588	0.53
183_L	205_L	0.588	0.53
62_G	547_T	0.588	0.53
89_W	92_A	0.588	0.53
620_I	642_A	0.585	0.52
638_F	651_H	0.585	0.52
131_S	140_P	0.585	0.52
271_L	279_S	0.584	0.52
63_R	396_R	0.584	0.52
220_S	227_G	0.584	0.52
237_T	240_Y	0.583	0.52
638_F	645_Y	0.583	0.52
76_I	80_S	0.583	0.52
488_T	516_T	0.582	0.52
113_A	397_M	0.582	0.52
45_T	49_V	0.582	0.52
210_L	217_T	0.581	0.52
283_Q	301_D	0.579	0.51
61_A	65_R	0.579	0.51
422_T	575_R	0.579	0.51
603_R	609_L	0.578	0.51
243_V	252_S	0.577	0.51
95_L	109_G	0.577	0.51
286_Q	290_R	0.575	0.51
152_V	235_R	0.575	0.51
249_E	255_H	0.575	0.51
242_F	252_S	0.574	0.51
184_K	539_L	0.572	0.51
589_V	596_P	0.572	0.51
441_R	492_T	0.572	0.51
653_Q	660_V	0.572	0.51
114_T	496_L	0.571	0.50
445_T	512_R	0.571	0.50
280_M	286_Q	0.570	0.50
136_W	142_Y	0.570	0.50
283_Q	302_P	0.569	0.50
238_L	253_S	0.567	0.50
314_A	322_G	0.566	0.50
338_L	341_I	0.566	0.50
273_R	314_A	0.566	0.50
242_F	255_H	0.565	0.50
399_L	564_G	0.565	0.50
215_N	219_L	0.565	0.50
346_A	556_A	0.564	0.50
635_I	656_D	0.562	0.49
306_R	467_V	0.561	0.49
638_F	653_Q	0.560	0.49
277_L	293_L	0.559	0.49
190_P	194_D	0.558	0.49
345_L	368_D	0.558	0.49
74_F	120_L	0.557	0.49
307_A	317_R	0.557	0.49
410_I	457_W	0.557	0.49
206_A	215_N	0.555	0.48
336_N	349_E	0.555	0.48
372_G	380_L	0.553	0.48
20_R	153_L	0.553	0.48
66_N	106_G	0.553	0.48
97_L	317_R	0.552	0.48
121_L	136_W	0.552	0.48
283_Q	309_T	0.552	0.48
364_E	370_P	0.551	0.48
143_L	146_G	0.551	0.48
96_T	99_T	0.551	0.48
209_L	471_I	0.551	0.48
549_A	552_R	0.551	0.48
28_T	48_M	0.550	0.48
317_R	322_G	0.550	0.48
381_S	385_T	0.550	0.48
379_R	468_L	0.550	0.48
45_T	498_C	0.549	0.48
329_K	344_Q	0.549	0.48
124_I	142_Y	0.548	0.48
535_Q	592_M	0.548	0.48
641_D	647_D	0.548	0.48
377_W	380_L	0.547	0.47
459_V	462_L	0.546	0.47
550_N	582_D	0.546	0.47
98_S	288_L	0.544	0.47
24_A	56_L	0.544	0.47
76_I	309_T	0.543	0.47
645_Y	650_L	0.542	0.47
70_T	455_V	0.542	0.47
30_A	72_F	0.542	0.47
172_R	216_Q	0.541	0.47
60_L	156_I	0.540	0.47
150_Y	405_Y	0.540	0.47
602_I	609_L	0.540	0.47
207_N	220_S	0.539	0.47
257_Q	264_H	0.538	0.46
220_S	224_R	0.538	0.46
495_V	516_T	0.538	0.46
20_R	154_T	0.538	0.46
237_T	254_S	0.538	0.46
212_A	222_L	0.537	0.46
76_I	650_L	0.537	0.46
571_Y	579_H	0.537	0.46
152_V	545_R	0.536	0.46
77_A	454_P	0.536	0.46
34_W	37_D	0.535	0.46
421_L	519_G	0.535	0.46
282_G	285_C	0.535	0.46
546_A	578_A	0.535	0.46
366_A	450_A	0.534	0.46
221_L	554_L	0.534	0.46
275_Q	286_Q	0.534	0.46
434_T	452_G	0.534	0.46
395_V	399_L	0.533	0.46
105_L	156_I	0.533	0.46
113_A	120_L	0.532	0.46
646_V	653_Q	0.531	0.46
652_H	655_A	0.531	0.46
251_A	536_F	0.531	0.46
335_L	340_A	0.531	0.46
204_A	216_Q	0.530	0.45
39_K	446_L	0.529	0.45
492_T	500_N	0.528	0.45
152_V	646_V	0.528	0.45
76_I	149_W	0.527	0.45
107_G	396_R	0.527	0.45
238_L	241_Y	0.527	0.45
182_E	186_R	0.527	0.45
395_V	450_A	0.526	0.45
50_A	288_L	0.525	0.45
120_L	128_L	0.525	0.45
280_M	292_I	0.525	0.45
101_G	153_L	0.524	0.45
415_H	499_F	0.524	0.45
614_H	619_Y	0.524	0.45
314_A	321_N	0.523	0.45
570_A	574_A	0.523	0.45
227_G	230_G	0.521	0.44
449_I	492_T	0.521	0.44
139_Q	180_Y	0.520	0.44
317_R	323_A	0.520	0.44
438_L	492_T	0.520	0.44
215_N	220_S	0.520	0.44
134_E	138_Q	0.520	0.44
538_N	542_M	0.519	0.44
182_E	279_S	0.519	0.44
575_R	621_S	0.519	0.44
258_Y	265_F	0.518	0.44
82_E	140_P	0.517	0.44
104_L	396_R	0.517	0.44
514_I	651_H	0.516	0.44
302_P	348_I	0.516	0.44
492_T	512_R	0.516	0.44
46_L	122_I	0.515	0.44
428_Q	530_I	0.514	0.43
640_D	649_A	0.513	0.43
210_L	220_S	0.513	0.43
31_F	122_I	0.513	0.43
336_N	340_A	0.513	0.43
270_V	274_F	0.510	0.43
426_V	449_I	0.510	0.43
632_N	662_E	0.509	0.43
23_I	544_E	0.509	0.43
181_L	334_L	0.508	0.43
393_H	534_W	0.508	0.43
244_A	564_G	0.507	0.43
91_F	98_S	0.507	0.43
296_Q	309_T	0.505	0.42
33_W	77_A	0.505	0.42
452_G	532_P	0.505	0.42
468_L	495_V	0.505	0.42
275_Q	278_M	0.505	0.42
513_V	635_I	0.503	0.42
653_Q	656_D	0.503	0.42
640_D	645_Y	0.502	0.42
417_Y	516_T	0.501	0.42
421_L	596_P	0.500	0.42
155_L	539_L	0.500	0.42

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4q4gX	1	0	36.3	0.97	Contact Map
2oltA	5	0.2622	29.9	0.971	Contact Map
4cgkA	3	0.2329	24.9	0.973	Contact Map
4ltoA	3	0.1743	19	0.974	Contact Map
4cbcA	3	0.1144	14.6	0.975	Contact Map
2f95B	2	0.0711	12.2	0.976	Contact Map
4eneA	2	0.2371	11	0.977	Contact Map
3l39A	3	0.2622	10.1	0.977	Contact Map
4yayA	1	0.1367	9.5	0.977	Contact Map
2l7nA	1	0.1925	8.8	0.978	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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