GREMLIN Database
YCBU - Uncharacterized fimbrial-like protein YcbU
UniProt: P75859 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13713
Length: 180 (164)
Sequences: 3483 (2745)
Seq/√Len: 214.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_L121_A2.9951.00
118_T165_T2.9421.00
122_V155_L2.9301.00
65_A68_T2.8111.00
123_Q156_R2.6941.00
43_D81_G2.6611.00
89_A177_L2.6591.00
76_N150_T2.6051.00
125_L156_R2.6011.00
123_Q158_K2.5221.00
105_L135_L2.3851.00
45_A80_T2.2651.00
157_Y169_A2.2141.00
78_D150_T2.2051.00
107_L169_A2.1851.00
119_G164_A2.1501.00
64_Q68_T2.0831.00
122_V171_A2.0611.00
126_D131_Q1.9721.00
105_L173_L1.9251.00
116_M168_N1.8601.00
134_P137_Q1.8171.00
72_A156_R1.8141.00
130_Q154_Q1.8051.00
76_N152_K1.7651.00
74_D154_Q1.7361.00
45_A78_D1.6921.00
95_G105_L1.6711.00
123_Q132_E1.6551.00
104_L158_K1.6511.00
98_D160_T1.6151.00
69_V123_Q1.5911.00
25_G28_Q1.5061.00
45_A48_S1.5041.00
94_S136_N1.4561.00
58_F70_S1.4461.00
56_G169_A1.4381.00
46_T51_Q1.4361.00
94_S176_D1.4291.00
11_I14_F1.4031.00
14_F17_L1.3581.00
90_D178_V1.3521.00
56_G73_A1.3471.00
128_Q131_Q1.3371.00
74_D152_K1.3351.00
103_T134_P1.3281.00
51_Q77_I1.2971.00
69_V156_R1.2901.00
109_D115_G1.2741.00
21_V25_G1.2611.00
48_S78_D1.2511.00
75_L124_I1.2511.00
56_G71_T1.2391.00
48_S51_Q1.2281.00
36_N57_D1.2201.00
18_N22_G1.2121.00
55_I157_Y1.2051.00
53_I75_L1.2041.00
88_G143_P1.2041.00
89_A149_N1.1851.00
104_L123_Q1.1611.00
63_F159_S1.1451.00
144_L149_N1.1321.00
109_D116_M1.1281.00
55_I169_A1.1181.00
55_I122_V1.1131.00
91_V151_L1.1081.00
12_L15_S1.0921.00
63_F164_A1.0911.00
64_Q159_S1.0911.00
69_V158_K1.0761.00
109_D168_N1.0721.00
77_I175_F1.0641.00
99_T102_P1.0631.00
92_L138_V1.0571.00
69_V125_L1.0451.00
13_F16_I1.0441.00
43_D80_T1.0431.00
97_A103_T1.0381.00
65_A159_S1.0271.00
72_A154_Q1.0201.00
124_I173_L1.0161.00
32_H172_V1.0111.00
29_V33_I1.0071.00
159_S164_A1.0061.00
93_F153_Y1.0001.00
93_F124_I0.9991.00
99_T121_A0.9981.00
39_D60_I0.9641.00
127_A152_K0.9641.00
105_L171_A0.9531.00
90_D180_Q0.9521.00
15_S18_N0.9360.99
159_S163_G0.9230.99
139_Q153_Y0.9210.99
20_H24_A0.9180.99
29_V175_F0.9150.99
59_N62_D0.9050.99
63_F120_I0.9030.99
63_F68_T0.9010.99
115_G168_N0.9000.99
90_D141_L0.8980.99
16_I20_H0.8930.99
96_E106_K0.8880.99
131_Q140_P0.8790.99
120_I157_Y0.8690.99
62_D70_S0.8640.99
117_A120_I0.8610.99
51_Q175_F0.8600.99
15_S19_I0.8580.99
58_F63_F0.8550.99
92_L178_V0.8510.99
22_G25_G0.8380.99
63_F160_T0.8350.99
141_L180_Q0.8350.99
21_V24_A0.8330.99
125_L154_Q0.8320.99
133_I139_Q0.8290.99
17_L20_H0.8280.99
88_G141_L0.8220.99
16_I21_V0.8160.99
98_D102_P0.8140.99
93_F175_F0.8130.99
95_G98_D0.8120.99
19_I22_G0.8120.99
121_A160_T0.8040.98
16_I19_I0.8000.98
97_A135_L0.7990.98
39_D83_A0.7970.98
108_T170_T0.7970.98
108_T172_V0.7940.98
14_F18_N0.7860.98
125_L130_Q0.7820.98
14_F19_I0.7820.98
58_F169_A0.7790.98
133_I153_Y0.7760.98
126_D130_Q0.7690.98
122_V169_A0.7670.98
23_M27_E0.7670.98
124_I135_L0.7650.98
20_H23_M0.7590.98
30_S50_L0.7580.98
19_I23_M0.7490.98
58_F157_Y0.7480.97
16_I22_G0.7470.97
79_I149_N0.7450.97
98_D106_K0.7370.97
66_A159_S0.7360.97
55_I155_L0.7350.97
107_L115_G0.7320.97
19_I25_G0.7310.97
17_L21_V0.7250.97
66_A119_G0.7230.97
34_Y54_H0.7220.97
18_N21_V0.7180.97
13_F17_L0.7100.97
37_V164_A0.7050.96
66_A162_A0.7050.96
98_D121_A0.7020.96
11_I19_I0.7010.96
11_I17_L0.6970.96
70_S157_Y0.6940.96
20_H25_G0.6910.96
18_N23_M0.6850.96
101_A104_L0.6830.96
119_G161_K0.6830.96
55_I123_Q0.6810.96
24_A28_Q0.6780.96
95_G172_V0.6750.95
34_Y52_N0.6730.95
27_E30_S0.6710.95
41_G157_Y0.6690.95
55_I73_A0.6640.95
68_T159_S0.6630.95
13_F19_I0.6550.95
92_L137_Q0.6520.94
60_I166_G0.6510.94
140_P143_P0.6510.94
54_H157_Y0.6500.94
66_A161_K0.6500.94
19_I24_A0.6490.94
120_I164_A0.6470.94
69_V72_A0.6340.94
56_G170_T0.6340.94
29_V36_N0.6330.94
83_A125_L0.6320.94
107_L170_T0.6280.93
46_T80_T0.6280.93
46_T49_A0.6270.93
125_L132_E0.6260.93
22_G26_P0.6240.93
89_A144_L0.6240.93
24_A27_E0.6230.93
11_I15_S0.6190.93
54_H73_A0.6160.93
15_S22_G0.6130.92
98_D101_A0.6060.92
14_F24_A0.6050.92
38_V83_A0.6010.92
72_A125_L0.5960.91
37_V58_F0.5950.91
157_Y170_T0.5940.91
135_L153_Y0.5940.91
91_V177_L0.5940.91
16_I24_A0.5930.91
32_H52_N0.5880.91
21_V28_Q0.5810.90
84_A146_A0.5790.90
17_L22_G0.5790.90
11_I16_I0.5760.90
60_I164_A0.5760.90
41_G84_A0.5750.90
52_N174_Y0.5730.90
107_L120_I0.5680.89
32_H50_L0.5670.89
159_S162_A0.5640.89
78_D148_D0.5590.89
53_I155_L0.5550.88
12_L16_I0.5540.88
14_F20_H0.5530.88
11_I18_N0.5530.88
119_G162_A0.5510.88
119_G160_T0.5500.88
98_D161_K0.5450.87
18_N24_A0.5400.87
101_A136_N0.5370.87
55_I156_R0.5360.86
90_D138_V0.5330.86
100_L103_T0.5320.86
93_F177_L0.5270.86
135_L173_L0.5240.85
96_E99_T0.5230.85
103_T132_E0.5210.85
53_I150_T0.5190.85
76_N97_A0.5170.84
90_D139_Q0.5150.84
138_V180_Q0.5130.84
88_G146_A0.5120.84
107_L117_A0.5110.84
107_L157_Y0.5100.84
18_N25_G0.5100.84
149_N153_Y0.5070.83
132_E135_L0.5050.83
22_G27_E0.5030.83
70_S73_A0.5020.83
108_T116_M0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jmrA 1 0.8389 100 0.249 Contact Map
2jtyA 1 0.8611 100 0.269 Contact Map
2xg5B 1 0.7722 100 0.27 Contact Map
2uy6B 2 0.7944 100 0.285 Contact Map
1pdkB 1 0.7667 100 0.295 Contact Map
3bwuF 1 0.6889 100 0.34 Contact Map
2w07B 1 0.6556 99.9 0.37 Contact Map
4dwhB 1 0.7444 99.9 0.371 Contact Map
3bfqG 1 0.7222 99.9 0.38 Contact Map
5afoA 1 0.9389 99.9 0.386 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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