SSUA - ECOLI - GREMLIN Contacts

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SSUA - Putative aliphatic sulfonates-binding protein

UniProt:	P75853	Sequences: MRNIIKLALAGLLSVSTFAVAAESSPEALRIGYQKGSIGMVLAKSHQLLEKRYPESKISWVEFPAGPQMLEALNVGSIDLGSTGDIPPIFAQAAGADLVYVGVEPPKPKAEVILVAENSPIKTVADLKGHKVAFQKGSSSHNLLLRALRQAGLKFTDIQPTYLTPADARAAFQQGNVDAWAIWDPYYSAALLQGGVRVLKDGTDLNQTGSFYLAARPYAEKNGAFIQGVLATFSEADALTRSQREQSIALLAKTMGLPAPVIASYLDHRPPTTIKPVNAEVAALQQQTADLFYENRLVPKKVDIRQRIWQPTQLEGKQL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13707
Length:	319 (297)
Sequences:	14250 (10754)
Seq/√Len:	624.0

ECOLI - SSUA TAUA
BACSU - SSUA YTLA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
52_R	231_A	3.605	1.00
243_Q	246_Q	3.474	1.00
239_L	243_Q	3.364	1.00
52_R	235_E	3.335	1.00
131_K	159_Q	3.284	1.00
99_V	216_R	3.218	1.00
218_Y	222_N	3.171	1.00
97_D	216_R	3.095	1.00
128_K	157_D	3.026	1.00
216_R	220_E	3.000	1.00
303_D	306_Q	2.953	1.00
51_K	235_E	2.939	1.00
217_P	221_K	2.866	1.00
227_Q	231_A	2.843	1.00
28_A	59_S	2.812	1.00
133_A	177_V	2.705	1.00
49_L	233_F	2.691	1.00
249_A	259_A	2.652	1.00
28_A	57_K	2.565	1.00
123_T	126_D	2.532	1.00
30_R	59_S	2.525	1.00
245_E	263_A	2.467	1.00
286_Q	290_D	2.408	1.00
238_A	242_S	2.315	1.00
26_P	57_K	2.269	1.00
290_D	294_E	2.252	1.00
222_N	225_F	2.182	1.00
154_K	157_D	2.164	1.00
46_H	246_Q	2.157	1.00
184_D	188_S	2.152	1.00
32_G	78_I	2.142	1.00
122_K	126_D	2.109	1.00
141_H	145_L	2.036	1.00
48_L	235_E	2.013	1.00
214_A	219_A	2.000	1.00
80_L	214_A	1.993	1.00
293_Y	301_K	1.930	1.00
130_H	178_D	1.916	1.00
259_A	263_A	1.895	1.00
149_R	294_E	1.876	1.00
163_L	171_A	1.834	1.00
48_L	239_L	1.782	1.00
263_A	267_D	1.773	1.00
224_A	228_G	1.753	1.00
246_Q	249_A	1.744	1.00
45_S	253_K	1.742	1.00
48_L	232_T	1.740	1.00
214_A	226_I	1.713	1.00
153_L	157_D	1.692	1.00
201_D	204_D	1.638	1.00
219_A	226_I	1.638	1.00
258_P	261_V	1.632	1.00
234_S	238_A	1.618	1.00
218_Y	226_I	1.588	1.00
239_L	246_Q	1.580	1.00
125_A	151_A	1.568	1.00
240_T	247_S	1.564	1.00
148_L	153_L	1.553	1.00
46_H	239_L	1.544	1.00
80_L	229_V	1.543	1.00
127_L	179_A	1.538	1.00
132_V	179_A	1.533	1.00
100_Y	211_F	1.527	1.00
282_A	286_Q	1.514	1.00
228_G	232_T	1.512	1.00
92_Q	216_R	1.511	1.00
80_L	226_I	1.508	1.00
223_G	227_Q	1.478	1.00
131_K	161_T	1.478	1.00
83_T	213_L	1.470	1.00
122_K	197_R	1.468	1.00
102_G	230_L	1.466	1.00
282_A	305_R	1.447	1.00
48_L	51_K	1.446	1.00
248_I	263_A	1.445	1.00
290_D	301_K	1.425	1.00
218_Y	225_F	1.410	1.00
52_R	228_G	1.404	1.00
125_A	128_K	1.377	1.00
189_A	193_Q	1.376	1.00
131_K	178_D	1.365	1.00
63_F	72_A	1.362	1.00
68_Q	71_E	1.351	1.00
69_M	81_G	1.333	1.00
148_L	158_I	1.326	1.00
124_V	147_A	1.309	1.00
47_Q	50_E	1.303	1.00
30_R	61_V	1.300	1.00
245_E	249_A	1.273	1.00
15_V	18_F	1.271	1.00
52_R	232_T	1.269	1.00
44_K	50_E	1.268	1.00
224_A	227_Q	1.263	1.00
168_A	180_W	1.255	1.00
260_P	263_A	1.232	1.00
164_T	167_D	1.230	1.00
264_S	267_D	1.228	1.00
39_G	237_D	1.219	1.00
283_A	287_Q	1.217	1.00
72_A	77_S	1.215	1.00
192_L	264_S	1.210	1.00
116_A	175_G	1.209	1.00
43_A	236_A	1.209	1.00
291_L	295_N	1.207	1.00
215_A	218_Y	1.191	1.00
124_V	151_A	1.180	1.00
177_V	180_W	1.172	1.00
53_Y	56_S	1.166	1.00
76_G	217_P	1.164	1.00
42_L	239_L	1.164	1.00
101_V	226_I	1.157	1.00
121_I	130_H	1.153	1.00
48_L	52_R	1.151	1.00
30_R	79_D	1.151	1.00
56_S	228_G	1.147	1.00
173_Q	193_Q	1.146	1.00
42_L	250_L	1.134	1.00
116_A	119_S	1.122	1.00
73_L	81_G	1.115	1.00
112_V	187_Y	1.110	1.00
99_V	219_A	1.110	1.00
146_R	149_R	1.106	1.00
43_A	49_L	1.095	1.00
50_E	53_Y	1.090	1.00
134_F	160_P	1.083	1.00
32_G	63_F	1.083	1.00
289_A	302_V	1.079	1.00
116_A	172_F	1.073	1.00
66_G	87_P	1.072	1.00
49_L	58_I	1.072	1.00
244_R	248_I	1.069	1.00
117_E	197_R	1.068	1.00
115_V	119_S	1.068	1.00
225_F	228_G	1.046	1.00
249_A	253_K	1.046	1.00
171_A	177_V	1.038	1.00
30_R	78_I	1.035	1.00
244_R	267_D	1.029	1.00
27_E	222_N	1.022	1.00
42_L	46_H	1.020	1.00
238_A	241_R	1.016	1.00
101_V	214_A	1.013	1.00
144_L	160_P	1.011	1.00
248_I	259_A	1.007	1.00
170_A	173_Q	0.996	1.00
246_Q	250_L	0.992	1.00
202_G	206_N	0.985	1.00
191_L	264_S	0.976	1.00
113_I	181_A	0.970	1.00
146_R	150_Q	0.966	1.00
25_S	222_N	0.961	1.00
169_R	173_Q	0.960	1.00
45_S	250_L	0.951	1.00
283_A	286_Q	0.949	1.00
53_Y	228_G	0.944	1.00
72_A	78_I	0.939	1.00
112_V	198_V	0.937	1.00
49_L	53_Y	0.929	1.00
289_A	301_K	0.927	1.00
80_L	101_V	0.927	1.00
73_L	213_L	0.926	1.00
187_Y	191_L	0.920	1.00
74_N	96_A	0.920	1.00
170_A	174_Q	0.920	1.00
88_P	213_L	0.917	1.00
101_V	230_L	0.915	1.00
18_F	21_A	0.907	1.00
172_F	177_V	0.905	1.00
290_D	293_Y	0.902	1.00
198_V	201_D	0.899	1.00
50_E	57_K	0.899	1.00
117_E	195_G	0.896	1.00
115_V	179_A	0.894	1.00
46_H	250_L	0.893	1.00
217_P	220_E	0.891	1.00
289_A	293_Y	0.883	1.00
120_P	197_R	0.883	1.00
21_A	24_S	0.883	1.00
239_L	247_S	0.880	1.00
128_K	153_L	0.873	1.00
132_V	158_I	0.872	1.00
83_T	88_P	0.871	1.00
260_P	264_S	0.865	1.00
118_N	175_G	0.864	1.00
27_E	30_R	0.863	1.00
97_D	217_P	0.863	1.00
147_A	151_A	0.859	1.00
286_Q	304_I	0.851	1.00
202_G	205_L	0.850	1.00
237_D	241_R	0.850	1.00
218_Y	223_G	0.847	1.00
84_G	87_P	0.846	1.00
56_S	225_F	0.838	1.00
219_A	223_G	0.838	1.00
31_I	58_I	0.836	1.00
252_A	255_M	0.835	1.00
113_I	179_A	0.835	1.00
192_L	261_V	0.833	1.00
93_A	299_P	0.831	1.00
121_I	126_D	0.830	1.00
214_A	218_Y	0.830	1.00
92_Q	307_R	0.826	1.00
145_L	155_F	0.825	1.00
42_L	240_T	0.825	1.00
212_Y	229_V	0.822	1.00
192_L	260_P	0.821	1.00
14_S	18_F	0.818	1.00
293_Y	300_K	0.817	1.00
287_Q	290_D	0.817	1.00
14_S	17_T	0.815	1.00
304_I	308_I	0.814	1.00
76_G	215_A	0.814	1.00
191_L	198_V	0.812	1.00
289_A	304_I	0.810	1.00
49_L	232_T	0.809	1.00
42_L	236_A	0.808	1.00
65_A	68_Q	0.805	1.00
189_A	192_L	0.804	1.00
188_S	192_L	0.801	1.00
216_R	219_A	0.799	1.00
114_L	187_Y	0.796	1.00
257_L	262_I	0.796	1.00
136_K	162_Y	0.793	1.00
79_D	215_A	0.793	1.00
144_L	148_L	0.792	1.00
228_G	231_A	0.791	1.00
232_T	235_E	0.791	1.00
37_S	41_V	0.790	1.00
133_A	168_A	0.786	1.00
27_E	225_F	0.778	1.00
11_G	14_S	0.778	1.00
281_V	284_L	0.777	1.00
48_L	236_A	0.777	1.00
239_L	242_S	0.772	1.00
29_L	218_Y	0.771	1.00
185_P	188_S	0.770	1.00
11_G	15_V	0.768	1.00
39_G	43_A	0.767	1.00
116_A	120_P	0.766	1.00
10_A	13_L	0.764	1.00
148_L	151_A	0.757	1.00
229_V	233_F	0.757	1.00
38_I	251_L	0.754	1.00
115_V	199_L	0.750	1.00
226_I	230_L	0.745	1.00
35_K	62_E	0.745	1.00
12_L	15_V	0.741	1.00
36_G	39_G	0.740	1.00
45_S	254_T	0.740	1.00
233_F	237_D	0.735	1.00
115_V	197_R	0.733	1.00
80_L	225_F	0.733	1.00
113_I	127_L	0.729	1.00
282_A	308_I	0.727	1.00
70_L	91_A	0.725	1.00
252_A	259_A	0.724	1.00
172_F	196_V	0.723	1.00
144_L	181_A	0.716	1.00
167_D	170_A	0.715	1.00
19_A	22_A	0.711	1.00
272_T	276_P	0.711	1.00
146_R	287_Q	0.710	1.00
262_I	265_Y	0.708	1.00
137_G	141_H	0.708	1.00
99_V	220_E	0.708	1.00
140_S	183_W	0.705	1.00
241_R	244_R	0.701	1.00
220_E	223_G	0.700	1.00
89_I	289_A	0.700	1.00
231_A	235_E	0.699	1.00
88_P	100_Y	0.696	1.00
248_I	266_L	0.696	1.00
265_Y	269_R	0.693	1.00
56_S	229_V	0.693	1.00
204_D	207_Q	0.692	1.00
236_A	240_T	0.692	1.00
136_K	141_H	0.691	1.00
195_G	198_V	0.689	1.00
149_R	295_N	0.687	1.00
73_L	78_I	0.682	1.00
276_P	279_A	0.682	1.00
13_L	16_S	0.680	1.00
172_F	180_W	0.680	1.00
10_A	14_S	0.679	1.00
142_N	291_L	0.675	1.00
200_K	204_D	0.673	1.00
118_N	197_R	0.672	1.00
43_A	48_L	0.672	1.00
42_L	247_S	0.670	1.00
141_H	160_P	0.670	1.00
279_A	282_A	0.669	1.00
286_Q	289_A	0.667	1.00
264_S	268_H	0.666	1.00
47_Q	51_K	0.664	1.00
31_I	229_V	0.663	1.00
232_T	236_A	0.661	1.00
184_D	187_Y	0.659	1.00
7_L	10_A	0.658	1.00
293_Y	298_V	0.657	1.00
49_L	56_S	0.654	1.00
79_D	218_Y	0.652	1.00
212_Y	233_F	0.649	1.00
171_A	176_N	0.648	1.00
13_L	17_T	0.643	1.00
94_A	299_P	0.639	1.00
26_P	222_N	0.638	1.00
145_L	160_P	0.637	1.00
56_S	232_T	0.636	1.00
44_K	254_T	0.634	1.00
41_V	45_S	0.632	1.00
186_Y	190_A	0.632	1.00
73_L	215_A	0.631	1.00
12_L	16_S	0.629	1.00
97_D	215_A	0.627	1.00
18_F	22_A	0.626	1.00
85_D	285_Q	0.626	1.00
85_D	211_F	0.626	1.00
214_A	229_V	0.620	1.00
25_S	225_F	0.619	1.00
245_E	259_A	0.618	1.00
81_G	213_L	0.615	1.00
39_G	42_L	0.615	1.00
7_L	13_L	0.614	1.00
245_E	248_I	0.614	1.00
244_R	247_S	0.613	1.00
218_Y	221_K	0.612	1.00
239_L	250_L	0.611	1.00
70_L	83_T	0.609	1.00
196_V	200_K	0.608	1.00
133_A	163_L	0.605	1.00
128_K	154_K	0.604	1.00
91_A	98_L	0.604	1.00
19_A	23_E	0.600	1.00
36_G	210_S	0.600	1.00
190_A	194_G	0.599	1.00
9_L	13_L	0.599	1.00
173_Q	195_G	0.596	1.00
27_E	31_I	0.594	1.00
203_T	206_N	0.593	1.00
128_K	148_L	0.591	1.00
188_S	191_L	0.591	1.00
114_L	191_L	0.590	1.00
131_K	177_V	0.590	1.00
70_L	213_L	0.590	1.00
222_N	226_I	0.589	1.00
190_A	196_V	0.588	1.00
100_Y	285_Q	0.587	1.00
271_P	275_K	0.585	1.00
71_E	75_V	0.585	1.00
129_G	157_D	0.584	1.00
279_A	283_A	0.583	1.00
273_T	276_P	0.583	1.00
120_P	130_H	0.582	1.00
92_Q	306_Q	0.580	1.00
35_K	41_V	0.579	1.00
22_A	25_S	0.579	1.00
195_G	199_L	0.579	1.00
26_P	59_S	0.579	1.00
289_A	298_V	0.576	1.00
44_K	57_K	0.575	1.00
104_E	212_Y	0.574	1.00
43_A	233_F	0.573	1.00
79_D	222_N	0.572	1.00
31_I	80_L	0.570	1.00
223_G	226_I	0.570	1.00
105_P	210_S	0.570	1.00
132_V	144_L	0.568	1.00
296_R	299_P	0.568	1.00
261_V	264_S	0.567	1.00
100_Y	280_E	0.565	1.00
80_L	218_Y	0.563	1.00
102_G	212_Y	0.562	1.00
284_L	287_Q	0.561	1.00
44_K	60_W	0.561	1.00
68_Q	72_A	0.556	1.00
99_V	103_V	0.554	1.00
85_D	288_T	0.553	1.00
145_L	149_R	0.552	1.00
17_T	21_A	0.550	1.00
271_P	274_I	0.548	1.00
8_A	14_S	0.545	0.99
251_L	262_I	0.545	0.99
249_A	252_A	0.545	0.99
182_I	186_Y	0.544	0.99
196_V	199_L	0.542	0.99
101_V	219_A	0.541	0.99
257_L	266_L	0.539	0.99
302_V	307_R	0.539	0.99
40_M	233_F	0.538	0.99
8_A	11_G	0.537	0.99
286_Q	305_R	0.535	0.99
42_L	48_L	0.534	0.99
117_E	120_P	0.532	0.99
234_S	237_D	0.532	0.99
191_L	194_G	0.531	0.99
117_E	194_G	0.531	0.99
149_R	155_F	0.531	0.99
7_L	12_L	0.528	0.99
105_P	209_G	0.528	0.99
277_V	280_E	0.527	0.99
125_A	153_L	0.526	0.99
115_V	120_P	0.525	0.99
235_E	238_A	0.525	0.99
10_A	15_V	0.524	0.99
191_L	268_H	0.524	0.99
175_G	178_D	0.523	0.99
169_R	172_F	0.523	0.99
227_Q	230_L	0.523	0.99
133_A	180_W	0.522	0.99
188_S	268_H	0.522	0.99
102_G	105_P	0.522	0.99
39_G	236_A	0.521	0.99
114_L	198_V	0.521	0.99
43_A	46_H	0.520	0.99
288_T	292_F	0.520	0.99
72_A	75_V	0.520	0.99
131_K	176_N	0.520	0.99
280_E	283_A	0.517	0.99
41_V	44_K	0.516	0.99
280_E	285_Q	0.516	0.99
130_H	179_A	0.515	0.99
83_T	87_P	0.515	0.99
155_F	160_P	0.514	0.99
38_I	42_L	0.513	0.99
25_S	228_G	0.512	0.99
146_R	291_L	0.512	0.99
90_F	94_A	0.512	0.99
250_L	253_K	0.511	0.99
230_L	234_S	0.511	0.99
29_L	40_M	0.511	0.99
275_K	279_A	0.510	0.99
42_L	47_Q	0.509	0.99
119_S	122_K	0.509	0.99
293_Y	296_R	0.509	0.99
43_A	47_Q	0.508	0.99
149_R	154_K	0.508	0.99
171_A	174_Q	0.508	0.99
123_T	151_A	0.507	0.99
61_V	72_A	0.506	0.99
257_L	261_V	0.506	0.99
145_L	295_N	0.506	0.99
90_F	93_A	0.505	0.99
234_S	277_V	0.505	0.99
121_I	124_V	0.503	0.99
165_P	168_A	0.502	0.99
12_L	18_F	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3qslA	1	0.9404	100	0.297	Contact Map
2x26A	1	0.9185	100	0.302	Contact Map
4nmyA	1	0.8966	100	0.307	Contact Map
2g29A	1	0.9185	100	0.309	Contact Map
3un6A	1	0.8903	100	0.313	Contact Map
2de3A	1	0.9028	100	0.319	Contact Map
3ix1A	2	0.8966	100	0.332	Contact Map
2i49A	1	0.9185	100	0.337	Contact Map
2x7qA	1	0.8903	100	0.369	Contact Map
4eswA	2	0.9154	100	0.379	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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