GREMLIN Database
SXY - Protein Sxy
UniProt: P75869 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13720
Length: 209 (190)
Sequences: 271 (203)
Seq/√Len: 14.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
118_R121_D4.0261.00
140_D143_A3.7991.00
41_A48_L3.7631.00
50_L98_L3.0930.98
50_L84_V2.5910.94
131_A153_W2.5860.94
123_P137_G2.4210.92
50_L156_L2.2670.89
144_L171_L2.2550.89
29_G177_G2.2240.88
81_Y179_H2.2110.88
138_I152_C2.1870.87
32_S39_V2.1290.86
36_D107_L2.0830.85
131_A135_E1.9720.81
125_M129_L1.9600.81
30_S81_Y1.9310.80
12_S48_L1.9170.79
136_V156_L1.8870.78
32_S68_L1.7260.71
151_M165_E1.7240.71
40_F49_Y1.7240.71
55_Q141_V1.7190.71
149_A172_E1.6820.69
157_R193_E1.6730.69
33_L95_L1.6140.66
89_W95_L1.6090.66
7_K10_Y1.6060.66
33_L126_S1.5590.63
16_L35_V1.5560.63
133_L171_L1.5550.63
19_L25_R1.5510.63
11_K14_E1.5370.62
141_V163_V1.5340.62
138_I158_Q1.5110.61
104_D108_K1.4970.60
29_G179_H1.4920.60
109_E141_V1.4850.59
25_R163_V1.4850.59
62_K193_E1.4790.59
39_V64_P1.4770.59
54_E99_S1.4720.59
37_D158_Q1.4540.58
21_T97_R1.4320.57
45_D183_L1.4320.57
39_V153_W1.4310.56
149_A175_I1.4220.56
43_V179_H1.4130.55
33_L157_R1.4100.55
126_S160_N1.4100.55
19_L73_C1.4100.55
60_C64_P1.3980.55
12_S25_R1.3920.54
116_R188_R1.3830.54
144_L182_A1.3460.52
32_S56_S1.3390.51
78_T169_F1.3350.51
123_P177_G1.3190.50
61_V157_R1.2800.48
101_Y104_D1.2670.47
45_D157_R1.2650.47
80_N166_K1.2480.46
150_K154_L1.2290.45
91_N97_R1.2280.45
144_L191_L1.2240.45
156_L163_V1.2150.45
25_R43_V1.2100.44
27_L126_S1.2030.44
48_L73_C1.1960.43
135_E169_F1.1940.43
54_E114_N1.1830.43
74_G95_L1.1690.42
56_S141_V1.1600.42
104_D107_L1.1570.41
18_T41_A1.1470.41
20_G35_V1.1440.41
59_Y153_W1.1440.41
48_L96_V1.1420.41
109_E163_V1.1360.40
84_V95_L1.1270.40
169_F192_A1.1260.40
18_T107_L1.1130.39
60_C142_R1.1130.39
39_V59_Y1.1120.39
32_S131_A1.1000.38
152_C175_I1.0940.38
150_K194_W1.0760.37
62_K94_K1.0670.37
56_S75_R1.0660.37
77_V103_L1.0650.37
89_W171_L1.0650.37
85_D88_L1.0620.36
36_D115_T1.0610.36
32_S64_P1.0560.36
25_R29_G1.0560.36
39_V131_A1.0510.36
109_E184_P1.0390.35
172_E191_L1.0380.35
91_N158_Q1.0360.35
172_E183_L1.0220.34
81_Y118_R1.0180.34
74_G190_E1.0000.33
13_Q31_Y0.9800.32
172_E187_R0.9760.32
47_E194_W0.9750.32
111_S157_R0.9670.32
95_L119_L0.9650.32
121_D125_M0.9640.31
73_C170_M0.9610.31
42_M153_W0.9570.31
60_C131_A0.9550.31
50_L82_Y0.9530.31
55_Q104_D0.9470.31
60_C84_V0.9440.31
127_F132_I0.9420.30
80_N135_E0.9410.30
168_L191_L0.9300.30
29_G81_Y0.9270.30
185_V189_Q0.9220.29
43_V49_Y0.9220.29
72_K177_G0.9200.29
47_E183_L0.9180.29
72_K123_P0.9040.29
133_L144_L0.9030.29
30_S179_H0.8970.28
20_G149_A0.8890.28
36_D98_L0.8880.28
147_L176_I0.8810.28
72_K106_A0.8800.28
25_R119_L0.8740.27
74_G171_L0.8740.27
64_P131_A0.8720.27
7_K131_A0.8690.27
27_L34_T0.8640.27
44_S135_E0.8610.27
30_S177_G0.8570.27
133_L156_L0.8520.26
8_R11_K0.8520.26
125_M170_M0.8460.26
22_I133_L0.8420.26
82_Y142_R0.8420.26
13_Q27_L0.8400.26
130_E148_G0.8340.26
11_K34_T0.8330.26
102_S156_L0.8210.25
16_L99_S0.8130.25
27_L57_A0.8060.24
87_S111_S0.8060.24
112_T153_W0.8050.24
29_G118_R0.7990.24
33_L47_E0.7970.24
50_L183_L0.7960.24
166_K183_L0.7950.24
82_Y96_V0.7920.24
91_N193_E0.7880.24
30_S118_R0.7880.24
88_L119_L0.7840.24
46_G176_I0.7820.23
148_G175_I0.7810.23
37_D167_I0.7810.23
64_P138_I0.7790.23
68_L181_A0.7730.23
96_V103_L0.7700.23
13_Q36_D0.7690.23
177_G191_L0.7690.23
62_K90_R0.7610.23
25_R136_V0.7590.23
67_W196_D0.7570.22
79_L171_L0.7560.22
132_I169_F0.7560.22
81_Y119_L0.7540.22
72_K179_H0.7470.22
118_R130_E0.7400.22
154_L195_A0.7350.22
32_S40_F0.7250.21
86_E90_R0.7250.21
9_I43_V0.7230.21
136_V159_Q0.7220.21
133_L152_C0.7190.21
165_E169_F0.7190.21
12_S125_M0.7180.21
74_G89_W0.7130.21
50_L105_A0.7110.21
45_D196_D0.7070.21
56_S188_R0.7030.20
27_L31_Y0.7030.20
51_R72_K0.7010.20
82_Y186_A0.6980.20
66_V127_F0.6920.20
76_S155_R0.6920.20
113_R128_H0.6910.20
57_A113_R0.6890.20
74_G170_M0.6870.20
80_N140_D0.6860.20
22_I35_V0.6820.20
81_Y98_L0.6820.20
37_D104_D0.6800.20
149_A184_P0.6770.20
124_N174_A0.6760.19
108_K111_S0.6740.19
20_G31_Y0.6720.19
97_R108_K0.6660.19
118_R179_H0.6660.19
50_L89_W0.6620.19
71_K126_S0.6610.19
153_W160_N0.6590.19
79_L183_L0.6580.19
49_Y183_L0.6560.19
104_D142_R0.6550.19
34_T134_G0.6550.19
35_V99_S0.6530.19
183_L187_R0.6530.19
89_W144_L0.6520.19
72_K191_L0.6510.19
29_G43_V0.6470.19
39_V127_F0.6430.18
144_L184_P0.6420.18
46_G59_Y0.6410.18
44_S125_M0.6350.18
121_D191_L0.6320.18
43_V190_E0.6320.18
132_I167_I0.6310.18
16_L23_E0.6290.18
27_L69_T0.6280.18
81_Y129_L0.6250.18
26_S29_G0.6220.18
98_L102_S0.6190.18
174_A191_L0.6140.17
96_V162_L0.6140.17
99_S144_L0.6130.17
54_E88_L0.6070.17
99_S153_W0.6070.17
24_Y37_D0.6030.17
101_Y105_A0.6010.17
37_D114_N0.6000.17
116_R182_A0.5980.17
101_Y196_D0.5970.17
26_S196_D0.5960.17
138_I175_I0.5950.17
25_R30_S0.5930.17
8_R32_S0.5920.17
118_R149_A0.5910.17
27_L42_M0.5900.17
95_L149_A0.5860.17
26_S131_A0.5860.17
27_L65_P0.5850.17
50_L194_W0.5840.16
64_P91_N0.5760.16
147_L166_K0.5760.16
131_A142_R0.5710.16
55_Q100_K0.5690.16
74_G184_P0.5650.16
37_D80_N0.5610.16
54_E107_L0.5580.16
119_L184_P0.5560.16
34_T169_F0.5540.16
143_A193_E0.5530.16
31_Y74_G0.5520.16
33_L110_K0.5510.15
132_I159_Q0.5510.15
14_E47_E0.5490.15
124_N148_G0.5440.15
60_C169_F0.5440.15
74_G103_L0.5440.15
163_V193_E0.5440.15
71_K144_L0.5410.15
45_D104_D0.5400.15
41_A77_V0.5370.15
35_V110_K0.5360.15
94_K97_R0.5330.15
119_L156_L0.5310.15
36_D150_K0.5240.15
48_L89_W0.5240.15
154_L184_P0.5230.15
64_P100_K0.5190.15
142_R186_A0.5190.15
47_E62_K0.5180.15
24_Y125_M0.5150.14
72_K173_G0.5140.14
65_P132_I0.5130.14
151_M157_R0.5120.14
90_R147_L0.5110.14
75_R136_V0.5030.14
28_F124_N0.5020.14
29_G106_A0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2od0A 2 0.4928 99.9 0.666 Contact Map
3mabA 2 0.4258 99.8 0.724 Contact Map
2fkiA 1 0.5215 82.2 0.938 Contact Map
2a1vA 1 0.5742 61.7 0.947 Contact Map
2kfpA 1 0.4928 53.3 0.95 Contact Map
2z43A 1 0.3971 36.8 0.954 Contact Map
1wcnA 1 0.3349 36.6 0.955 Contact Map
2i1qA 1 0.3828 29.3 0.957 Contact Map
3k4gA 1 0.3636 19 0.96 Contact Map
1z3eB 1 0.3206 17 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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