GREMLIN Database
ELFA - Fimbrial subunit ElfA
UniProt: P75855 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13709
Length: 179 (161)
Sequences: 3304 (2597)
Seq/√Len: 204.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
118_T164_T3.0951.00
107_A121_A3.0681.00
122_L155_V3.0601.00
44_T83_D2.8581.00
123_Q158_I2.8151.00
125_Y156_D2.7911.00
66_T69_Q2.7741.00
123_Q156_D2.7531.00
92_A176_I2.7061.00
78_P150_T2.6981.00
108_F135_P2.6621.00
46_V82_K2.5681.00
157_Y168_V2.4651.00
110_N168_V2.3641.00
119_N163_A2.3151.00
80_E150_T2.1211.00
116_A167_N2.0491.00
108_F172_T2.0051.00
126_M130_T1.9751.00
122_L170_A1.9441.00
65_Q69_Q1.9421.00
129_G154_K1.9401.00
78_P152_T1.8641.00
46_V80_E1.7151.00
76_D154_K1.6531.00
26_A29_D1.6511.00
46_V49_T1.6301.00
47_A52_S1.5961.00
97_N175_H1.5381.00
134_T137_T1.5081.00
91_N143_L1.4971.00
76_D152_T1.4731.00
49_T52_S1.4661.00
106_T134_T1.4511.00
37_K58_D1.4411.00
107_A158_I1.4321.00
97_N136_D1.4301.00
77_V124_M1.4131.00
49_T80_E1.4131.00
56_L157_Y1.4081.00
93_T177_N1.3921.00
73_V156_D1.3911.00
98_G108_F1.3831.00
70_V123_Q1.3591.00
57_P72_G1.3501.00
14_C17_S1.3441.00
144_L149_Q1.3311.00
57_P75_I1.3111.00
57_P168_V1.3091.00
52_S79_I1.2811.00
22_A26_A1.2471.00
107_A123_Q1.1871.00
102_T105_I1.1861.00
59_V71_S1.1521.00
64_L163_A1.1441.00
66_T159_A1.1391.00
100_A135_P1.1361.00
159_A162_K1.1331.00
30_G34_F1.1191.00
16_T19_V1.1111.00
102_T121_A1.1101.00
92_A149_Q1.1091.00
19_V23_D1.1031.00
64_L159_A1.0781.00
44_T82_K1.0771.00
93_T141_N1.0741.00
56_L168_V1.0731.00
91_N141_N1.0701.00
20_M24_D1.0691.00
30_G174_F1.0621.00
100_A106_T1.0581.00
17_S20_M1.0541.00
108_F170_A1.0531.00
63_K71_S1.0531.00
101_D160_T1.0521.00
95_T177_N1.0491.00
94_F151_L1.0421.00
67_N162_K1.0361.00
101_D105_I1.0221.00
95_T138_E1.0211.00
115_D167_N1.0201.00
124_M172_T1.0101.00
33_T171_V0.9951.00
40_A61_A0.9921.00
127_N152_T0.9891.00
70_V156_D0.9851.00
13_V16_T0.9721.00
60_S63_K0.9610.99
64_L160_T0.9440.99
21_A25_N0.9410.99
59_V157_Y0.9410.99
19_V22_A0.9300.99
120_V157_Y0.9280.99
110_N115_D0.9240.99
96_F153_F0.9200.99
65_Q159_A0.9160.99
111_Q171_V0.9060.99
54_V77_V0.9060.99
140_G143_L0.9040.99
12_V15_A0.9010.99
117_A120_V0.8900.99
16_T20_M0.8890.99
56_L122_L0.8870.99
64_L69_Q0.8850.99
101_D104_Q0.8800.99
125_Y154_K0.8780.99
59_V168_V0.8660.99
38_V163_A0.8640.99
20_M23_D0.8600.99
18_S22_A0.8560.99
159_A163_A0.8550.99
31_S51_D0.8540.99
64_L120_V0.8450.99
35_N53_V0.8400.99
70_V73_V0.8390.99
70_V158_I0.8350.99
123_Q131_T0.8310.99
81_L149_Q0.8290.98
15_A18_S0.8280.98
18_S21_A0.8270.98
119_N161_G0.8270.98
96_F124_M0.8270.98
59_V64_L0.8250.98
93_T139_T0.8210.98
71_S75_I0.8160.98
93_T138_E0.8120.98
42_A157_Y0.8110.98
111_Q169_N0.8090.98
17_S22_A0.8050.98
13_V17_S0.8030.98
17_S21_A0.8020.98
15_A20_M0.8010.98
61_A165_S0.7990.98
121_A160_T0.7880.98
33_T51_D0.7860.98
52_S174_F0.7740.98
104_Q107_A0.7700.98
79_I174_F0.7670.98
122_L168_V0.7660.97
20_M25_N0.7560.97
94_F176_I0.7540.97
35_N55_T0.7490.97
145_Q149_Q0.7400.97
19_V24_D0.7380.97
125_Y131_T0.7340.97
23_D26_A0.7310.97
25_N29_D0.7170.96
40_A85_D0.7170.96
110_N169_N0.7140.96
99_T109_A0.7140.96
158_I162_K0.7070.96
18_S23_D0.7050.96
56_L155_V0.7020.96
24_D28_T0.6990.96
120_V163_A0.6940.96
111_Q116_A0.6900.95
47_A50_K0.6850.95
95_T98_G0.6830.95
72_G75_I0.6790.95
56_L123_Q0.6760.95
33_T53_V0.6750.95
22_A25_N0.6720.95
78_P100_A0.6570.94
85_D125_Y0.6570.94
25_N28_T0.6540.94
67_N159_A0.6490.94
21_A24_D0.6430.93
55_T75_I0.6380.93
55_T157_Y0.6310.93
47_A82_K0.6290.93
21_A26_A0.6290.93
56_L75_I0.6250.92
88_V94_F0.6250.92
28_T31_S0.6240.92
30_G36_G0.6240.92
38_V59_V0.6220.92
67_N119_N0.6220.92
70_V125_Y0.6210.92
97_N173_N0.6200.92
12_V16_T0.6190.92
16_T23_D0.6190.92
13_V162_K0.6170.92
22_A29_D0.6080.91
103_T106_T0.6060.91
48_A52_S0.6000.91
56_L156_D0.5990.91
110_N120_V0.5960.90
61_A163_A0.5910.90
57_P169_N0.5900.90
54_V155_V0.5850.90
32_V48_A0.5840.90
46_V148_D0.5840.90
73_V154_K0.5750.89
101_D109_A0.5710.88
133_I153_F0.5710.88
23_D28_T0.5700.88
125_Y129_G0.5690.88
48_A80_E0.5690.88
105_I108_F0.5680.88
126_M131_T0.5670.88
12_V17_S0.5670.88
64_L68_G0.5670.88
82_K148_D0.5660.88
131_T134_T0.5630.88
92_A139_T0.5630.88
121_A158_I0.5630.88
110_N117_A0.5540.87
77_V155_V0.5530.87
69_Q159_A0.5510.87
95_T136_D0.5500.87
135_P172_T0.5500.87
133_I139_T0.5500.87
14_C21_A0.5480.86
121_A134_T0.5460.86
101_D106_T0.5440.86
125_Y158_I0.5420.86
33_T169_N0.5420.86
53_V173_N0.5380.85
142_I145_Q0.5370.85
101_D107_A0.5360.85
61_A71_S0.5320.85
15_A19_V0.5320.85
119_N160_T0.5290.84
54_V150_T0.5280.84
67_N160_T0.5270.84
80_E148_D0.5270.84
86_T146_D0.5250.84
171_V176_I0.5230.84
64_L157_Y0.5220.84
101_D121_A0.5190.83
85_D88_V0.5180.83
67_N163_A0.5140.83
96_F174_F0.5140.83
30_G79_I0.5130.83
128_D140_G0.5120.82
92_A144_L0.5100.82
64_L67_N0.5080.82
12_V19_V0.5060.82
108_F122_L0.5030.81
63_K72_G0.5010.81
110_N163_A0.5010.81
67_N161_G0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jmrA 1 0.838 100 0.25 Contact Map
2jtyA 1 0.8659 100 0.256 Contact Map
2xg5B 1 0.7765 100 0.28 Contact Map
2uy6B 2 0.7989 100 0.288 Contact Map
1pdkB 1 0.7709 100 0.294 Contact Map
3bwuF 1 0.6872 99.9 0.353 Contact Map
4dwhB 1 0.7486 99.9 0.373 Contact Map
2w07B 1 0.648 99.9 0.381 Contact Map
3bfqG 1 0.7207 99.9 0.39 Contact Map
5afoA 1 0.9497 99.9 0.399 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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