MACA - ECOLI - GREMLIN Contacts

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MACA - Macrolide export protein MacA

UniProt:	P75830	Sequences: MKKRKTVKKRYVIALVIVIAGLITLWRILNAPVPTYQTLIVRPGDLQQSVLATGKLDALRKVDVGAQVSGQLKTLSVAIGDKVKKDQLLGVIDPEQAENQIKEVEATLMELRAQRQQAEAELKLARVTYSRQQRLAQTKAVSQQDLDTAATEMAVKQAQIGTIDAQIKRNQASLDTAKTNLDYTRIVAPMAGEVTQITTLQGQTVIAAQQAPNILTLADMSAMLVKAQVSEADVIHLKPGQKAWFTVLGDPLTRYEGQIKDVLPTPEKVNDAIFYYARFEVPNPNGLLRLDMTAQVHIQLTDVKNVLTIPLSALGDPVGDNRYKVKLLRNGETREREVTIGARNDTDVEIVKGLEAGDEVVIGEAKPGAAQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13694
Length:	371 (336)
Sequences:	22518 (18001)
Seq/√Len:	982.0

ECOLI - MACA ACRE ACRA MDTE MDTA CUSB EMRK EMRA YIBH YHII YIAV MDTN YDHJ YBHG AAEA
BACSU - YKNX YVRP

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
74_T	91_V	3.080	1.00
88_L	185_R	2.980	1.00
339_T	352_K	2.733	1.00
40_I	359_E	2.647	1.00
84_K	191_A	2.597	1.00
126_R	130_S	2.435	1.00
57_D	226_K	2.384	1.00
336_R	358_D	2.358	1.00
150_A	154_A	2.347	1.00
260_K	280_E	2.340	1.00
105_E	178_K	2.318	1.00
311_L	348_V	2.315	1.00
91_V	185_R	2.246	1.00
132_Q	141_V	2.230	1.00
325_V	328_L	2.209	1.00
76_S	91_V	2.140	1.00
43_P	356_A	2.128	1.00
133_Q	137_Q	2.114	1.00
67_Q	183_Y	2.106	1.00
308_T	347_D	2.098	1.00
94_P	98_E	2.089	1.00
84_K	87_Q	2.081	1.00
132_Q	149_A	2.073	1.00
257_G	279_F	2.064	1.00
44_G	347_D	2.055	1.00
82_K	193_E	2.024	1.00
143_Q	147_D	2.013	1.00
88_L	187_V	2.009	1.00
195_T	218_A	1.994	1.00
244_W	256_E	1.985	1.00
244_W	254_R	1.947	1.00
355_E	358_D	1.905	1.00
324_K	335_E	1.904	1.00
133_Q	150_A	1.881	1.00
124_L	128_T	1.877	1.00
242_K	256_E	1.852	1.00
136_A	143_Q	1.842	1.00
253_T	287_L	1.834	1.00
76_S	88_L	1.829	1.00
44_G	308_T	1.812	1.00
227_A	296_V	1.811	1.00
136_A	146_L	1.794	1.00
101_I	174_L	1.791	1.00
226_K	276_Y	1.772	1.00
25_L	28_I	1.750	1.00
85_K	191_A	1.740	1.00
49_S	297_H	1.736	1.00
122_L	153_M	1.722	1.00
56_L	225_V	1.718	1.00
224_L	278_R	1.711	1.00
341_G	349_E	1.701	1.00
103_E	173_S	1.690	1.00
129_Y	133_Q	1.684	1.00
101_I	178_K	1.679	1.00
145_D	148_T	1.671	1.00
322_R	337_E	1.656	1.00
72_L	199_T	1.655	1.00
126_R	153_M	1.652	1.00
340_I	348_V	1.641	1.00
341_G	351_V	1.639	1.00
339_T	351_V	1.634	1.00
98_E	102_K	1.614	1.00
63_D	213_N	1.606	1.00
129_Y	146_L	1.596	1.00
243_A	279_F	1.586	1.00
22_L	26_W	1.574	1.00
333_T	361_V	1.568	1.00
227_A	279_F	1.562	1.00
43_P	305_N	1.560	1.00
102_K	105_E	1.559	1.00
324_K	328_L	1.545	1.00
148_T	152_E	1.543	1.00
45_D	304_K	1.532	1.00
116_Q	119_E	1.525	1.00
22_L	25_L	1.500	1.00
328_L	334_R	1.495	1.00
219_D	222_A	1.491	1.00
168_K	171_Q	1.482	1.00
317_P	335_E	1.480	1.00
60_R	219_D	1.479	1.00
78_A	81_D	1.471	1.00
72_L	90_G	1.469	1.00
146_L	150_A	1.465	1.00
108_L	174_L	1.464	1.00
303_V	349_E	1.460	1.00
123_K	126_R	1.460	1.00
266_P	275_Y	1.456	1.00
129_Y	153_M	1.454	1.00
225_V	294_A	1.453	1.00
175_D	178_K	1.451	1.00
228_Q	276_Y	1.449	1.00
61_K	216_T	1.441	1.00
342_A	349_E	1.439	1.00
98_E	181_L	1.427	1.00
122_L	126_R	1.423	1.00
51_L	297_H	1.422	1.00
327_L	336_R	1.420	1.00
119_E	123_K	1.418	1.00
37_Q	363_G	1.393	1.00
41_V	307_L	1.381	1.00
73_K	93_D	1.368	1.00
247_V	294_A	1.363	1.00
171_Q	175_D	1.361	1.00
258_Q	280_E	1.360	1.00
21_G	25_L	1.352	1.00
311_L	346_T	1.349	1.00
130_S	133_Q	1.342	1.00
101_I	105_E	1.335	1.00
51_L	295_Q	1.325	1.00
246_T	254_R	1.319	1.00
242_K	258_Q	1.316	1.00
123_K	127_V	1.314	1.00
41_V	357_G	1.311	1.00
129_Y	150_A	1.311	1.00
134_R	138_T	1.309	1.00
176_T	180_N	1.305	1.00
100_Q	103_E	1.303	1.00
56_L	223_M	1.295	1.00
100_Q	180_N	1.292	1.00
128_T	148_T	1.291	1.00
63_D	216_T	1.271	1.00
244_W	297_H	1.269	1.00
70_G	92_I	1.267	1.00
244_W	299_Q	1.259	1.00
89_L	215_L	1.257	1.00
38_T	359_E	1.255	1.00
174_L	178_K	1.255	1.00
108_L	167_I	1.252	1.00
222_A	280_E	1.249	1.00
123_K	154_A	1.248	1.00
309_I	360_V	1.243	1.00
230_S	233_D	1.239	1.00
97_A	184_T	1.237	1.00
88_L	91_V	1.231	1.00
100_Q	176_T	1.230	1.00
206_I	209_Q	1.222	1.00
246_T	297_H	1.221	1.00
194_V	215_L	1.221	1.00
306_V	349_E	1.220	1.00
134_R	137_Q	1.215	1.00
261_D	278_R	1.215	1.00
133_Q	146_L	1.199	1.00
130_S	134_R	1.194	1.00
39_L	362_I	1.186	1.00
164_D	168_K	1.185	1.00
326_K	336_R	1.183	1.00
144_Q	148_T	1.183	1.00
102_K	175_D	1.183	1.00
69_S	207_A	1.180	1.00
307_L	356_A	1.179	1.00
188_A	217_L	1.176	1.00
226_K	278_R	1.171	1.00
77_V	87_Q	1.160	1.00
196_Q	216_T	1.149	1.00
178_K	182_D	1.147	1.00
128_T	132_Q	1.141	1.00
258_Q	282_P	1.137	1.00
90_G	215_L	1.133	1.00
74_T	201_Q	1.125	1.00
105_E	174_L	1.125	1.00
338_V	350_I	1.121	1.00
250_D	255_Y	1.116	1.00
311_L	343_R	1.106	1.00
23_I	27_R	1.100	1.00
131_R	147_D	1.098	1.00
25_L	29_L	1.091	1.00
24_T	28_I	1.090	1.00
225_V	296_V	1.080	1.00
245_F	281_V	1.078	1.00
263_L	276_Y	1.077	1.00
197_I	200_L	1.074	1.00
73_K	91_V	1.074	1.00
78_A	197_I	1.073	1.00
94_P	184_T	1.071	1.00
59_L	222_A	1.068	1.00
101_I	181_L	1.062	1.00
344_N	347_D	1.060	1.00
259_I	279_F	1.056	1.00
90_G	186_I	1.040	1.00
197_I	215_L	1.035	1.00
329_R	334_R	1.033	1.00
234_V	275_Y	1.032	1.00
343_R	348_V	1.029	1.00
316_D	323_Y	1.028	1.00
325_V	338_V	1.027	1.00
117_Q	121_E	1.023	1.00
314_L	348_V	1.021	1.00
323_Y	326_K	1.021	1.00
62_V	190_M	1.019	1.00
67_Q	71_Q	1.013	1.00
108_L	171_Q	1.009	1.00
233_D	236_H	1.009	1.00
72_L	205_V	1.005	1.00
66_A	186_I	1.000	1.00
132_Q	145_D	0.996	1.00
121_E	155_V	0.982	1.00
121_E	152_E	0.970	1.00
328_L	332_E	0.969	1.00
224_L	280_E	0.965	1.00
121_E	124_L	0.964	1.00
56_L	288_L	0.962	1.00
79_I	196_Q	0.958	1.00
225_V	245_F	0.956	1.00
45_D	305_N	0.953	1.00
47_Q	299_Q	0.951	1.00
40_I	357_G	0.949	1.00
59_L	224_L	0.947	1.00
77_V	215_L	0.945	1.00
124_L	148_T	0.941	1.00
198_T	216_T	0.939	1.00
75_L	201_Q	0.937	1.00
205_V	214_I	0.929	1.00
167_I	171_Q	0.928	1.00
283_N	286_G	0.920	1.00
56_L	294_A	0.920	1.00
188_A	191_A	0.919	1.00
198_T	213_N	0.918	1.00
127_V	147_D	0.914	1.00
124_L	151_T	0.914	1.00
150_A	153_M	0.906	1.00
179_T	183_Y	0.902	1.00
90_G	197_I	0.900	1.00
238_K	241_Q	0.899	1.00
139_K	143_Q	0.897	1.00
91_V	94_P	0.895	1.00
69_S	206_I	0.894	1.00
106_A	172_A	0.894	1.00
128_T	144_Q	0.892	1.00
245_F	257_G	0.886	1.00
127_V	130_S	0.886	1.00
82_K	286_G	0.885	1.00
96_Q	100_Q	0.883	1.00
47_Q	302_D	0.883	1.00
103_E	107_T	0.882	1.00
107_T	173_S	0.877	1.00
250_D	253_T	0.874	1.00
247_V	250_D	0.873	1.00
327_L	358_D	0.869	1.00
94_P	185_R	0.868	1.00
81_D	87_Q	0.868	1.00
246_T	295_Q	0.866	1.00
147_D	150_A	0.864	1.00
48_Q	236_H	0.863	1.00
90_G	214_I	0.860	1.00
117_Q	166_Q	0.859	1.00
49_S	299_Q	0.859	1.00
26_W	29_L	0.858	1.00
77_V	197_I	0.851	1.00
99_N	172_A	0.850	1.00
104_V	170_N	0.846	1.00
104_V	177_A	0.843	1.00
82_K	191_A	0.838	1.00
45_D	302_D	0.838	1.00
299_Q	302_D	0.837	1.00
267_E	270_N	0.834	1.00
59_L	280_E	0.833	1.00
328_L	333_T	0.831	1.00
179_T	182_D	0.830	1.00
23_I	26_W	0.828	1.00
322_R	325_V	0.826	1.00
341_G	348_V	0.826	1.00
95_E	179_T	0.826	1.00
223_M	290_L	0.825	1.00
58_A	290_L	0.822	1.00
68_V	97_A	0.822	1.00
99_N	179_T	0.820	1.00
73_K	94_P	0.819	1.00
55_K	271_D	0.816	1.00
121_E	125_A	0.811	1.00
303_V	306_V	0.802	1.00
222_A	282_P	0.799	1.00
61_K	218_A	0.794	1.00
328_L	359_E	0.793	1.00
163_I	166_Q	0.792	1.00
71_Q	204_T	0.791	1.00
43_P	307_L	0.790	1.00
229_V	277_A	0.789	1.00
192_G	217_L	0.787	1.00
75_L	90_G	0.786	1.00
52_A	227_A	0.779	1.00
38_T	328_L	0.776	1.00
173_S	176_T	0.776	1.00
329_R	332_E	0.774	1.00
177_A	180_N	0.773	1.00
66_A	205_V	0.770	1.00
190_M	217_L	0.770	1.00
152_E	155_V	0.768	1.00
79_I	197_I	0.765	1.00
329_R	336_R	0.758	1.00
42_R	356_A	0.757	1.00
259_I	277_A	0.754	1.00
145_D	149_A	0.748	1.00
39_L	42_R	0.747	1.00
48_Q	301_T	0.746	1.00
67_Q	96_Q	0.746	1.00
141_V	145_D	0.744	1.00
77_V	194_V	0.744	1.00
36_Y	361_V	0.741	1.00
118_A	121_E	0.739	1.00
128_T	152_E	0.737	1.00
124_L	127_V	0.735	1.00
103_E	176_T	0.734	1.00
60_R	201_Q	0.733	1.00
149_A	152_E	0.732	1.00
14_A	18_V	0.731	1.00
100_Q	177_A	0.730	1.00
336_R	355_E	0.729	1.00
82_K	220_M	0.729	1.00
66_A	90_G	0.728	1.00
312_S	363_G	0.726	1.00
106_A	165_A	0.726	1.00
323_Y	335_E	0.725	1.00
328_L	331_G	0.723	1.00
166_Q	169_R	0.721	1.00
39_L	310_P	0.720	1.00
166_Q	170_N	0.719	1.00
246_T	252_L	0.718	1.00
64_V	189_P	0.717	1.00
227_A	298_I	0.710	1.00
101_I	177_A	0.707	1.00
119_E	171_Q	0.701	1.00
229_V	237_L	0.698	1.00
100_Q	104_V	0.698	1.00
151_T	155_V	0.698	1.00
46_L	344_N	0.696	1.00
317_P	322_R	0.696	1.00
24_T	27_R	0.693	1.00
54_G	294_A	0.690	1.00
228_Q	267_E	0.689	1.00
177_A	181_L	0.688	1.00
224_L	260_K	0.687	1.00
323_Y	340_I	0.685	1.00
50_V	233_D	0.683	1.00
83_V	89_L	0.683	1.00
142_S	145_D	0.682	1.00
153_M	164_D	0.676	1.00
69_S	204_T	0.674	1.00
107_T	169_R	0.671	1.00
245_F	279_F	0.667	1.00
41_V	358_D	0.663	1.00
98_E	101_I	0.663	1.00
350_I	354_L	0.663	1.00
193_E	220_M	0.662	1.00
96_Q	180_N	0.658	1.00
57_D	224_L	0.656	1.00
262_V	277_A	0.652	1.00
245_F	296_V	0.652	1.00
60_R	200_L	0.650	1.00
347_D	351_V	0.650	1.00
41_V	354_L	0.649	1.00
341_G	353_G	0.647	1.00
52_A	229_V	0.647	1.00
336_R	353_G	0.645	1.00
309_I	313_A	0.644	1.00
99_N	103_E	0.643	1.00
59_L	219_D	0.641	1.00
314_L	323_Y	0.640	1.00
340_I	350_I	0.640	1.00
136_A	139_K	0.639	1.00
239_P	262_V	0.638	1.00
119_E	122_L	0.636	1.00
322_R	326_K	0.635	1.00
72_L	214_I	0.635	1.00
289_R	292_M	0.633	1.00
221_S	286_G	0.633	1.00
173_S	177_A	0.631	1.00
125_A	152_E	0.629	1.00
73_K	76_S	0.627	1.00
313_A	362_I	0.625	1.00
170_N	174_L	0.623	1.00
260_K	278_R	0.621	1.00
19_I	23_I	0.620	1.00
331_G	359_E	0.618	1.00
40_I	43_P	0.616	1.00
169_R	173_S	0.616	1.00
130_S	153_M	0.616	1.00
60_R	190_M	0.615	1.00
329_R	358_D	0.614	1.00
50_V	300_L	0.612	1.00
20_A	24_T	0.611	1.00
164_D	167_I	0.609	1.00
97_A	177_A	0.608	1.00
228_Q	274_F	0.608	1.00
310_P	313_A	0.607	1.00
14_A	21_G	0.606	1.00
136_A	141_V	0.606	1.00
131_R	144_Q	0.605	1.00
120_A	124_L	0.605	1.00
171_Q	174_L	0.604	1.00
99_N	102_K	0.603	1.00
172_A	175_D	0.602	1.00
65_G	209_Q	0.602	1.00
97_A	101_I	0.601	1.00
203_Q	209_Q	0.601	1.00
248_L	295_Q	0.599	1.00
66_A	214_I	0.598	1.00
126_R	164_D	0.598	1.00
118_A	170_N	0.595	1.00
213_N	216_T	0.594	1.00
42_R	347_D	0.591	1.00
104_V	107_T	0.589	1.00
175_D	179_T	0.588	1.00
94_P	181_L	0.588	1.00
163_I	167_I	0.587	1.00
64_V	215_L	0.587	1.00
321_N	325_V	0.586	1.00
170_N	173_S	0.586	1.00
309_I	314_L	0.585	1.00
245_F	294_A	0.584	1.00
209_Q	213_N	0.584	1.00
143_Q	150_A	0.583	1.00
182_D	187_V	0.580	1.00
20_A	23_I	0.579	1.00
62_V	189_P	0.579	1.00
323_Y	328_L	0.578	1.00
199_T	203_Q	0.576	1.00
247_V	288_L	0.575	1.00
52_A	233_D	0.575	1.00
38_T	362_I	0.573	1.00
58_A	218_A	0.571	1.00
48_Q	300_L	0.568	1.00
225_V	281_V	0.565	1.00
65_G	213_N	0.565	1.00
17_I	20_A	0.564	1.00
39_L	347_D	0.564	1.00
256_E	282_P	0.564	1.00
231_E	293_T	0.562	1.00
125_A	128_T	0.561	1.00
321_N	324_K	0.561	1.00
242_K	299_Q	0.560	1.00
48_Q	342_A	0.557	1.00
46_L	342_A	0.557	1.00
62_V	217_L	0.556	1.00
200_L	203_Q	0.556	1.00
180_N	183_Y	0.556	1.00
322_R	328_L	0.556	1.00
141_V	146_L	0.552	1.00
133_Q	136_A	0.552	1.00
52_A	298_I	0.551	1.00
127_V	151_T	0.550	1.00
39_L	309_I	0.549	1.00
151_T	154_A	0.549	1.00
118_A	122_L	0.549	1.00
143_Q	146_L	0.549	1.00
63_D	203_Q	0.548	1.00
66_A	92_I	0.548	1.00
18_V	21_G	0.547	1.00
267_E	276_Y	0.546	1.00
46_L	308_T	0.546	1.00
255_Y	288_L	0.546	1.00
254_R	297_H	0.545	1.00
275_Y	292_M	0.544	1.00
39_L	43_P	0.543	1.00
42_R	308_T	0.543	1.00
327_L	334_R	0.542	1.00
19_I	22_L	0.540	1.00
77_V	81_D	0.540	1.00
52_A	296_V	0.540	1.00
218_A	290_L	0.538	1.00
154_A	164_D	0.538	1.00
237_L	259_I	0.538	1.00
308_T	349_E	0.538	1.00
58_A	61_K	0.538	1.00
125_A	149_A	0.537	1.00
279_F	296_V	0.537	1.00
76_S	87_Q	0.535	1.00
313_A	360_V	0.532	1.00
221_S	284_P	0.532	1.00
312_S	362_I	0.531	1.00
16_V	19_I	0.527	1.00
243_A	298_I	0.526	1.00
97_A	180_N	0.526	1.00
73_K	201_Q	0.526	1.00
11_Y	25_L	0.524	1.00
266_P	271_D	0.523	1.00
199_T	214_I	0.523	1.00
86_D	187_V	0.522	1.00
12_V	16_V	0.522	1.00
227_A	277_A	0.520	1.00
186_I	214_I	0.519	1.00
253_T	285_N	0.518	1.00
46_L	349_E	0.518	1.00
116_Q	120_A	0.515	1.00
307_L	353_G	0.514	1.00
144_Q	147_D	0.514	1.00
243_A	257_G	0.514	1.00
165_A	168_K	0.513	1.00
240_G	259_I	0.512	1.00
197_I	201_Q	0.511	1.00
70_G	205_V	0.510	1.00
105_E	116_Q	0.510	1.00
125_A	163_I	0.510	1.00
326_K	358_D	0.509	1.00
220_M	286_G	0.508	1.00
57_D	61_K	0.508	1.00
249_G	252_L	0.508	1.00
122_L	129_Y	0.507	1.00
105_E	108_L	0.507	1.00
124_L	152_E	0.505	1.00
11_Y	14_A	0.505	1.00
64_V	190_M	0.504	1.00
128_T	149_A	0.502	1.00
223_M	283_N	0.500	1.00
36_Y	333_T	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3fppA	3	0.7197	100	0.202	Contact Map
4dk0A	5	0.8706	100	0.218	Contact Map
3lnnA	6	0.903	100	0.272	Contact Map
1vf7A	5	0.6092	100	0.285	Contact Map
4l8jA	2	0.8302	100	0.308	Contact Map
3ne5B	3	0.7978	100	0.313	Contact Map
4kkuA	1	0.6631	100	0.364	Contact Map
2f1mA	2	0.628	100	0.403	Contact Map
4tkoB	1	0.6658	100	0.446	Contact Map
2k32A	1	0.31	99.8	0.705	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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