GREMLIN Database
YCBL - Uncharacterized protein YcbL
UniProt: P75849 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13704
Length: 215 (179)
Sequences: 17739 (12652)
Seq/√Len: 945.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_L50_M3.7701.00
129_C138_V3.7121.00
54_L65_A2.9811.00
116_T123_T2.7331.00
51_Q77_F2.6241.00
118_S123_T2.6071.00
116_T125_Q2.4111.00
124_L141_D2.3991.00
125_Q142_D2.3581.00
53_L139_F2.2861.00
126_V137_V2.2821.00
27_A51_Q2.2481.00
39_K71_H2.2361.00
113_E178_K2.2011.00
77_F109_R2.1991.00
146_L189_I2.1451.00
80_E112_N2.0991.00
184_D202_R2.0861.00
75_P109_R2.0201.00
126_V139_F1.8841.00
141_D144_A1.8371.00
82_E135_G1.8341.00
16_S189_I1.7941.00
51_Q75_P1.7881.00
26_A47_L1.7611.00
167_D170_Q1.7551.00
25_L48_T1.7371.00
79_P128_H1.7341.00
145_K185_D1.7191.00
41_E45_S1.6411.00
69_A108_D1.6231.00
19_W47_L1.6161.00
77_F111_L1.6001.00
29_V148_I1.5711.00
19_W26_A1.5681.00
184_D199_G1.5261.00
112_N115_D1.5231.00
39_K43_D1.5161.00
67_E71_H1.4911.00
29_V55_T1.4801.00
27_A53_L1.4721.00
200_Y204_H1.4641.00
172_I176_K1.4611.00
41_E44_D1.4381.00
125_Q140_F1.4361.00
16_S148_I1.4171.00
79_P137_V1.4171.00
39_K72_Y1.4161.00
65_A76_V1.4031.00
122_V141_D1.3891.00
35_A67_E1.3831.00
127_L140_F1.3691.00
80_E110_W1.3161.00
138_V147_L1.3031.00
42_V49_L1.2901.00
140_F147_L1.2771.00
127_L178_K1.2591.00
187_I195_L1.2381.00
49_L74_V1.2171.00
66_A70_Q1.2121.00
111_L137_V1.2111.00
140_F186_V1.2101.00
40_Q44_D1.2061.00
146_L187_I1.2021.00
129_C174_S1.1981.00
109_R115_D1.1791.00
83_D110_W1.1741.00
36_E40_Q1.1631.00
49_L72_Y1.1521.00
134_P170_Q1.1511.00
35_A39_K1.1431.00
138_V179_L1.1411.00
170_Q173_S1.1401.00
22_Q121_N1.1151.00
66_A69_A1.1131.00
188_F196_S1.1061.00
81_K128_H1.1041.00
31_P52_I1.0931.00
178_K181_P1.0911.00
35_A64_A1.0871.00
26_A49_L1.0851.00
69_A76_V1.0661.00
28_L49_L1.0491.00
114_G125_Q1.0381.00
136_H150_G1.0341.00
176_K180_L1.0321.00
168_H172_I1.0301.00
118_S121_N1.0281.00
131_G174_S1.0251.00
147_L182_L1.0161.00
43_D71_H1.0041.00
133_T136_H0.9951.00
113_E128_H0.9821.00
164_P167_D0.9751.00
40_Q43_D0.9581.00
152_V179_L0.9471.00
149_S188_F0.9341.00
122_V144_A0.9271.00
25_L51_Q0.9271.00
198_L201_E0.9221.00
199_G203_L0.9211.00
155_K194_P0.9201.00
67_E70_Q0.9161.00
17_L26_A0.9161.00
138_V152_V0.9151.00
17_L41_E0.9131.00
55_T150_G0.9041.00
59_L63_G0.9041.00
52_I74_V0.9031.00
34_D37_K0.9001.00
15_C38_I0.8991.00
27_A124_L0.8941.00
78_G82_E0.8941.00
57_G78_G0.8911.00
81_K84_E0.8881.00
152_V171_L0.8801.00
78_G107_P0.8801.00
54_L76_V0.8671.00
180_L204_H0.8641.00
196_S201_E0.8621.00
161_S168_H0.8571.00
129_C152_V0.8571.00
53_L124_L0.8521.00
168_H171_L0.8501.00
158_V161_S0.8501.00
140_F182_L0.8451.00
169_N173_S0.8451.00
119_I122_V0.8441.00
75_P108_D0.8351.00
27_A119_I0.8321.00
18_I29_V0.8251.00
161_S171_L0.8181.00
80_E83_D0.8121.00
197_T200_Y0.8061.00
31_P65_A0.8021.00
123_T142_D0.7991.00
15_C32_G0.7981.00
57_G82_E0.7941.00
156_G200_Y0.7921.00
189_I195_L0.7891.00
152_V174_S0.7801.00
37_K41_E0.7761.00
156_G204_H0.7711.00
28_L31_P0.7671.00
160_R163_F0.7581.00
52_I65_A0.7581.00
187_I197_T0.7571.00
147_L188_F0.7561.00
125_Q182_L0.7531.00
129_C136_H0.7521.00
26_A50_M0.7491.00
176_K181_P0.7481.00
37_K40_Q0.7471.00
111_L139_F0.7441.00
19_W41_E0.7361.00
180_L202_R0.7351.00
107_P110_W0.7351.00
124_L139_F0.7341.00
188_F198_L0.7331.00
23_T121_N0.7291.00
136_H152_V0.7291.00
82_E133_T0.7251.00
111_L126_V0.7251.00
179_L198_L0.7231.00
116_T142_D0.7151.00
155_K204_H0.7141.00
13_Q32_G0.7121.00
127_L138_V0.7101.00
19_W24_R0.7091.00
149_S190_P0.7081.00
141_D146_L0.7061.00
22_Q25_L0.7061.00
34_D38_I0.7051.00
134_P165_R0.7031.00
65_A69_A0.7031.00
57_G135_G0.6991.00
51_Q109_R0.6961.00
140_F145_K0.6931.00
148_I189_I0.6871.00
128_H137_V0.6861.00
140_F184_D0.6851.00
156_G159_G0.6821.00
154_F159_G0.6801.00
19_W23_T0.6781.00
52_I76_V0.6751.00
29_V139_F0.6711.00
19_W45_S0.6701.00
105_L108_D0.6691.00
145_K183_G0.6671.00
17_L28_L0.6671.00
54_L62_V0.6641.00
16_S191_G0.6631.00
13_Q191_G0.6621.00
8_V15_C0.6521.00
66_A105_L0.6461.00
28_L42_V0.6461.00
14_N191_G0.6451.00
142_D145_K0.6441.00
111_L115_D0.6441.00
58_H61_H0.6381.00
112_N128_H0.6381.00
28_L68_L0.6361.00
50_M75_P0.6331.00
82_E85_F0.6291.00
36_E39_K0.6271.00
68_L72_Y0.6261.00
38_I41_E0.6251.00
38_I42_V0.6251.00
11_F59_L0.6241.00
64_A67_E0.6201.00
127_L182_L0.6201.00
25_L120_G0.6201.00
19_W22_Q0.6161.00
8_V34_D0.6091.00
29_V53_L0.6081.00
184_D188_F0.6041.00
79_P82_E0.6031.00
130_P174_S0.6021.00
128_H178_K0.5951.00
8_V13_Q0.5951.00
18_I141_D0.5941.00
36_E67_E0.5941.00
78_G83_D0.5911.00
175_I180_L0.5891.00
69_A73_G0.5851.00
18_I27_A0.5771.00
117_I126_V0.5751.00
151_D192_H0.5731.00
53_L137_V0.5721.00
171_L175_I0.5691.00
183_G186_V0.5661.00
123_T143_R0.5661.00
33_G38_I0.5651.00
173_S176_K0.5641.00
9_T13_Q0.5601.00
77_F115_D0.5601.00
114_G178_K0.5571.00
155_K196_S0.5531.00
24_R46_G0.5531.00
35_A38_I0.5521.00
43_D46_G0.5511.00
200_Y203_L0.5511.00
52_I68_L0.5511.00
196_S200_Y0.5491.00
165_R168_H0.5471.00
131_G161_S0.5461.00
62_V65_A0.5461.00
77_F108_D0.5451.00
26_A42_V0.5431.00
172_I180_L0.5421.00
66_A103_Q0.5421.00
55_T139_F0.5381.00
17_L42_V0.5371.00
24_R47_L0.5351.00
165_R171_L0.5351.00
173_S178_K0.5271.00
153_I188_F0.5261.00
120_G123_T0.5221.00
14_N193_G0.5201.00
53_L117_I0.5191.00
28_L38_I0.5171.00
155_K200_Y0.5171.00
35_A71_H0.5161.00
157_G160_R0.5131.00
154_F158_V0.5091.00
115_D126_V0.5081.00
198_L202_R0.5041.00
42_V72_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xf4A 2 0.9767 100 0.244 Contact Map
3tp9A 2 0.9395 100 0.245 Contact Map
3r2uA 4 0.9349 100 0.246 Contact Map
4yslA 2 0.9907 100 0.257 Contact Map
4efzA 2 0.9767 100 0.261 Contact Map
1qh5A 1 0.8791 100 0.264 Contact Map
1xm8A 1 0.8884 100 0.273 Contact Map
2zwrA 1 0.9535 100 0.273 Contact Map
2p18A 1 0.8884 100 0.275 Contact Map
2qedA 1 0.8651 100 0.289 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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