GREMLIN Database
YCBX - Uncharacterized protein YcbX
UniProt: P75863 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13716
Length: 369 (362)
Sequences: 165 (93)
Seq/√Len: 4.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_L168_M4.6560.95
200_V247_L4.3450.93
54_M114_F4.2170.92
251_N339_E3.3340.78
155_L166_V2.9170.67
54_M232_F2.8940.67
10_H149_L2.8270.65
175_L247_L2.8130.64
360_V365_L2.7550.62
11_P14_S2.6380.59
173_P176_V2.5240.55
66_L364_A2.4490.53
46_I268_P2.4460.53
184_E266_T2.4270.52
22_H261_V2.3890.51
152_E156_R2.3040.48
199_D250_R2.2680.47
151_N168_M2.2670.47
319_I365_L2.2610.47
76_A114_F2.2590.47
150_A183_W2.2360.46
238_N314_N2.2250.46
114_F232_F2.2200.46
104_D117_E2.1680.44
177_V261_V2.1470.43
303_N332_R2.1190.42
337_E366_K2.0920.42
70_A131_V2.0730.41
222_A267_A2.0660.41
192_R262_E2.0450.40
354_I365_L2.0410.40
87_D100_R2.0390.40
66_L105_A2.0300.40
150_A166_V1.9540.37
20_L183_W1.9430.37
109_W161_R1.9040.36
292_D364_A1.9000.36
7_L13_K1.8790.35
7_L11_P1.8790.35
291_V360_V1.8610.35
21_T61_P1.8470.34
314_N317_I1.8440.34
155_L236_Q1.8440.34
151_N177_V1.8420.34
209_F236_Q1.8180.33
21_T65_G1.8100.33
315_Q344_K1.7480.31
157_D183_W1.7400.31
166_V209_F1.7370.31
107_N250_R1.7290.31
155_L214_P1.7130.30
106_I178_S1.6820.30
8_F62_V1.6790.30
6_R12_V1.6680.29
61_P266_T1.6630.29
291_V365_L1.6510.29
291_V315_Q1.6060.28
22_H137_V1.5970.27
16_R57_F1.5950.27
42_D46_I1.5910.27
314_N366_K1.5880.27
61_P184_E1.5730.27
292_D337_E1.5630.27
192_R241_V1.5600.26
150_A156_R1.5600.26
69_T117_E1.5520.26
157_D232_F1.5370.26
183_W232_F1.5340.26
74_S200_V1.5330.26
334_Q363_T1.5220.26
18_I295_W1.5050.25
135_N155_L1.4850.25
41_P54_M1.4810.25
151_N180_A1.4730.24
106_I356_C1.4710.24
12_V68_L1.4570.24
189_K265_A1.4560.24
127_M317_I1.4510.24
63_H356_C1.4460.24
339_E363_T1.4440.24
114_F183_W1.4350.23
163_P327_I1.4330.23
337_E364_A1.4320.23
46_I221_P1.4310.23
48_A170_Q1.4040.23
213_S216_K1.3970.23
54_M190_V1.3880.22
187_R269_A1.3860.22
98_T128_T1.3830.22
333_V356_C1.3820.22
38_I182_A1.3800.22
317_I333_V1.3590.22
144_G246_N1.3470.22
332_R353_T1.3450.21
9_I67_H1.3370.21
4_L14_S1.3300.21
49_R93_W1.3280.21
38_I178_S1.3170.21
7_L183_W1.3090.21
291_V319_I1.3070.21
196_V248_I1.3010.21
298_Q317_I1.2970.20
84_A104_D1.2950.20
150_A158_L1.2920.20
190_V265_A1.2820.20
346_S360_V1.2760.20
203_P246_N1.2730.20
334_Q353_T1.2660.20
68_L104_D1.2580.20
78_V332_R1.2580.20
7_L14_S1.2560.20
170_Q249_A1.2470.19
295_W332_R1.2450.19
336_L345_K1.2390.19
349_G364_A1.2340.19
145_Y264_L1.2310.19
16_R217_G1.2280.19
30_L251_N1.2160.19
225_P228_T1.2120.19
317_I330_S1.2110.19
53_Q212_V1.2070.19
92_V97_F1.2070.19
97_F211_T1.2050.19
238_N317_I1.2020.19
294_D298_Q1.2000.19
35_I351_D1.1990.18
150_A168_M1.1980.18
64_D79_R1.1970.18
352_G362_K1.1950.18
343_L346_S1.1890.18
142_A194_G1.1790.18
144_G211_T1.1790.18
341_T351_D1.1740.18
4_L13_K1.1730.18
4_L11_P1.1730.18
337_E342_P1.1650.18
97_F118_V1.1640.18
5_I14_S1.1620.18
281_A327_I1.1560.18
157_D274_A1.1490.18
83_F203_P1.1440.17
142_A272_Y1.1430.17
49_R144_G1.1420.17
51_F168_M1.1420.17
291_V363_T1.1410.17
10_H13_K1.1380.17
53_Q140_S1.1360.17
43_G203_P1.1330.17
49_R253_G1.1310.17
307_V367_L1.1280.17
48_A55_V1.1270.17
32_F80_F1.1270.17
291_V345_K1.1260.17
210_T246_N1.1190.17
150_A209_F1.1180.17
97_F130_R1.1150.17
44_T179_G1.1130.17
289_A334_Q1.1100.17
288_D364_A1.1080.17
298_Q333_V1.0970.17
296_Q308_L1.0960.17
214_P236_Q1.0910.16
183_W237_D1.0880.16
106_I263_I1.0840.16
190_V216_K1.0840.16
292_D299_A1.0830.16
190_V199_D1.0830.16
277_A352_G1.0750.16
148_L202_K1.0740.16
20_L165_S1.0720.16
216_K307_V1.0670.16
144_G210_T1.0630.16
286_Q301_R1.0630.16
320_P343_L1.0570.16
110_L230_Q1.0560.16
190_V197_V1.0550.16
352_G367_L1.0500.16
92_V211_T1.0500.16
214_P227_K1.0300.15
9_I13_K1.0270.15
214_P339_E1.0260.15
213_S344_K1.0260.15
19_G315_Q1.0260.15
204_C243_F1.0250.15
332_R351_D1.0250.15
72_D175_L1.0200.15
144_G203_P1.0180.15
227_K231_S1.0170.15
241_V245_Q1.0130.15
49_R142_A1.0110.15
53_Q69_T1.0100.15
167_K178_S1.0040.15
110_L236_Q0.9930.15
298_Q336_L0.9920.15
289_A336_L0.9860.15
112_G327_I0.9790.15
158_L228_T0.9780.15
311_Q328_C0.9780.15
313_E329_G0.9780.15
309_L328_C0.9780.15
323_C329_G0.9780.15
311_Q324_R0.9780.15
311_Q329_G0.9780.15
313_E328_C0.9780.15
323_C328_C0.9780.15
324_R329_G0.9780.15
311_Q323_C0.9780.15
313_E324_R0.9780.15
309_L323_C0.9780.15
313_E323_C0.9780.15
309_L329_G0.9780.15
309_L313_E0.9780.15
309_L324_R0.9780.15
324_R328_C0.9780.15
290_N346_S0.9770.15
159_Q165_S0.9720.14
95_T102_A0.9680.14
7_L35_I0.9660.14
307_V343_L0.9610.14
69_T261_V0.9580.14
83_F225_P0.9540.14
305_Q316_G0.9540.14
115_S151_N0.9520.14
195_D333_V0.9510.14
50_Q147_Y0.9480.14
9_I32_F0.9470.14
333_V339_E0.9430.14
135_N166_V0.9410.14
54_M250_R0.9410.14
148_L198_F0.9410.14
209_F212_V0.9400.14
21_T32_F0.9390.14
68_L214_P0.9340.14
91_E94_G0.9260.14
211_T246_N0.9260.14
79_R200_V0.9220.14
55_V209_F0.9220.14
106_I339_E0.9130.14
178_S342_P0.9060.13
360_V363_T0.9050.13
68_L110_L0.9050.13
18_I341_T0.9040.13
45_F132_K0.9020.13
142_A198_F0.9020.13
23_A208_I0.8970.13
208_I223_G0.8960.13
16_R270_K0.8940.13
68_L342_P0.8920.13
45_F102_A0.8910.13
8_F140_S0.8850.13
42_D298_Q0.8850.13
53_Q67_H0.8850.13
124_G262_E0.8810.13
304_N318_R0.8780.13
183_W295_W0.8700.13
63_H337_E0.8690.13
293_I300_F0.8680.13
93_W210_T0.8630.13
49_R210_T0.8580.13
119_Q225_P0.8580.13
212_V258_G0.8540.13
43_G225_P0.8500.13
19_G254_V0.8500.13
115_S364_A0.8490.13
205_S321_Y0.8490.13
288_D291_V0.8480.13
83_F246_N0.8450.13
74_S195_D0.8440.13
110_L122_W0.8400.13
47_T93_W0.8370.12
284_T301_R0.8360.12
184_E364_A0.8350.12
261_V265_A0.8350.12
262_E303_N0.8340.12
157_D231_S0.8340.12
43_G228_T0.8330.12
128_T269_A0.8320.12
100_R337_E0.8310.12
327_I333_V0.8310.12
17_G65_G0.8310.12
32_F61_P0.8280.12
117_E201_V0.8270.12
290_N301_R0.8270.12
301_R349_G0.8190.12
106_I342_P0.8180.12
113_F232_F0.8180.12
293_I296_Q0.8160.12
287_P291_V0.8130.12
317_I334_Q0.8120.12
124_G155_L0.8100.12
44_T90_T0.8090.12
263_I366_K0.8080.12
149_L247_L0.8030.12
336_L349_G0.8000.12
183_W356_C0.7980.12
102_A132_K0.7980.12
287_P290_N0.7970.12
319_I330_S0.7970.12
18_I284_T0.7960.12
304_N352_G0.7940.12
54_M76_A0.7930.12
110_L164_A0.7930.12
294_D299_A0.7880.12
93_W246_N0.7880.12
335_L355_L0.7880.12
135_N236_Q0.7870.12
346_S358_S0.7860.12
59_P223_G0.7850.12
203_P225_P0.7850.12
303_N354_I0.7840.12
16_R139_L0.7750.12
47_T246_N0.7740.12
22_H327_I0.7710.12
159_Q254_V0.7680.12
4_L247_L0.7650.12
286_Q342_P0.7650.12
192_R224_E0.7640.11
78_V342_P0.7610.11
35_I294_D0.7590.11
351_D362_K0.7570.11
165_S366_K0.7530.11
286_Q366_K0.7510.11
167_K261_V0.7510.11
95_T106_I0.7500.11
106_I278_D0.7470.11
49_R225_P0.7410.11
31_A149_L0.7410.11
74_S183_W0.7400.11
9_I115_S0.7380.11
197_V265_A0.7380.11
115_S337_E0.7380.11
25_A366_K0.7340.11
66_L137_V0.7330.11
114_F190_V0.7280.11
53_Q363_T0.7280.11
183_W236_Q0.7270.11
336_L365_L0.7260.11
113_F132_K0.7240.11
290_N345_K0.7220.11
190_V195_D0.7210.11
297_G330_S0.7200.11
345_K349_G0.7190.11
57_F217_G0.7190.11
38_I89_P0.7180.11
297_G319_I0.7150.11
222_A260_E0.7140.11
330_S362_K0.7140.11
297_G334_Q0.7130.11
302_G316_G0.7110.11
43_G93_W0.7100.11
84_A208_I0.7070.11
21_T56_R0.7070.11
97_F203_P0.7060.11
124_G168_M0.7050.11
46_I108_K0.7030.11
317_I336_L0.7030.11
9_I270_K0.7000.11
137_V155_L0.6990.11
74_S290_N0.6990.11
176_V349_G0.6980.11
40_E150_A0.6970.11
55_V308_L0.6960.11
111_S204_C0.6950.11
189_K238_N0.6940.11
106_I181_S0.6920.11
97_F102_A0.6920.11
18_I263_I0.6900.11
20_L295_W0.6880.11
115_S360_V0.6870.11
151_N175_L0.6870.11
168_M245_Q0.6860.11
298_Q366_K0.6840.10
299_A366_K0.6840.10
333_V349_G0.6820.10
287_P360_V0.6810.10
83_F144_G0.6800.10
289_A356_C0.6780.10
148_L204_C0.6760.10
315_Q330_S0.6750.10
124_G192_R0.6690.10
298_Q349_G0.6680.10
241_V332_R0.6680.10
236_Q284_T0.6680.10
294_D336_L0.6670.10
63_H314_N0.6670.10
170_Q198_F0.6670.10
84_A334_Q0.6650.10
341_T366_K0.6630.10
198_F251_N0.6630.10
170_Q211_T0.6630.10
122_W162_C0.6630.10
195_D286_Q0.6620.10
294_D366_K0.6610.10
57_F102_A0.6600.10
55_V64_D0.6560.10
79_R114_F0.6550.10
315_Q363_T0.6500.10
294_D345_K0.6490.10
211_T249_A0.6470.10
287_P341_T0.6470.10
305_Q352_G0.6460.10
318_R349_G0.6420.10
93_W142_A0.6390.10
102_A118_V0.6380.10
315_Q362_K0.6380.10
317_I356_C0.6370.10
51_F104_D0.6350.10
149_L194_G0.6330.10
292_D341_T0.6300.10
314_N330_S0.6300.10
19_G363_T0.6280.10
287_P342_P0.6280.10
333_V365_L0.6270.10
18_I62_V0.6270.10
32_F217_G0.6250.10
83_F272_Y0.6240.10
38_I168_M0.6200.10
12_V178_S0.6190.10
115_S365_L0.6190.10
43_G224_E0.6170.10
263_I337_E0.6130.10
125_P240_D0.6130.10
336_L366_K0.6130.10
127_M314_N0.6110.10
133_R248_I0.6090.10
4_L25_A0.6080.10
63_H319_I0.6040.10
115_S314_N0.6040.10
280_T363_T0.6030.10
301_R318_R0.6010.10
18_I354_I0.6010.10
183_W252_S0.5990.10
20_L366_K0.5970.09
192_R308_L0.5950.09
86_Q231_S0.5910.09
314_N333_V0.5900.09
349_G356_C0.5900.09
6_R103_P0.5890.09
300_F353_T0.5890.09
60_S352_G0.5880.09
283_I337_E0.5880.09
294_D362_K0.5870.09
43_G49_R0.5860.09
49_R228_T0.5860.09
22_H215_E0.5850.09
53_Q99_A0.5840.09
46_I119_Q0.5830.09
9_I131_V0.5800.09
290_N319_I0.5780.09
297_G307_V0.5780.09
87_D123_V0.5770.09
20_L140_S0.5720.09
205_S240_D0.5700.09
115_S155_L0.5690.09
216_K222_A0.5670.09
93_W264_L0.5670.09
158_L255_I0.5660.09
175_L220_H0.5640.09
56_R261_V0.5630.09
283_I363_T0.5610.09
323_C331_C0.5600.09
328_C331_C0.5600.09
324_R331_C0.5600.09
313_E331_C0.5600.09
309_L331_C0.5600.09
311_Q331_C0.5600.09
333_V367_L0.5590.09
194_G239_G0.5590.09
191_I245_Q0.5580.09
14_S49_R0.5580.09
47_T83_F0.5580.09
71_P187_R0.5560.09
80_F334_Q0.5560.09
298_Q318_R0.5550.09
82_D219_K0.5530.09
71_P225_P0.5530.09
12_V182_A0.5520.09
299_A341_T0.5510.09
113_F295_W0.5500.09
36_F80_F0.5470.09
44_T199_D0.5460.09
18_I64_D0.5460.09
201_V213_S0.5450.09
8_F157_D0.5450.09
66_L288_D0.5440.09
78_V189_K0.5430.09
296_Q349_G0.5430.09
118_V130_R0.5410.09
117_E164_A0.5400.09
330_S345_K0.5400.09
40_E248_I0.5400.09
286_Q334_Q0.5400.09
27_V263_I0.5390.09
294_D339_E0.5390.09
27_V265_A0.5370.09
64_D349_G0.5350.09
19_G218_Q0.5350.09
354_I360_V0.5340.09
130_R170_Q0.5290.09
341_T364_A0.5280.09
189_K218_Q0.5280.09
48_A211_T0.5280.09
93_W224_E0.5260.09
38_I41_P0.5260.09
81_A191_I0.5240.09
17_G57_F0.5240.09
43_G192_R0.5240.09
153_A346_S0.5230.09
195_D251_N0.5220.09
28_S151_N0.5210.09
182_A265_A0.5210.09
15_M59_P0.5210.09
115_S284_T0.5200.09
57_F103_P0.5200.09
155_L183_W0.5190.09
187_R199_D0.5190.09
36_F107_N0.5190.09
72_D222_A0.5180.09
285_Q294_D0.5180.09
9_I61_P0.5170.09
214_P295_W0.5170.09
83_F142_A0.5160.09
42_D317_I0.5150.09
224_E228_T0.5140.09
3_T362_K0.5130.09
144_G202_K0.5130.09
76_A156_R0.5120.09
288_D301_R0.5120.09
70_A247_L0.5110.09
156_R183_W0.5110.09
84_A108_K0.5090.09
47_T249_A0.5090.09
291_V332_R0.5090.09
83_F210_T0.5070.09
9_I53_Q0.5060.09
304_N345_K0.5050.09
141_F204_C0.5050.09
236_Q307_V0.5030.09
292_D301_R0.5030.09
191_I247_L0.5020.08
54_M183_W0.5010.08
203_P210_T0.5010.08
93_W253_G0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2exnA 1 0.3442 100 0.8 Contact Map
1oruA 2 0.4661 100 0.804 Contact Map
1o65A 1 0.5745 99.7 0.894 Contact Map
3zyyX 2 0.2222 99.6 0.903 Contact Map
4n58A 4 0.2249 99.6 0.904 Contact Map
1doiA 5 0.2873 99.6 0.907 Contact Map
1frdA 1 0.2249 99.5 0.909 Contact Map
1awdA 2 0.2195 99.5 0.91 Contact Map
1qoaA 1 0.2249 99.5 0.911 Contact Map
4itkA 1 0.2222 99.5 0.911 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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