GREMLIN Database
RLMC - 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC
UniProt: P75817 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13427
Length: 375 (362)
Sequences: 4837 (3549)
Seq/√Len: 186.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
352_E373_V3.7861.00
343_I372_L3.5811.00
23_E26_S3.4951.00
45_C353_R3.3171.00
29_T33_K3.2851.00
257_Q284_Q3.2301.00
76_H79_G3.1161.00
224_T227_D2.9971.00
304_V321_L2.9771.00
142_L170_V2.8881.00
251_C305_L2.8321.00
91_P129_E2.6381.00
24_Q362_H2.5971.00
228_W353_R2.4081.00
195_A202_P2.3731.00
83_D102_K2.3691.00
197_R202_P2.3031.00
351_I370_T2.2841.00
30_A34_N2.2811.00
236_H257_Q2.1921.00
321_L329_I2.1811.00
29_T46_A2.1691.00
204_W273_Q2.1531.00
306_V313_I2.1471.00
70_P74_M2.1041.00
288_L293_F2.0931.00
322_S347_P2.0881.00
225_A332_S2.0811.00
70_P73_G2.0771.00
187_Y192_Q2.0761.00
242_C260_G2.0451.00
197_R200_D2.0261.00
206_R270_C2.0171.00
262_E268_I1.9281.00
202_P277_E1.9031.00
302_E327_R1.8941.00
29_T47_P1.8911.00
238_W301_P1.8811.00
318_C346_L1.8691.00
21_I25_L1.8521.00
54_G92_A1.8501.00
289_D292_Q1.8421.00
242_C268_I1.8331.00
25_L49_S1.8221.00
318_C345_E1.8091.00
273_Q276_A1.8031.00
193_A204_W1.7971.00
221_L357_F1.7891.00
339_M368_V1.7771.00
315_K319_D1.7711.00
223_A227_D1.7451.00
130_S133_D1.7291.00
313_I318_C1.7271.00
92_A96_P1.7081.00
167_V192_Q1.6741.00
280_L283_L1.6721.00
93_S129_E1.6701.00
48_V357_F1.6671.00
74_M79_G1.6421.00
97_V136_M1.6241.00
339_M370_T1.6011.00
226_R254_P1.5831.00
11_C14_C1.5791.00
36_L354_V1.5741.00
63_V125_I1.5721.00
169_T187_Y1.5721.00
57_N215_P1.5651.00
137_M167_V1.5631.00
107_R157_W1.5581.00
48_V220_Q1.5411.00
32_L356_L1.5371.00
328_F373_V1.5261.00
20_P23_E1.5241.00
339_M343_I1.5221.00
219_S223_A1.5181.00
237_M255_D1.5131.00
26_S29_T1.4871.00
322_S348_G1.4841.00
224_T355_Q1.4841.00
45_C355_Q1.4831.00
265_S269_A1.4821.00
41_V344_R1.4801.00
32_L366_Y1.4751.00
70_P106_A1.4551.00
94_F127_L1.4531.00
100_A161_Q1.4481.00
235_K302_E1.4401.00
158_L165_L1.4381.00
118_K176_H1.4371.00
36_L343_I1.4341.00
234_V256_M1.4291.00
5_L84_L1.4221.00
350_R373_V1.4171.00
304_V326_P1.4171.00
248_G258_L1.4151.00
159_H189_T1.4131.00
232_L235_K1.4081.00
260_G271_A1.4011.00
148_L151_L1.3961.00
14_C87_C1.3921.00
11_C87_C1.3891.00
30_A33_K1.3861.00
105_I122_L1.3781.00
126_L139_R1.3671.00
201_V253_T1.3611.00
73_G79_G1.3551.00
135_G166_K1.3411.00
86_D95_A1.3361.00
201_V249_L1.3151.00
19_Q23_E1.3111.00
199_N250_H1.3081.00
6_Y9_G1.3001.00
166_K191_Q1.2901.00
77_R80_T1.2821.00
269_A272_K1.2811.00
100_A162_L1.2791.00
71_L74_M1.2691.00
64_S81_P1.2651.00
26_S30_A1.2521.00
229_V303_L1.2461.00
260_G285_F1.2441.00
271_A285_F1.2311.00
152_R156_P1.2311.00
3_C11_C1.2211.00
335_N338_T1.2171.00
195_A204_W1.2161.00
275_A285_F1.2081.00
54_G88_P1.2031.00
135_G191_Q1.2001.00
224_T228_W1.1971.00
249_L275_A1.1931.00
228_W371_L1.1931.00
96_P164_Q1.1801.00
185_E208_Q1.1791.00
6_Y18_M1.1751.00
66_S70_P1.1741.00
156_P160_E1.1671.00
319_D323_T1.1661.00
260_G283_L1.1661.00
236_H259_T1.1621.00
352_E371_L1.1501.00
55_F363_T1.1491.00
73_G76_H1.1491.00
132_S197_R1.1411.00
249_L283_L1.1401.00
121_E144_S1.1351.00
93_S96_P1.1311.00
74_M78_D1.1311.00
315_K345_E1.1271.00
36_L339_M1.1261.00
255_D282_R1.1201.00
204_W277_E1.1021.00
368_V372_L1.0991.00
224_T369_L1.0951.00
145_D184_T1.0871.00
343_I351_I1.0871.00
33_K37_A1.0851.00
16_W27_A1.0851.00
252_A280_L1.0821.00
59_A90_Y1.0771.00
19_Q27_A1.0761.00
248_G283_L1.0701.00
93_S136_M1.0631.00
231_Q237_M1.0611.00
353_R371_L1.0591.00
154_A157_W1.0561.00
151_L155_L1.0551.00
157_W161_Q1.0511.00
192_Q196_E1.0511.00
225_A330_I1.0471.00
121_E143_R1.0461.00
220_Q223_A1.0441.00
261_I293_F1.0391.00
51_P220_Q1.0381.00
85_C99_A1.0371.00
200_D253_T1.0361.00
273_Q277_E1.0351.00
25_L47_P1.0331.00
169_T207_P1.0311.00
133_D197_R1.0281.00
265_S287_A1.0281.00
35_L336_A1.0251.00
151_L158_L1.0241.00
3_C14_C1.0241.00
199_N219_S1.0181.00
269_A273_Q1.0121.00
220_Q357_F1.0111.00
329_I349_F1.0100.99
103_P106_A1.0090.99
44_W356_L1.0020.99
215_P218_A1.0010.99
53_Q362_H0.9970.99
97_V162_L0.9900.99
224_T353_R0.9890.99
240_L317_L0.9890.99
54_G86_D0.9880.99
48_V355_Q0.9860.99
138_L165_L0.9810.99
33_K44_W0.9800.99
209_S270_C0.9790.99
150_Q153_K0.9780.99
319_D345_E0.9780.99
242_C271_A0.9770.99
242_C285_F0.9750.99
274_S278_L0.9730.99
329_I346_L0.9730.99
209_S267_A0.9700.99
231_Q235_K0.9660.99
15_Q364_A0.9630.99
272_K284_Q0.9620.99
201_V252_A0.9610.99
343_I370_T0.9600.99
52_E362_H0.9560.99
36_L340_A0.9550.99
172_I186_I0.9500.99
185_E207_P0.9490.99
139_R207_P0.9470.99
301_P304_V0.9450.99
326_P349_F0.9400.99
155_L159_H0.9380.99
45_C228_W0.9380.99
97_V100_A0.9250.99
249_L280_L0.9250.99
4_A86_D0.9240.99
54_G95_A0.9220.99
199_N223_A0.9210.99
259_T301_P0.9200.99
156_P159_H0.9160.99
229_V330_I0.9160.99
224_T357_F0.9150.99
129_E136_M0.9130.99
3_C87_C0.9100.99
237_M303_L0.9100.99
290_S294_A0.9090.99
259_T286_Q0.9070.99
195_A277_E0.9040.99
369_L373_V0.9030.99
43_E353_R0.9010.99
73_G78_D0.9010.99
201_V280_L0.9010.99
216_A219_S0.9010.99
230_R328_F0.8990.99
276_A281_T0.8990.99
231_Q255_D0.8980.99
325_A374_K0.8930.99
218_A246_G0.8900.99
226_R253_T0.8890.99
102_K106_A0.8880.99
135_G195_A0.8840.99
328_F371_L0.8790.99
217_V359_M0.8760.99
231_Q303_L0.8750.99
40_P340_A0.8680.98
93_S164_Q0.8670.98
263_I289_D0.8670.98
226_R250_H0.8660.98
213_T359_M0.8640.98
140_F143_R0.8610.98
157_W160_E0.8580.98
268_I287_A0.8550.98
190_E196_E0.8520.98
259_T299_D0.8520.98
165_L168_I0.8470.98
48_V224_T0.8420.98
190_E198_F0.8410.98
228_W355_Q0.8360.98
217_V220_Q0.8340.98
100_A103_P0.8310.98
154_A158_L0.8290.98
370_T373_V0.8270.98
69_K73_G0.8250.98
63_V73_G0.8250.98
351_I372_L0.8240.98
237_M251_C0.8210.98
140_F144_S0.8200.98
241_F291_T0.8180.98
238_W294_A0.8150.98
21_I49_S0.8110.98
193_A196_E0.8100.98
239_D260_G0.8080.98
286_Q293_F0.8080.98
175_V183_E0.8070.98
170_V188_L0.8060.98
354_V370_T0.8060.98
90_Y94_F0.8000.97
330_I369_L0.7990.97
143_R174_P0.7980.97
306_V321_L0.7960.97
108_A157_W0.7940.97
75_L79_G0.7920.97
171_N182_G0.7880.97
236_H256_M0.7870.97
122_L140_F0.7860.97
327_R373_V0.7850.97
226_R251_C0.7820.97
70_P75_L0.7810.97
35_L340_A0.7800.97
22_P26_S0.7760.97
237_M258_L0.7760.97
104_F108_A0.7750.97
28_K358_D0.7730.97
272_K276_A0.7730.97
6_Y15_Q0.7720.97
210_F334_C0.7710.97
21_I52_E0.7700.97
225_A305_L0.7700.97
322_S345_E0.7690.97
205_I211_F0.7620.97
51_P216_A0.7620.97
351_I354_V0.7600.96
169_T185_E0.7600.96
235_K255_D0.7600.96
132_S219_S0.7560.96
334_C367_E0.7550.96
266_E269_A0.7550.96
97_V138_L0.7540.96
204_W270_C0.7540.96
158_L162_L0.7540.96
330_I371_L0.7540.96
47_P356_L0.7520.96
221_L359_M0.7500.96
103_P161_Q0.7480.96
69_K74_M0.7450.96
67_V70_P0.7440.96
291_T314_G0.7440.96
213_T339_M0.7430.96
248_G285_F0.7410.96
38_D42_E0.7410.96
327_R349_F0.7410.96
222_Y247_F0.7390.96
169_T172_I0.7370.96
59_A94_F0.7360.96
70_P76_H0.7320.96
17_I53_Q0.7310.96
108_A150_Q0.7310.96
70_P79_G0.7300.96
194_L197_R0.7300.96
236_H299_D0.7300.96
194_L198_F0.7290.96
171_N174_P0.7270.95
242_C262_E0.7220.95
99_A103_P0.7210.95
63_V105_I0.7200.95
50_G216_A0.7140.95
90_Y95_A0.7130.95
151_L186_I0.7110.95
91_P95_A0.7060.95
268_I272_K0.7060.95
196_E211_F0.7040.95
101_L125_I0.7030.95
153_K157_W0.7020.95
147_K150_Q0.7010.95
189_T192_Q0.6990.94
35_L39_F0.6980.94
368_V373_V0.6940.94
187_Y190_E0.6930.94
63_V122_L0.6920.94
257_Q299_D0.6920.94
29_T44_W0.6920.94
11_C17_I0.6900.94
147_K151_L0.6890.94
71_L106_A0.6880.94
288_L294_A0.6870.94
173_Q177_M0.6860.94
57_N211_F0.6840.94
325_A348_G0.6840.94
46_A356_L0.6820.94
252_A258_L0.6820.94
190_E194_L0.6820.94
228_W369_L0.6770.93
4_A85_C0.6750.93
71_L105_I0.6740.93
153_K156_P0.6730.93
171_N185_E0.6700.93
123_K173_Q0.6680.93
151_L154_A0.6640.93
91_P94_F0.6640.93
6_Y53_Q0.6640.93
4_A88_P0.6640.93
69_K106_A0.6630.93
126_L141_V0.6630.93
222_Y250_H0.6590.93
331_Y339_M0.6560.92
144_S174_P0.6550.92
314_G318_C0.6540.92
226_R248_G0.6510.92
34_N37_A0.6510.92
35_L337_Q0.6470.92
39_F42_E0.6470.92
27_A31_D0.6460.92
159_H162_L0.6460.92
105_I110_L0.6420.92
145_D174_P0.6400.91
44_W354_V0.6390.91
259_T284_Q0.6390.91
74_M77_R0.6390.91
228_W330_I0.6370.91
220_Q224_T0.6360.91
35_L38_D0.6360.91
62_V124_Y0.6330.91
104_F154_A0.6270.91
162_L165_L0.6270.91
21_I358_D0.6270.91
173_Q178_A0.6270.91
137_M141_V0.6260.90
191_Q195_A0.6240.90
332_S369_L0.6240.90
317_L321_L0.6220.90
62_V81_P0.6200.90
103_P107_R0.6200.90
334_C360_F0.6190.90
150_Q157_W0.6170.90
212_Q334_C0.6170.90
23_E27_A0.6160.90
292_Q295_T0.6150.90
208_Q266_E0.6140.90
230_R254_P0.6140.90
322_S346_L0.6130.90
69_K75_L0.6110.89
291_T316_P0.6110.89
32_L368_V0.6100.89
97_V165_L0.6090.89
10_R77_R0.6080.89
24_Q358_D0.6080.89
85_C102_K0.6050.89
356_L366_Y0.6030.89
196_E199_N0.6010.89
357_F369_L0.6010.89
120_G123_K0.6000.89
14_C17_I0.6000.89
221_L369_L0.6000.89
42_E343_I0.5990.88
360_F367_E0.5990.88
201_V250_H0.5990.88
38_D337_Q0.5970.88
241_F290_S0.5960.88
61_M94_F0.5910.88
167_V171_N0.5910.88
61_M240_L0.5890.88
198_F218_A0.5890.88
61_M98_F0.5890.88
137_M140_F0.5880.88
168_I189_T0.5870.87
316_P319_D0.5870.87
21_I50_G0.5860.87
289_D293_F0.5810.87
210_F367_E0.5810.87
265_S272_K0.5810.87
337_Q341_K0.5810.87
217_V357_F0.5800.87
240_L304_V0.5780.87
171_N178_A0.5780.87
247_F305_L0.5770.87
71_L75_L0.5760.86
69_K76_H0.5740.86
44_W47_P0.5720.86
268_I285_F0.5700.86
148_L152_R0.5700.86
211_F244_V0.5690.86
39_F341_K0.5680.86
210_F360_F0.5670.86
333_S338_T0.5640.85
159_H163_P0.5630.85
221_L332_S0.5610.85
203_L244_V0.5590.85
137_M205_I0.5590.85
149_A152_R0.5580.85
321_L324_M0.5570.85
50_G214_N0.5560.85
166_K194_L0.5550.84
261_I290_S0.5540.84
368_V371_L0.5530.84
366_Y371_L0.5530.84
5_L10_R0.5530.84
150_Q154_A0.5490.84
16_W19_Q0.5480.84
73_G102_K0.5450.83
291_T295_T0.5450.83
366_Y372_L0.5440.83
319_D347_P0.5430.83
66_S72_L0.5430.83
194_L199_N0.5430.83
192_Q198_F0.5420.83
104_F158_L0.5410.83
314_G317_L0.5400.83
75_L78_D0.5390.83
271_A283_L0.5380.83
51_P217_V0.5380.83
101_L140_F0.5370.82
362_H365_H0.5330.82
198_F219_S0.5310.82
210_F308_P0.5310.82
129_E134_G0.5310.82
237_M256_M0.5310.82
126_L181_E0.5290.82
310_R334_C0.5290.82
42_E351_I0.5290.82
173_Q176_H0.5270.81
39_F340_A0.5260.81
227_D353_R0.5260.81
173_Q180_M0.5250.81
336_A366_Y0.5250.81
62_V76_H0.5240.81
31_D337_Q0.5240.81
262_E267_A0.5220.81
172_I184_T0.5220.81
178_A311_R0.5220.81
306_V331_Y0.5220.81
303_L330_I0.5210.81
104_F161_Q0.5200.80
101_L105_I0.5180.80
166_K171_N0.5170.80
5_L85_C0.5150.80
53_Q88_P0.5150.80
167_V172_I0.5140.80
290_S317_L0.5130.80
58_K222_Y0.5130.80
29_T355_Q0.5120.79
142_L145_D0.5120.79
141_V145_D0.5110.79
97_V127_L0.5110.79
321_L326_P0.5110.79
342_D345_E0.5100.79
50_G217_V0.5090.79
292_Q316_P0.5070.79
313_I345_E0.5070.79
72_L76_H0.5060.79
5_L88_P0.5060.79
244_V248_G0.5050.78
76_H80_T0.5050.78
327_R350_R0.5050.78
222_Y246_G0.5050.78
55_F213_T0.5040.78
34_N38_D0.5040.78
151_L170_V0.5040.78
235_K303_L0.5030.78
96_P100_A0.5030.78
201_V278_L0.5020.78
167_V187_Y0.5010.78
29_T356_L0.5010.78
62_V178_A0.5010.78
226_R237_M0.5000.78
308_P334_C0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jjqA 1 0.8827 100 0.264 Contact Map
1uwvA 1 0.92 100 0.309 Contact Map
3bt7A 1 0.9227 100 0.342 Contact Map
3vseA 1 0.88 100 0.643 Contact Map
4dmgA 2 0.8693 100 0.668 Contact Map
2b78A 1 0.872 100 0.674 Contact Map
1wxxA 2 0.8667 100 0.68 Contact Map
3c0kA 2 0.8747 100 0.689 Contact Map
3k6rA 1 0.6507 100 0.716 Contact Map
2as0A 2 0.88 100 0.719 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0114 seconds.