SXY - ECOLI - GREMLIN Contacts

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SXY - Protein Sxy

UniProt:	P75869	Sequences: MKSLSYKRIYKSQEYLATLGTIEYRSLFGSYSLTVDDTVFAMVSDGELYLRACEQSAQYCVKHPPVWLTYKKCGRSVTLNYYRVDESLWRNQLKLVRLSKYSLDAALKEKSTRNTRERLKDLPNMSFHLEAILGEVGIKDVRALRILGAKMCWLRLRQQNSLVTEKILFMLEGAIIGIHEAALPVARRQELAEWADSLTPKQEFPAELE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13720
Length:	209 (190)
Sequences:	271 (203)
Seq/√Len:	14.7

ECOLI - SXY

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
118_R	121_D	4.026	1.00
140_D	143_A	3.799	1.00
41_A	48_L	3.763	1.00
50_L	98_L	3.093	0.98
50_L	84_V	2.591	0.94
131_A	153_W	2.586	0.94
123_P	137_G	2.421	0.92
50_L	156_L	2.267	0.89
144_L	171_L	2.255	0.89
29_G	177_G	2.224	0.88
81_Y	179_H	2.211	0.88
138_I	152_C	2.187	0.87
32_S	39_V	2.129	0.86
36_D	107_L	2.083	0.85
131_A	135_E	1.972	0.81
125_M	129_L	1.960	0.81
30_S	81_Y	1.931	0.80
12_S	48_L	1.917	0.79
136_V	156_L	1.887	0.78
32_S	68_L	1.726	0.71
151_M	165_E	1.724	0.71
40_F	49_Y	1.724	0.71
55_Q	141_V	1.719	0.71
149_A	172_E	1.682	0.69
157_R	193_E	1.673	0.69
33_L	95_L	1.614	0.66
89_W	95_L	1.609	0.66
7_K	10_Y	1.606	0.66
33_L	126_S	1.559	0.63
16_L	35_V	1.556	0.63
133_L	171_L	1.555	0.63
19_L	25_R	1.551	0.63
11_K	14_E	1.537	0.62
141_V	163_V	1.534	0.62
138_I	158_Q	1.511	0.61
104_D	108_K	1.497	0.60
29_G	179_H	1.492	0.60
109_E	141_V	1.485	0.59
25_R	163_V	1.485	0.59
62_K	193_E	1.479	0.59
39_V	64_P	1.477	0.59
54_E	99_S	1.472	0.59
37_D	158_Q	1.454	0.58
21_T	97_R	1.432	0.57
45_D	183_L	1.432	0.57
39_V	153_W	1.431	0.56
149_A	175_I	1.422	0.56
43_V	179_H	1.413	0.55
33_L	157_R	1.410	0.55
126_S	160_N	1.410	0.55
19_L	73_C	1.410	0.55
60_C	64_P	1.398	0.55
12_S	25_R	1.392	0.54
116_R	188_R	1.383	0.54
144_L	182_A	1.346	0.52
32_S	56_S	1.339	0.51
78_T	169_F	1.335	0.51
123_P	177_G	1.319	0.50
61_V	157_R	1.280	0.48
101_Y	104_D	1.267	0.47
45_D	157_R	1.265	0.47
80_N	166_K	1.248	0.46
150_K	154_L	1.229	0.45
91_N	97_R	1.228	0.45
144_L	191_L	1.224	0.45
156_L	163_V	1.215	0.45
25_R	43_V	1.210	0.44
27_L	126_S	1.203	0.44
48_L	73_C	1.196	0.43
135_E	169_F	1.194	0.43
54_E	114_N	1.183	0.43
74_G	95_L	1.169	0.42
56_S	141_V	1.160	0.42
104_D	107_L	1.157	0.41
18_T	41_A	1.147	0.41
20_G	35_V	1.144	0.41
59_Y	153_W	1.144	0.41
48_L	96_V	1.142	0.41
109_E	163_V	1.136	0.40
84_V	95_L	1.127	0.40
169_F	192_A	1.126	0.40
18_T	107_L	1.113	0.39
60_C	142_R	1.113	0.39
39_V	59_Y	1.112	0.39
32_S	131_A	1.100	0.38
152_C	175_I	1.094	0.38
150_K	194_W	1.076	0.37
62_K	94_K	1.067	0.37
56_S	75_R	1.066	0.37
77_V	103_L	1.065	0.37
89_W	171_L	1.065	0.37
85_D	88_L	1.062	0.36
36_D	115_T	1.061	0.36
32_S	64_P	1.056	0.36
25_R	29_G	1.056	0.36
39_V	131_A	1.051	0.36
109_E	184_P	1.039	0.35
172_E	191_L	1.038	0.35
91_N	158_Q	1.036	0.35
172_E	183_L	1.022	0.34
81_Y	118_R	1.018	0.34
74_G	190_E	1.000	0.33
13_Q	31_Y	0.980	0.32
172_E	187_R	0.976	0.32
47_E	194_W	0.975	0.32
111_S	157_R	0.967	0.32
95_L	119_L	0.965	0.32
121_D	125_M	0.964	0.31
73_C	170_M	0.961	0.31
42_M	153_W	0.957	0.31
60_C	131_A	0.955	0.31
50_L	82_Y	0.953	0.31
55_Q	104_D	0.947	0.31
60_C	84_V	0.944	0.31
127_F	132_I	0.942	0.30
80_N	135_E	0.941	0.30
168_L	191_L	0.930	0.30
29_G	81_Y	0.927	0.30
185_V	189_Q	0.922	0.29
43_V	49_Y	0.922	0.29
72_K	177_G	0.920	0.29
47_E	183_L	0.918	0.29
72_K	123_P	0.904	0.29
133_L	144_L	0.903	0.29
30_S	179_H	0.897	0.28
20_G	149_A	0.889	0.28
36_D	98_L	0.888	0.28
147_L	176_I	0.881	0.28
72_K	106_A	0.880	0.28
25_R	119_L	0.874	0.27
74_G	171_L	0.874	0.27
64_P	131_A	0.872	0.27
7_K	131_A	0.869	0.27
27_L	34_T	0.864	0.27
44_S	135_E	0.861	0.27
30_S	177_G	0.857	0.27
133_L	156_L	0.852	0.26
8_R	11_K	0.852	0.26
125_M	170_M	0.846	0.26
22_I	133_L	0.842	0.26
82_Y	142_R	0.842	0.26
13_Q	27_L	0.840	0.26
130_E	148_G	0.834	0.26
11_K	34_T	0.833	0.26
102_S	156_L	0.821	0.25
16_L	99_S	0.813	0.25
27_L	57_A	0.806	0.24
87_S	111_S	0.806	0.24
112_T	153_W	0.805	0.24
29_G	118_R	0.799	0.24
33_L	47_E	0.797	0.24
50_L	183_L	0.796	0.24
166_K	183_L	0.795	0.24
82_Y	96_V	0.792	0.24
91_N	193_E	0.788	0.24
30_S	118_R	0.788	0.24
88_L	119_L	0.784	0.24
46_G	176_I	0.782	0.23
148_G	175_I	0.781	0.23
37_D	167_I	0.781	0.23
64_P	138_I	0.779	0.23
68_L	181_A	0.773	0.23
96_V	103_L	0.770	0.23
13_Q	36_D	0.769	0.23
177_G	191_L	0.769	0.23
62_K	90_R	0.761	0.23
25_R	136_V	0.759	0.23
67_W	196_D	0.757	0.22
79_L	171_L	0.756	0.22
132_I	169_F	0.756	0.22
81_Y	119_L	0.754	0.22
72_K	179_H	0.747	0.22
118_R	130_E	0.740	0.22
154_L	195_A	0.735	0.22
32_S	40_F	0.725	0.21
86_E	90_R	0.725	0.21
9_I	43_V	0.723	0.21
136_V	159_Q	0.722	0.21
133_L	152_C	0.719	0.21
165_E	169_F	0.719	0.21
12_S	125_M	0.718	0.21
74_G	89_W	0.713	0.21
50_L	105_A	0.711	0.21
45_D	196_D	0.707	0.21
56_S	188_R	0.703	0.20
27_L	31_Y	0.703	0.20
51_R	72_K	0.701	0.20
82_Y	186_A	0.698	0.20
66_V	127_F	0.692	0.20
76_S	155_R	0.692	0.20
113_R	128_H	0.691	0.20
57_A	113_R	0.689	0.20
74_G	170_M	0.687	0.20
80_N	140_D	0.686	0.20
22_I	35_V	0.682	0.20
81_Y	98_L	0.682	0.20
37_D	104_D	0.680	0.20
149_A	184_P	0.677	0.20
124_N	174_A	0.676	0.19
108_K	111_S	0.674	0.19
20_G	31_Y	0.672	0.19
97_R	108_K	0.666	0.19
118_R	179_H	0.666	0.19
50_L	89_W	0.662	0.19
71_K	126_S	0.661	0.19
153_W	160_N	0.659	0.19
79_L	183_L	0.658	0.19
49_Y	183_L	0.656	0.19
104_D	142_R	0.655	0.19
34_T	134_G	0.655	0.19
35_V	99_S	0.653	0.19
183_L	187_R	0.653	0.19
89_W	144_L	0.652	0.19
72_K	191_L	0.651	0.19
29_G	43_V	0.647	0.19
39_V	127_F	0.643	0.18
144_L	184_P	0.642	0.18
46_G	59_Y	0.641	0.18
44_S	125_M	0.635	0.18
121_D	191_L	0.632	0.18
43_V	190_E	0.632	0.18
132_I	167_I	0.631	0.18
16_L	23_E	0.629	0.18
27_L	69_T	0.628	0.18
81_Y	129_L	0.625	0.18
26_S	29_G	0.622	0.18
98_L	102_S	0.619	0.18
174_A	191_L	0.614	0.17
96_V	162_L	0.614	0.17
99_S	144_L	0.613	0.17
54_E	88_L	0.607	0.17
99_S	153_W	0.607	0.17
24_Y	37_D	0.603	0.17
101_Y	105_A	0.601	0.17
37_D	114_N	0.600	0.17
116_R	182_A	0.598	0.17
101_Y	196_D	0.597	0.17
26_S	196_D	0.596	0.17
138_I	175_I	0.595	0.17
25_R	30_S	0.593	0.17
8_R	32_S	0.592	0.17
118_R	149_A	0.591	0.17
27_L	42_M	0.590	0.17
95_L	149_A	0.586	0.17
26_S	131_A	0.586	0.17
27_L	65_P	0.585	0.17
50_L	194_W	0.584	0.16
64_P	91_N	0.576	0.16
147_L	166_K	0.576	0.16
131_A	142_R	0.571	0.16
55_Q	100_K	0.569	0.16
74_G	184_P	0.565	0.16
37_D	80_N	0.561	0.16
54_E	107_L	0.558	0.16
119_L	184_P	0.556	0.16
34_T	169_F	0.554	0.16
143_A	193_E	0.553	0.16
31_Y	74_G	0.552	0.16
33_L	110_K	0.551	0.15
132_I	159_Q	0.551	0.15
14_E	47_E	0.549	0.15
124_N	148_G	0.544	0.15
60_C	169_F	0.544	0.15
74_G	103_L	0.544	0.15
163_V	193_E	0.544	0.15
71_K	144_L	0.541	0.15
45_D	104_D	0.540	0.15
41_A	77_V	0.537	0.15
35_V	110_K	0.536	0.15
94_K	97_R	0.533	0.15
119_L	156_L	0.531	0.15
36_D	150_K	0.524	0.15
48_L	89_W	0.524	0.15
154_L	184_P	0.523	0.15
64_P	100_K	0.519	0.15
142_R	186_A	0.519	0.15
47_E	62_K	0.518	0.15
24_Y	125_M	0.515	0.14
72_K	173_G	0.514	0.14
65_P	132_I	0.513	0.14
151_M	157_R	0.512	0.14
90_R	147_L	0.511	0.14
75_R	136_V	0.503	0.14
28_F	124_N	0.502	0.14
29_G	106_A	0.500	0.14

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2od0A	2	0.4928	99.9	0.666	Contact Map
3mabA	2	0.4258	99.8	0.724	Contact Map
2fkiA	1	0.5215	82.2	0.938	Contact Map
2a1vA	1	0.5742	61.7	0.947	Contact Map
2kfpA	1	0.4928	53.3	0.95	Contact Map
2z43A	1	0.3971	36.8	0.954	Contact Map
1wcnA	1	0.3349	36.6	0.955	Contact Map
2i1qA	1	0.3828	29.3	0.957	Contact Map
3k4gA	1	0.3636	19	0.96	Contact Map
1z3eB	1	0.3206	17	0.961	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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