GREMLIN Database
ZAPC - Cell division protein ZapC
UniProt: P75862 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13715
Length: 180 (166)
Sequences: 220 (127)
Seq/√Len: 9.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_R13_Y4.1110.99
20_M101_H3.4930.97
84_A137_L3.3940.96
57_Y75_A3.0690.93
93_P159_K2.8760.91
5_P128_V2.7780.89
13_Y16_E2.7000.88
90_P159_K2.3430.79
27_G83_V2.3410.79
53_D138_C2.2980.77
81_A127_L2.2420.76
128_V136_A2.2310.75
78_V117_L2.1910.74
84_A94_K2.1840.74
11_W20_M2.1740.73
37_K60_F2.1440.72
5_P161_M1.9250.63
76_E155_G1.8910.62
53_D86_R1.8210.59
153_Q156_D1.7850.57
20_M48_G1.7800.57
124_V140_L1.7500.56
66_D118_S1.7480.56
5_P9_W1.7440.55
3_I150_R1.6820.53
24_L80_N1.6500.51
43_A159_K1.6380.51
92_M156_D1.6360.51
34_F82_L1.6110.49
42_D165_L1.5800.48
136_A162_N1.5390.46
100_S123_Q1.5280.46
119_D129_V1.5000.44
53_D89_K1.4990.44
36_R74_K1.4870.44
3_I20_M1.4830.44
97_H146_V1.4720.43
40_T129_V1.4700.43
30_F161_M1.4690.43
151_A170_N1.4580.43
21_M29_L1.3630.38
20_M105_W1.3460.38
21_M89_K1.3030.36
115_V126_L1.3030.36
90_P137_L1.3010.36
145_V151_A1.2840.35
53_D87_Y1.2770.35
132_G135_A1.2690.34
77_L154_L1.2670.34
65_R105_W1.2620.34
28_M135_A1.2570.34
76_E86_R1.2130.32
114_C146_V1.2110.32
140_L152_M1.2080.32
142_Q153_Q1.2070.32
109_P162_N1.1810.31
89_K137_L1.1800.31
137_L163_D1.1680.30
64_C167_P1.1640.30
21_M53_D1.1620.30
29_L152_M1.1550.30
20_M29_L1.1430.29
3_I143_P1.1390.29
33_R154_L1.1390.29
29_L72_E1.1370.29
38_M163_D1.1300.29
32_S83_V1.1280.29
57_Y72_E1.1230.29
28_M132_G1.1200.29
26_N70_S1.1070.28
110_G162_N1.1070.28
21_M135_A1.0850.27
12_Y21_M1.0790.27
7_D21_M1.0750.27
38_M83_V1.0700.27
118_S128_V1.0690.27
117_L164_R1.0580.26
41_P157_A1.0370.26
107_P136_A1.0300.25
42_D137_L1.0200.25
31_R76_E0.9980.24
37_K161_M0.9890.24
20_M83_V0.9850.24
76_E80_N0.9820.24
60_F77_L0.9800.24
4_K28_M0.9740.23
91_Q144_C0.9740.23
5_P30_F0.9560.23
34_F84_A0.9540.23
25_A83_V0.9530.23
33_R155_G0.9500.23
49_F90_P0.9470.23
54_A98_F0.9400.22
62_E108_M0.9390.22
99_V106_V0.9360.22
18_D141_A0.9320.22
39_L79_L0.9210.22
83_V97_H0.9180.22
57_Y169_V0.9170.22
18_D126_L0.9160.22
119_D128_V0.9020.21
94_K163_D0.8890.21
67_F87_Y0.8860.21
14_D21_M0.8840.21
34_F38_M0.8830.21
20_M39_L0.8790.20
52_D56_L0.8790.20
53_D107_P0.8770.20
30_F158_I0.8750.20
79_L86_R0.8710.20
92_M144_C0.8680.20
69_L94_K0.8640.20
50_C99_V0.8570.20
67_F131_S0.8510.20
21_M86_R0.8490.20
83_V146_V0.8420.19
76_E141_A0.8410.19
64_C78_V0.8410.19
74_K82_L0.8400.19
6_D10_R0.8350.19
54_A164_R0.8310.19
57_Y111_D0.8240.19
98_F117_L0.8180.19
97_H114_C0.8170.19
103_E147_I0.8170.19
44_F107_P0.8150.19
32_S80_N0.8150.19
116_W128_V0.8140.19
88_L94_K0.8100.19
133_E163_D0.8100.19
38_M132_G0.8080.18
41_P80_N0.7990.18
37_K43_A0.7970.18
139_L157_A0.7950.18
49_F159_K0.7930.18
51_V77_L0.7920.18
77_L155_G0.7870.18
132_G142_Q0.7850.18
21_M31_R0.7740.18
17_H152_M0.7730.18
119_D124_V0.7720.17
43_A62_E0.7700.17
91_Q109_P0.7650.17
50_C68_N0.7580.17
3_I117_L0.7570.17
48_G143_P0.7550.17
129_V160_I0.7520.17
20_M136_A0.7510.17
147_I160_I0.7500.17
26_N114_C0.7480.17
125_N157_A0.7430.17
39_L101_H0.7420.17
13_Y18_D0.7380.17
104_M123_Q0.7380.17
12_Y163_D0.7370.17
70_S152_M0.7360.17
106_V138_C0.7330.16
72_E82_L0.7290.16
77_L84_A0.7230.16
25_A139_L0.7150.16
57_Y104_M0.7130.16
119_D144_C0.7010.16
130_E162_N0.7010.16
7_D87_Y0.7000.16
66_D102_G0.6990.16
59_S124_V0.6900.15
6_D58_F0.6860.15
88_L129_V0.6840.15
55_A138_C0.6830.15
61_E74_K0.6820.15
20_M65_R0.6810.15
31_R75_A0.6810.15
146_V160_I0.6730.15
102_G128_V0.6710.15
32_S141_A0.6710.15
59_S151_A0.6680.15
119_D146_V0.6680.15
18_D127_L0.6650.15
5_P11_W0.6580.15
155_G162_N0.6570.15
21_M93_P0.6560.15
139_L155_G0.6550.15
115_V165_L0.6550.15
133_E162_N0.6540.15
90_P135_A0.6540.15
89_K135_A0.6520.15
101_H150_R0.6520.15
141_A154_L0.6380.14
28_M46_P0.6370.14
20_M36_R0.6340.14
57_Y126_L0.6310.14
37_K162_N0.6290.14
146_V152_M0.6240.14
7_D77_L0.6200.14
50_C131_S0.6150.14
50_C54_A0.6080.14
49_F96_W0.6050.14
107_P135_A0.6010.13
26_N139_L0.5950.13
28_M80_N0.5940.13
110_G161_M0.5940.13
71_K166_K0.5940.13
126_L140_L0.5920.13
114_C125_N0.5890.13
80_N161_M0.5830.13
4_K86_R0.5820.13
18_D168_Q0.5800.13
157_A163_D0.5790.13
19_R23_D0.5690.13
34_F155_G0.5670.13
53_D135_A0.5660.13
89_K130_E0.5600.13
20_M116_W0.5590.13
15_E26_N0.5590.13
81_A139_L0.5580.13
100_S170_N0.5580.13
16_E48_G0.5570.13
64_C74_K0.5570.13
35_A114_C0.5570.13
26_N29_L0.5570.13
100_S168_Q0.5560.13
119_D141_A0.5550.12
4_K98_F0.5550.12
4_K155_G0.5510.12
3_I61_E0.5480.12
22_L30_F0.5460.12
91_Q169_V0.5460.12
95_S150_R0.5440.12
91_Q124_V0.5400.12
54_A135_A0.5390.12
44_F78_V0.5360.12
104_M121_H0.5350.12
99_V116_W0.5340.12
3_I125_N0.5340.12
3_I57_Y0.5330.12
15_E70_S0.5320.12
140_L151_A0.5300.12
100_S163_D0.5280.12
4_K52_D0.5270.12
27_G145_V0.5250.12
24_L86_R0.5190.12
86_R98_F0.5150.12
150_R160_I0.5140.12
9_W20_M0.5130.12
79_L96_W0.5110.12
68_N170_N0.5100.12
156_D160_I0.5060.12
23_D76_E0.5000.11
98_F164_R0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j81j 1 0.4611 8.5 0.964 Contact Map
2kfwA 1 0.8278 8.3 0.964 Contact Map
3j61Z 1 0.4278 8 0.964 Contact Map
4a18N 1 0.4222 7.8 0.964 Contact Map
2y8gA 1 0.3056 7.5 0.965 Contact Map
4ovkA 1 0.3944 7 0.965 Contact Map
4fl3A 1 0.4333 5.7 0.967 Contact Map
3d8cA 2 0.4278 5.2 0.967 Contact Map
4g26A 1 0.5222 5.1 0.967 Contact Map
4ujrM 1 0.4222 5 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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