GREMLIN Database
YCAN - Uncharacterized HTH-type transcriptional regulator YcaN
UniProt: P75836 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13698
Length: 302 (287)
Sequences: 79842 (58057)
Seq/√Len: 3427.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_P76_E3.5701.00
17_N26_E3.3831.00
157_V289_K2.6931.00
98_N140_F2.6011.00
69_R83_E2.4101.00
230_V237_G2.2931.00
13_A26_E2.2231.00
173_Y189_H2.2031.00
114_G291_G2.1991.00
164_K241_Y2.1861.00
158_A161_P2.1751.00
161_P266_G2.1681.00
94_T125_E2.1251.00
22_A25_D2.1061.00
94_T123_K2.0851.00
16_R71_R2.0801.00
158_A266_G2.0701.00
182_H185_D2.0251.00
47_I62_A2.0241.00
10_T37_S2.0131.00
12_F67_Y1.9611.00
231_L252_R1.9591.00
69_R76_E1.9571.00
227_L247_Y1.9551.00
114_G287_Y1.9471.00
96_K125_E1.9331.00
12_F71_R1.9261.00
161_P264_R1.9211.00
13_A16_R1.8981.00
169_A256_V1.8871.00
192_V235_G1.8771.00
12_F16_R1.8751.00
10_T34_I1.8671.00
73_A77_I1.8661.00
13_A17_N1.8651.00
15_A59_L1.8521.00
231_L247_Y1.8341.00
166_C241_Y1.8291.00
67_Y71_R1.8021.00
20_F38_I1.7971.00
51_N58_S1.7321.00
66_L80_M1.7001.00
190_Q217_N1.6701.00
65_N83_E1.6581.00
166_C255_C1.6581.00
156_S268_Q1.6551.00
178_G185_D1.6391.00
115_F284_F1.6091.00
134_D139_G1.6041.00
16_R26_E1.5791.00
15_A67_Y1.5751.00
12_F70_L1.5621.00
17_N22_A1.5591.00
155_I273_N1.5591.00
11_F67_Y1.5521.00
200_K204_W1.5511.00
10_T29_L1.5401.00
133_V137_Q1.5121.00
90_T121_D1.5111.00
21_R31_S1.4911.00
7_D37_S1.4831.00
7_D44_R1.4621.00
61_E64_S1.4611.00
115_F122_I1.4531.00
157_V271_Y1.4461.00
48_R51_N1.4391.00
19_S22_A1.4311.00
7_D40_T1.4251.00
69_R72_P1.4231.00
30_S33_A1.4211.00
13_A27_L1.4091.00
12_F74_F1.4081.00
285_L289_K1.4051.00
277_M281_L1.4021.00
155_I271_Y1.3851.00
147_S268_Q1.3831.00
145_R270_Y1.3801.00
4_N7_D1.3721.00
69_R79_I1.3681.00
171_P252_R1.3611.00
73_A80_M1.3581.00
105_R224_D1.3521.00
5_M77_I1.3491.00
92_T121_D1.3421.00
271_Y285_L1.3311.00
136_V153_D1.3251.00
114_G118_E1.3251.00
269_I285_L1.3141.00
283_A286_D1.3111.00
96_K127_T1.2991.00
163_V242_E1.2971.00
134_D140_F1.2921.00
135_I143_G1.2901.00
142_A281_L1.2851.00
116_T217_N1.2781.00
53_T58_S1.2721.00
169_A236_I1.2701.00
44_R81_L1.2671.00
66_L81_L1.2621.00
189_H236_I1.2581.00
142_A269_I1.2511.00
76_E79_I1.2501.00
226_E237_G1.2451.00
247_Y252_R1.2411.00
241_Y245_K1.2311.00
118_E287_Y1.2281.00
245_K249_D1.2191.00
68_E72_P1.2121.00
39_K43_Q1.2051.00
228_E231_L1.2001.00
64_S68_E1.1971.00
241_Y255_C1.1931.00
69_R80_M1.1911.00
171_P254_E1.1891.00
65_N68_E1.1831.00
116_T190_Q1.1771.00
113_V117_R1.1741.00
179_K254_E1.1741.00
11_F50_F1.1721.00
114_G117_R1.1641.00
158_A268_Q1.1601.00
207_A212_I1.1591.00
174_F189_H1.1571.00
156_S270_Y1.1471.00
29_L33_A1.1401.00
11_F15_A1.1231.00
192_V226_E1.1181.00
36_H39_K1.1111.00
95_L284_F1.1101.00
36_H40_T1.1061.00
11_F49_L1.1041.00
190_Q215_A1.1021.00
113_V232_M1.0941.00
180_P259_D1.0931.00
125_E219_I1.0921.00
35_S39_K1.0891.00
286_D289_K1.0881.00
119_Y283_A1.0771.00
72_P79_I1.0741.00
9_A78_Q1.0721.00
6_S9_A1.0711.00
168_A255_C1.0701.00
20_F57_V1.0691.00
220_L226_E1.0681.00
8_F70_L1.0651.00
14_V23_A1.0641.00
115_F287_Y1.0631.00
104_A128_T1.0631.00
73_A76_E1.0601.00
13_A23_A1.0521.00
282_R286_D1.0471.00
287_Y291_G1.0451.00
111_L288_V1.0361.00
227_L231_L1.0361.00
65_N69_R1.0291.00
37_S40_T1.0291.00
59_L63_G1.0221.00
110_S232_M1.0161.00
136_V151_E1.0151.00
255_C258_E1.0141.00
170_T233_G1.0131.00
157_V285_L1.0111.00
228_E232_M1.0081.00
181_R185_D0.9981.00
201_P204_W0.9861.00
81_L85_N0.9851.00
164_K264_R0.9821.00
183_P260_W0.9801.00
78_Q82_D0.9751.00
78_Q81_L0.9741.00
10_T27_L0.9731.00
167_V236_I0.9721.00
29_L34_I0.9691.00
168_A244_I0.9661.00
201_P206_F0.9631.00
15_A50_F0.9561.00
246_E250_T0.9541.00
115_F119_Y0.9521.00
11_F59_L0.9451.00
14_V20_F0.9441.00
75_D79_I0.9431.00
118_E290_T0.9411.00
66_L70_L0.9381.00
134_D137_Q0.9381.00
287_Y290_T0.9261.00
220_L229_A0.9251.00
278_S281_L0.9191.00
169_A173_Y0.9181.00
23_A34_I0.9121.00
193_V216_G0.9091.00
50_F57_V0.9071.00
111_L287_Y0.8991.00
40_T43_Q0.8981.00
47_I84_M0.8951.00
11_F41_L0.8931.00
173_Y176_R0.8931.00
123_K215_A0.8891.00
173_Y190_Q0.8871.00
15_A63_G0.8861.00
98_N143_G0.8861.00
140_F143_G0.8801.00
22_A26_E0.8781.00
127_T134_D0.8781.00
98_N145_R0.8731.00
153_D273_N0.8711.00
203_H207_A0.8691.00
272_P275_Q0.8661.00
68_E71_R0.8651.00
101_R222_D0.8631.00
173_Y177_Y0.8611.00
147_S266_G0.8551.00
18_Q58_S0.8531.00
169_A174_F0.8521.00
21_R25_D0.8501.00
244_I247_Y0.8431.00
203_H206_F0.8421.00
122_I280_G0.8401.00
154_M270_Y0.8381.00
286_D290_T0.8371.00
185_D188_N0.8371.00
72_P75_D0.8341.00
6_S37_S0.8341.00
191_C214_V0.8331.00
177_Y190_Q0.8331.00
97_I142_A0.8331.00
168_A237_G0.8311.00
65_N87_F0.8231.00
174_F179_K0.8231.00
27_L34_I0.8221.00
53_T56_S0.8121.00
277_M282_R0.8101.00
190_Q216_G0.8081.00
132_L136_V0.8051.00
175_A189_H0.8021.00
206_F210_L0.8001.00
5_M74_F0.7981.00
62_A84_M0.7971.00
155_I158_A0.7961.00
160_G163_V0.7921.00
11_F66_L0.7901.00
18_Q64_S0.7871.00
39_K48_R0.7871.00
127_T140_F0.7811.00
14_V38_I0.7791.00
93_G280_G0.7791.00
113_V234_A0.7781.00
31_S35_S0.7781.00
247_Y250_T0.7771.00
15_A18_Q0.7771.00
172_E176_R0.7721.00
248_L251_G0.7691.00
16_R67_Y0.7651.00
244_I248_L0.7651.00
91_P119_Y0.7641.00
77_I80_M0.7641.00
170_T234_A0.7631.00
17_N23_A0.7621.00
184_H187_L0.7621.00
76_E80_M0.7611.00
14_V50_F0.7581.00
79_I83_E0.7571.00
182_H259_D0.7521.00
164_K262_T0.7511.00
18_Q56_S0.7491.00
62_A87_F0.7481.00
164_K257_L0.7481.00
279_C283_A0.7441.00
118_E283_A0.7431.00
229_A234_A0.7421.00
187_L212_I0.7401.00
116_T234_A0.7401.00
62_A65_N0.7371.00
142_A284_F0.7361.00
77_I81_L0.7351.00
85_N88_R0.7341.00
7_D10_T0.7311.00
136_V154_M0.7281.00
111_L291_G0.7271.00
114_G290_T0.7271.00
168_A248_L0.7231.00
168_A239_L0.7201.00
184_H210_L0.7191.00
59_L64_S0.7191.00
200_K219_I0.7161.00
58_S64_S0.7151.00
9_A13_A0.7111.00
248_L255_C0.7101.00
96_K140_F0.7091.00
80_M84_M0.7091.00
204_W207_A0.7071.00
205_Q208_K0.7061.00
70_L73_A0.7031.00
222_D225_A0.7021.00
14_V34_I0.6991.00
176_R254_E0.6981.00
51_N60_T0.6981.00
20_F34_I0.6981.00
201_P205_Q0.6981.00
115_F283_A0.6981.00
169_A254_E0.6951.00
99_A104_A0.6941.00
33_A37_S0.6921.00
240_L243_Q0.6911.00
144_V288_V0.6871.00
182_H260_W0.6861.00
170_T173_Y0.6861.00
93_G122_I0.6821.00
62_A66_L0.6741.00
71_R75_D0.6731.00
195_R219_I0.6711.00
141_D281_L0.6691.00
188_N215_A0.6681.00
96_K141_D0.6671.00
42_E47_I0.6661.00
194_F226_E0.6641.00
51_N56_S0.6641.00
218_I229_A0.6621.00
169_A175_A0.6621.00
75_D78_Q0.6611.00
123_K219_I0.6611.00
64_S67_Y0.6591.00
61_E65_N0.6521.00
205_Q209_E0.6521.00
20_F56_S0.6511.00
204_W208_K0.6501.00
66_L84_M0.6491.00
180_P257_L0.6451.00
283_A287_Y0.6451.00
246_E249_D0.6441.00
99_A108_L0.6421.00
206_F209_E0.6411.00
42_E52_R0.6391.00
95_L280_G0.6381.00
70_L74_F0.6381.00
79_I82_D0.6371.00
172_E254_E0.6361.00
138_Q272_P0.6351.00
172_E175_A0.6311.00
172_E233_G0.6301.00
6_S40_T0.6261.00
23_A27_L0.6251.00
191_C236_I0.6241.00
38_I42_E0.6231.00
25_D28_G0.6221.00
160_G267_F0.6201.00
69_R73_A0.6191.00
9_A12_F0.6191.00
171_P251_G0.6181.00
195_R221_D0.6111.00
135_I270_Y0.6031.00
14_V19_S0.6031.00
279_C282_R0.6001.00
275_Q278_S0.5991.00
167_V186_L0.5981.00
105_R228_E0.5941.00
142_A285_L0.5931.00
65_N84_M0.5921.00
200_K203_H0.5921.00
82_D86_D0.5901.00
174_F177_Y0.5891.00
202_F205_Q0.5881.00
92_T123_K0.5871.00
167_V238_Y0.5861.00
95_L142_A0.5851.00
229_A235_G0.5851.00
128_T222_D0.5841.00
108_L111_L0.5831.00
226_E230_V0.5831.00
155_I274_R0.5801.00
284_F288_V0.5801.00
202_F206_F0.5761.00
167_V191_C0.5751.00
163_V265_P0.5751.00
59_L67_Y0.5751.00
45_L84_M0.5741.00
32_S36_H0.5721.00
178_G181_R0.5721.00
6_S10_T0.5711.00
146_L265_P0.5701.00
33_A36_H0.5681.00
45_L66_L0.5681.00
110_S114_G0.5681.00
175_A178_G0.5671.00
110_S113_V0.5671.00
207_A214_V0.5671.00
135_I154_M0.5651.00
128_T221_D0.5651.00
50_F59_L0.5601.00
165_L238_Y0.5571.00
271_Y282_R0.5561.00
9_A74_F0.5551.00
220_L225_A0.5551.00
196_Y219_I0.5541.00
30_S36_H0.5531.00
47_I51_N0.5471.00
175_A181_R0.5451.00
68_E83_E0.5411.00
45_L48_R0.5401.00
239_L244_I0.5391.00
10_T38_I0.5341.00
74_F78_Q0.5331.00
174_F178_G0.5321.00
223_V240_L0.5311.00
173_Y236_I0.5311.00
180_P185_D0.5281.00
38_I50_F0.5241.00
133_V139_G0.5211.00
187_L213_A0.5181.00
74_F77_I0.5181.00
11_F63_G0.5171.00
103_A107_F0.5171.00
129_D134_D0.5151.00
93_G119_Y0.5151.00
144_V269_I0.5141.00
159_I269_I0.5131.00
105_R222_D0.5121.00
10_T23_A0.5091.00
29_L37_S0.5071.00
20_F31_S0.5061.00
48_R62_A0.5051.00
20_F52_R0.5031.00
18_Q57_V0.5031.00
169_A176_R0.5031.00
82_D85_N0.5031.00
147_S156_S0.5031.00
112_L124_V0.5031.00
69_R84_M0.5031.00
93_G121_D0.5011.00
98_N127_T0.5011.00
281_L285_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fzvA 4 0.947 100 0.09 Contact Map
2esnA 3 0.9636 100 0.111 Contact Map
3szpA 3 0.9603 100 0.112 Contact Map
3hhgA 3 0.9702 100 0.115 Contact Map
1ixcA 4 0.9536 100 0.119 Contact Map
1uthA 2 0.7384 100 0.119 Contact Map
3fxqA 3 0.957 100 0.12 Contact Map
1al3A 1 0.7053 100 0.13 Contact Map
2h9bA 2 0.6854 100 0.131 Contact Map
2h98A 2 0.6854 100 0.132 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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