GREMLIN Database
MACA - Macrolide export protein MacA
UniProt: P75830 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13694
Length: 371 (336)
Sequences: 22518 (18001)
Seq/√Len: 982.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_T91_V3.0801.00
88_L185_R2.9801.00
339_T352_K2.7331.00
40_I359_E2.6471.00
84_K191_A2.5971.00
126_R130_S2.4351.00
57_D226_K2.3841.00
336_R358_D2.3581.00
150_A154_A2.3471.00
260_K280_E2.3401.00
105_E178_K2.3181.00
311_L348_V2.3151.00
91_V185_R2.2461.00
132_Q141_V2.2301.00
325_V328_L2.2091.00
76_S91_V2.1401.00
43_P356_A2.1281.00
133_Q137_Q2.1141.00
67_Q183_Y2.1061.00
308_T347_D2.0981.00
94_P98_E2.0891.00
84_K87_Q2.0811.00
132_Q149_A2.0731.00
257_G279_F2.0641.00
44_G347_D2.0551.00
82_K193_E2.0241.00
143_Q147_D2.0131.00
88_L187_V2.0091.00
195_T218_A1.9941.00
244_W256_E1.9851.00
244_W254_R1.9471.00
355_E358_D1.9051.00
324_K335_E1.9041.00
133_Q150_A1.8811.00
124_L128_T1.8771.00
242_K256_E1.8521.00
136_A143_Q1.8421.00
253_T287_L1.8341.00
76_S88_L1.8291.00
44_G308_T1.8121.00
227_A296_V1.8111.00
136_A146_L1.7941.00
101_I174_L1.7911.00
226_K276_Y1.7721.00
25_L28_I1.7501.00
85_K191_A1.7401.00
49_S297_H1.7361.00
122_L153_M1.7221.00
56_L225_V1.7181.00
224_L278_R1.7111.00
341_G349_E1.7011.00
103_E173_S1.6901.00
129_Y133_Q1.6841.00
101_I178_K1.6791.00
145_D148_T1.6711.00
322_R337_E1.6561.00
72_L199_T1.6551.00
126_R153_M1.6521.00
340_I348_V1.6411.00
341_G351_V1.6391.00
339_T351_V1.6341.00
98_E102_K1.6141.00
63_D213_N1.6061.00
129_Y146_L1.5961.00
243_A279_F1.5861.00
22_L26_W1.5741.00
333_T361_V1.5681.00
227_A279_F1.5621.00
43_P305_N1.5601.00
102_K105_E1.5591.00
324_K328_L1.5451.00
148_T152_E1.5431.00
45_D304_K1.5321.00
116_Q119_E1.5251.00
22_L25_L1.5001.00
328_L334_R1.4951.00
219_D222_A1.4911.00
168_K171_Q1.4821.00
317_P335_E1.4801.00
60_R219_D1.4791.00
78_A81_D1.4711.00
72_L90_G1.4691.00
146_L150_A1.4651.00
108_L174_L1.4641.00
303_V349_E1.4601.00
123_K126_R1.4601.00
266_P275_Y1.4561.00
129_Y153_M1.4541.00
225_V294_A1.4531.00
175_D178_K1.4511.00
228_Q276_Y1.4491.00
61_K216_T1.4411.00
342_A349_E1.4391.00
98_E181_L1.4271.00
122_L126_R1.4231.00
51_L297_H1.4221.00
327_L336_R1.4201.00
119_E123_K1.4181.00
37_Q363_G1.3931.00
41_V307_L1.3811.00
73_K93_D1.3681.00
247_V294_A1.3631.00
171_Q175_D1.3611.00
258_Q280_E1.3601.00
21_G25_L1.3521.00
311_L346_T1.3491.00
130_S133_Q1.3421.00
101_I105_E1.3351.00
51_L295_Q1.3251.00
246_T254_R1.3191.00
242_K258_Q1.3161.00
123_K127_V1.3141.00
41_V357_G1.3111.00
129_Y150_A1.3111.00
134_R138_T1.3091.00
176_T180_N1.3051.00
100_Q103_E1.3031.00
56_L223_M1.2951.00
100_Q180_N1.2921.00
128_T148_T1.2911.00
63_D216_T1.2711.00
244_W297_H1.2691.00
70_G92_I1.2671.00
244_W299_Q1.2591.00
89_L215_L1.2571.00
38_T359_E1.2551.00
174_L178_K1.2551.00
108_L167_I1.2521.00
222_A280_E1.2491.00
123_K154_A1.2481.00
309_I360_V1.2431.00
230_S233_D1.2391.00
97_A184_T1.2371.00
88_L91_V1.2311.00
100_Q176_T1.2301.00
206_I209_Q1.2221.00
246_T297_H1.2211.00
194_V215_L1.2211.00
306_V349_E1.2201.00
134_R137_Q1.2151.00
261_D278_R1.2151.00
133_Q146_L1.1991.00
130_S134_R1.1941.00
39_L362_I1.1861.00
164_D168_K1.1851.00
326_K336_R1.1831.00
144_Q148_T1.1831.00
102_K175_D1.1831.00
69_S207_A1.1801.00
307_L356_A1.1791.00
188_A217_L1.1761.00
226_K278_R1.1711.00
77_V87_Q1.1601.00
196_Q216_T1.1491.00
178_K182_D1.1471.00
128_T132_Q1.1411.00
258_Q282_P1.1371.00
90_G215_L1.1331.00
74_T201_Q1.1251.00
105_E174_L1.1251.00
338_V350_I1.1211.00
250_D255_Y1.1161.00
311_L343_R1.1061.00
23_I27_R1.1001.00
131_R147_D1.0981.00
25_L29_L1.0911.00
24_T28_I1.0901.00
225_V296_V1.0801.00
245_F281_V1.0781.00
263_L276_Y1.0771.00
197_I200_L1.0741.00
73_K91_V1.0741.00
78_A197_I1.0731.00
94_P184_T1.0711.00
59_L222_A1.0681.00
101_I181_L1.0621.00
344_N347_D1.0601.00
259_I279_F1.0561.00
90_G186_I1.0401.00
197_I215_L1.0351.00
329_R334_R1.0331.00
234_V275_Y1.0321.00
343_R348_V1.0291.00
316_D323_Y1.0281.00
325_V338_V1.0271.00
117_Q121_E1.0231.00
314_L348_V1.0211.00
323_Y326_K1.0211.00
62_V190_M1.0191.00
67_Q71_Q1.0131.00
108_L171_Q1.0091.00
233_D236_H1.0091.00
72_L205_V1.0051.00
66_A186_I1.0001.00
132_Q145_D0.9961.00
121_E155_V0.9821.00
121_E152_E0.9701.00
328_L332_E0.9691.00
224_L280_E0.9651.00
121_E124_L0.9641.00
56_L288_L0.9621.00
79_I196_Q0.9581.00
225_V245_F0.9561.00
45_D305_N0.9531.00
47_Q299_Q0.9511.00
40_I357_G0.9491.00
59_L224_L0.9471.00
77_V215_L0.9451.00
124_L148_T0.9411.00
198_T216_T0.9391.00
75_L201_Q0.9371.00
205_V214_I0.9291.00
167_I171_Q0.9281.00
283_N286_G0.9201.00
56_L294_A0.9201.00
188_A191_A0.9191.00
198_T213_N0.9181.00
127_V147_D0.9141.00
124_L151_T0.9141.00
150_A153_M0.9061.00
179_T183_Y0.9021.00
90_G197_I0.9001.00
238_K241_Q0.8991.00
139_K143_Q0.8971.00
91_V94_P0.8951.00
69_S206_I0.8941.00
106_A172_A0.8941.00
128_T144_Q0.8921.00
245_F257_G0.8861.00
127_V130_S0.8861.00
82_K286_G0.8851.00
96_Q100_Q0.8831.00
47_Q302_D0.8831.00
103_E107_T0.8821.00
107_T173_S0.8771.00
250_D253_T0.8741.00
247_V250_D0.8731.00
327_L358_D0.8691.00
94_P185_R0.8681.00
81_D87_Q0.8681.00
246_T295_Q0.8661.00
147_D150_A0.8641.00
48_Q236_H0.8631.00
90_G214_I0.8601.00
117_Q166_Q0.8591.00
49_S299_Q0.8591.00
26_W29_L0.8581.00
77_V197_I0.8511.00
99_N172_A0.8501.00
104_V170_N0.8461.00
104_V177_A0.8431.00
82_K191_A0.8381.00
45_D302_D0.8381.00
299_Q302_D0.8371.00
267_E270_N0.8341.00
59_L280_E0.8331.00
328_L333_T0.8311.00
179_T182_D0.8301.00
23_I26_W0.8281.00
322_R325_V0.8261.00
341_G348_V0.8261.00
95_E179_T0.8261.00
223_M290_L0.8251.00
58_A290_L0.8221.00
68_V97_A0.8221.00
99_N179_T0.8201.00
73_K94_P0.8191.00
55_K271_D0.8161.00
121_E125_A0.8111.00
303_V306_V0.8021.00
222_A282_P0.7991.00
61_K218_A0.7941.00
328_L359_E0.7931.00
163_I166_Q0.7921.00
71_Q204_T0.7911.00
43_P307_L0.7901.00
229_V277_A0.7891.00
192_G217_L0.7871.00
75_L90_G0.7861.00
52_A227_A0.7791.00
38_T328_L0.7761.00
173_S176_T0.7761.00
329_R332_E0.7741.00
177_A180_N0.7731.00
66_A205_V0.7701.00
190_M217_L0.7701.00
152_E155_V0.7681.00
79_I197_I0.7651.00
329_R336_R0.7581.00
42_R356_A0.7571.00
259_I277_A0.7541.00
145_D149_A0.7481.00
39_L42_R0.7471.00
48_Q301_T0.7461.00
67_Q96_Q0.7461.00
141_V145_D0.7441.00
77_V194_V0.7441.00
36_Y361_V0.7411.00
118_A121_E0.7391.00
128_T152_E0.7371.00
124_L127_V0.7351.00
103_E176_T0.7341.00
60_R201_Q0.7331.00
149_A152_E0.7321.00
14_A18_V0.7311.00
100_Q177_A0.7301.00
336_R355_E0.7291.00
82_K220_M0.7291.00
66_A90_G0.7281.00
312_S363_G0.7261.00
106_A165_A0.7261.00
323_Y335_E0.7251.00
328_L331_G0.7231.00
166_Q169_R0.7211.00
39_L310_P0.7201.00
166_Q170_N0.7191.00
246_T252_L0.7181.00
64_V189_P0.7171.00
227_A298_I0.7101.00
101_I177_A0.7071.00
119_E171_Q0.7011.00
229_V237_L0.6981.00
100_Q104_V0.6981.00
151_T155_V0.6981.00
46_L344_N0.6961.00
317_P322_R0.6961.00
24_T27_R0.6931.00
54_G294_A0.6901.00
228_Q267_E0.6891.00
177_A181_L0.6881.00
224_L260_K0.6871.00
323_Y340_I0.6851.00
50_V233_D0.6831.00
83_V89_L0.6831.00
142_S145_D0.6821.00
153_M164_D0.6761.00
69_S204_T0.6741.00
107_T169_R0.6711.00
245_F279_F0.6671.00
41_V358_D0.6631.00
98_E101_I0.6631.00
350_I354_L0.6631.00
193_E220_M0.6621.00
96_Q180_N0.6581.00
57_D224_L0.6561.00
262_V277_A0.6521.00
245_F296_V0.6521.00
60_R200_L0.6501.00
347_D351_V0.6501.00
41_V354_L0.6491.00
341_G353_G0.6471.00
52_A229_V0.6471.00
336_R353_G0.6451.00
309_I313_A0.6441.00
99_N103_E0.6431.00
59_L219_D0.6411.00
314_L323_Y0.6401.00
340_I350_I0.6401.00
136_A139_K0.6391.00
239_P262_V0.6381.00
119_E122_L0.6361.00
322_R326_K0.6351.00
72_L214_I0.6351.00
289_R292_M0.6331.00
221_S286_G0.6331.00
173_S177_A0.6311.00
125_A152_E0.6291.00
73_K76_S0.6271.00
313_A362_I0.6251.00
170_N174_L0.6231.00
260_K278_R0.6211.00
19_I23_I0.6201.00
331_G359_E0.6181.00
40_I43_P0.6161.00
169_R173_S0.6161.00
130_S153_M0.6161.00
60_R190_M0.6151.00
329_R358_D0.6141.00
50_V300_L0.6121.00
20_A24_T0.6111.00
164_D167_I0.6091.00
97_A177_A0.6081.00
228_Q274_F0.6081.00
310_P313_A0.6071.00
14_A21_G0.6061.00
136_A141_V0.6061.00
131_R144_Q0.6051.00
120_A124_L0.6051.00
171_Q174_L0.6041.00
99_N102_K0.6031.00
172_A175_D0.6021.00
65_G209_Q0.6021.00
97_A101_I0.6011.00
203_Q209_Q0.6011.00
248_L295_Q0.5991.00
66_A214_I0.5981.00
126_R164_D0.5981.00
118_A170_N0.5951.00
213_N216_T0.5941.00
42_R347_D0.5911.00
104_V107_T0.5891.00
175_D179_T0.5881.00
94_P181_L0.5881.00
163_I167_I0.5871.00
64_V215_L0.5871.00
321_N325_V0.5861.00
170_N173_S0.5861.00
309_I314_L0.5851.00
245_F294_A0.5841.00
209_Q213_N0.5841.00
143_Q150_A0.5831.00
182_D187_V0.5801.00
20_A23_I0.5791.00
62_V189_P0.5791.00
323_Y328_L0.5781.00
199_T203_Q0.5761.00
247_V288_L0.5751.00
52_A233_D0.5751.00
38_T362_I0.5731.00
58_A218_A0.5711.00
48_Q300_L0.5681.00
225_V281_V0.5651.00
65_G213_N0.5651.00
17_I20_A0.5641.00
39_L347_D0.5641.00
256_E282_P0.5641.00
231_E293_T0.5621.00
125_A128_T0.5611.00
321_N324_K0.5611.00
242_K299_Q0.5601.00
48_Q342_A0.5571.00
46_L342_A0.5571.00
62_V217_L0.5561.00
200_L203_Q0.5561.00
180_N183_Y0.5561.00
322_R328_L0.5561.00
141_V146_L0.5521.00
133_Q136_A0.5521.00
52_A298_I0.5511.00
127_V151_T0.5501.00
39_L309_I0.5491.00
151_T154_A0.5491.00
118_A122_L0.5491.00
143_Q146_L0.5491.00
63_D203_Q0.5481.00
66_A92_I0.5481.00
18_V21_G0.5471.00
267_E276_Y0.5461.00
46_L308_T0.5461.00
255_Y288_L0.5461.00
254_R297_H0.5451.00
275_Y292_M0.5441.00
39_L43_P0.5431.00
42_R308_T0.5431.00
327_L334_R0.5421.00
19_I22_L0.5401.00
77_V81_D0.5401.00
52_A296_V0.5401.00
218_A290_L0.5381.00
154_A164_D0.5381.00
237_L259_I0.5381.00
308_T349_E0.5381.00
58_A61_K0.5381.00
125_A149_A0.5371.00
279_F296_V0.5371.00
76_S87_Q0.5351.00
313_A360_V0.5321.00
221_S284_P0.5321.00
312_S362_I0.5311.00
16_V19_I0.5271.00
243_A298_I0.5261.00
97_A180_N0.5261.00
73_K201_Q0.5261.00
11_Y25_L0.5241.00
266_P271_D0.5231.00
199_T214_I0.5231.00
86_D187_V0.5221.00
12_V16_V0.5221.00
227_A277_A0.5201.00
186_I214_I0.5191.00
253_T285_N0.5181.00
46_L349_E0.5181.00
116_Q120_A0.5151.00
307_L353_G0.5141.00
144_Q147_D0.5141.00
243_A257_G0.5141.00
165_A168_K0.5131.00
240_G259_I0.5121.00
197_I201_Q0.5111.00
70_G205_V0.5101.00
105_E116_Q0.5101.00
125_A163_I0.5101.00
326_K358_D0.5091.00
220_M286_G0.5081.00
57_D61_K0.5081.00
249_G252_L0.5081.00
122_L129_Y0.5071.00
105_E108_L0.5071.00
124_L152_E0.5051.00
11_Y14_A0.5051.00
64_V190_M0.5041.00
128_T149_A0.5021.00
223_M283_N0.5001.00
36_Y333_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fppA 3 0.7197 100 0.202 Contact Map
4dk0A 5 0.8706 100 0.218 Contact Map
3lnnA 6 0.903 100 0.272 Contact Map
1vf7A 5 0.6092 100 0.285 Contact Map
4l8jA 2 0.8302 100 0.308 Contact Map
3ne5B 3 0.7978 100 0.313 Contact Map
4kkuA 1 0.6631 100 0.364 Contact Map
2f1mA 2 0.628 100 0.403 Contact Map
4tkoB 1 0.6658 100 0.446 Contact Map
2k32A 1 0.31 99.8 0.705 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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