GREMLIN Database
YCAM - Inner membrane transporter YcaM
UniProt: P75835 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13697
Length: 476 (420)
Sequences: 25020 (16630)
Seq/√Len: 811.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
143_M349_L4.3051.00
331_S343_N4.3021.00
394_A398_L3.2761.00
334_R343_N3.0281.00
233_K237_K2.9131.00
11_R229_R2.7861.00
230_N233_K2.6611.00
74_S325_S2.6501.00
228_T234_E2.6371.00
323_A333_C2.5701.00
90_A322_D2.5631.00
175_A256_A2.5241.00
336_N342_V2.5171.00
136_L353_A2.4731.00
48_F247_A2.4681.00
331_S334_R2.4381.00
386_L423_F2.3971.00
16_A241_C2.3931.00
461_G465_I2.3521.00
61_Q396_V2.3161.00
12_W241_C2.2881.00
173_A177_T2.2001.00
226_N324_D2.1741.00
291_T295_I2.1401.00
144_W148_R2.1271.00
78_K86_A2.0551.00
320_L324_D2.0491.00
277_Y280_Q2.0361.00
12_W234_E2.0341.00
346_F350_V2.0271.00
147_S342_V1.9961.00
227_Q317_K1.9911.00
16_A245_M1.9901.00
15_I228_T1.9881.00
151_K155_I1.9731.00
274_G278_A1.9701.00
140_I353_A1.9701.00
136_L356_I1.9651.00
143_M345_Y1.9461.00
12_W16_A1.9331.00
237_K241_C1.9301.00
45_V49_A1.9171.00
81_M394_A1.8931.00
162_I166_V1.8731.00
78_K83_P1.8541.00
11_R14_N1.8521.00
332_L347_L1.8481.00
426_T429_A1.8431.00
415_A419_G1.8391.00
94_W348_T1.8241.00
135_T356_I1.8191.00
326_K330_A1.8181.00
448_Q451_L1.8181.00
58_I389_F1.8101.00
447_F450_A1.8001.00
459_L463_G1.7791.00
49_A53_T1.7661.00
420_I424_A1.7521.00
6_Q335_T1.7251.00
451_L455_T1.7101.00
262_D265_N1.7041.00
77_I89_A1.6871.00
416_M420_I1.6861.00
230_N234_E1.6851.00
140_I349_L1.6841.00
81_M390_V1.6761.00
14_N158_S1.6661.00
336_N340_T1.6601.00
422_C426_T1.6441.00
44_W47_I1.6281.00
277_Y281_K1.6271.00
431_L435_F1.6111.00
240_L244_V1.6111.00
101_L352_V1.6041.00
190_N193_W1.6021.00
449_L453_V1.5891.00
166_V170_L1.5881.00
146_A309_V1.5791.00
147_S346_F1.5371.00
105_P308_L1.5351.00
89_A387_W1.5331.00
338_S342_V1.5321.00
429_A432_T1.5281.00
19_S242_L1.5131.00
139_F352_V1.5121.00
82_G85_L1.5011.00
278_A283_G1.4931.00
271_M277_Y1.4931.00
112_L134_L1.4911.00
319_L344_G1.4851.00
7_E339_G1.4841.00
456_P460_V1.4831.00
434_I437_K1.4791.00
10_L14_N1.4771.00
455_T458_V1.4681.00
271_M274_G1.4631.00
394_A397_R1.4591.00
460_V463_G1.4521.00
183_E186_I1.4421.00
224_Y313_D1.4071.00
389_F422_C1.3961.00
105_P139_F1.3961.00
244_V248_V1.3961.00
167_M299_A1.3951.00
108_I138_L1.3891.00
428_F432_T1.3881.00
43_S207_T1.3841.00
330_A333_C1.3801.00
414_L418_V1.3781.00
454_A458_V1.3771.00
424_A428_F1.3731.00
401_K404_P1.3721.00
192_T195_T1.3721.00
81_M85_L1.3701.00
447_F451_L1.3671.00
315_P348_T1.3541.00
273_N277_Y1.3541.00
429_A433_G1.3491.00
56_A243_A1.3481.00
39_V204_Y1.3451.00
230_N237_K1.3441.00
41_V44_W1.3421.00
422_C425_F1.3391.00
148_R338_S1.3351.00
77_I387_W1.3311.00
143_M346_F1.3301.00
316_L345_Y1.3241.00
343_N347_L1.3241.00
320_L335_T1.3231.00
44_W52_F1.3181.00
40_V44_W1.3101.00
139_F349_L1.3061.00
418_V422_C1.3061.00
176_V256_A1.3041.00
66_F79_H1.3021.00
459_L462_L1.3001.00
457_F461_G1.2961.00
192_T197_I1.2951.00
14_N154_K1.2951.00
422_C429_A1.2861.00
334_R342_V1.2691.00
70_K226_N1.2631.00
294_V298_I1.2561.00
445_W449_L1.2551.00
44_W51_Y1.2531.00
136_L140_I1.2521.00
55_Y389_F1.2511.00
40_V43_S1.2501.00
450_A454_A1.2501.00
172_V252_L1.2481.00
179_P259_M1.2431.00
330_A334_R1.2411.00
80_T391_A1.2411.00
445_W448_Q1.2361.00
274_G277_Y1.2331.00
108_I301_T1.2221.00
45_V52_F1.2221.00
430_C433_G1.2211.00
6_Q320_L1.2061.00
12_W237_K1.2061.00
416_M419_G1.2011.00
453_V457_F1.2001.00
142_F308_L1.1951.00
455_T459_L1.1851.00
390_V394_A1.1841.00
13_Y17_L1.1831.00
56_A239_M1.1831.00
31_N35_N1.1811.00
417_T420_I1.1801.00
10_L15_I1.1801.00
23_V246_V1.1731.00
104_K307_A1.1701.00
433_G436_P1.1651.00
417_T421_W1.1611.00
234_E237_K1.1601.00
231_P236_P1.1581.00
448_Q457_F1.1571.00
32_N36_Q1.1521.00
248_V252_L1.1501.00
32_N40_V1.1491.00
57_L240_L1.1481.00
280_Q293_M1.1471.00
10_L154_K1.1441.00
434_I438_M1.1431.00
165_F169_L1.1411.00
41_V45_V1.1361.00
446_T449_L1.1341.00
24_W27_G1.1321.00
451_L454_A1.1311.00
75_T79_H1.1261.00
319_L328_I1.1241.00
426_T430_C1.1231.00
419_G422_C1.1211.00
449_L455_T1.1191.00
461_G464_L1.1181.00
171_Y175_A1.1171.00
446_T450_A1.1031.00
39_V197_I1.1011.00
263_S266_I1.0951.00
397_R400_Q1.0881.00
274_G283_G1.0841.00
15_I238_G1.0821.00
175_A260_M1.0811.00
430_C434_I1.0801.00
229_R234_E1.0801.00
448_Q455_T1.0791.00
445_W451_L1.0781.00
19_S221_I1.0781.00
448_Q459_L1.0681.00
445_W459_L1.0591.00
416_M433_G1.0571.00
279_F283_G1.0531.00
47_I211_L1.0521.00
77_I85_L1.0471.00
390_V423_F1.0471.00
459_L464_L1.0421.00
419_G433_G1.0411.00
59_V73_V1.0401.00
133_G137_V1.0391.00
94_W319_L1.0381.00
400_Q404_P1.0371.00
156_V160_A1.0351.00
9_Q229_R1.0271.00
18_M224_Y1.0261.00
414_L419_G1.0241.00
44_W48_F1.0191.00
343_N346_F1.0171.00
454_A457_F1.0121.00
132_Q136_L1.0091.00
275_Q280_Q1.0081.00
109_L134_L1.0081.00
324_D333_C1.0071.00
193_W196_F1.0061.00
275_Q283_G1.0041.00
41_V255_L1.0031.00
176_V180_A1.0021.00
170_L174_M1.0011.00
157_G309_V0.9991.00
143_M147_S0.9981.00
63_G76_W0.9941.00
191_I195_T0.9931.00
427_A431_L0.9891.00
402_Y405_E0.9861.00
145_V156_V0.9851.00
44_W49_A0.9851.00
112_L116_M0.9801.00
335_T339_G0.9801.00
155_I159_V0.9791.00
459_L465_I0.9761.00
458_V462_L0.9761.00
283_G292_L0.9751.00
49_A417_T0.9671.00
190_N194_E0.9661.00
87_Y91_W0.9651.00
74_S321_G0.9631.00
350_V354_I0.9631.00
150_M313_D0.9581.00
189_T194_E0.9581.00
20_F245_M0.9581.00
205_I428_F0.9511.00
191_I194_E0.9491.00
42_F45_V0.9471.00
169_L173_A0.9461.00
275_Q279_F0.9411.00
397_R416_M0.9381.00
433_G437_K0.9351.00
61_Q64_S0.9341.00
45_V51_Y0.9311.00
448_Q453_V0.9251.00
452_N456_P0.9231.00
419_G423_F0.9211.00
65_T402_Y0.9201.00
137_V141_F0.9181.00
65_T404_P0.9171.00
160_A306_A0.9141.00
43_S51_Y0.9091.00
193_W197_I0.9021.00
140_I144_W0.9001.00
431_L434_I0.8981.00
68_D75_T0.8941.00
184_V187_A0.8931.00
447_F456_P0.8891.00
446_T451_L0.8851.00
216_G381_M0.8821.00
454_A460_V0.8781.00
17_L158_S0.8751.00
312_I349_L0.8731.00
79_H399_A0.8721.00
399_A402_Y0.8701.00
225_V235_F0.8691.00
20_F246_V0.8681.00
25_G28_N0.8671.00
141_F305_V0.8631.00
283_G288_M0.8621.00
451_L463_G0.8621.00
455_T460_V0.8611.00
449_L454_A0.8571.00
425_F429_A0.8551.00
172_V256_A0.8531.00
103_Q213_F0.8531.00
276_Y280_Q0.8521.00
447_F464_L0.8501.00
386_L390_V0.8491.00
447_F455_T0.8481.00
48_F215_V0.8421.00
78_K325_S0.8411.00
414_L417_T0.8401.00
419_G429_A0.8391.00
219_E223_P0.8391.00
451_L457_F0.8341.00
457_F460_V0.8331.00
423_F427_A0.8331.00
206_T210_M0.8331.00
450_A453_V0.8321.00
460_V464_L0.8301.00
147_S340_T0.8291.00
332_L343_N0.8291.00
39_V44_W0.8271.00
112_L301_T0.8251.00
33_Y40_V0.8221.00
9_Q151_K0.8211.00
241_C245_M0.8211.00
450_A459_L0.8201.00
447_F453_V0.8191.00
265_N281_K0.8181.00
447_F454_A0.8171.00
275_Q278_A0.8171.00
142_F309_V0.8161.00
24_W29_V0.8131.00
186_I189_T0.8081.00
147_S336_N0.8071.00
31_N34_A0.8041.00
109_L135_T0.8041.00
103_Q374_L0.8021.00
190_N195_T0.8011.00
393_I416_M0.8011.00
13_Y158_S0.8001.00
255_L259_M0.8001.00
198_P202_F0.7961.00
164_M303_G0.7951.00
14_N155_I0.7921.00
165_F249_C0.7861.00
30_V107_A0.7851.00
155_I158_S0.7841.00
453_V456_P0.7801.00
280_Q290_N0.7801.00
71_G74_S0.7791.00
448_Q461_G0.7791.00
108_I305_V0.7761.00
247_A251_I0.7761.00
445_W450_A0.7751.00
220_K314_A0.7741.00
451_L461_G0.7661.00
134_L137_V0.7661.00
451_L465_I0.7641.00
342_V346_F0.7641.00
451_L456_P0.7641.00
71_G75_T0.7621.00
349_L353_A0.7601.00
336_N339_G0.7601.00
422_C431_L0.7571.00
174_M283_G0.7561.00
64_S405_E0.7551.00
172_V176_V0.7541.00
45_V251_I0.7531.00
91_W328_I0.7431.00
189_T192_T0.7431.00
450_A455_T0.7421.00
62_L392_F0.7421.00
290_N294_V0.7411.00
47_I51_Y0.7391.00
426_T433_G0.7371.00
419_G430_C0.7361.00
77_I391_A0.7361.00
328_I332_L0.7351.00
40_V254_S0.7321.00
142_F312_I0.7291.00
452_N455_T0.7281.00
445_W455_T0.7271.00
449_L459_L0.7271.00
171_Y279_F0.7251.00
192_T196_F0.7251.00
108_I304_Q0.7251.00
448_Q454_A0.7241.00
84_G88_L0.7241.00
462_L465_I0.7231.00
132_Q356_I0.7191.00
9_Q150_M0.7181.00
139_F356_I0.7181.00
393_I419_G0.7181.00
144_W147_S0.7181.00
65_T400_Q0.7171.00
449_L457_F0.7161.00
416_M436_P0.7131.00
393_I420_I0.7131.00
456_P463_G0.7121.00
6_Q317_K0.7111.00
392_F396_V0.7071.00
22_T310_F0.7051.00
396_V400_Q0.7051.00
435_F438_M0.7051.00
106_Q373_L0.7051.00
85_L387_W0.7041.00
45_V48_F0.7041.00
376_L380_V0.7031.00
6_Q227_Q0.6991.00
446_T453_V0.6971.00
185_H189_T0.6961.00
80_T394_A0.6961.00
446_T459_L0.6951.00
47_I52_F0.6911.00
38_L258_G0.6901.00
422_C433_G0.6901.00
12_W238_G0.6881.00
451_L460_V0.6871.00
449_L458_V0.6871.00
148_R152_S0.6851.00
422_C436_P0.6841.00
198_P201_D0.6821.00
420_I423_F0.6771.00
451_L458_V0.6761.00
176_V252_L0.6761.00
395_V399_A0.6751.00
43_S47_I0.6731.00
197_I201_D0.6721.00
13_Y155_I0.6721.00
177_T180_A0.6681.00
116_M119_D0.6661.00
50_L425_F0.6661.00
415_A422_C0.6661.00
62_L76_W0.6661.00
273_N276_Y0.6651.00
391_A395_V0.6641.00
393_I397_R0.6631.00
291_T294_V0.6621.00
74_S78_K0.6611.00
117_K120_G0.6601.00
456_P459_L0.6591.00
183_E187_A0.6581.00
449_L452_N0.6571.00
39_V42_F0.6561.00
425_F428_F0.6561.00
43_S48_F0.6551.00
146_A345_Y0.6541.00
448_Q456_P0.6531.00
337_A342_V0.6511.00
418_V426_T0.6481.00
458_V465_I0.6471.00
118_G121_S0.6461.00
429_A434_I0.6431.00
136_L357_M0.6421.00
216_G385_Y0.6421.00
146_A313_D0.6421.00
425_F432_T0.6411.00
24_W164_M0.6401.00
41_V258_G0.6391.00
38_L41_V0.6381.00
404_P408_F0.6381.00
448_Q465_I0.6361.00
189_T193_W0.6361.00
350_V353_A0.6361.00
267_P271_M0.6341.00
48_F52_F0.6331.00
236_P239_M0.6311.00
21_I161_G0.6301.00
91_W455_T0.6291.00
179_P256_A0.6281.00
109_L131_L0.6271.00
100_Y377_N0.6261.00
419_G425_F0.6251.00
445_W454_A0.6241.00
446_T455_T0.6231.00
172_V253_G0.6231.00
81_M391_A0.6221.00
116_M120_G0.6211.00
80_T395_V0.6201.00
52_F57_L0.6191.00
449_L462_L0.6181.00
245_M249_C0.6171.00
58_I419_G0.6161.00
288_M291_T0.6161.00
379_V430_C0.6151.00
447_F461_G0.6151.00
230_N236_P0.6141.00
449_L464_L0.6131.00
404_P407_V0.6131.00
100_Y103_Q0.6121.00
422_C435_F0.6111.00
449_L463_G0.6101.00
422_C432_T0.6081.00
154_K158_S0.6071.00
203_T206_T0.6061.00
20_F161_G0.6061.00
93_Y97_H0.6051.00
59_V388_V0.6051.00
450_A457_F0.6051.00
433_G438_M0.6051.00
445_W458_V0.6031.00
451_L459_L0.6031.00
97_H311_S0.6031.00
450_A463_G0.6011.00
453_V464_L0.5991.00
422_C430_C0.5991.00
174_M178_A0.5981.00
56_A218_A0.5971.00
417_T422_C0.5961.00
16_A238_G0.5961.00
426_T434_I0.5951.00
450_A456_P0.5931.00
152_S155_I0.5931.00
332_L344_G0.5921.00
98_I351_L0.5921.00
453_V463_G0.5921.00
96_V381_M0.5891.00
331_S347_L0.5881.00
380_V384_R0.5871.00
341_P344_G0.5861.00
16_A19_S0.5861.00
323_A332_L0.5841.00
139_F353_A0.5841.00
451_L462_L0.5831.00
92_T384_R0.5821.00
458_V464_L0.5811.00
191_I196_F0.5811.00
226_N320_L0.5801.00
65_T405_E0.5771.00
452_N463_G0.5771.00
70_K320_L0.5761.00
102_A355_L0.5751.00
138_L308_L0.5741.00
273_N280_Q0.5741.00
9_Q13_Y0.5731.00
429_A436_P0.5731.00
147_S338_S0.5701.00
426_T438_M0.5701.00
458_V461_G0.5701.00
316_L344_G0.5691.00
111_A300_N0.5691.00
278_A282_L0.5681.00
425_F433_G0.5681.00
454_A465_I0.5671.00
295_I299_A0.5651.00
19_S23_V0.5621.00
298_I302_L0.5621.00
41_V51_Y0.5621.00
163_A299_A0.5611.00
317_K320_L0.5611.00
42_F46_F0.5611.00
112_L138_L0.5601.00
44_W50_L0.5591.00
99_P376_L0.5581.00
23_V242_L0.5571.00
147_S345_Y0.5571.00
96_V99_P0.5561.00
180_A184_V0.5551.00
81_M84_G0.5531.00
312_I316_L0.5521.00
22_T311_S0.5521.00
195_T198_P0.5511.00
216_G219_E0.5491.00
445_W462_L0.5491.00
256_A259_M0.5481.00
197_I204_Y0.5481.00
115_A298_I0.5471.00
276_Y279_F0.5461.00
193_W198_P0.5461.00
319_L347_L0.5441.00
74_S90_A0.5421.00
241_C244_V0.5411.00
45_V53_T0.5411.00
38_L263_S0.5401.00
453_V458_V0.5391.00
114_W297_A0.5381.00
140_I143_M0.5371.00
85_L88_L0.5371.00
142_F305_V0.5351.00
199_H202_F0.5351.00
450_A460_V0.5351.00
222_S239_M0.5341.00
403_K407_V0.5331.00
149_G152_S0.5321.00
245_M248_V0.5311.00
13_Y16_A0.5311.00
109_L112_L0.5311.00
419_G436_P0.5311.00
422_C438_M0.5311.00
335_T338_S0.5301.00
63_G222_S0.5301.00
73_V219_E0.5291.00
432_T435_F0.5251.00
445_W456_P0.5251.00
39_V43_S0.5241.00
453_V462_L0.5231.00
431_L436_P0.5231.00
223_P314_A0.5231.00
8_K229_R0.5231.00
74_S86_A0.5221.00
453_V460_V0.5211.00
260_M278_A0.5191.00
35_N206_T0.5191.00
425_F431_L0.5191.00
163_A167_M0.5181.00
102_A373_L0.5181.00
392_F419_G0.5181.00
454_A461_G0.5171.00
429_A437_K0.5161.00
68_D79_H0.5161.00
419_G431_L0.5151.00
253_G257_M0.5151.00
42_F204_Y0.5141.00
31_N36_Q0.5141.00
62_L80_T0.5141.00
452_N458_V0.5141.00
47_I50_L0.5131.00
447_F458_V0.5131.00
53_T421_W0.5121.00
457_F465_I0.5121.00
273_N283_G0.5121.00
454_A459_L0.5121.00
252_L256_A0.5121.00
58_I408_F0.5111.00
414_L433_G0.5101.00
187_A193_W0.5091.00
154_K309_V0.5091.00
143_M312_I0.5051.00
415_A429_A0.5021.00
138_L305_V0.5011.00
104_K107_A0.5011.00
425_F434_I0.5011.00
60_G64_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8761 100 0.312 Contact Map
4djkA 2 0.916 100 0.313 Contact Map
3giaA 1 0.8866 100 0.366 Contact Map
3dh4A 3 0.8803 98.9 0.86 Contact Map
2xq2A 2 0.8739 98.8 0.862 Contact Map
2jlnA 1 0.8866 98.4 0.879 Contact Map
2a65A 2 0.9265 98.2 0.885 Contact Map
4xp4A 1 0.9349 97.9 0.893 Contact Map
4wgvA 2 0.7752 97.6 0.9 Contact Map
4us3A 1 0.8382 97.3 0.906 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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