GREMLIN Database
SSUA - Putative aliphatic sulfonates-binding protein
UniProt: P75853 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13707
Length: 319 (297)
Sequences: 14250 (10754)
Seq/√Len: 624.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_R231_A3.6051.00
243_Q246_Q3.4741.00
239_L243_Q3.3641.00
52_R235_E3.3351.00
131_K159_Q3.2841.00
99_V216_R3.2181.00
218_Y222_N3.1711.00
97_D216_R3.0951.00
128_K157_D3.0261.00
216_R220_E3.0001.00
303_D306_Q2.9531.00
51_K235_E2.9391.00
217_P221_K2.8661.00
227_Q231_A2.8431.00
28_A59_S2.8121.00
133_A177_V2.7051.00
49_L233_F2.6911.00
249_A259_A2.6521.00
28_A57_K2.5651.00
123_T126_D2.5321.00
30_R59_S2.5251.00
245_E263_A2.4671.00
286_Q290_D2.4081.00
238_A242_S2.3151.00
26_P57_K2.2691.00
290_D294_E2.2521.00
222_N225_F2.1821.00
154_K157_D2.1641.00
46_H246_Q2.1571.00
184_D188_S2.1521.00
32_G78_I2.1421.00
122_K126_D2.1091.00
141_H145_L2.0361.00
48_L235_E2.0131.00
214_A219_A2.0001.00
80_L214_A1.9931.00
293_Y301_K1.9301.00
130_H178_D1.9161.00
259_A263_A1.8951.00
149_R294_E1.8761.00
163_L171_A1.8341.00
48_L239_L1.7821.00
263_A267_D1.7731.00
224_A228_G1.7531.00
246_Q249_A1.7441.00
45_S253_K1.7421.00
48_L232_T1.7401.00
214_A226_I1.7131.00
153_L157_D1.6921.00
201_D204_D1.6381.00
219_A226_I1.6381.00
258_P261_V1.6321.00
234_S238_A1.6181.00
218_Y226_I1.5881.00
239_L246_Q1.5801.00
125_A151_A1.5681.00
240_T247_S1.5641.00
148_L153_L1.5531.00
46_H239_L1.5441.00
80_L229_V1.5431.00
127_L179_A1.5381.00
132_V179_A1.5331.00
100_Y211_F1.5271.00
282_A286_Q1.5141.00
228_G232_T1.5121.00
92_Q216_R1.5111.00
80_L226_I1.5081.00
223_G227_Q1.4781.00
131_K161_T1.4781.00
83_T213_L1.4701.00
122_K197_R1.4681.00
102_G230_L1.4661.00
282_A305_R1.4471.00
48_L51_K1.4461.00
248_I263_A1.4451.00
290_D301_K1.4251.00
218_Y225_F1.4101.00
52_R228_G1.4041.00
125_A128_K1.3771.00
189_A193_Q1.3761.00
131_K178_D1.3651.00
63_F72_A1.3621.00
68_Q71_E1.3511.00
69_M81_G1.3331.00
148_L158_I1.3261.00
124_V147_A1.3091.00
47_Q50_E1.3031.00
30_R61_V1.3001.00
245_E249_A1.2731.00
15_V18_F1.2711.00
52_R232_T1.2691.00
44_K50_E1.2681.00
224_A227_Q1.2631.00
168_A180_W1.2551.00
260_P263_A1.2321.00
164_T167_D1.2301.00
264_S267_D1.2281.00
39_G237_D1.2191.00
283_A287_Q1.2171.00
72_A77_S1.2151.00
192_L264_S1.2101.00
116_A175_G1.2091.00
43_A236_A1.2091.00
291_L295_N1.2071.00
215_A218_Y1.1911.00
124_V151_A1.1801.00
177_V180_W1.1721.00
53_Y56_S1.1661.00
76_G217_P1.1641.00
42_L239_L1.1641.00
101_V226_I1.1571.00
121_I130_H1.1531.00
48_L52_R1.1511.00
30_R79_D1.1511.00
56_S228_G1.1471.00
173_Q193_Q1.1461.00
42_L250_L1.1341.00
116_A119_S1.1221.00
73_L81_G1.1151.00
112_V187_Y1.1101.00
99_V219_A1.1101.00
146_R149_R1.1061.00
43_A49_L1.0951.00
50_E53_Y1.0901.00
134_F160_P1.0831.00
32_G63_F1.0831.00
289_A302_V1.0791.00
116_A172_F1.0731.00
66_G87_P1.0721.00
49_L58_I1.0721.00
244_R248_I1.0691.00
117_E197_R1.0681.00
115_V119_S1.0681.00
225_F228_G1.0461.00
249_A253_K1.0461.00
171_A177_V1.0381.00
30_R78_I1.0351.00
244_R267_D1.0291.00
27_E222_N1.0221.00
42_L46_H1.0201.00
238_A241_R1.0161.00
101_V214_A1.0131.00
144_L160_P1.0111.00
248_I259_A1.0071.00
170_A173_Q0.9961.00
246_Q250_L0.9921.00
202_G206_N0.9851.00
191_L264_S0.9761.00
113_I181_A0.9701.00
146_R150_Q0.9661.00
25_S222_N0.9611.00
169_R173_Q0.9601.00
45_S250_L0.9511.00
283_A286_Q0.9491.00
53_Y228_G0.9441.00
72_A78_I0.9391.00
112_V198_V0.9371.00
49_L53_Y0.9291.00
289_A301_K0.9271.00
80_L101_V0.9271.00
73_L213_L0.9261.00
187_Y191_L0.9201.00
74_N96_A0.9201.00
170_A174_Q0.9201.00
88_P213_L0.9171.00
101_V230_L0.9151.00
18_F21_A0.9071.00
172_F177_V0.9051.00
290_D293_Y0.9021.00
198_V201_D0.8991.00
50_E57_K0.8991.00
117_E195_G0.8961.00
115_V179_A0.8941.00
46_H250_L0.8931.00
217_P220_E0.8911.00
289_A293_Y0.8831.00
120_P197_R0.8831.00
21_A24_S0.8831.00
239_L247_S0.8801.00
128_K153_L0.8731.00
132_V158_I0.8721.00
83_T88_P0.8711.00
260_P264_S0.8651.00
118_N175_G0.8641.00
27_E30_R0.8631.00
97_D217_P0.8631.00
147_A151_A0.8591.00
286_Q304_I0.8511.00
202_G205_L0.8501.00
237_D241_R0.8501.00
218_Y223_G0.8471.00
84_G87_P0.8461.00
56_S225_F0.8381.00
219_A223_G0.8381.00
31_I58_I0.8361.00
252_A255_M0.8351.00
113_I179_A0.8351.00
192_L261_V0.8331.00
93_A299_P0.8311.00
121_I126_D0.8301.00
214_A218_Y0.8301.00
92_Q307_R0.8261.00
145_L155_F0.8251.00
42_L240_T0.8251.00
212_Y229_V0.8221.00
192_L260_P0.8211.00
14_S18_F0.8181.00
293_Y300_K0.8171.00
287_Q290_D0.8171.00
14_S17_T0.8151.00
304_I308_I0.8141.00
76_G215_A0.8141.00
191_L198_V0.8121.00
289_A304_I0.8101.00
49_L232_T0.8091.00
42_L236_A0.8081.00
65_A68_Q0.8051.00
189_A192_L0.8041.00
188_S192_L0.8011.00
216_R219_A0.7991.00
114_L187_Y0.7961.00
257_L262_I0.7961.00
136_K162_Y0.7931.00
79_D215_A0.7931.00
144_L148_L0.7921.00
228_G231_A0.7911.00
232_T235_E0.7911.00
37_S41_V0.7901.00
133_A168_A0.7861.00
27_E225_F0.7781.00
11_G14_S0.7781.00
281_V284_L0.7771.00
48_L236_A0.7771.00
239_L242_S0.7721.00
29_L218_Y0.7711.00
185_P188_S0.7701.00
11_G15_V0.7681.00
39_G43_A0.7671.00
116_A120_P0.7661.00
10_A13_L0.7641.00
148_L151_A0.7571.00
229_V233_F0.7571.00
38_I251_L0.7541.00
115_V199_L0.7501.00
226_I230_L0.7451.00
35_K62_E0.7451.00
12_L15_V0.7411.00
36_G39_G0.7401.00
45_S254_T0.7401.00
233_F237_D0.7351.00
115_V197_R0.7331.00
80_L225_F0.7331.00
113_I127_L0.7291.00
282_A308_I0.7271.00
70_L91_A0.7251.00
252_A259_A0.7241.00
172_F196_V0.7231.00
144_L181_A0.7161.00
167_D170_A0.7151.00
19_A22_A0.7111.00
272_T276_P0.7111.00
146_R287_Q0.7101.00
262_I265_Y0.7081.00
137_G141_H0.7081.00
99_V220_E0.7081.00
140_S183_W0.7051.00
241_R244_R0.7011.00
220_E223_G0.7001.00
89_I289_A0.7001.00
231_A235_E0.6991.00
88_P100_Y0.6961.00
248_I266_L0.6961.00
265_Y269_R0.6931.00
56_S229_V0.6931.00
204_D207_Q0.6921.00
236_A240_T0.6921.00
136_K141_H0.6911.00
195_G198_V0.6891.00
149_R295_N0.6871.00
73_L78_I0.6821.00
276_P279_A0.6821.00
13_L16_S0.6801.00
172_F180_W0.6801.00
10_A14_S0.6791.00
142_N291_L0.6751.00
200_K204_D0.6731.00
118_N197_R0.6721.00
43_A48_L0.6721.00
42_L247_S0.6701.00
141_H160_P0.6701.00
279_A282_A0.6691.00
286_Q289_A0.6671.00
264_S268_H0.6661.00
47_Q51_K0.6641.00
31_I229_V0.6631.00
232_T236_A0.6611.00
184_D187_Y0.6591.00
7_L10_A0.6581.00
293_Y298_V0.6571.00
49_L56_S0.6541.00
79_D218_Y0.6521.00
212_Y233_F0.6491.00
171_A176_N0.6481.00
13_L17_T0.6431.00
94_A299_P0.6391.00
26_P222_N0.6381.00
145_L160_P0.6371.00
56_S232_T0.6361.00
44_K254_T0.6341.00
41_V45_S0.6321.00
186_Y190_A0.6321.00
73_L215_A0.6311.00
12_L16_S0.6291.00
97_D215_A0.6271.00
18_F22_A0.6261.00
85_D285_Q0.6261.00
85_D211_F0.6261.00
214_A229_V0.6201.00
25_S225_F0.6191.00
245_E259_A0.6181.00
81_G213_L0.6151.00
39_G42_L0.6151.00
7_L13_L0.6141.00
245_E248_I0.6141.00
244_R247_S0.6131.00
218_Y221_K0.6121.00
239_L250_L0.6111.00
70_L83_T0.6091.00
196_V200_K0.6081.00
133_A163_L0.6051.00
128_K154_K0.6041.00
91_A98_L0.6041.00
19_A23_E0.6001.00
36_G210_S0.6001.00
190_A194_G0.5991.00
9_L13_L0.5991.00
173_Q195_G0.5961.00
27_E31_I0.5941.00
203_T206_N0.5931.00
128_K148_L0.5911.00
188_S191_L0.5911.00
114_L191_L0.5901.00
131_K177_V0.5901.00
70_L213_L0.5901.00
222_N226_I0.5891.00
190_A196_V0.5881.00
100_Y285_Q0.5871.00
271_P275_K0.5851.00
71_E75_V0.5851.00
129_G157_D0.5841.00
279_A283_A0.5831.00
273_T276_P0.5831.00
120_P130_H0.5821.00
92_Q306_Q0.5801.00
35_K41_V0.5791.00
22_A25_S0.5791.00
195_G199_L0.5791.00
26_P59_S0.5791.00
289_A298_V0.5761.00
44_K57_K0.5751.00
104_E212_Y0.5741.00
43_A233_F0.5731.00
79_D222_N0.5721.00
31_I80_L0.5701.00
223_G226_I0.5701.00
105_P210_S0.5701.00
132_V144_L0.5681.00
296_R299_P0.5681.00
261_V264_S0.5671.00
100_Y280_E0.5651.00
80_L218_Y0.5631.00
102_G212_Y0.5621.00
284_L287_Q0.5611.00
44_K60_W0.5611.00
68_Q72_A0.5561.00
99_V103_V0.5541.00
85_D288_T0.5531.00
145_L149_R0.5521.00
17_T21_A0.5501.00
271_P274_I0.5481.00
8_A14_S0.5450.99
251_L262_I0.5450.99
249_A252_A0.5450.99
182_I186_Y0.5440.99
196_V199_L0.5420.99
101_V219_A0.5410.99
257_L266_L0.5390.99
302_V307_R0.5390.99
40_M233_F0.5380.99
8_A11_G0.5370.99
286_Q305_R0.5350.99
42_L48_L0.5340.99
117_E120_P0.5320.99
234_S237_D0.5320.99
191_L194_G0.5310.99
117_E194_G0.5310.99
149_R155_F0.5310.99
7_L12_L0.5280.99
105_P209_G0.5280.99
277_V280_E0.5270.99
125_A153_L0.5260.99
115_V120_P0.5250.99
235_E238_A0.5250.99
10_A15_V0.5240.99
191_L268_H0.5240.99
175_G178_D0.5230.99
169_R172_F0.5230.99
227_Q230_L0.5230.99
133_A180_W0.5220.99
188_S268_H0.5220.99
102_G105_P0.5220.99
39_G236_A0.5210.99
114_L198_V0.5210.99
43_A46_H0.5200.99
288_T292_F0.5200.99
72_A75_V0.5200.99
131_K176_N0.5200.99
280_E283_A0.5170.99
41_V44_K0.5160.99
280_E285_Q0.5160.99
130_H179_A0.5150.99
83_T87_P0.5150.99
155_F160_P0.5140.99
38_I42_L0.5130.99
25_S228_G0.5120.99
146_R291_L0.5120.99
90_F94_A0.5120.99
250_L253_K0.5110.99
230_L234_S0.5110.99
29_L40_M0.5110.99
275_K279_A0.5100.99
42_L47_Q0.5090.99
119_S122_K0.5090.99
293_Y296_R0.5090.99
43_A47_Q0.5080.99
149_R154_K0.5080.99
171_A174_Q0.5080.99
123_T151_A0.5070.99
61_V72_A0.5060.99
257_L261_V0.5060.99
145_L295_N0.5060.99
90_F93_A0.5050.99
234_S277_V0.5050.99
121_I124_V0.5030.99
165_P168_A0.5020.99
12_L18_F0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qslA 1 0.9404 100 0.297 Contact Map
2x26A 1 0.9185 100 0.302 Contact Map
4nmyA 1 0.8966 100 0.307 Contact Map
2g29A 1 0.9185 100 0.309 Contact Map
3un6A 1 0.8903 100 0.313 Contact Map
2de3A 1 0.9028 100 0.319 Contact Map
3ix1A 2 0.8966 100 0.332 Contact Map
2i49A 1 0.9185 100 0.337 Contact Map
2x7qA 1 0.8903 100 0.369 Contact Map
4eswA 2 0.9154 100 0.379 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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