GREMLIN Database
YCAQ - Uncharacterized protein YcaQ
UniProt: P75843 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13701
Length: 410 (375)
Sequences: 1119 (762)
Seq/√Len: 39.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
302_E308_S5.4591.00
213_D250_Q4.9401.00
186_D190_R4.8961.00
39_S95_S4.2521.00
130_I172_K4.2121.00
96_D214_N4.0521.00
133_I173_V3.7811.00
338_R358_Q3.2811.00
177_E184_V3.2061.00
132_H136_K3.1281.00
101_R104_M3.1201.00
242_R251_I3.0921.00
343_M384_A3.0761.00
38_I81_L2.8781.00
212_L241_W2.7551.00
49_I313_C2.7501.00
7_S10_D2.7231.00
344_H351_E2.7211.00
210_I213_D2.6401.00
134_H189_H2.6041.00
82_M97_F2.4891.00
295_V301_A2.4871.00
51_I342_K2.4741.00
5_H255_H2.3991.00
344_H347_T2.3961.00
55_S293_P2.3531.00
57_Y67_Y2.3491.00
108_E172_K2.3351.00
376_T380_N2.3301.00
174_M188_T2.2721.00
285_S370_G2.2691.00
53_A69_A2.2431.00
44_L60_L2.2120.99
222_F227_L2.1990.99
84_Y104_M2.1650.99
203_S206_E2.1010.99
216_A227_L2.0820.99
209_I244_A2.0700.99
331_H370_G2.0600.99
285_S331_H1.9660.99
55_S311_L1.9400.99
30_S33_D1.9140.98
127_A131_Q1.9030.98
55_S58_L1.8870.98
67_Y72_L1.8660.98
352_V379_A1.8300.98
374_A377_D1.8190.98
133_I139_V1.8170.98
140_R143_D1.7710.97
318_P322_Y1.7710.97
353_I390_G1.7690.97
55_S289_S1.7580.97
348_G385_T1.7390.97
31_L74_E1.7210.97
131_Q135_D1.7090.97
53_A57_Y1.7080.97
46_I91_F1.6930.97
6_L10_D1.6890.96
246_A263_W1.6870.96
105_L204_Q1.6810.96
96_D99_L1.6760.96
301_A335_L1.6700.96
153_G156_E1.6500.96
219_L222_F1.6490.96
128_Q132_H1.6480.96
313_C325_F1.6200.96
14_L278_G1.6190.95
132_H144_F1.6110.95
105_L201_L1.6060.95
349_I388_T1.6030.95
48_T325_F1.6020.95
21_L282_A1.5990.95
372_R389_L1.5820.95
214_N231_Y1.5630.95
132_H139_V1.5610.94
217_R253_A1.5540.94
209_I248_Q1.5460.94
302_E310_R1.5410.94
76_L91_F1.5380.94
136_K139_V1.5290.94
130_I167_L1.5080.93
151_A154_W1.4680.92
293_P311_L1.4640.92
352_V355_L1.4590.92
9_A333_G1.3960.90
224_E228_A1.3910.90
204_Q208_E1.3650.89
288_L330_L1.3620.89
131_Q134_H1.3590.89
48_T181_F1.3570.89
11_A221_I1.3520.89
161_K165_E1.3470.89
137_G186_D1.3360.88
35_P39_S1.3330.88
8_L306_D1.3260.88
57_Y73_D1.3050.87
130_I134_H1.3030.87
89_A161_K1.3000.87
308_S321_Q1.2960.87
347_T351_E1.2950.87
329_L337_G1.2900.86
163_H167_L1.2880.86
349_I386_R1.2860.86
244_A247_E1.2810.86
229_D232_R1.2760.86
307_F335_L1.2730.86
127_A172_K1.2720.86
113_K118_W1.2700.86
6_L14_L1.2690.86
129_L163_H1.2590.85
17_A279_K1.2380.84
133_I186_D1.2350.84
361_I367_L1.2140.83
86_A96_D1.2130.83
6_L221_I1.2100.83
222_F251_I1.1980.82
89_A291_F1.1960.82
299_K303_Q1.1860.81
94_R98_R1.1860.81
123_E127_A1.1820.81
216_A242_R1.1790.81
192_M196_D1.1790.81
265_H268_L1.1790.81
43_L296_W1.1770.81
238_L242_R1.1750.81
37_T60_L1.1740.81
165_E183_R1.1710.81
55_S291_F1.1670.80
362_K365_T1.1610.80
224_E239_A1.1550.80
329_L355_L1.1450.79
55_S296_W1.1410.79
329_L371_L1.1390.79
287_V339_M1.1380.79
155_W161_K1.1330.78
187_L190_R1.1270.78
144_F160_H1.1240.78
208_E237_A1.1230.78
213_D245_R1.1210.78
48_T313_C1.1150.77
224_E242_R1.1100.77
140_R182_Q1.1030.76
20_G40_R1.1010.76
51_I138_P1.0890.76
310_R315_T1.0880.75
157_W161_K1.0840.75
264_L268_L1.0820.75
96_D231_Y1.0760.75
289_S311_L1.0690.74
351_E390_G1.0630.74
145_E160_H1.0600.74
99_L210_I1.0590.73
7_S318_P1.0590.73
35_P75_S1.0560.73
331_H371_L1.0560.73
285_S336_V1.0550.73
223_R303_Q1.0540.73
89_A165_E1.0530.73
225_Q299_K1.0450.72
82_M98_R1.0440.72
217_R265_H1.0410.72
82_M94_R1.0400.72
291_F311_L1.0380.72
90_C100_I1.0370.72
117_A121_E1.0370.72
126_I167_L1.0360.72
168_F183_R1.0320.71
368_Q372_R1.0250.71
83_E178_R1.0230.71
107_P169_T1.0230.71
216_A251_I1.0230.71
229_D295_V1.0200.71
52_V378_F1.0180.70
288_L335_L1.0180.70
23_N36_A1.0180.70
58_L327_L1.0140.70
118_W123_E1.0120.70
105_L196_D1.0100.70
331_H367_L1.0050.69
332_R370_G1.0020.69
322_Y338_R1.0010.69
58_L296_W0.9980.69
331_H336_V0.9950.69
284_H332_R0.9910.68
48_T87_H0.9910.68
307_F358_Q0.9900.68
312_E321_Q0.9810.68
294_V301_A0.9740.67
361_I365_T0.9730.67
42_S93_P0.9700.67
150_G153_G0.9670.66
252_I267_D0.9660.66
169_T175_V0.9640.66
37_T41_M0.9630.66
161_K185_Y0.9630.66
246_A253_A0.9630.66
312_E328_P0.9580.66
125_E129_L0.9530.65
10_D278_G0.9530.65
226_W303_Q0.9520.65
287_V329_L0.9480.65
380_N383_Q0.9480.65
136_K144_F0.9440.65
54_R87_H0.9410.64
128_Q131_Q0.9360.64
8_L304_L0.9360.64
189_H197_D0.9340.64
90_C296_W0.9330.64
154_W180_N0.9310.63
301_A311_L0.9310.63
226_W297_D0.9290.63
88_E314_Y0.9170.62
155_W291_F0.9150.62
149_K153_G0.9130.62
289_S327_L0.9020.61
51_I263_W0.9000.61
284_H333_G0.8990.61
89_A155_W0.8960.60
155_W181_F0.8960.60
317_A353_I0.8930.60
82_M86_A0.8930.60
23_N40_R0.8840.59
264_L267_D0.8830.59
126_I172_K0.8750.59
84_Y88_E0.8730.58
123_E126_I0.8690.58
201_L369_K0.8670.58
124_A321_Q0.8660.58
214_N217_R0.8660.58
174_M191_V0.8630.58
101_R201_L0.8630.58
99_L202_V0.8580.57
58_L183_R0.8570.57
372_R376_T0.8560.57
149_K154_W0.8560.57
97_F188_T0.8540.57
378_F382_Q0.8530.57
166_G170_A0.8510.56
78_R206_E0.8490.56
40_R217_R0.8490.56
85_W165_E0.8480.56
326_V338_R0.8450.56
229_D381_W0.8370.55
142_A182_Q0.8360.55
93_P96_D0.8330.55
291_F300_R0.8320.55
386_R390_G0.8280.54
209_I213_D0.8280.54
85_W161_K0.8270.54
144_F164_L0.8260.54
42_S214_N0.8230.54
142_A152_S0.8210.54
44_L293_P0.8210.54
92_M100_I0.8180.53
176_I193_P0.8160.53
342_K353_I0.8140.53
65_G381_W0.8110.53
6_L11_A0.8070.52
225_Q261_N0.8060.52
307_F360_G0.8040.52
127_A135_D0.7950.51
118_W122_H0.7930.51
222_F242_R0.7930.51
312_E319_K0.7920.51
99_L207_A0.7910.51
52_V339_M0.7850.50
243_E247_E0.7850.50
206_E210_I0.7850.50
288_L328_P0.7830.50
92_M162_R0.7830.50
144_F173_V0.7820.50
194_D198_E0.7810.50
212_L238_L0.7810.50
259_L262_L0.7800.50
161_K183_R0.7800.50
222_F226_W0.7790.50
42_S163_H0.7780.50
15_H294_V0.7780.50
97_F174_M0.7760.50
46_I183_R0.7750.50
128_Q144_F0.7750.50
326_V358_Q0.7730.49
215_S233_L0.7700.49
176_I289_S0.7670.49
48_T155_W0.7640.49
179_R184_V0.7640.49
337_G355_L0.7630.48
235_R315_T0.7620.48
5_H257_E0.7590.48
49_I324_Y0.7560.48
87_H300_R0.7530.48
149_K152_S0.7530.48
203_S253_A0.7510.47
84_Y92_M0.7510.47
294_V335_L0.7510.47
312_E322_Y0.7510.47
11_A220_G0.7510.47
54_R181_F0.7500.47
83_E300_R0.7490.47
260_G385_T0.7470.47
106_A204_Q0.7460.47
317_A334_Q0.7450.47
87_H291_F0.7450.47
49_I325_F0.7430.47
255_H376_T0.7420.47
53_A154_W0.7410.46
52_V81_L0.7410.46
92_M242_R0.7390.46
30_S35_P0.7380.46
26_R92_M0.7360.46
313_C341_A0.7310.46
228_A235_R0.7290.45
339_M352_V0.7270.45
13_N280_L0.7270.45
287_V348_G0.7270.45
48_T161_K0.7270.45
87_H215_S0.7240.45
164_L327_L0.7240.45
334_Q363_P0.7220.45
334_Q370_G0.7210.45
38_I75_S0.7210.45
13_N279_K0.7200.45
194_D200_D0.7160.44
110_M169_T0.7140.44
43_L381_W0.7120.44
188_T192_M0.7120.44
329_L382_Q0.7120.44
76_L337_G0.7110.44
158_K188_T0.7110.44
237_A240_A0.7100.44
160_H293_P0.7100.44
344_H349_I0.7090.44
307_F312_E0.7080.44
87_H181_F0.7050.43
139_V172_K0.7040.43
156_E175_V0.7030.43
60_L164_L0.7010.43
136_K143_D0.7000.43
126_I129_L0.7000.43
27_R33_D0.6990.43
195_W239_A0.6980.43
41_M293_P0.6950.42
60_L160_H0.6920.42
14_L268_L0.6900.42
175_V387_V0.6890.42
134_H202_V0.6890.42
304_L317_A0.6890.42
116_D124_A0.6880.42
239_A243_E0.6870.42
18_A381_W0.6860.42
88_E168_F0.6850.41
346_Q349_I0.6840.41
156_E180_N0.6830.41
92_M315_T0.6830.41
219_L297_D0.6820.41
195_W203_S0.6820.41
228_A238_L0.6790.41
46_I83_E0.6780.41
71_W75_S0.6780.41
99_L214_N0.6780.41
207_A352_V0.6770.41
225_Q238_L0.6770.41
6_L343_M0.6770.41
51_I353_I0.6750.41
20_G62_S0.6740.41
257_E387_V0.6730.40
37_T44_L0.6720.40
151_A346_Q0.6720.40
167_L309_Y0.6710.40
62_S65_G0.6680.40
215_S222_F0.6680.40
227_L291_F0.6680.40
50_N353_I0.6670.40
268_L282_A0.6660.40
376_T386_R0.6660.40
27_R34_I0.6650.40
129_L167_L0.6650.40
112_W123_E0.6650.40
33_D64_L0.6640.40
58_L311_L0.6640.40
326_V356_W0.6630.40
62_S312_E0.6620.39
46_I168_F0.6610.39
42_S218_S0.6590.39
130_I334_Q0.6580.39
355_L368_Q0.6580.39
185_Y338_R0.6550.39
164_L312_E0.6540.39
213_D266_D0.6540.39
309_Y325_F0.6510.39
212_L242_R0.6480.38
210_I214_N0.6480.38
315_T318_P0.6480.38
289_S293_P0.6460.38
215_S227_L0.6450.38
318_P337_G0.6440.38
77_A164_L0.6440.38
351_E388_T0.6440.38
161_K291_F0.6430.38
46_I89_A0.6410.38
221_I262_L0.6380.37
221_I311_L0.6370.37
242_R263_W0.6350.37
41_M164_L0.6340.37
213_D265_H0.6330.37
46_I87_H0.6330.37
11_A14_L0.6330.37
174_M308_S0.6320.37
73_D215_S0.6320.37
27_R30_S0.6300.37
181_F291_F0.6300.37
241_W244_A0.6300.37
312_E315_T0.6300.37
211_M279_K0.6240.36
70_Q95_S0.6220.36
186_D305_F0.6210.36
133_I137_G0.6210.36
126_I163_H0.6190.36
301_A307_F0.6180.36
42_S202_V0.6180.36
107_P163_H0.6170.36
58_L289_S0.6140.35
11_A18_A0.6120.35
219_L226_W0.6120.35
85_W190_R0.6110.35
94_R196_D0.6100.35
161_K181_F0.6100.35
204_Q222_F0.6090.35
99_L183_R0.6070.35
21_L57_Y0.6020.34
29_A64_L0.5980.34
198_E386_R0.5980.34
48_T54_R0.5980.34
31_L35_P0.5980.34
55_S160_H0.5970.34
226_W299_K0.5960.34
204_Q237_A0.5950.34
116_D119_M0.5940.34
205_T388_T0.5930.34
240_A388_T0.5930.34
37_T64_L0.5920.34
112_W170_A0.5910.33
105_L108_E0.5910.33
111_G169_T0.5910.33
152_S156_E0.5910.33
88_E169_T0.5870.33
296_W301_A0.5870.33
142_A180_N0.5860.33
64_L287_V0.5860.33
346_Q351_E0.5860.33
337_G386_R0.5850.33
56_P87_H0.5850.33
53_A300_R0.5840.33
256_V359_E0.5830.33
339_M355_L0.5830.33
111_G139_V0.5820.33
285_S329_L0.5820.33
119_M122_H0.5810.33
210_I250_Q0.5810.33
296_W314_Y0.5810.33
92_M288_L0.5810.33
16_L19_Q0.5800.33
334_Q361_I0.5790.33
100_I104_M0.5790.33
91_F94_R0.5770.32
49_I59_V0.5720.32
5_H34_I0.5720.32
132_H135_D0.5700.32
322_Y358_Q0.5700.32
212_L239_A0.5690.32
279_K378_F0.5680.32
168_F181_F0.5680.32
126_I207_A0.5670.32
240_A295_V0.5670.32
334_Q373_Q0.5650.31
83_E87_H0.5640.31
46_I178_R0.5640.31
86_A234_K0.5640.31
127_A136_K0.5630.31
225_Q242_R0.5620.31
344_H353_I0.5620.31
355_L389_L0.5620.31
97_F201_L0.5610.31
191_V288_L0.5610.31
122_H172_K0.5570.31
296_W299_K0.5560.31
87_H222_F0.5560.31
43_L86_A0.5550.31
29_A33_D0.5550.31
307_F338_R0.5540.31
49_I181_F0.5540.31
183_R381_W0.5530.30
208_E241_W0.5510.30
291_F324_Y0.5500.30
116_D120_Q0.5500.30
237_A263_W0.5490.30
311_L358_Q0.5470.30
125_E163_H0.5460.30
11_A254_V0.5450.30
157_W342_K0.5440.30
54_R185_Y0.5440.30
148_R154_W0.5430.30
283_T333_G0.5430.30
53_A291_F0.5400.29
298_R320_R0.5400.29
281_T369_K0.5400.29
114_Y119_M0.5390.29
186_D189_H0.5380.29
193_P196_D0.5380.29
13_N333_G0.5380.29
70_Q74_E0.5340.29
8_L257_E0.5320.29
55_S288_L0.5310.29
24_K372_R0.5300.29
54_R291_F0.5280.29
82_M88_E0.5280.29
124_A128_Q0.5270.29
48_T311_L0.5270.29
109_K236_P0.5260.28
19_Q85_W0.5250.28
50_N351_E0.5250.28
205_T369_K0.5250.28
292_D320_R0.5240.28
318_P349_I0.5240.28
19_Q183_R0.5230.28
180_N284_H0.5220.28
307_F326_V0.5180.28
245_R251_I0.5180.28
44_L294_V0.5180.28
153_G180_N0.5170.28
38_I42_S0.5160.28
32_E204_Q0.5160.28
119_M163_H0.5160.28
66_N335_L0.5160.28
230_Y233_L0.5140.28
291_F381_W0.5140.28
77_A80_E0.5140.28
26_R30_S0.5130.27
124_A135_D0.5130.27
41_M55_S0.5130.27
157_W345_R0.5130.27
85_W220_G0.5120.27
140_R179_R0.5110.27
75_S317_A0.5110.27
227_L301_A0.5100.27
120_Q255_H0.5100.27
6_L225_Q0.5100.27
304_L334_Q0.5080.27
70_Q73_D0.5080.27
362_K369_K0.5070.27
311_L325_F0.5060.27
61_F81_L0.5060.27
354_S368_Q0.5060.27
93_P99_L0.5040.27
155_W165_E0.5030.27
183_R259_L0.5030.27
64_L183_R0.5030.27
58_L139_V0.5030.27
21_L294_V0.5020.27
200_D247_E0.5000.27
73_D365_T0.5000.27
219_L227_L0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fu4A 2 0.1927 77.5 0.967 Contact Map
4lb6B 2 0.1537 71.4 0.968 Contact Map
4kmfA 1 0.1512 65.6 0.97 Contact Map
2htjA 1 0.1976 65 0.97 Contact Map
1qgpA 1 0.178 62.8 0.97 Contact Map
1qbjA 1 0.1537 59.9 0.971 Contact Map
2heoA 1 0.1415 59.5 0.971 Contact Map
1xmkA 1 0.1902 57.1 0.971 Contact Map
2mh2A 1 0.1439 55.9 0.972 Contact Map
3eyiA 1 0.1488 53.9 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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