GREMLIN Database
ELFG - Uncharacterized fimbrial-like protein ElfG
UniProt: P75858 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13712
Length: 356 (324)
Sequences: 224 (184)
Seq/√Len: 10.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
300_T331_Y4.8491.00
236_V345_F4.0050.99
336_T340_P3.9340.99
189_E206_V3.8800.99
82_C146_C3.6190.98
275_S354_N3.4690.97
80_C175_G3.0000.93
301_D305_N2.8740.92
172_P213_G2.8040.90
120_L187_L2.7650.90
278_A288_I2.6950.89
130_V207_L2.5420.85
173_F215_I2.5090.85
292_R340_P2.4730.84
167_L215_I2.4700.84
231_V256_L2.4600.83
180_P213_G2.4200.82
115_A170_L2.3590.81
287_A297_V2.3070.79
114_L169_I2.2960.79
100_L124_G2.2380.77
214_T220_S2.1730.75
104_G114_L2.1500.74
18_A63_V2.1480.74
219_G292_R2.0600.70
106_N117_K2.0470.70
334_S340_P2.0430.70
122_V137_T2.0080.68
76_Y160_G2.0020.68
173_F219_G1.9890.68
290_T347_A1.9570.66
272_V354_N1.9020.64
80_C180_P1.8770.63
93_A96_A1.8350.61
219_G334_S1.8220.61
307_I312_G1.8050.60
292_R336_T1.7900.59
173_F190_C1.7750.58
18_A21_L1.7560.58
119_L164_S1.7380.57
206_V228_T1.7370.57
270_V326_A1.7340.57
226_G229_I1.7300.56
295_V342_T1.7250.56
319_P354_N1.7080.55
107_W206_V1.7080.55
46_V184_L1.7070.55
48_F184_L1.7030.55
212_S274_L1.7010.55
174_V222_S1.6920.55
100_L108_Y1.6780.54
122_V132_F1.6470.53
172_P266_N1.6370.52
109_K170_L1.6360.52
233_L345_F1.6200.51
297_V335_T1.5930.50
179_I294_G1.5920.50
188_Y206_V1.5580.48
137_T160_G1.5560.48
70_W163_G1.5460.48
160_G163_G1.5100.46
58_N82_C1.4980.46
130_V156_Q1.4790.45
122_V163_G1.4710.44
175_G295_V1.4680.44
36_H39_Q1.4600.44
137_T159_S1.4500.43
231_V347_A1.4480.43
167_L264_T1.4470.43
221_C262_C1.4260.42
117_K292_R1.4210.42
311_G331_Y1.4190.42
229_I324_S1.4160.42
163_G209_Y1.4110.42
111_N205_P1.4090.42
179_I213_G1.4090.42
190_C340_P1.4010.41
287_A295_V1.3990.41
218_L345_F1.3980.41
219_G337_G1.3940.41
160_G207_L1.3630.40
251_A324_S1.3590.39
218_L236_V1.3440.39
299_V305_N1.3370.38
103_L294_G1.3340.38
289_K297_V1.3230.38
240_N250_G1.3180.38
224_N229_I1.3150.37
22_M25_C1.3100.37
20_V26_A1.3040.37
222_S227_E1.3030.37
48_F182_M1.3020.37
80_C295_V1.3020.37
226_G294_G1.3010.37
281_D348_T1.2860.36
221_C332_P1.2750.36
296_G333_V1.2740.36
40_G233_L1.2720.36
352_R355_F1.2690.35
324_S350_T1.2680.35
285_P305_N1.2660.35
80_C108_Y1.2580.35
106_N115_A1.2560.35
227_E347_A1.2470.35
184_L187_L1.2430.34
265_G322_A1.2330.34
35_C287_A1.2220.33
226_G296_G1.2050.33
113_Y260_V1.1940.32
309_P342_T1.1910.32
241_F334_S1.1900.32
217_S294_G1.1880.32
20_V56_E1.1840.32
22_M26_A1.1780.32
203_G235_D1.1650.31
33_G163_G1.1640.31
20_V25_C1.1590.31
231_V339_P1.1550.31
126_S138_G1.1540.31
47_N112_D1.1490.31
182_M213_G1.1390.30
186_R208_V1.1350.30
185_A207_L1.1330.30
118_V211_L1.1230.30
125_S128_T1.1230.30
219_G265_G1.1180.29
19_A303_Q1.1080.29
116_A185_A1.1060.29
35_C80_C1.1060.29
19_A25_C1.1010.29
82_C203_G1.0990.29
118_V185_A1.0970.29
92_W118_V1.0870.28
233_L256_L1.0840.28
218_L227_E1.0830.28
262_C332_P1.0790.28
314_L322_A1.0770.28
126_S184_L1.0680.27
258_I295_V1.0670.27
175_G342_T1.0550.27
274_L316_L1.0490.27
324_S334_S1.0480.27
108_Y160_G1.0480.27
176_S355_F1.0450.27
106_N354_N1.0450.27
118_V191_Y1.0400.26
107_W168_K1.0400.26
110_I229_I1.0390.26
297_V340_P1.0390.26
286_Q333_V1.0380.26
215_I301_D1.0370.26
172_P314_L1.0350.26
274_L353_I1.0330.26
219_G340_P1.0310.26
237_F240_N1.0250.26
32_S307_I1.0230.26
122_V160_G1.0220.26
102_Y294_G1.0210.26
271_N342_T1.0150.26
73_S100_L1.0150.26
89_S276_L1.0120.25
335_T340_P1.0090.25
81_D295_V1.0010.25
257_A328_M1.0010.25
84_K114_L1.0000.25
327_R349_A1.0000.25
48_F65_D0.9990.25
137_T189_E0.9990.25
324_S331_Y0.9980.25
209_Y268_G0.9970.25
348_T351_V0.9910.25
161_N294_G0.9900.25
174_V297_V0.9890.25
25_C29_A0.9850.24
37_T206_V0.9850.24
297_V350_T0.9830.24
89_S278_A0.9810.24
278_A286_Q0.9800.24
243_V334_S0.9760.24
275_S340_P0.9750.24
120_L167_L0.9720.24
307_I334_S0.9660.24
247_K253_T0.9570.24
61_G349_A0.9550.23
276_L330_V0.9540.23
94_F187_L0.9520.23
114_L173_F0.9510.23
111_N173_F0.9500.23
132_F159_S0.9460.23
130_V134_N0.9420.23
115_A215_I0.9410.23
117_K177_V0.9340.23
251_A297_V0.9340.23
251_A334_S0.9300.23
134_N137_T0.9270.23
178_V278_A0.9260.23
231_V234_G0.9240.22
290_T348_T0.9220.22
173_F213_G0.9210.22
273_N327_R0.9200.22
175_G340_P0.9200.22
298_V351_V0.9170.22
341_E346_E0.9160.22
270_V275_S0.9140.22
258_I292_R0.9090.22
61_G74_N0.9090.22
28_T295_V0.9080.22
167_L331_Y0.9070.22
334_S337_G0.9050.22
101_V184_L0.9050.22
72_E189_E0.9020.22
293_P353_I0.8960.22
44_I191_Y0.8950.22
289_K335_T0.8910.21
245_G336_T0.8910.21
166_S291_S0.8900.21
99_P198_S0.8890.21
173_F180_P0.8810.21
25_C28_T0.8780.21
49_G94_F0.8740.21
114_L213_G0.8740.21
256_L328_M0.8690.21
96_A279_T0.8690.21
54_E171_Q0.8670.21
314_L326_A0.8640.21
219_G241_F0.8620.21
107_W178_V0.8610.20
305_N333_V0.8600.20
307_I310_A0.8580.20
265_G268_G0.8540.20
184_L272_V0.8540.20
70_W185_A0.8540.20
316_L352_R0.8500.20
107_W117_K0.8470.20
221_C343_G0.8470.20
295_V352_R0.8470.20
215_I265_G0.8440.20
100_L207_L0.8380.20
132_F163_G0.8300.20
236_V291_S0.8270.19
33_G146_C0.8270.19
292_R337_G0.8250.19
161_N233_L0.8250.19
46_V211_L0.8240.19
166_S185_A0.8210.19
109_K330_V0.8190.19
110_I115_A0.8150.19
169_I334_S0.8140.19
170_L304_N0.8140.19
63_V132_F0.8130.19
109_K112_D0.8110.19
19_A178_V0.8100.19
108_Y168_K0.8070.19
316_L350_T0.8070.19
190_C292_R0.8050.19
250_G284_Y0.8040.19
223_V236_V0.8010.19
113_Y352_R0.8010.19
283_S336_T0.7990.19
267_A279_T0.7970.19
217_S272_V0.7970.19
130_V185_A0.7960.19
286_Q298_V0.7950.19
307_I324_S0.7940.19
167_L187_L0.7930.19
171_Q326_A0.7890.18
30_A82_C0.7850.18
265_G328_M0.7840.18
278_A285_P0.7840.18
245_G334_S0.7810.18
34_Q239_A0.7810.18
129_A347_A0.7780.18
95_A201_T0.7700.18
163_G268_G0.7680.18
231_V260_V0.7660.18
106_N324_S0.7660.18
18_A39_Q0.7650.18
24_W29_A0.7620.18
275_S324_S0.7620.18
127_P164_S0.7620.18
205_P235_D0.7610.18
113_Y116_A0.7610.18
213_G345_F0.7590.18
238_A264_T0.7590.18
42_P56_E0.7570.18
56_E139_G0.7560.17
290_T297_V0.7540.17
56_E328_M0.7530.17
97_D111_N0.7500.17
161_N304_N0.7490.17
222_S261_R0.7480.17
228_T327_R0.7470.17
33_G76_Y0.7470.17
157_G215_I0.7460.17
20_V71_N0.7440.17
107_W188_Y0.7360.17
180_P340_P0.7350.17
85_D135_V0.7350.17
186_R227_E0.7340.17
168_K182_M0.7340.17
35_C241_F0.7330.17
36_H73_S0.7320.17
219_G336_T0.7290.17
201_T278_A0.7290.17
76_Y337_G0.7260.17
72_E80_C0.7250.17
121_Q161_N0.7240.17
18_A92_W0.7170.16
104_G347_A0.7150.16
244_V346_E0.7140.16
172_P234_G0.7110.16
218_L223_V0.7110.16
43_Y339_P0.7090.16
78_V157_G0.7090.16
25_C71_N0.7070.16
70_W170_L0.7030.16
243_V253_T0.7010.16
35_C340_P0.7000.16
241_F340_P0.6990.16
246_H330_V0.6980.16
61_G295_V0.6980.16
192_N295_V0.6950.16
54_E184_L0.6940.16
261_R330_V0.6940.16
259_P328_M0.6920.16
328_M351_V0.6910.16
73_S272_V0.6910.16
222_S241_F0.6900.16
214_T291_S0.6850.16
33_G82_C0.6800.16
109_K333_V0.6790.16
245_G309_P0.6770.15
56_E294_G0.6760.15
160_G187_L0.6740.15
32_S81_D0.6730.15
301_D336_T0.6650.15
18_A23_L0.6620.15
116_A209_Y0.6610.15
38_T64_K0.6600.15
172_P260_V0.6540.15
275_S355_F0.6520.15
116_A168_K0.6500.15
24_W30_A0.6500.15
113_Y216_N0.6500.15
50_V63_V0.6410.15
54_E57_A0.6400.15
246_H331_Y0.6400.15
60_A154_G0.6400.15
219_G264_T0.6380.15
217_S349_A0.6370.15
82_C231_V0.6370.15
281_D335_T0.6370.15
207_L316_L0.6350.14
78_V299_V0.6350.14
96_A99_P0.6350.14
109_K276_L0.6340.14
200_T329_N0.6340.14
41_N106_N0.6340.14
310_A334_S0.6330.14
262_C343_G0.6300.14
312_G328_M0.6290.14
85_D184_L0.6240.14
134_N199_C0.6240.14
110_I161_N0.6220.14
110_I316_L0.6210.14
234_G345_F0.6200.14
281_D307_I0.6200.14
58_N340_P0.6200.14
28_T99_P0.6200.14
260_V267_A0.6200.14
248_P335_T0.6200.14
104_G227_E0.6180.14
247_K350_T0.6180.14
174_V225_A0.6170.14
33_G276_L0.6150.14
288_I334_S0.6150.14
72_E207_L0.6120.14
278_A296_G0.6110.14
107_W317_S0.6100.14
184_L295_V0.6090.14
126_S258_I0.6090.14
22_M97_D0.6090.14
276_L288_I0.6090.14
133_E318_I0.6080.14
96_A100_L0.6080.14
69_Q84_K0.6070.14
159_S207_L0.6000.14
78_V206_V0.5990.14
335_T348_T0.5990.14
45_G48_F0.5990.14
56_E232_D0.5970.14
277_T289_K0.5940.14
37_T160_G0.5940.14
201_T206_V0.5930.14
263_N286_Q0.5920.14
113_Y337_G0.5920.14
248_P333_V0.5920.14
132_F136_G0.5910.14
179_I315_P0.5910.14
178_V214_T0.5910.14
56_E127_P0.5900.13
86_N148_P0.5900.13
173_F334_S0.5890.13
275_S297_V0.5890.13
93_A100_L0.5880.13
188_Y236_V0.5880.13
174_V309_P0.5870.13
281_D331_Y0.5860.13
286_Q306_I0.5820.13
116_A206_V0.5810.13
265_G270_V0.5810.13
159_S282_P0.5770.13
80_C176_S0.5770.13
110_I258_I0.5770.13
173_F222_S0.5750.13
31_Y39_Q0.5690.13
241_F326_A0.5680.13
213_G219_G0.5670.13
119_L288_I0.5660.13
175_G180_P0.5650.13
134_N201_T0.5650.13
267_A291_S0.5650.13
82_C167_L0.5640.13
248_P345_F0.5640.13
117_K215_I0.5640.13
260_V347_A0.5640.13
270_V300_T0.5640.13
77_Y210_Y0.5620.13
97_D199_C0.5610.13
120_L185_A0.5610.13
79_S147_D0.5610.13
23_L301_D0.5600.13
316_L351_V0.5600.13
245_G292_R0.5600.13
226_G238_A0.5590.13
240_N355_F0.5580.13
255_E353_I0.5580.13
131_P245_G0.5550.13
287_A298_V0.5540.13
28_T198_S0.5510.13
322_A347_A0.5500.13
56_E169_I0.5470.13
251_A316_L0.5460.13
165_F346_E0.5460.13
283_S326_A0.5450.13
224_N254_A0.5440.13
294_G337_G0.5430.12
102_Y105_D0.5420.12
60_A172_P0.5400.12
127_P132_F0.5380.12
179_I248_P0.5370.12
275_S352_R0.5370.12
95_A206_V0.5360.12
161_N209_Y0.5360.12
189_E233_L0.5350.12
25_C39_Q0.5290.12
172_P175_G0.5290.12
278_A351_V0.5290.12
217_S230_E0.5290.12
61_G292_R0.5240.12
200_T259_P0.5240.12
231_V254_A0.5240.12
21_L125_S0.5220.12
94_F121_Q0.5210.12
292_R334_S0.5190.12
313_T355_F0.5150.12
309_P352_R0.5140.12
239_A258_I0.5140.12
115_A229_I0.5140.12
316_L324_S0.5130.12
93_A187_L0.5120.12
43_Y208_V0.5120.12
61_G111_N0.5110.12
325_I349_A0.5110.12
219_G294_G0.5100.12
335_T352_R0.5090.12
278_A301_D0.5070.12
215_I323_D0.5050.12
307_I331_Y0.5030.12
221_C296_G0.5020.12
176_S214_T0.5020.12
76_Y207_L0.5020.12
116_A160_G0.5010.12
183_A186_R0.5010.12
175_G241_F0.5000.12
135_V141_T0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5afoA 1 0.8848 100 0.503 Contact Map
1n12A 1 0.3511 99.8 0.808 Contact Map
2w07B 1 0.3315 99.7 0.817 Contact Map
1pdkB 1 0.382 99.7 0.82 Contact Map
2jmrA 1 0.4073 99.7 0.823 Contact Map
2xg5B 1 0.3848 99.7 0.825 Contact Map
2jtyA 1 0.4157 99.7 0.825 Contact Map
3jwnH 1 0.7528 99.7 0.828 Contact Map
3bwuF 1 0.3315 99.7 0.831 Contact Map
2uy6B 2 0.4045 99.6 0.832 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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