GREMLIN Database
AMID - N-acetylmuramoyl-L-alanine amidase AmiD
UniProt: P75820 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13687
Length: 276 (229)
Sequences: 1119 (712)
Seq/√Len: 47.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_V164_V6.4441.00
219_L238_Q4.1541.00
142_I182_P4.1261.00
120_L145_L4.0241.00
139_P185_Q3.7801.00
47_L149_A3.7101.00
184_Q188_Q3.5911.00
232_D235_P3.0941.00
74_V145_L3.0161.00
103_S169_I2.9771.00
136_P180_L2.8671.00
74_V120_L2.7911.00
246_Q256_G2.6101.00
54_D62_T2.3011.00
35_R95_E2.2951.00
47_L153_I2.2521.00
215_T219_L2.2471.00
225_Y249_F2.1471.00
219_L235_P2.1001.00
63_L73_L2.1001.00
261_E265_I2.0961.00
36_Q67_Q2.0120.99
146_I189_Q2.0110.99
185_Q189_Q1.9980.99
218_L258_A1.9920.99
47_L163_V1.9580.99
93_E152_I1.9540.99
56_F75_P1.8690.99
179_P247_M1.8350.99
62_T66_K1.8160.99
123_R135_A1.7940.99
153_I163_V1.7630.99
92_P95_E1.7400.98
164_V169_I1.7380.98
192_G248_H1.7260.98
234_T238_Q1.7170.98
193_A225_Y1.7100.98
49_I145_L1.6730.98
91_V97_A1.6670.98
206_G209_P1.6610.98
151_D155_R1.6470.98
135_A180_L1.6450.98
246_Q262_T1.6340.98
59_S63_L1.6160.97
110_R113_D1.6140.97
49_I149_A1.5930.97
215_T238_Q1.5830.97
235_P238_Q1.5710.97
149_A191_I1.5670.97
111_L169_I1.5670.97
221_L267_E1.5610.97
99_H117_G1.5190.96
57_D61_A1.4960.96
225_Y248_H1.4480.95
195_P200_V1.4340.95
131_V134_F1.4290.95
139_P143_Q1.4060.94
93_E155_R1.4040.94
172_Q240_R1.4030.94
225_Y269_L1.3940.94
44_I156_Y1.3690.93
219_L234_T1.3640.93
250_R259_D1.3630.93
264_A268_A1.3560.93
48_V169_I1.3550.93
246_Q255_N1.3420.93
51_Y178_G1.3250.92
106_R162_N1.3080.92
250_R261_E1.3080.92
62_T65_D1.2870.91
134_F137_F1.2820.91
47_L158_I1.2740.90
72_Y148_L1.2560.90
195_P265_I1.2460.89
103_S164_V1.2390.89
225_Y266_A1.2350.89
60_L73_L1.2290.89
256_G262_T1.2260.89
87_I144_A1.2060.88
37_A95_E1.2010.88
249_F269_L1.1950.87
123_R134_F1.1850.87
218_L262_T1.1790.87
96_L110_R1.1740.86
215_T234_T1.1680.86
190_G194_W1.1630.86
72_Y93_E1.1630.86
125_W179_P1.1530.85
149_A163_V1.1520.85
152_I155_R1.1510.85
225_Y270_L1.1480.85
262_T265_I1.1480.85
53_A125_W1.1470.85
219_L232_D1.1440.85
96_L108_A1.1240.84
52_T119_E1.1130.83
153_I191_I1.1110.83
49_I120_L1.0960.82
103_S111_L1.0750.81
45_K162_N1.0740.81
46_V111_L1.0740.81
53_A179_P1.0390.79
61_A65_D1.0380.79
230_K237_E1.0370.79
263_Q270_L1.0290.78
31_L34_R1.0250.78
58_S62_T1.0190.77
131_V135_A1.0180.77
236_R240_R1.0170.77
229_V241_V1.0110.77
50_H166_H1.0110.77
76_A135_A1.0070.77
145_L186_L0.9990.76
199_R203_Y0.9970.76
104_A107_G0.9900.75
143_Q147_P0.9820.75
171_P222_L0.9790.75
250_R255_N0.9790.75
234_T239_R0.9680.74
96_L113_D0.9630.73
73_L90_L0.9400.71
108_A113_D0.9380.71
137_F180_L0.9360.71
75_P88_W0.9350.71
47_L152_I0.9210.70
170_A173_R0.9170.70
55_D59_S0.8900.67
56_F121_E0.8900.67
232_D238_Q0.8880.67
53_A59_S0.8830.67
209_P212_P0.8810.66
150_K154_A0.8660.65
250_R265_I0.8580.64
172_Q244_A0.8570.64
206_G215_T0.8560.64
132_K135_A0.8550.64
104_A109_T0.8440.63
239_R243_M0.8430.63
125_W135_A0.8330.62
208_A239_R0.8310.62
212_P215_T0.8270.62
197_A253_L0.8250.61
215_T235_P0.8240.61
41_Y96_L0.8220.61
163_V225_Y0.8030.59
123_R131_V0.8020.59
63_L250_R0.7940.58
230_K234_T0.7940.58
238_Q241_V0.7930.58
175_D243_M0.7920.58
234_T237_E0.7880.58
142_I189_Q0.7870.58
56_F88_W0.7820.57
242_I257_E0.7800.57
134_F180_L0.7780.57
99_H174_K0.7770.57
74_V87_I0.7740.56
131_V175_D0.7730.56
48_V111_L0.7710.56
165_A186_L0.7700.56
137_F167_A0.7690.56
237_E243_M0.7630.55
234_T258_A0.7580.55
56_F76_A0.7580.55
85_P144_A0.7580.55
75_P86_R0.7560.55
241_V266_A0.7510.54
116_I152_I0.7460.54
43_R114_T0.7440.53
69_S115_S0.7420.53
233_M236_R0.7400.53
145_L149_A0.7360.53
124_G176_D0.7350.53
104_A108_A0.7310.52
205_A214_D0.7260.52
51_Y179_P0.7260.52
217_S267_E0.7230.51
120_L137_F0.7220.51
125_W134_F0.7190.51
32_D91_V0.7180.51
104_A228_D0.7180.51
132_K153_I0.7170.51
213_V266_A0.7160.51
56_F59_S0.7150.51
258_A262_T0.7130.50
75_P84_K0.7090.50
154_A157_H0.7080.50
260_A264_A0.7070.50
115_S183_W0.7070.50
40_A95_E0.7030.49
35_R92_P0.7020.49
108_A114_T0.6980.49
158_I162_N0.6940.48
191_I248_H0.6940.48
73_L121_E0.6900.48
101_G174_K0.6900.48
216_A231_P0.6880.48
55_D58_S0.6840.47
228_D237_E0.6830.47
220_E224_R0.6810.47
124_G171_P0.6790.47
69_S183_W0.6790.47
100_A117_G0.6780.47
191_I194_W0.6740.47
45_K114_T0.6700.46
206_G210_H0.6650.46
59_S73_L0.6640.46
137_F183_W0.6620.45
208_A234_T0.6590.45
125_W133_Y0.6580.45
223_A230_K0.6550.45
131_V140_A0.6530.44
255_N262_T0.6520.44
149_A165_A0.6480.44
216_A220_E0.6470.44
183_W187_A0.6460.44
54_D58_S0.6450.44
189_Q223_A0.6440.44
75_P121_E0.6440.44
195_P248_H0.6420.43
52_T176_D0.6410.43
142_I146_I0.6400.43
60_L64_T0.6390.43
204_L260_A0.6380.43
208_A236_R0.6370.43
146_I185_Q0.6340.43
53_A123_R0.6330.42
115_S158_I0.6320.42
193_A249_F0.6310.42
163_V191_I0.6310.42
218_L242_I0.6280.42
167_A183_W0.6280.42
243_M247_M0.6270.42
187_A190_G0.6270.42
205_A213_V0.6260.42
116_I151_D0.6250.42
93_E148_L0.6240.42
159_K162_N0.6220.41
173_R176_D0.6200.41
213_V216_A0.6190.41
63_L90_L0.6130.41
99_H115_S0.6100.40
52_T174_K0.6090.40
124_G173_R0.6070.40
60_L88_W0.6030.40
259_D262_T0.6030.40
195_P261_E0.6010.39
219_L241_V0.6000.39
150_K157_H0.6000.39
124_G141_Q0.5990.39
143_Q236_R0.5940.39
212_P218_L0.5940.39
243_M254_Y0.5930.39
147_P151_D0.5930.39
165_A216_A0.5920.39
31_L89_Q0.5910.38
183_W227_Y0.5910.38
219_L233_M0.5900.38
152_I175_D0.5880.38
226_G244_A0.5860.38
56_F84_K0.5850.38
215_T241_V0.5850.38
252_T265_I0.5840.38
233_M237_E0.5830.38
59_S64_T0.5830.38
242_I255_N0.5830.38
56_F73_L0.5820.38
153_I200_V0.5810.38
153_I157_H0.5800.37
48_V173_R0.5800.37
206_G212_P0.5780.37
146_I150_K0.5770.37
165_A176_D0.5720.37
36_Q64_T0.5720.37
184_Q196_D0.5680.36
172_Q241_V0.5680.36
122_N141_Q0.5680.36
87_I148_L0.5680.36
220_E231_P0.5670.36
193_A248_H0.5660.36
131_V180_L0.5650.36
207_R211_T0.5630.36
68_V137_F0.5630.36
47_L191_I0.5620.36
59_S248_H0.5580.35
45_K110_R0.5580.35
119_E166_H0.5570.35
72_Y183_W0.5560.35
30_Q157_H0.5550.35
93_E116_I0.5550.35
156_Y162_N0.5520.35
125_W132_K0.5510.35
32_D35_R0.5500.35
124_G174_K0.5490.35
250_R256_G0.5490.35
51_Y122_N0.5480.34
203_Y268_A0.5480.34
68_V72_Y0.5470.34
50_H119_E0.5430.34
209_P218_L0.5380.34
54_D125_W0.5370.34
219_L230_K0.5360.33
263_Q267_E0.5360.33
59_S62_T0.5350.33
51_Y167_A0.5340.33
229_V232_D0.5320.33
228_D240_R0.5270.33
221_L263_Q0.5250.32
143_Q208_A0.5240.32
32_D36_Q0.5240.32
221_L224_R0.5230.32
208_A266_A0.5220.32
172_Q266_A0.5220.32
95_E156_Y0.5180.32
69_S91_V0.5160.32
122_N176_D0.5160.32
46_V108_A0.5160.32
222_L226_G0.5130.31
102_I110_R0.5120.31
86_R150_K0.5110.31
66_K76_A0.5110.31
221_L270_L0.5100.31
157_H220_E0.5100.31
145_L191_I0.5100.31
42_P45_K0.5090.31
60_L111_L0.5080.31
122_N174_K0.5080.31
191_I242_I0.5080.31
209_P234_T0.5080.31
122_N170_A0.5080.31
141_Q181_F0.5070.31
242_I266_A0.5070.31
54_D138_E0.5060.31
213_V263_Q0.5060.31
34_R39_A0.5060.31
242_I252_T0.5050.31
227_Y245_F0.5040.31
139_P142_I0.5040.31
186_L190_G0.5030.31
100_A170_A0.5030.31
108_A111_L0.5030.31
106_R161_E0.5010.30
63_L69_S0.5010.30
44_I116_I0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bolA 2 0.8696 100 0.278 Contact Map
3d2yA 3 0.9275 100 0.3 Contact Map
4bxjA 4 0.8696 100 0.301 Contact Map
1j3gA 1 0.6051 100 0.548 Contact Map
4ivvA 1 0.5399 100 0.586 Contact Map
4knkA 1 0.663 100 0.604 Contact Map
3rdrA 4 0.5217 100 0.607 Contact Map
1yb0A 3 0.5471 100 0.613 Contact Map
4olsA 2 0.5543 100 0.616 Contact Map
2rkqA 1 0.5326 100 0.633 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0086 seconds.