GREMLIN Database
LTAE - Low specificity L-threonine aldolase
UniProt: P75823 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13690
Length: 333 (297)
Sequences: 21386 (14439)
Seq/√Len: 837.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
258_W321_A3.7371.00
153_W157_R3.4911.00
262_Q324_A3.4151.00
258_W317_R3.2971.00
117_A158_E3.2821.00
42_Y243_K3.0571.00
42_Y239_I3.0551.00
297_R329_A3.0351.00
145_P148_Y2.9271.00
251_E255_N2.6201.00
153_W163_L2.5291.00
104_D115_K2.4341.00
262_Q265_E2.4261.00
157_R187_Y2.4241.00
115_K118_M2.4141.00
75_E101_Q2.2971.00
167_G191_F2.2851.00
193_I206_L2.2661.00
133_L156_T2.2321.00
254_D317_R2.2121.00
258_W262_Q2.2051.00
137_N170_I2.1781.00
80_Q104_D2.1371.00
113_L155_F2.1271.00
115_K119_K2.1251.00
117_A155_F2.0971.00
180_E183_E2.0851.00
240_Y243_K1.9981.00
262_Q321_A1.9831.00
117_A159_R1.9711.00
316_S319_Q1.9511.00
117_A121_K1.8731.00
266_A328_R1.8711.00
322_E326_H1.8111.00
112_P115_K1.8021.00
250_Q254_D1.7601.00
257_A261_E1.7571.00
135_L152_A1.7511.00
293_Y296_A1.7141.00
148_Y154_E1.7111.00
255_N317_R1.7051.00
259_M311_T1.7031.00
132_L164_H1.6711.00
195_L238_G1.6301.00
297_R326_H1.6281.00
43_A206_L1.6221.00
309_L323_V1.6111.00
154_E158_E1.5971.00
239_I243_K1.5941.00
261_E265_E1.5501.00
75_E78_V1.5471.00
116_V152_A1.5291.00
209_G214_I1.5221.00
322_E325_A1.5211.00
170_I191_F1.5071.00
135_L139_H1.5031.00
165_V188_C1.4851.00
218_I221_R1.4841.00
156_T163_L1.4811.00
74_E129_R1.4701.00
113_L148_Y1.4511.00
269_D281_R1.4151.00
219_R222_K1.4141.00
157_R189_D1.4121.00
75_E129_R1.4031.00
42_Y246_V1.4021.00
240_Y244_N1.4011.00
52_A208_V1.3991.00
101_Q119_K1.3941.00
147_E154_E1.3741.00
41_D45_E1.3691.00
155_F159_R1.3651.00
77_I119_K1.3631.00
74_E131_K1.3591.00
227_G230_Q1.3441.00
38_A239_I1.3441.00
256_A260_A1.3431.00
156_T161_L1.3391.00
251_E254_D1.3271.00
114_D117_A1.3251.00
45_E246_V1.3151.00
75_E99_Q1.3061.00
69_H190_S1.3051.00
286_N289_A1.3001.00
164_H192_T1.2951.00
133_L161_L1.2941.00
266_A324_A1.2941.00
259_M320_L1.2921.00
293_Y297_R1.2911.00
301_I309_L1.2791.00
199_L312_H1.2731.00
147_E185_T1.2661.00
242_L246_V1.2651.00
205_S208_V1.2631.00
260_A264_R1.2581.00
301_I307_V1.2571.00
262_Q266_A1.2541.00
75_E128_A1.2421.00
133_L152_A1.2411.00
225_G228_M1.2391.00
291_G303_A1.2391.00
249_L253_H1.2271.00
50_E211_R1.2211.00
61_A192_T1.2081.00
147_E183_E1.2001.00
41_D44_A1.1931.00
38_A42_Y1.1911.00
135_L165_V1.1861.00
153_W187_Y1.1751.00
120_I155_F1.1741.00
248_R252_D1.1651.00
114_D118_M1.1591.00
218_I222_K1.1521.00
228_M231_S1.1511.00
37_N41_D1.1471.00
66_L134_S1.1471.00
262_Q328_R1.1411.00
167_G170_I1.1401.00
280_V309_L1.1361.00
71_E74_E1.1351.00
317_R321_A1.1351.00
117_A148_Y1.1321.00
236_A239_I1.1321.00
65_A190_S1.1271.00
54_F57_T1.1251.00
55_L58_G1.1221.00
217_A222_K1.1191.00
262_Q325_A1.1151.00
295_K300_L1.1131.00
225_G229_R1.1101.00
253_H257_A1.1041.00
226_G229_R1.1031.00
217_A221_R1.1011.00
116_V120_I1.0981.00
241_A245_N1.0931.00
299_V322_E1.0871.00
121_K159_R1.0831.00
154_E187_Y1.0741.00
171_F193_I1.0711.00
292_E296_A1.0701.00
231_S234_L1.0651.00
120_I161_L1.0641.00
41_D52_A1.0631.00
34_P38_A1.0611.00
75_E130_T1.0541.00
217_A220_W1.0521.00
271_M281_R1.0491.00
259_M263_L1.0451.00
65_A164_H1.0441.00
134_S164_H1.0351.00
62_N164_H1.0351.00
205_S209_G1.0341.00
44_A52_A1.0331.00
188_C191_F1.0271.00
258_W320_L1.0261.00
78_V82_A1.0211.00
269_D283_G1.0211.00
93_A100_P1.0201.00
292_E295_K1.0161.00
289_A292_E1.0121.00
62_N66_L1.0111.00
299_V323_V1.0111.00
190_S213_Y1.0101.00
51_A211_R1.0071.00
236_A240_Y1.0051.00
55_L61_A0.9961.00
261_E264_R0.9921.00
247_A250_Q0.9891.00
206_L209_G0.9871.00
240_Y245_N0.9711.00
255_N258_W0.9681.00
75_E121_K0.9621.00
177_Y183_E0.9571.00
325_A329_A0.9551.00
47_S208_V0.9481.00
318_E321_A0.9441.00
226_G230_Q0.9441.00
211_R215_K0.9441.00
120_I159_R0.9401.00
57_T60_Q0.9381.00
138_T275_T0.9381.00
248_R251_E0.9371.00
294_M326_H0.9361.00
121_K129_R0.9321.00
265_E328_R0.9321.00
153_W188_C0.9281.00
195_L200_G0.9221.00
116_V133_L0.9181.00
138_T170_I0.9161.00
42_Y45_E0.9151.00
210_N213_Y0.9131.00
289_A293_Y0.9111.00
312_H315_V0.9081.00
35_T38_A0.8971.00
49_K208_V0.8921.00
220_W223_M0.8871.00
146_R165_V0.8691.00
38_A41_D0.8681.00
177_Y180_E0.8671.00
82_A85_Y0.8611.00
47_S171_F0.8601.00
113_L116_V0.8561.00
311_T320_L0.8551.00
321_A325_A0.8541.00
251_E317_R0.8531.00
121_K128_A0.8511.00
259_M262_Q0.8501.00
42_Y46_L0.8501.00
252_D256_A0.8501.00
72_R97_S0.8491.00
82_A86_L0.8471.00
48_G182_K0.8451.00
294_M301_I0.8451.00
135_L163_L0.8401.00
56_P60_Q0.8401.00
55_L221_R0.8371.00
63_L67_L0.8341.00
249_L252_D0.8341.00
155_F158_E0.8331.00
178_G183_E0.8331.00
75_E79_G0.8311.00
39_L235_A0.8211.00
195_L206_L0.8181.00
222_K225_G0.8121.00
70_C132_L0.8121.00
189_D210_N0.8111.00
274_D277_M0.8111.00
233_I237_A0.8101.00
226_G231_S0.8051.00
36_V235_A0.8031.00
109_G269_D0.8021.00
39_L239_I0.8001.00
80_Q102_P0.7991.00
54_F58_G0.7981.00
259_M278_L0.7961.00
43_A193_I0.7951.00
315_V319_Q0.7941.00
50_E210_N0.7921.00
248_R313_L0.7921.00
260_A278_L0.7901.00
62_N85_Y0.7891.00
223_M226_G0.7871.00
65_A207_L0.7821.00
62_N65_A0.7821.00
225_G230_Q0.7821.00
255_N320_L0.7751.00
209_G213_Y0.7751.00
119_K128_A0.7711.00
132_L162_A0.7711.00
224_T228_M0.7691.00
55_L64_V0.7691.00
113_L117_A0.7691.00
223_M227_G0.7681.00
35_T239_I0.7681.00
247_A251_E0.7651.00
70_C98_I0.7651.00
237_A241_A0.7631.00
70_C74_E0.7611.00
66_L70_C0.7601.00
288_A291_G0.7581.00
225_G231_S0.7581.00
182_K185_T0.7551.00
213_Y216_R0.7541.00
254_D258_W0.7541.00
288_A292_E0.7531.00
77_I116_V0.7521.00
258_W261_E0.7501.00
157_R163_L0.7501.00
103_I119_K0.7471.00
323_V327_W0.7471.00
241_A244_N0.7461.00
290_L307_V0.7461.00
93_A98_I0.7421.00
164_H190_S0.7381.00
282_V290_L0.7361.00
299_V326_H0.7351.00
323_V326_H0.7291.00
32_D36_V0.7271.00
37_N40_Q0.7261.00
58_G168_A0.7171.00
66_L132_L0.7151.00
238_G241_A0.7141.00
86_L134_S0.7141.00
258_W324_A0.7131.00
48_G180_E0.7111.00
78_V102_P0.7071.00
76_Y93_A0.7071.00
32_D37_N0.7041.00
176_A183_E0.7021.00
163_L188_C0.7021.00
47_S193_I0.7021.00
84_N88_E0.7011.00
321_A324_A0.7001.00
171_F199_L0.6981.00
221_R224_T0.6971.00
256_A278_L0.6971.00
103_I116_V0.6951.00
21_M24_P0.6941.00
217_A226_G0.6941.00
222_K226_G0.6931.00
260_A273_Q0.6921.00
291_G301_I0.6911.00
211_R214_I0.6901.00
70_C76_Y0.6891.00
287_A305_P0.6891.00
318_E322_E0.6881.00
324_A328_R0.6871.00
259_M309_L0.6851.00
239_I242_L0.6841.00
171_F198_G0.6841.00
162_A190_S0.6811.00
28_D32_D0.6811.00
287_A303_A0.6771.00
153_W156_T0.6731.00
203_V207_L0.6731.00
111_L116_V0.6721.00
268_A271_M0.6671.00
179_C182_K0.6641.00
263_L327_W0.6641.00
221_R225_G0.6641.00
276_N279_F0.6631.00
251_E313_L0.6631.00
113_L145_P0.6621.00
224_T227_G0.6611.00
63_L95_L0.6581.00
88_E222_K0.6571.00
141_G270_V0.6531.00
320_L323_V0.6521.00
325_A328_R0.6511.00
121_K158_E0.6441.00
28_D31_G0.6421.00
291_G295_K0.6411.00
181_L184_I0.6401.00
152_A163_L0.6391.00
299_V302_N0.6371.00
319_Q322_E0.6351.00
99_Q121_K0.6321.00
71_E95_L0.6321.00
326_H329_A0.6301.00
137_N191_F0.6291.00
44_A49_K0.6281.00
242_L245_N0.6271.00
111_L144_L0.6271.00
77_I130_T0.6271.00
227_G231_S0.6261.00
71_E96_G0.6251.00
180_E184_I0.6231.00
219_R223_M0.6181.00
259_M323_V0.6151.00
254_D257_A0.6121.00
222_K227_G0.6101.00
86_L89_A0.6091.00
116_V155_F0.6071.00
131_K162_A0.6051.00
85_Y89_A0.6041.00
310_V314_D0.6031.00
203_V208_V0.6021.00
29_V32_D0.6011.00
65_A192_T0.6011.00
104_D119_K0.5991.00
212_D215_K0.5981.00
51_A214_I0.5981.00
294_M299_V0.5971.00
319_Q323_V0.5961.00
67_L95_L0.5931.00
128_A131_K0.5931.00
253_H256_A0.5931.00
137_N167_G0.5891.00
179_C183_E0.5871.00
277_M280_V0.5871.00
69_H162_A0.5861.00
216_R220_W0.5851.00
218_I223_M0.5851.00
290_L293_Y0.5821.00
241_A246_V0.5801.00
288_A303_A0.5791.00
63_L66_L0.5781.00
260_A270_V0.5771.00
309_L327_W0.5771.00
238_G244_N0.5741.00
181_L185_T0.5741.00
175_V178_G0.5721.00
193_I208_V0.5691.00
24_P27_D0.5691.00
202_P237_A0.5661.00
237_A240_Y0.5651.00
100_P103_I0.5651.00
224_T230_Q0.5641.00
103_I111_L0.5611.00
43_A52_A0.5591.00
223_M228_M0.5581.00
215_K219_R0.5581.00
63_L68_S0.5581.00
64_V68_S0.5571.00
162_A213_Y0.5561.00
320_L324_A0.5561.00
137_N144_L0.5551.00
263_L324_A0.5521.00
172_N175_V0.5511.00
79_G105_A0.5511.00
154_E157_R0.5501.00
239_I244_N0.5481.00
296_A299_V0.5481.00
178_G181_L0.5481.00
266_A325_A0.5461.00
51_A209_G0.5421.00
59_T63_L0.5421.00
43_A195_L0.5411.00
113_L152_A0.5411.00
118_M127_F0.5411.00
135_L146_R0.5411.00
240_Y246_V0.5401.00
43_A242_L0.5391.00
93_A96_G0.5361.00
319_Q324_A0.5351.00
46_L179_C0.5321.00
112_P117_A0.5291.00
238_G242_L0.5291.00
107_A110_T0.5291.00
252_D255_N0.5281.00
136_E140_N0.5271.00
84_N134_S0.5271.00
33_D37_N0.5251.00
35_T236_A0.5231.00
232_G235_A0.5221.00
290_L294_M0.5211.00
183_E186_Q0.5211.00
279_F285_E0.5201.00
239_I246_V0.5151.00
162_A189_D0.5151.00
144_L152_A0.5141.00
203_V206_L0.5131.00
199_L313_L0.5131.00
62_N192_T0.5121.00
250_Q253_H0.5111.00
138_T143_V0.5091.00
101_Q121_K0.5081.00
78_V100_P0.5061.00
136_E139_H0.5061.00
234_L239_I0.5061.00
273_Q276_N0.5051.00
279_F306_I0.5051.00
165_V191_F0.5041.00
315_V320_L0.5031.00
235_A239_I0.5011.00
67_L71_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jg8A 4 0.997 100 0.323 Contact Map
4lnjA 4 0.997 100 0.327 Contact Map
3wgcA 4 0.988 100 0.342 Contact Map
2w8tA 2 0.958 100 0.386 Contact Map
1v72A 4 0.979 100 0.398 Contact Map
3kkiA 2 0.9459 100 0.399 Contact Map
1fc4A 2 0.967 100 0.402 Contact Map
3wy7A 2 0.9429 100 0.404 Contact Map
3tqxA 2 0.967 100 0.407 Contact Map
1bs0A 2 0.9459 100 0.419 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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