GREMLIN Database
HCR - NADH oxidoreductase HCR
UniProt: P75824 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13691
Length: 322 (303)
Sequences: 5383 (3931)
Seq/√Len: 225.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
256_T264_S4.0731.00
113_K141_D3.4391.00
75_R87_R3.2271.00
20_E26_T3.2251.00
15_H30_I3.1261.00
12_M97_L2.9621.00
263_E274_R2.7621.00
14_V89_V2.7541.00
253_P256_T2.7281.00
11_R94_Y2.6341.00
27_I85_L2.5981.00
131_R159_E2.5811.00
90_K93_D2.5581.00
17_I25_W2.5371.00
250_F261_A2.4831.00
240_K251_Y2.4771.00
132_W136_N2.4591.00
283_T310_A2.3981.00
259_L271_A2.3961.00
26_T70_T2.3931.00
123_V144_V2.3121.00
19_Q25_W2.3121.00
289_E316_Q2.2971.00
16_H91_R2.2951.00
148_V154_V2.2471.00
240_K249_E2.2161.00
285_V308_V2.1591.00
13_Q94_Y2.1521.00
13_Q30_I2.1271.00
75_R83_Q2.1211.00
11_R96_W2.1051.00
204_A208_D2.1011.00
197_T223_F2.0391.00
241_F258_L2.0281.00
118_A146_Y1.9621.00
85_L89_V1.9341.00
28_S68_Y1.9141.00
45_V71_L1.9081.00
200_T210_V1.8861.00
77_D80_V1.8711.00
117_L206_Y1.8141.00
258_L308_V1.7611.00
256_T261_A1.7421.00
17_I91_R1.7351.00
44_L56_A1.7221.00
113_K143_R1.7071.00
16_H28_S1.7041.00
150_T153_D1.7021.00
285_V290_Y1.7001.00
242_T249_E1.6731.00
299_T302_E1.6291.00
43_A97_L1.6251.00
26_T156_F1.6191.00
83_Q87_R1.6191.00
116_L130_R1.6091.00
243_K262_L1.6051.00
260_E274_R1.5981.00
147_N206_Y1.5931.00
119_A206_Y1.5931.00
157_A161_R1.5921.00
22_P152_Q1.5901.00
258_L310_A1.5731.00
28_S70_T1.5601.00
118_A126_I1.5591.00
117_L210_V1.5511.00
46_S96_W1.5131.00
243_K246_P1.5051.00
47_V81_G1.4991.00
18_T26_T1.4971.00
300_D304_A1.4811.00
115_L198_V1.4621.00
250_F265_N1.4581.00
211_E226_K1.4391.00
89_V93_D1.4311.00
34_Y69_I1.4281.00
45_V85_L1.4271.00
282_K307_Y1.4261.00
113_K196_R1.4231.00
151_P157_A1.4151.00
60_S72_T1.4091.00
289_E317_G1.3951.00
253_P261_A1.3911.00
23_D153_D1.3881.00
89_V95_L1.3851.00
118_A144_V1.3841.00
14_V29_L1.3681.00
211_E224_K1.3561.00
269_V310_A1.3431.00
73_V85_L1.3321.00
111_E114_F1.3111.00
106_C133_L1.2941.00
263_E271_A1.2871.00
208_D212_Q1.2371.00
282_K309_L1.2261.00
116_L142_V1.2171.00
17_I27_I1.2121.00
20_E156_F1.2011.00
72_T155_I1.2011.00
291_T316_Q1.1961.00
84_W88_D1.1951.00
192_D196_R1.1911.00
17_I90_K1.1911.00
12_M34_Y1.1901.00
24_V155_I1.1901.00
198_V214_V1.1841.00
32_H94_Y1.1801.00
242_T247_A1.1771.00
13_Q32_H1.1761.00
130_R142_V1.1671.00
200_T207_M1.1611.00
252_A261_A1.1571.00
12_M29_L1.1561.00
290_Y315_P1.1541.00
37_Y59_I1.1511.00
211_E215_K1.1491.00
207_M224_K1.1471.00
147_N182_L1.1461.00
12_M32_H1.1421.00
260_E263_E1.1401.00
49_N84_W1.1351.00
151_P178_I1.1341.00
243_K250_F1.1331.00
74_R153_D1.1321.00
37_Y61_S1.1211.00
26_T72_T1.1171.00
39_A132_W1.1051.00
154_V169_A1.1041.00
14_V27_I1.1011.00
27_I89_V1.0951.00
211_E222_F1.0871.00
148_V153_D1.0831.00
176_G181_R1.0791.00
114_F140_A1.0771.00
151_P161_R1.0641.00
27_I73_V1.0621.00
186_L189_G1.0571.00
290_Y313_C1.0521.00
29_L71_L1.0511.00
198_V219_V1.0501.00
154_V157_A1.0471.00
127_M156_F1.0451.00
168_V171_N1.0401.00
298_L302_E1.0381.00
212_Q216_A1.0361.00
184_R188_A1.0341.00
257_T260_E1.0341.00
293_S314_H1.0251.00
62_T131_R1.0241.00
209_W213_E1.0231.00
59_I69_I1.0171.00
15_H68_Y1.0161.00
47_V53_T1.0141.00
82_S86_T1.0141.00
238_G251_Y1.0061.00
18_T28_S1.0001.00
298_L306_G0.9941.00
262_L269_V0.9941.00
106_C129_M0.9821.00
261_A265_N0.9751.00
188_A217_L0.9691.00
126_I144_V0.9641.00
70_T159_E0.9571.00
45_V95_L0.9561.00
185_E188_A0.9551.00
23_D74_R0.9511.00
187_L190_V0.9471.00
271_A274_R0.9441.00
24_V121_C0.9431.00
284_K307_Y0.9421.00
12_M95_L0.9421.00
176_G180_G0.9411.00
181_R205_P0.9381.00
240_K318_D0.9371.00
53_T80_V0.9291.00
12_M31_C0.9271.00
245_Q248_R0.9261.00
184_R213_E0.9261.00
253_P264_S0.9251.00
296_M309_L0.9150.99
200_T211_E0.9150.99
284_K306_G0.9120.99
302_E305_E0.9080.99
15_H28_S0.9070.99
145_I190_V0.9060.99
183_T186_L0.9030.99
214_V222_F0.9030.99
134_A142_V0.9020.99
25_W86_T0.8960.99
291_T314_H0.8940.99
130_R144_V0.8920.99
47_V84_W0.8920.99
184_R216_A0.8910.99
108_D132_W0.8890.99
200_T222_F0.8860.99
175_E178_I0.8820.99
195_S221_R0.8800.99
61_S70_T0.8710.99
30_I68_Y0.8650.99
57_Y82_S0.8630.99
112_D197_T0.8620.99
262_L310_A0.8620.99
175_E179_A0.8600.99
209_W212_Q0.8590.99
243_K248_R0.8570.99
212_Q215_K0.8540.99
207_M226_K0.8530.99
21_T153_D0.8490.99
177_F180_G0.8480.99
116_L133_L0.8430.99
259_L263_E0.8420.99
38_R105_T0.8370.99
268_P271_A0.8370.99
61_S65_V0.8360.99
158_D162_N0.8360.99
48_R84_W0.8310.99
37_Y128_S0.8300.99
116_L129_M0.8270.99
46_S54_L0.8260.99
290_Y317_G0.8250.99
127_M131_R0.8200.99
197_T221_R0.8190.99
208_D226_K0.8190.99
248_R267_V0.8180.99
248_R265_N0.8140.99
10_W35_Y0.8140.99
112_D195_S0.8130.99
116_L126_I0.8120.99
31_C34_Y0.8120.99
113_K193_L0.8070.99
108_D136_N0.8050.99
177_F181_R0.8050.99
165_V170_E0.8030.99
44_L101_M0.8020.99
193_L196_R0.7990.99
17_I93_D0.7990.99
176_G179_A0.7960.99
23_D75_R0.7950.99
214_V219_V0.7930.99
117_L187_L0.7930.99
263_E268_P0.7920.99
107_D110_A0.7870.98
41_Q102_G0.7850.98
114_F197_T0.7840.98
130_R134_A0.7820.98
106_C114_F0.7780.98
62_T135_K0.7750.98
158_D161_R0.7740.98
176_G182_L0.7730.98
134_A163_Y0.7730.98
217_L220_T0.7710.98
47_V85_L0.7710.98
237_S318_D0.7700.98
205_P209_W0.7700.98
10_W31_C0.7680.98
146_Y155_I0.7670.98
60_S70_T0.7660.98
239_L317_G0.7660.98
232_A235_A0.7650.98
208_D211_E0.7580.98
167_L170_E0.7530.98
117_L145_I0.7480.98
76_I83_Q0.7440.98
256_T260_E0.7410.98
46_S98_S0.7380.98
298_L303_I0.7320.98
213_E216_A0.7320.98
119_A205_P0.7320.98
302_E306_G0.7300.98
44_L54_L0.7290.97
164_P167_L0.7270.97
297_T302_E0.7210.97
22_P153_D0.7200.97
200_T224_K0.7200.97
69_I97_L0.7190.97
63_P66_S0.7190.97
272_A280_C0.7180.97
43_A59_I0.7180.97
277_V280_C0.7180.97
35_Y99_D0.7160.97
303_I306_G0.7140.97
271_A277_V0.7100.97
244_L286_V0.7100.97
119_A203_P0.7100.97
169_A173_V0.7060.97
119_A147_N0.7060.97
65_V68_Y0.7040.97
104_F129_M0.7010.97
147_N176_G0.7000.97
151_P177_F0.6990.97
29_L95_L0.6960.97
123_V146_Y0.6900.97
24_V72_T0.6890.96
38_R102_G0.6890.96
70_T131_R0.6880.96
174_T179_A0.6880.96
38_R41_Q0.6860.96
186_L190_V0.6840.96
10_W99_D0.6820.96
74_R155_I0.6790.96
62_T65_V0.6770.96
173_V179_A0.6680.96
262_L267_V0.6670.96
259_L269_V0.6640.96
251_Y254_V0.6630.96
204_A226_K0.6610.96
290_Y308_V0.6610.96
147_N170_E0.6600.96
258_L283_T0.6570.95
45_V97_L0.6560.95
136_N140_A0.6560.95
43_A69_I0.6550.95
252_A258_L0.6540.95
173_V176_G0.6530.95
283_T308_V0.6520.95
294_S297_T0.6510.95
76_I79_G0.6490.95
44_L98_S0.6480.95
12_M43_A0.6470.95
178_I184_R0.6450.95
55_R129_M0.6440.95
119_A181_R0.6430.95
77_D83_Q0.6420.95
53_T81_G0.6400.95
58_T126_I0.6400.95
205_P208_D0.6370.95
301_A304_A0.6370.95
43_A71_L0.6370.95
230_P234_A0.6330.94
64_G135_K0.6310.94
208_D224_K0.6300.94
159_E162_N0.6300.94
315_P318_D0.6290.94
207_M210_V0.6260.94
213_E217_L0.6250.94
307_Y310_A0.6240.94
63_P132_W0.6240.94
308_V313_C0.6210.94
36_P66_S0.6210.94
133_L140_A0.6200.94
261_A264_S0.6190.94
198_V210_V0.6180.94
258_L262_L0.6160.94
129_M199_M0.6130.93
112_D196_R0.6110.93
192_D195_S0.6060.93
167_L171_N0.6030.93
257_T314_H0.6010.93
170_E173_V0.5970.92
210_V213_E0.5970.92
175_E180_G0.5970.92
181_R209_W0.5960.92
145_I186_L0.5960.92
126_I130_R0.5950.92
75_R86_T0.5950.92
131_R163_Y0.5930.92
119_A209_W0.5920.92
134_A166_T0.5920.92
144_V160_W0.5920.92
257_T312_S0.5890.92
297_T301_A0.5890.92
270_V310_A0.5880.92
114_F133_L0.5870.92
35_Y69_I0.5870.92
242_T287_S0.5870.92
309_L312_S0.5870.92
49_N53_T0.5860.92
130_R163_Y0.5860.92
14_V17_I0.5850.92
290_Y305_E0.5840.92
114_F199_M0.5830.92
88_D93_D0.5820.92
177_F183_T0.5820.92
113_K195_S0.5790.91
20_E72_T0.5750.91
297_T303_I0.5750.91
113_K140_A0.5740.91
260_E264_S0.5730.91
38_R108_D0.5710.91
239_L247_A0.5690.91
115_L196_R0.5680.91
292_V296_M0.5660.90
291_T313_C0.5660.90
56_A101_M0.5650.90
173_V178_I0.5650.90
21_T155_I0.5630.90
37_Y65_V0.5630.90
42_Y292_V0.5620.90
118_A148_V0.5620.90
301_A305_E0.5610.90
293_S313_C0.5610.90
60_S156_F0.5600.90
275_A295_T0.5580.90
165_V168_V0.5570.90
251_Y265_N0.5570.90
282_K302_E0.5510.89
248_R262_L0.5510.89
108_D140_A0.5500.89
177_F182_L0.5500.89
304_A307_Y0.5490.89
148_V169_A0.5470.89
156_F160_W0.5450.89
292_V303_I0.5450.89
141_D196_R0.5440.89
32_H97_L0.5440.89
23_D149_R0.5430.89
21_T24_V0.5430.89
280_C309_L0.5420.88
39_A63_P0.5410.88
169_A175_E0.5400.88
277_V295_T0.5390.88
241_F250_F0.5380.88
112_D140_A0.5350.88
106_C199_M0.5340.88
115_L145_I0.5340.88
206_Y209_W0.5340.88
232_A236_T0.5330.88
25_W73_V0.5320.87
292_V312_S0.5300.87
230_P295_T0.5280.87
283_T286_V0.5260.87
180_G183_T0.5220.87
192_D217_L0.5200.86
292_V313_C0.5200.86
237_S254_V0.5200.86
239_L314_H0.5190.86
60_S128_S0.5180.86
64_G136_N0.5170.86
174_T178_I0.5170.86
282_K296_M0.5160.86
71_L75_R0.5150.86
19_Q23_D0.5150.86
300_D303_I0.5150.86
75_R82_S0.5130.86
275_A280_C0.5120.85
218_G221_R0.5120.85
229_T277_V0.5120.85
129_M148_V0.5110.85
83_Q88_D0.5110.85
132_W135_K0.5110.85
178_I186_L0.5100.85
169_A174_T0.5100.85
25_W85_L0.5080.85
238_G254_V0.5070.85
128_S131_R0.5070.85
188_A216_A0.5060.85
107_D223_F0.5040.85
250_F262_L0.5030.84
146_Y154_V0.5030.84
15_H91_R0.5020.84
121_C155_I0.5020.84
160_W163_Y0.5020.84
110_A140_A0.5010.84
277_V296_M0.5010.84
115_L143_R0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2piaA 1 0.9658 100 0.307 Contact Map
1gvhA 3 0.7205 100 0.499 Contact Map
1cqxA 2 0.7205 100 0.504 Contact Map
1ep3B 2 0.7826 100 0.515 Contact Map
4g1vA 3 0.7267 100 0.524 Contact Map
1krhA 1 0.705 100 0.525 Contact Map
4ylfA 1 0.7702 100 0.529 Contact Map
1tvcA 1 0.7205 100 0.53 Contact Map
1qfjA 1 0.6677 100 0.538 Contact Map
4eh1A 2 0.6801 100 0.543 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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