GREMLIN Database
ELFC - Probable outer membrane usher protein ElfC
UniProt: P75857 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13711
Length: 866 (777)
Sequences: 2655 (1991)
Seq/√Len: 71.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_C125_C5.1741.00
252_D266_R4.7501.00
666_R683_A4.6631.00
706_V737_A4.5201.00
698_G733_V4.4601.00
181_F201_L4.3121.00
800_A833_V4.2561.00
296_A337_E4.2491.00
785_V825_L4.1981.00
332_L344_S4.1111.00
361_I389_W4.0931.00
361_I387_L4.0691.00
288_V300_I4.0631.00
265_F382_F4.0621.00
668_G681_N3.9171.00
526_G551_Y3.8421.00
336_K342_V3.6381.00
709_A776_E3.5941.00
297_Q336_K3.3681.00
690_A695_I3.3601.00
688_L697_L3.3501.00
334_E342_V3.3201.00
802_A820_L3.3011.00
211_P239_R3.2701.00
829_G847_Y3.2431.00
293_K341_S3.2121.00
67_V83_N3.1411.00
529_Y550_G3.1231.00
638_S655_S3.0841.00
70_V139_F3.0221.00
301_K306_T2.9621.00
566_Y577_Q2.9611.00
553_T560_L2.9301.00
802_A831_I2.9191.00
365_V385_A2.9081.00
335_I343_N2.8911.00
609_S621_Q2.8751.00
705_N772_L2.8411.00
73_V145_R2.8321.00
640_Q653_S2.8091.00
789_T845_I2.8071.00
214_L237_L2.7451.00
665_A684_L2.7221.00
181_F199_Y2.6821.00
214_L235_S2.6631.00
206_G215_R2.6441.00
70_V86_F2.6271.00
299_T306_T2.6261.00
293_K343_N2.6161.00
830_T844_H2.6061.00
427_D447_R2.5961.00
663_A684_L2.5811.00
552_N561_G2.5761.00
172_I707_L2.5291.00
138_T147_E2.5141.00
218_S230_W2.5121.00
183_G199_Y2.4871.00
709_A774_L2.4711.00
140_N143_K2.4641.00
241_V244_L2.4531.00
845_I863_A2.4461.00
696_T727_D2.4401.00
789_T833_V2.4321.00
207_V214_L2.4251.00
174_A772_L2.4231.00
253_D265_F2.4151.00
802_A833_V2.4151.00
433_S479_T2.4141.00
67_V85_N2.4081.00
86_F97_A2.3721.00
691_H696_T2.3701.00
137_V148_I2.3401.00
688_L695_I2.3311.00
301_K332_L2.2991.00
173_N207_V2.2791.00
289_R318_E2.2561.00
38_W41_P2.2511.00
656_M667_V2.2451.00
69_R83_N2.2451.00
249_T271_A2.2441.00
128_L135_A2.2361.00
563_S580_A2.2241.00
706_V745_I2.2111.00
299_T336_K2.1921.00
687_S698_G2.1881.00
110_N113_A2.1571.00
185_N197_D2.1571.00
177_L205_S2.1551.00
743_N767_P2.1121.00
830_T846_N2.1081.00
534_Q545_R2.1071.00
179_Y686_G2.0891.00
530_L549_F2.0871.00
409_A429_T2.0801.00
132_I135_A2.0771.00
687_S701_L2.0691.00
127_P130_E2.0581.00
301_K334_E2.0571.00
692_S774_L2.0521.00
790_S796_L2.0391.00
274_D362_K2.0271.00
558_L583_F2.0161.00
175_L207_V2.0111.00
72_I84_V2.0001.00
710_A713_A1.9911.00
790_S794_I1.9911.00
565_N578_V1.9781.00
707_L731_Y1.9731.00
693_Q774_L1.9461.00
430_Q444_Q1.9071.00
260_F400_G1.8981.00
642_G651_N1.8851.00
831_I845_I1.8781.00
249_T253_D1.8741.00
789_T820_L1.8661.00
691_H731_Y1.8621.00
398_Y427_D1.8581.00
162_Y165_P1.8521.00
426_F448_F1.8521.00
292_A312_V1.8461.00
298_I335_I1.8371.00
265_F366_T1.8331.00
240_A740_Y1.8261.00
238_Q247_E1.8231.00
611_T619_T1.8191.00
562_I581_L1.8071.00
402_Q476_L1.8051.00
693_Q709_A1.8031.00
300_I319_I1.7811.00
742_E764_N1.7761.00
783_A827_A1.7711.00
73_V147_E1.7661.00
63_I95_I1.7531.00
701_L705_N1.7421.00
213_R768_T1.7391.00
609_S623_L1.7361.00
660_G665_A1.7291.00
74_L155_I1.7241.00
100_T103_S1.7201.00
755_N783_A1.7181.00
525_Y551_Y1.7171.00
279_D741_R1.7021.00
73_V78_I1.7011.00
239_R248_L1.6981.00
561_G582_N1.6901.00
266_R371_R1.6831.00
555_I560_L1.6771.00
240_A247_E1.6761.00
216_N232_N1.6721.00
63_I141_V1.6691.00
608_T624_G1.6681.00
639_V654_A1.6611.00
630_L634_N1.6591.00
796_L833_V1.6551.00
613_I618_H1.6440.99
140_N147_E1.6430.99
800_A835_W1.6400.99
246_G363_Y1.6380.99
703_E769_K1.6290.99
724_L732_T1.6280.99
253_D366_T1.6250.99
432_K440_E1.6230.99
335_I345_Y1.6220.99
445_S469_S1.6210.99
710_A779_A1.6160.99
250_V268_V1.6130.99
220_W228_A1.6100.99
216_N235_S1.5950.99
175_L690_A1.5950.99
332_L346_S1.5940.99
333_V345_Y1.5920.99
789_T796_L1.5910.99
422_G450_Y1.5900.99
84_V97_A1.5850.99
170_E242_I1.5850.99
71_D81_T1.5780.99
445_S467_R1.5760.99
805_D809_A1.5750.99
369_K381_K1.5700.99
390_G396_T1.5630.99
241_V270_L1.5630.99
265_F269_Q1.5610.99
828_K848_E1.5590.99
275_N769_K1.5580.99
334_E344_S1.5500.99
176_L705_N1.5490.99
716_T726_T1.5480.99
274_D360_R1.5340.99
391_G397_W1.5310.99
687_S705_N1.5310.99
660_G663_A1.5220.99
101_T105_D1.5100.99
299_T309_Q1.5040.99
176_L772_L1.5010.99
654_A669_Y1.4990.99
836_G841_Q1.4980.99
395_T416_F1.4970.99
759_E778_N1.4850.99
333_V347_V1.4840.99
172_I774_L1.4840.99
408_R432_K1.4750.99
629_L637_Y1.4740.99
103_S107_M1.4670.99
259_F411_M1.4630.99
347_V355_L1.4620.99
297_Q309_Q1.4550.99
398_Y413_G1.4360.99
288_V331_L1.4360.99
432_K442_K1.4250.99
718_V734_V1.4240.99
269_Q364_A1.4220.98
671_Y678_Q1.4170.98
212_W239_R1.4170.98
787_M861_M1.3990.98
364_A386_T1.3990.98
369_K379_E1.3980.98
205_S216_N1.3910.98
788_K862_D1.3870.98
240_A768_T1.3860.98
180_S685_S1.3800.98
630_L635_L1.3670.98
149_S313_S1.3610.98
273_D769_K1.3590.98
631_D634_N1.3580.98
139_F146_L1.3470.98
358_Q393_W1.3420.98
513_K535_Q1.3420.98
330_D346_S1.3390.98
270_L365_V1.3310.98
635_L658_Y1.3300.98
767_P773_V1.3230.98
261_D475_T1.3220.98
564_W579_F1.3140.97
788_K819_S1.3070.97
462_Q515_Q1.3060.97
176_L206_G1.3050.97
110_N156_K1.2970.97
643_Y650_A1.2940.97
689_V707_L1.2940.97
832_S844_H1.2930.97
558_L585_L1.2910.97
564_W577_Q1.2880.97
664_D685_S1.2810.97
86_F95_I1.2790.97
709_A731_Y1.2770.97
787_M822_M1.2740.97
526_G553_T1.2720.97
789_T814_I1.2660.97
319_I322_L1.2650.97
395_T414_L1.2550.97
689_V705_N1.2460.97
560_L581_L1.2410.96
139_F144_L1.2400.96
217_N234_S1.2390.96
785_V849_L1.2310.96
444_Q470_T1.2250.96
173_N209_L1.2250.96
717_R751_S1.2220.96
241_V248_L1.2130.96
157_S320_S1.2070.96
223_S226_Q1.2050.96
607_M623_L1.2030.96
155_I313_S1.2010.96
173_N772_L1.1970.96
367_L381_K1.1890.95
65_P88_E1.1890.95
557_D589_L1.1830.95
512_G536_T1.1820.95
696_T729_R1.1790.95
295_N337_E1.1790.95
370_Y480_M1.1750.95
787_M845_I1.1750.95
787_M820_L1.1720.95
150_V155_I1.1720.95
300_I310_T1.1700.95
445_S538_W1.1650.95
183_G682_Y1.1600.95
511_R538_W1.1490.95
74_L79_V1.1470.94
149_S314_P1.1460.94
390_G422_G1.1450.94
299_T334_E1.1440.94
252_D371_R1.1410.94
768_T771_A1.1410.94
296_A339_D1.1400.94
187_I678_Q1.1370.94
562_I579_F1.1340.94
437_D441_H1.1240.94
829_G849_L1.1220.94
330_D348_P1.1200.94
802_A822_M1.1190.94
178_G204_N1.1140.94
105_D156_K1.1140.94
832_S842_I1.1130.94
71_D78_I1.1130.94
838_A841_Q1.1110.93
797_R835_W1.1110.93
457_L520_Q1.1100.93
714_E728_W1.1020.93
287_V318_E1.1010.93
170_E211_P1.0990.93
160_R323_Y1.0980.93
726_T730_G1.0930.93
285_A357_R1.0910.93
826_P829_G1.0870.93
687_S733_V1.0860.93
167_R742_E1.0850.93
531_S548_Q1.0830.93
726_T784_R1.0770.92
322_L325_T1.0750.92
622_N638_S1.0740.92
528_F551_Y1.0710.92
59_K92_E1.0710.92
266_R369_K1.0680.92
173_N692_S1.0660.92
624_G638_S1.0660.92
613_I619_T1.0650.92
102_E106_A1.0640.92
833_V845_I1.0640.92
297_Q311_Y1.0590.92
132_I154_A1.0550.92
516_V530_L1.0530.91
441_H472_G1.0450.91
263_V402_Q1.0400.91
801_I810_N1.0370.91
356_Q387_L1.0360.91
269_Q366_T1.0350.91
304_G332_L1.0340.91
696_T731_Y1.0310.91
475_T478_D1.0290.91
84_V146_L1.0280.90
82_R106_A1.0270.90
300_I308_Y1.0220.90
624_G653_S1.0210.90
710_A716_T1.0180.90
659_K664_D1.0160.90
689_V772_L1.0160.90
213_R770_G1.0160.90
691_H694_G1.0150.90
696_T707_L1.0070.90
797_R800_A1.0030.89
208_N215_R1.0000.89
213_R771_A0.9980.89
522_L525_Y0.9980.89
519_S529_Y0.9970.89
652_G671_Y0.9960.89
607_M625_L0.9880.89
765_V773_V0.9880.89
54_L58_E0.9860.89
655_S668_G0.9840.88
104_L109_V0.9840.88
135_A150_V0.9830.88
835_W842_I0.9820.88
605_A625_L0.9800.88
428_A446_Y0.9800.88
356_Q361_I0.9750.88
172_I772_L0.9740.88
36_E59_K0.9730.88
245_K277_L0.9710.88
47_D50_M0.9700.88
659_K699_Q0.9700.88
41_P45_K0.9640.87
635_L656_M0.9630.87
405_E616_E0.9620.87
278_P390_G0.9610.87
71_D145_R0.9600.87
353_P382_F0.9580.87
76_Q147_E0.9570.87
719_A746_A0.9560.87
253_D269_Q0.9550.87
383_A403_Y0.9540.87
254_Y264_S0.9510.87
183_G197_D0.9510.87
478_D481_Y0.9510.87
610_N622_N0.9390.86
172_I692_S0.9390.86
417_N423_A0.9380.86
212_W237_L0.9350.86
290_G317_F0.9310.86
55_S58_E0.9310.86
396_T422_G0.9300.85
136_S149_S0.9230.85
657_D664_D0.9220.85
72_I82_R0.9190.85
785_V824_G0.9180.85
298_I312_V0.9170.85
727_D730_G0.9170.85
216_N230_W0.9150.85
706_V773_V0.9120.84
367_L383_A0.9110.84
805_D808_Q0.9100.84
459_T468_Y0.9100.84
382_F476_L0.9090.84
693_Q697_L0.9070.84
233_L371_R0.9050.84
789_T863_A0.8970.83
204_N217_N0.8940.83
211_P768_T0.8940.83
322_L357_R0.8930.83
783_A850_T0.8930.83
763_V775_A0.8930.83
476_L480_M0.8920.83
232_N252_D0.8900.83
352_V362_K0.8900.83
792_Q795_P0.8870.83
748_D751_S0.8860.83
425_S449_L0.8840.82
783_A859_T0.8810.82
717_R748_D0.8810.82
434_T440_E0.8810.82
737_A741_R0.8810.82
104_L148_I0.8780.82
128_L132_I0.8780.82
272_S363_Y0.8780.82
687_S690_A0.8760.82
356_Q360_R0.8750.82
79_V107_M0.8740.82
317_F337_E0.8740.82
222_R228_A0.8710.82
329_G390_G0.8700.81
715_N725_K0.8700.81
382_F402_Q0.8690.81
418_L424_I0.8670.81
744_R762_V0.8670.81
271_A364_A0.8660.81
258_D473_F0.8650.81
651_N678_Q0.8640.81
782_G824_G0.8630.81
169_D172_I0.8600.81
76_Q662_F0.8590.81
708_I718_V0.8580.81
161_G280_S0.8580.81
121_D124_A0.8560.80
696_T733_V0.8560.80
399_G411_M0.8550.80
325_T460_N0.8540.80
708_I734_V0.8540.80
560_L583_F0.8540.80
522_L526_G0.8500.80
689_V733_V0.8500.80
333_V608_T0.8460.80
184_A679_Q0.8450.80
295_N314_P0.8450.80
290_G686_G0.8440.79
365_V387_L0.8430.79
756_V781_A0.8420.79
674_N678_Q0.8410.79
707_L774_L0.8390.79
50_M53_D0.8390.79
637_Y641_Q0.8380.79
567_S578_V0.8360.79
611_T621_Q0.8350.79
294_S341_S0.8350.79
669_Y678_Q0.8350.79
171_G694_G0.8350.79
84_V300_I0.8340.79
98_C355_L0.8310.78
210_G239_R0.8280.78
286_P290_G0.8260.78
237_L250_V0.8260.78
814_I820_L0.8250.78
862_D865_C0.8250.78
784_R823_A0.8240.78
236_Y770_G0.8230.78
40_D43_F0.8210.78
283_G325_T0.8180.77
72_I335_I0.8170.77
759_E780_H0.8170.77
282_K741_R0.8160.77
255_T265_F0.8150.77
406_Y434_T0.8150.77
97_A103_S0.8070.76
355_L390_G0.8070.76
153_I318_E0.8060.76
473_F650_A0.8040.76
713_A779_A0.8030.76
293_K337_E0.8030.76
641_Q652_G0.8020.76
474_Y482_K0.8020.76
699_Q723_G0.8020.76
703_E739_S0.8010.76
815_D819_S0.8010.76
282_K323_Y0.8000.76
624_G640_Q0.7990.76
170_E768_T0.7970.75
828_K846_N0.7960.75
760_N763_V0.7950.75
335_I347_V0.7940.75
53_D56_R0.7940.75
246_G270_L0.7940.75
449_L462_Q0.7930.75
699_Q724_L0.7920.75
75_N730_G0.7910.75
717_R725_K0.7880.75
250_V253_D0.7870.74
40_D60_G0.7870.74
566_Y575_A0.7850.74
825_L829_G0.7840.74
587_L590_L0.7840.74
441_H474_Y0.7840.74
248_L270_L0.7790.74
689_V701_L0.7790.74
397_W847_Y0.7790.74
97_A146_L0.7780.74
264_S370_Y0.7780.74
753_K756_V0.7770.74
829_G848_E0.7750.73
292_A317_F0.7730.73
245_K272_S0.7700.73
391_G414_L0.7700.73
711_P776_E0.7700.73
272_S277_L0.7690.73
790_S795_P0.7690.73
429_T445_S0.7680.73
176_L687_S0.7640.72
354_L415_G0.7630.72
663_A698_G0.7620.72
821_Y858_I0.7620.72
36_E58_E0.7600.72
724_L735_P0.7590.72
459_T518_I0.7590.72
178_G705_N0.7560.71
313_S316_A0.7560.71
326_S509_T0.7550.71
101_T177_L0.7550.71
200_F219_T0.7540.71
568_K575_A0.7530.71
45_K51_V0.7530.71
708_I720_N0.7510.71
547_L564_W0.7500.71
178_G687_S0.7500.71
691_H707_L0.7490.71
478_D510_K0.7490.71
109_V150_V0.7460.70
268_V791_K0.7460.70
286_P292_A0.7450.70
286_P390_G0.7450.70
464_M516_V0.7440.70
529_Y548_Q0.7440.70
359_G390_G0.7430.70
69_R81_T0.7420.70
290_G329_G0.7380.70
274_D282_K0.7380.70
796_L818_G0.7380.70
804_L808_Q0.7360.69
398_Y411_M0.7360.69
180_S718_V0.7360.69
366_T384_Q0.7360.69
459_T520_Q0.7350.69
749_A761_A0.7350.69
398_Y447_R0.7340.69
100_T137_V0.7330.69
155_I268_V0.7330.69
445_S466_Y0.7330.69
860_R863_A0.7310.69
218_S232_N0.7290.69
508_Y540_T0.7280.69
585_L617_G0.7280.69
535_Q544_D0.7270.69
247_E273_D0.7270.69
857_A861_M0.7270.69
337_E341_S0.7270.69
225_G403_Y0.7250.68
674_N677_Q0.7250.68
310_T319_I0.7250.68
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226_Q383_A0.5050.42
622_N640_Q0.5050.42
172_I688_L0.5040.42
398_Y429_T0.5040.42
631_D838_A0.5040.42
248_L636_S0.5040.42
44_F575_A0.5040.42
178_G653_S0.5040.42
322_L331_L0.5040.42
710_A747_L0.5030.42
106_A148_I0.5030.42
704_T723_G0.5030.42
243_P442_K0.5030.42
84_V692_S0.5030.42
721_S724_L0.5030.42
780_H821_Y0.5020.42
364_A588_N0.5020.42
78_I81_T0.5020.42
52_A57_F0.5020.42
516_V801_I0.5010.42
471_S538_W0.5010.42
344_S519_S0.5010.42
326_S445_S0.5010.42
97_A137_V0.5010.42
399_G739_S0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rfzB 2 0.8938 100 0.079 Contact Map
3fipA 1 0.5058 100 0.467 Contact Map
3fcgA 2 0.0866 100 0.845 Contact Map
4b0mA 1 0.149 100 0.848 Contact Map
3bwuD 1 0.1397 99.9 0.859 Contact Map
2xetA 1 0.0982 99.6 0.907 Contact Map
3l48A 1 0.097 99.4 0.917 Contact Map
4oq1A 1 0.2009 93 0.968 Contact Map
3phsA 1 0.2021 83.7 0.973 Contact Map
3e8vA 1 0.0878 80.3 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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