LONH - ECOLI - GREMLIN Contacts

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LONH - Putative Lon protease homolog

UniProt:	P75867	Sequences: MTITKLAWRDLVPDTDSYQEIFAQPHLIDENDPLFSDTQPRLQFALEQLLHTRASSSFMLAKAPEESEYLNLIANAARTLQSDAGQLVGGHYEVSGHSIRLRHAVSADDNFATLTQVVAADWVEAEQLFGCLRQFNGDITLQPGLVHQANGGILIISLRTLLAQPLLWMRLKNIVNRERFDWVAFDESRPLPVSVPSMPLKLKVILVGERESLADFQEMEPELSEQAIYSEFEDTLQIVDAESVTQWCRWVTFTARHNHLPAPGADAWPILIREAARYTGEQETLPLSPQWILRQCKEVASLCDGDTFSGEQLNLMLQQREWREGFLAERMQDEILQEQILIETEGERIGQINALSVIEFPGHPRAFGEPSRISCVVHIGDGEFTDIERKAELGGNIHAKGMMIMQAFLMSELQLEQQIPFSASLTFEQSYSEVDGDSASMAELCALISALADVPVNQSIAITGSVDQFGRAQPVGGLNEKIEGFFAICQQRELTGKQGVIIPTANVRHLSLHSELVKAVEEGKFTIWAVDDVTDALPLLLNLVWDGEGQTTLMQTIQERIAQASQQEGRHRFPWPLRWLNWFIPN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13718
Length:	586 (493)
Sequences:	4181 (2408)
Seq/√Len:	108.5

ECOLI - LONH LON
BACSU - LON1 LON2
HALSA - LONB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
504_T	531_D	5.809	1.00
475_V	478_L	5.352	1.00
504_T	507_V	4.634	1.00
243_S	265_A	3.903	1.00
499_G	528_W	3.596	1.00
144_G	154_L	3.483	1.00
238_I	244_V	3.239	1.00
375_C	446_A	3.193	1.00
528_W	539_L	3.185	1.00
530_V	535_D	3.055	1.00
377_V	450_A	2.971	1.00
499_G	526_T	2.937	1.00
142_Q	200_L	2.927	1.00
247_W	263_P	2.891	1.00
518_K	521_E	2.848	1.00
309_S	312_Q	2.777	1.00
502_I	529_A	2.747	1.00
412_E	534_T	2.719	1.00
441_M	536_A	2.687	1.00
482_I	527_I	2.658	1.00
493_E	524_K	2.610	1.00
461_A	497_K	2.607	1.00
150_N	200_L	2.565	1.00
459_S	498_Q	2.562	1.00
264_G	267_A	2.486	1.00
298_E	315_L	2.449	1.00
270_I	274_E	2.419	1.00
416_E	420_P	2.416	1.00
530_V	536_A	2.396	1.00
499_G	539_L	2.377	1.00
501_I	539_L	2.353	1.00
535_D	538_P	2.342	1.00
445_C	536_A	2.216	1.00
507_V	529_A	2.203	1.00
93_E	96_G	2.199	1.00
531_D	535_D	2.186	1.00
78_R	82_S	2.178	1.00
396_N	399_A	2.153	1.00
86_Q	96_G	2.134	1.00
444_L	466_V	2.133	1.00
501_I	530_V	2.115	1.00
510_L	529_A	2.091	1.00
83_D	93_E	2.086	1.00
386_D	402_M	2.075	1.00
85_G	93_E	2.046	1.00
162_L	174_I	2.044	1.00
80_L	93_E	2.043	1.00
478_L	502_I	2.030	1.00
441_M	472_A	2.026	1.00
83_D	86_Q	2.006	1.00
86_Q	89_G	1.993	1.00
349_I	453_D	1.980	1.00
150_N	203_K	1.960	1.00
234_D	519_A	1.957	1.00
90_G	94_V	1.954	1.00
115_T	154_L	1.937	1.00
80_L	85_G	1.934	1.00
220_E	225_E	1.928	1.00
250_W	290_Q	1.903	1.00
254_T	290_Q	1.882	1.00
247_W	289_P	1.873	1.00
292_I	308_F	1.866	1.00
445_C	540_L	1.845	1.00
381_D	419_I	1.823	1.00
444_L	533_V	1.815	1.00
501_I	536_A	1.799	1.00
454_V	541_L	1.794	1.00
347_E	542_N	1.792	1.00
264_G	309_S	1.783	1.00
145_L	200_L	1.768	1.00
48_Q	52_T	1.764	1.00
274_E	320_R	1.762	1.00
87_L	91_H	1.752	1.00
502_I	510_L	1.734	1.00
86_Q	93_E	1.733	1.00
113_T	149_A	1.727	1.00
237_Q	269_P	1.713	1.00
233_E	273_R	1.706	1.00
270_I	310_G	1.700	1.00
460_I	499_G	1.696	1.00
266_D	310_G	1.669	1.00
399_A	403_M	1.666	1.00
482_I	500_V	1.660	1.00
128_L	182_W	1.658	1.00
448_I	537_L	1.657	1.00
314_N	514_S	1.655	1.00
83_D	96_G	1.649	1.00
457_N	499_G	1.644	1.00
288_S	291_W	1.638	1.00
373_I	442_A	1.628	1.00
271_L	292_I	1.627	1.00
58_F	61_A	1.617	1.00
85_G	96_G	1.606	1.00
298_E	316_M	1.595	1.00
76_A	96_G	1.593	1.00
213_L	225_E	1.592	1.00
92_Y	96_G	1.576	1.00
312_Q	316_M	1.573	1.00
13_P	16_D	1.573	1.00
356_S	371_S	1.563	1.00
347_E	458_Q	1.560	1.00
212_S	215_D	1.556	1.00
123_V	194_S	1.555	1.00
370_P	495_T	1.550	1.00
475_V	502_I	1.537	1.00
270_I	313_L	1.535	1.00
250_W	286_P	1.528	1.00
263_P	292_I	1.519	1.00
80_L	83_D	1.512	1.00
352_I	456_V	1.511	1.00
375_C	450_A	1.499	1.00
11_L	16_D	1.498	1.00
382_G	422_S	1.496	1.00
41_R	63_A	1.494	1.00
537_L	541_L	1.492	1.00
249_R	286_P	1.477	1.00
441_M	530_V	1.476	1.00
297_K	301_S	1.467	1.00
518_K	523_G	1.467	1.00
409_L	448_I	1.463	1.00
43_Q	47_E	1.459	1.00
80_L	96_G	1.448	1.00
82_S	96_G	1.442	1.00
475_V	482_I	1.438	1.00
76_A	83_D	1.437	1.00
267_A	313_L	1.436	1.00
427_F	443_E	1.430	1.00
445_C	456_V	1.422	1.00
482_I	525_F	1.415	1.00
295_Q	306_D	1.411	1.00
270_I	320_R	1.403	1.00
454_V	543_L	1.397	1.00
482_I	502_I	1.388	1.00
89_G	93_E	1.387	1.00
76_A	93_E	1.386	1.00
83_D	90_G	1.377	1.00
385_T	403_M	1.376	1.00
247_W	268_W	1.367	1.00
80_L	97_H	1.363	1.00
192_P	199_P	1.363	1.00
213_L	220_E	1.361	1.00
238_I	243_S	1.359	1.00
408_F	412_E	1.357	1.00
72_L	76_A	1.354	1.00
423_A	447_L	1.354	1.00
502_I	527_I	1.349	1.00
237_Q	265_A	1.332	1.00
355_L	500_V	1.331	0.99
117_V	144_G	1.324	0.99
323_R	505_A	1.323	0.99
257_H	260_L	1.311	0.99
250_W	289_P	1.300	0.99
460_I	528_W	1.296	0.99
103_H	155_I	1.286	0.99
114_L	155_I	1.285	0.99
133_R	197_S	1.282	0.99
58_F	62_K	1.282	0.99
294_R	316_M	1.281	0.99
81_Q	90_G	1.280	0.99
408_F	533_V	1.272	0.99
295_Q	299_V	1.266	0.99
386_D	399_A	1.263	0.99
37_D	41_R	1.259	0.99
267_A	310_G	1.243	0.99
77_A	94_V	1.242	0.99
377_V	421_F	1.236	0.99
69_Y	73_I	1.236	0.99
442_A	536_A	1.235	0.99
262_A	307_T	1.233	0.99
378_H	407_A	1.226	0.99
90_G	93_E	1.220	0.99
406_Q	423_A	1.214	0.99
271_L	317_L	1.213	0.99
319_Q	514_S	1.212	0.99
478_L	482_I	1.211	0.99
119_A	156_I	1.206	0.99
261_P	295_Q	1.187	0.99
305_G	312_Q	1.187	0.99
92_Y	95_S	1.186	0.99
93_E	97_H	1.186	0.99
57_S	63_A	1.185	0.99
478_L	529_A	1.184	0.99
352_I	446_A	1.182	0.99
352_I	442_A	1.175	0.99
8_W	11_L	1.173	0.99
77_A	90_G	1.170	0.99
251_V	258_N	1.164	0.99
474_P	505_A	1.161	0.99
271_L	289_P	1.156	0.99
288_S	321_E	1.154	0.99
79_T	83_D	1.153	0.99
85_G	89_G	1.147	0.98
79_T	96_G	1.147	0.98
351_Q	372_R	1.146	0.98
77_A	96_G	1.143	0.98
348_R	471_R	1.141	0.98
30_E	33_P	1.137	0.98
74_A	77_A	1.132	0.98
87_L	90_G	1.126	0.98
418_Q	451_L	1.125	0.98
265_A	269_P	1.122	0.98
82_S	90_G	1.119	0.98
312_Q	315_L	1.117	0.98
75_N	79_T	1.114	0.98
123_V	126_E	1.111	0.98
298_E	303_C	1.108	0.98
378_H	410_M	1.107	0.98
106_S	207_V	1.103	0.98
82_S	86_Q	1.103	0.98
90_G	96_G	1.091	0.98
84_A	87_L	1.086	0.98
73_I	76_A	1.081	0.98
521_E	527_I	1.079	0.98
232_F	479_N	1.078	0.98
530_V	539_L	1.076	0.98
392_E	396_N	1.074	0.98
83_D	97_H	1.071	0.98
76_A	86_Q	1.071	0.98
108_D	111_F	1.064	0.98
460_I	539_L	1.056	0.97
83_D	87_L	1.055	0.97
46_L	53_R	1.054	0.97
115_T	144_G	1.054	0.97
467_D	471_R	1.054	0.97
324_E	369_E	1.052	0.97
263_P	313_L	1.052	0.97
243_S	268_W	1.047	0.97
423_A	451_L	1.040	0.97
261_P	292_I	1.037	0.97
82_S	87_L	1.032	0.97
113_T	148_Q	1.030	0.97
262_A	305_G	1.028	0.97
74_A	78_R	1.027	0.97
145_L	150_N	1.021	0.97
16_D	19_Q	1.020	0.97
73_I	77_A	1.019	0.97
445_C	462_I	1.018	0.97
393_L	427_F	1.018	0.97
269_P	273_R	1.014	0.97
264_G	307_T	1.009	0.97
65_E	79_T	1.008	0.97
460_I	540_L	1.008	0.97
76_A	79_T	1.007	0.97
498_Q	524_K	1.006	0.97
383_E	422_S	1.001	0.96
536_A	540_L	0.997	0.96
380_G	422_S	0.994	0.96
353_N	370_P	0.993	0.96
80_L	94_V	0.992	0.96
283_E	288_S	0.989	0.96
500_V	525_F	0.986	0.96
467_D	473_Q	0.982	0.96
159_R	174_I	0.981	0.96
510_L	527_I	0.981	0.96
20_E	23_A	0.979	0.96
66_E	69_Y	0.977	0.96
41_R	60_L	0.974	0.96
72_L	80_L	0.973	0.96
89_G	96_G	0.972	0.96
346_G	349_I	0.968	0.96
80_L	90_G	0.964	0.96
283_E	287_L	0.953	0.95
353_N	372_R	0.952	0.95
308_F	313_L	0.951	0.95
67_S	70_L	0.951	0.95
102_R	228_I	0.950	0.95
429_Q	467_D	0.949	0.95
67_S	71_N	0.948	0.95
454_V	542_N	0.944	0.95
104_A	108_D	0.935	0.95
510_L	516_L	0.934	0.95
11_L	20_E	0.932	0.95
77_A	83_D	0.930	0.95
77_A	81_Q	0.930	0.95
77_A	86_Q	0.929	0.95
448_I	541_L	0.928	0.95
82_S	93_E	0.925	0.94
270_I	314_N	0.925	0.94
145_L	204_V	0.923	0.94
65_E	76_A	0.921	0.94
441_M	444_L	0.918	0.94
441_M	445_C	0.915	0.94
85_G	90_G	0.915	0.94
91_H	94_V	0.904	0.94
349_I	455_P	0.903	0.94
144_G	147_H	0.899	0.94
237_Q	272_I	0.899	0.94
286_P	290_Q	0.897	0.94
213_L	216_F	0.894	0.93
417_Q	451_L	0.890	0.93
68_E	72_L	0.889	0.93
76_A	80_L	0.888	0.93
65_E	80_L	0.887	0.93
377_V	451_L	0.887	0.93
85_G	88_V	0.885	0.93
12_V	15_T	0.883	0.93
60_L	63_A	0.882	0.93
50_L	53_R	0.875	0.93
466_V	533_V	0.874	0.93
68_E	76_A	0.872	0.93
65_E	69_Y	0.872	0.93
80_L	84_A	0.872	0.93
84_A	88_V	0.871	0.92
392_E	395_G	0.868	0.92
376_V	407_A	0.865	0.92
72_L	83_D	0.865	0.92
532_D	535_D	0.863	0.92
402_M	425_L	0.862	0.92
65_E	72_L	0.859	0.92
384_F	406_Q	0.857	0.92
441_M	533_V	0.857	0.92
73_I	94_V	0.855	0.92
212_S	220_E	0.855	0.92
73_I	93_E	0.855	0.92
192_P	197_S	0.852	0.92
18_Y	22_F	0.850	0.92
143_P	147_H	0.848	0.91
471_R	531_D	0.847	0.91
82_S	85_G	0.846	0.91
357_V	484_G	0.845	0.91
355_L	461_A	0.842	0.91
533_V	537_L	0.841	0.91
457_N	542_N	0.838	0.91
356_S	484_G	0.837	0.91
28_I	31_N	0.837	0.91
218_E	221_P	0.836	0.91
103_H	109_D	0.835	0.91
266_D	523_G	0.828	0.90
441_M	462_I	0.827	0.90
349_I	452_A	0.826	0.90
16_D	20_E	0.822	0.90
103_H	107_A	0.821	0.90
80_L	91_H	0.821	0.90
379_I	421_F	0.821	0.90
116_Q	223_L	0.819	0.90
295_Q	316_M	0.818	0.90
218_E	223_L	0.818	0.90
68_E	83_D	0.817	0.90
457_N	540_L	0.817	0.90
53_R	59_M	0.816	0.90
79_T	85_G	0.812	0.90
17_S	21_I	0.811	0.90
145_L	148_Q	0.809	0.89
122_W	194_S	0.808	0.89
110_N	205_I	0.808	0.89
46_L	54_A	0.807	0.89
22_F	26_H	0.807	0.89
215_D	220_E	0.804	0.89
75_N	95_S	0.802	0.89
85_G	92_Y	0.800	0.89
267_A	308_F	0.799	0.89
76_A	82_S	0.798	0.89
86_Q	90_G	0.798	0.89
45_A	63_A	0.798	0.89
421_F	451_L	0.798	0.89
158_L	206_L	0.798	0.89
77_A	80_L	0.796	0.89
392_E	429_Q	0.796	0.89
248_C	252_T	0.795	0.89
504_T	535_D	0.794	0.89
410_M	418_Q	0.792	0.88
72_L	81_Q	0.790	0.88
114_L	153_I	0.789	0.88
84_A	90_G	0.786	0.88
50_L	54_A	0.785	0.88
442_A	484_G	0.784	0.88
83_D	88_V	0.782	0.88
56_S	59_M	0.782	0.88
73_I	97_H	0.780	0.88
315_L	523_G	0.779	0.88
91_H	95_S	0.776	0.87
250_W	253_F	0.776	0.87
369_E	373_I	0.775	0.87
12_V	17_S	0.770	0.87
402_M	442_A	0.770	0.87
37_D	60_L	0.769	0.87
9_R	14_D	0.769	0.87
83_D	89_G	0.766	0.87
80_L	86_Q	0.765	0.87
100_R	103_H	0.760	0.86
75_N	78_R	0.759	0.86
454_V	545_W	0.758	0.86
87_L	96_G	0.758	0.86
162_L	215_D	0.758	0.86
72_L	96_G	0.757	0.86
77_A	93_E	0.756	0.86
462_I	536_A	0.755	0.86
72_L	85_G	0.754	0.86
498_Q	526_T	0.754	0.86
482_I	493_E	0.753	0.86
89_G	97_H	0.751	0.86
354_A	373_I	0.749	0.85
506_N	509_H	0.748	0.85
100_R	109_D	0.746	0.85
83_D	94_V	0.743	0.85
103_H	111_F	0.742	0.85
88_V	96_G	0.742	0.85
147_H	199_P	0.740	0.85
220_E	223_L	0.740	0.85
76_A	87_L	0.740	0.85
109_D	112_A	0.739	0.85
52_T	55_S	0.739	0.85
106_S	109_D	0.739	0.85
8_W	13_P	0.737	0.85
57_S	64_P	0.737	0.85
260_L	299_V	0.736	0.84
69_Y	76_A	0.735	0.84
493_E	520_V	0.734	0.84
273_R	325_G	0.734	0.84
383_E	403_M	0.731	0.84
82_S	94_V	0.730	0.84
76_A	90_G	0.730	0.84
102_R	107_A	0.730	0.84
74_A	93_E	0.730	0.84
218_E	222_E	0.727	0.84
76_A	85_G	0.725	0.84
103_H	108_D	0.721	0.83
9_R	13_P	0.721	0.83
482_I	516_L	0.720	0.83
79_T	86_Q	0.720	0.83
186_D	249_R	0.720	0.83
533_V	536_A	0.719	0.83
41_R	45_A	0.719	0.83
42_L	54_A	0.717	0.83
264_G	311_E	0.716	0.83
233_E	269_P	0.715	0.83
418_Q	421_F	0.714	0.83
72_L	93_E	0.713	0.83
53_R	61_A	0.712	0.82
263_P	308_F	0.711	0.82
397_I	435_D	0.711	0.82
42_L	60_L	0.709	0.82
87_L	93_E	0.709	0.82
250_W	255_A	0.707	0.82
448_I	533_V	0.707	0.82
455_P	542_N	0.707	0.82
33_P	39_Q	0.706	0.82
70_L	80_L	0.705	0.82
231_E	236_L	0.704	0.82
459_S	497_K	0.703	0.82
72_L	90_G	0.702	0.82
77_A	82_S	0.700	0.81
114_L	118_V	0.700	0.81
8_W	21_I	0.700	0.81
88_V	92_Y	0.699	0.81
472_A	536_A	0.699	0.81
222_E	226_Q	0.695	0.81
273_R	324_E	0.693	0.81
25_P	28_I	0.693	0.81
72_L	87_L	0.691	0.81
507_V	510_L	0.691	0.81
91_H	96_G	0.691	0.81
101_L	107_A	0.690	0.80
85_G	94_V	0.690	0.80
444_L	448_I	0.689	0.80
33_P	37_D	0.687	0.80
482_I	529_A	0.687	0.80
298_E	313_L	0.686	0.80
351_Q	471_R	0.684	0.80
266_D	270_I	0.684	0.80
408_F	444_L	0.683	0.80
425_L	447_L	0.682	0.80
425_L	443_E	0.682	0.80
56_S	63_A	0.681	0.80
79_T	93_E	0.680	0.80
84_A	96_G	0.680	0.80
35_F	57_S	0.678	0.79
76_A	84_A	0.677	0.79
117_V	154_L	0.677	0.79
251_V	261_P	0.675	0.79
247_W	251_V	0.673	0.79
76_A	94_V	0.673	0.79
88_V	93_E	0.673	0.79
475_V	506_N	0.673	0.79
402_M	443_E	0.672	0.79
410_M	422_S	0.671	0.79
379_I	415_L	0.670	0.79
482_I	510_L	0.670	0.79
482_I	521_E	0.669	0.78
307_T	311_E	0.669	0.78
228_I	231_E	0.668	0.78
384_F	402_M	0.668	0.78
68_E	73_I	0.667	0.78
69_Y	72_L	0.667	0.78
65_E	71_N	0.666	0.78
345_E	458_Q	0.665	0.78
142_Q	145_L	0.665	0.78
79_T	92_Y	0.663	0.78
19_Q	41_R	0.660	0.77
107_A	111_F	0.660	0.77
220_E	227_A	0.658	0.77
89_G	94_V	0.658	0.77
123_V	165_P	0.656	0.77
57_S	61_A	0.656	0.77
72_L	79_T	0.656	0.77
73_I	83_D	0.654	0.77
79_T	84_A	0.654	0.77
94_V	97_H	0.653	0.77
43_Q	52_T	0.653	0.77
516_L	521_E	0.653	0.77
39_Q	43_Q	0.652	0.77
57_S	62_K	0.651	0.77
105_V	108_D	0.651	0.77
69_Y	77_A	0.650	0.76
514_S	518_K	0.649	0.76
479_N	483_E	0.649	0.76
16_D	23_A	0.648	0.76
379_I	420_P	0.648	0.76
442_A	445_C	0.647	0.76
353_N	458_Q	0.646	0.76
20_E	24_Q	0.646	0.76
293_L	297_K	0.646	0.76
35_F	39_Q	0.644	0.76
104_A	107_A	0.639	0.75
103_H	110_N	0.639	0.75
409_L	447_L	0.637	0.75
65_E	68_E	0.637	0.75
227_A	230_S	0.637	0.75
67_S	73_I	0.636	0.75
85_G	97_H	0.635	0.75
501_I	540_L	0.635	0.75
157_S	160_T	0.634	0.75
542_N	545_W	0.633	0.75
100_R	111_F	0.632	0.74
8_W	20_E	0.632	0.74
72_L	75_N	0.631	0.74
445_C	541_L	0.629	0.74
81_Q	86_Q	0.628	0.74
315_L	518_K	0.628	0.74
11_L	14_D	0.626	0.74
76_A	81_Q	0.626	0.74
174_I	200_L	0.626	0.74
74_A	96_G	0.625	0.74
129_F	167_L	0.625	0.74
502_I	507_V	0.623	0.73
45_A	56_S	0.622	0.73
85_G	95_S	0.621	0.73
66_E	70_L	0.621	0.73
237_Q	243_S	0.620	0.73
86_Q	92_Y	0.620	0.73
155_I	207_V	0.620	0.73
529_A	535_D	0.619	0.73
84_A	94_V	0.618	0.73
149_A	300_A	0.618	0.73
349_I	458_Q	0.618	0.73
33_P	44_F	0.617	0.73
53_R	60_L	0.617	0.73
192_P	196_P	0.615	0.72
68_E	74_A	0.615	0.72
70_L	86_Q	0.615	0.72
122_W	162_L	0.612	0.72
80_L	87_L	0.612	0.72
347_E	457_N	0.612	0.72
81_Q	87_L	0.612	0.72
456_V	541_L	0.611	0.72
19_Q	23_A	0.610	0.72
72_L	86_Q	0.610	0.72
12_V	16_D	0.610	0.72
514_S	521_E	0.609	0.72
442_A	462_I	0.609	0.72
410_M	417_Q	0.605	0.71
75_N	87_L	0.605	0.71
213_L	227_A	0.604	0.71
100_R	112_A	0.600	0.71
68_E	88_V	0.599	0.70
263_P	295_Q	0.599	0.70
222_E	225_E	0.599	0.70
255_A	296_C	0.595	0.70
104_A	186_D	0.594	0.70
23_A	27_L	0.594	0.70
457_N	497_K	0.594	0.70
73_I	86_Q	0.594	0.70
141_L	182_W	0.592	0.70
45_A	60_L	0.591	0.69
264_G	310_G	0.591	0.69
69_Y	92_Y	0.591	0.69
75_N	96_G	0.591	0.69
105_V	110_N	0.590	0.69
221_P	226_Q	0.590	0.69
118_V	146_V	0.590	0.69
100_R	106_S	0.590	0.69
110_N	153_I	0.589	0.69
119_A	129_F	0.588	0.69
49_L	52_T	0.587	0.69
107_A	112_A	0.586	0.69
373_I	427_F	0.585	0.69
231_E	235_T	0.585	0.69
251_V	259_H	0.584	0.68
296_C	299_V	0.583	0.68
462_I	501_I	0.583	0.68
162_L	171_L	0.583	0.68
69_Y	80_L	0.582	0.68
538_P	543_L	0.582	0.68
242_E	268_W	0.581	0.68
232_F	519_A	0.581	0.68
409_L	466_V	0.580	0.68
36_S	40_P	0.580	0.68
108_D	113_T	0.579	0.68
353_N	494_L	0.579	0.68
266_D	269_P	0.579	0.68
299_V	409_L	0.577	0.68
445_C	537_L	0.576	0.67
77_A	84_A	0.576	0.67
417_Q	421_F	0.576	0.67
267_A	270_I	0.575	0.67
500_V	527_I	0.575	0.67
74_A	83_D	0.575	0.67
71_N	98_S	0.575	0.67
8_W	24_Q	0.575	0.67
35_F	42_L	0.574	0.67
81_Q	94_V	0.574	0.67
535_D	539_L	0.573	0.67
24_Q	27_L	0.572	0.67
215_D	218_E	0.572	0.67
103_H	106_S	0.572	0.67
259_H	262_A	0.572	0.67
76_A	88_V	0.572	0.67
84_A	93_E	0.570	0.67
9_R	12_V	0.570	0.67
170_R	174_I	0.570	0.67
182_W	202_L	0.570	0.67
100_R	107_A	0.568	0.66
88_V	91_H	0.567	0.66
161_L	206_L	0.565	0.66
88_V	94_V	0.565	0.66
42_L	53_R	0.564	0.66
103_H	112_A	0.564	0.66
347_E	459_S	0.564	0.66
59_M	64_P	0.563	0.66
144_G	192_P	0.563	0.66
251_V	254_T	0.562	0.66
51_H	64_P	0.562	0.66
70_L	78_R	0.561	0.65
190_P	199_P	0.561	0.65
42_L	46_L	0.561	0.65
456_V	540_L	0.560	0.65
120_A	145_L	0.560	0.65
263_P	289_P	0.559	0.65
72_L	92_Y	0.559	0.65
72_L	84_A	0.558	0.65
266_D	315_L	0.558	0.65
66_E	72_L	0.558	0.65
134_Q	184_A	0.556	0.65
495_T	498_Q	0.555	0.65
61_A	64_P	0.554	0.64
131_C	134_Q	0.553	0.64
65_E	87_L	0.553	0.64
115_T	122_W	0.552	0.64
421_F	453_D	0.552	0.64
352_I	409_L	0.552	0.64
72_L	77_A	0.552	0.64
69_Y	81_Q	0.552	0.64
538_P	544_V	0.550	0.64
404_I	407_A	0.550	0.64
164_Q	167_L	0.549	0.64
61_A	76_A	0.548	0.64
445_C	501_I	0.548	0.64
70_L	96_G	0.547	0.63
353_N	427_F	0.547	0.63
105_V	109_D	0.546	0.63
99_I	103_H	0.544	0.63
296_C	300_A	0.543	0.63
517_V	521_E	0.543	0.63
72_L	82_S	0.543	0.63
21_I	24_Q	0.543	0.63
323_R	508_R	0.542	0.63
68_E	92_Y	0.542	0.63
314_N	318_Q	0.540	0.62
77_A	98_S	0.539	0.62
159_R	162_L	0.539	0.62
293_L	296_C	0.539	0.62
493_E	519_A	0.537	0.62
32_D	36_S	0.536	0.62
82_S	95_S	0.536	0.62
355_L	370_P	0.535	0.62
271_L	319_Q	0.535	0.62
416_E	419_I	0.534	0.62
314_N	320_R	0.533	0.61
99_I	112_A	0.532	0.61
71_N	77_A	0.532	0.61
352_I	372_R	0.531	0.61
36_S	39_Q	0.531	0.61
105_V	111_F	0.531	0.61
128_L	173_N	0.529	0.61
85_G	91_H	0.529	0.61
79_T	87_L	0.528	0.61
42_L	50_L	0.527	0.61
53_R	56_S	0.527	0.61
345_E	455_P	0.527	0.61
53_R	57_S	0.526	0.60
472_A	530_V	0.525	0.60
456_V	459_S	0.525	0.60
8_W	14_D	0.525	0.60
272_I	285_L	0.524	0.60
475_V	529_A	0.523	0.60
102_R	143_P	0.523	0.60
56_S	64_P	0.522	0.60
274_E	324_E	0.522	0.60
144_G	197_S	0.522	0.60
70_L	77_A	0.521	0.60
79_T	90_G	0.521	0.60
157_S	161_L	0.521	0.60
184_A	191_L	0.520	0.60
159_R	208_G	0.519	0.59
116_Q	190_P	0.519	0.59
271_L	313_L	0.519	0.59
208_G	386_D	0.518	0.59
346_G	531_D	0.517	0.59
158_L	212_S	0.517	0.59
106_S	111_F	0.516	0.59
267_A	312_Q	0.516	0.59
523_G	526_T	0.514	0.59
75_N	92_Y	0.513	0.59
107_A	110_N	0.513	0.59
230_S	494_L	0.513	0.59
24_Q	44_F	0.512	0.58
108_D	245_T	0.512	0.58
69_Y	94_V	0.510	0.58
57_S	60_L	0.509	0.58
501_I	528_W	0.509	0.58
471_R	532_D	0.509	0.58
79_T	88_V	0.508	0.58
109_D	113_T	0.508	0.58
102_R	109_D	0.507	0.58
211_E	219_M	0.507	0.58
507_V	514_S	0.507	0.58
10_D	14_D	0.506	0.58
83_D	91_H	0.506	0.58
75_N	80_L	0.506	0.58
372_R	450_A	0.505	0.57
126_E	169_M	0.505	0.57
235_T	241_A	0.505	0.57
83_D	92_Y	0.505	0.57
65_E	91_H	0.504	0.57
325_G	495_T	0.504	0.57
482_I	501_I	0.502	0.57
15_T	19_Q	0.502	0.57
131_C	187_E	0.502	0.57
250_W	254_T	0.501	0.57
319_Q	508_R	0.500	0.57

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4fwgA	3	0.8123	100	0.472	Contact Map
3k1jA	4	0.8174	100	0.622	Contact Map
3m6aA	3	0.7645	100	0.658	Contact Map
3wu4A	3	0.3225	100	0.792	Contact Map
1xhkA	2	0.3038	100	0.792	Contact Map
2x36A	3	0.3174	100	0.794	Contact Map
1z0wA	3	0.3447	100	0.796	Contact Map
4gitA	2	0.1536	99.9	0.867	Contact Map
1qzmA	1	0.1553	99.6	0.907	Contact Map
3f8tA	1	0.4863	99.1	0.929	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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