GREMLIN Database
YBJI - Flavin mononucleotide phosphatase YbjI
UniProt: P75809 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13678
Length: 271 (256)
Sequences: 10979 (8997)
Seq/√Len: 562.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
248_G257_D4.1201.00
17_D251_N3.4541.00
212_V226_A3.1211.00
249_S252_R2.9081.00
223_L229_S2.8901.00
22_N253_E2.7331.00
4_K209_E2.7291.00
25_R253_E2.5751.00
200_Q210_V2.5551.00
25_R260_D2.4881.00
8_V40_F2.4411.00
237_S241_A2.4231.00
16_S20_T2.3961.00
44_S51_L2.3521.00
224_R242_A2.3081.00
197_R225_Q2.2241.00
207_D225_Q2.0401.00
191_H221_E2.0121.00
24_E28_A1.8961.00
220_I239_V1.8811.00
32_Q35_A1.8661.00
80_F198_Q1.8411.00
220_I242_A1.8371.00
217_G238_A1.8301.00
32_Q260_D1.8161.00
3_I211_V1.7861.00
237_S240_V1.7831.00
217_G236_G1.7771.00
229_S244_K1.7741.00
248_G252_R1.7741.00
231_A243_A1.7631.00
30_Y40_F1.7561.00
27_M57_E1.7351.00
85_S88_A1.7291.00
5_L41_V1.7261.00
7_A196_L1.7191.00
33_M38_I1.7061.00
206_D209_E1.7041.00
197_R201_K1.6891.00
74_S77_K1.6581.00
198_Q202_L1.6371.00
32_Q36_Q1.6241.00
198_Q201_K1.6001.00
230_F258_V1.5831.00
228_F244_K1.5801.00
228_F245_Y1.5771.00
239_V242_A1.5641.00
245_Y262_V1.5591.00
194_N197_R1.5371.00
193_A225_Q1.5311.00
196_L222_M1.5201.00
10_M15_L1.5171.00
82_G198_Q1.5131.00
22_N26_F1.5081.00
3_I38_I1.5001.00
8_V213_F1.4781.00
39_R203_W1.4761.00
97_L115_L1.4631.00
138_N141_N1.4541.00
91_T172_I1.4491.00
245_Y258_V1.4401.00
28_A32_Q1.4391.00
96_L151_L1.4361.00
212_V222_M1.4311.00
25_R257_D1.4211.00
213_F255_V1.4181.00
26_F253_E1.3921.00
208_S227_G1.3821.00
162_Q166_H1.3751.00
27_M31_Q1.3721.00
3_I228_F1.3381.00
231_A235_A1.3371.00
3_I209_E1.3341.00
7_A43_A1.3011.00
233_E249_S1.2911.00
34_K61_E1.2861.00
81_N145_I1.2811.00
223_L239_V1.2771.00
88_A91_T1.2751.00
213_F258_V1.2741.00
29_Q256_L1.2731.00
207_D210_V1.2471.00
200_Q207_D1.2451.00
88_A172_I1.2401.00
86_K90_A1.2391.00
174_V221_E1.2201.00
238_A241_A1.2141.00
220_I224_R1.2121.00
245_Y261_K1.2101.00
82_G187_I1.2071.00
78_D81_N1.2041.00
157_L160_Q1.1861.00
29_Q260_D1.1851.00
16_S251_N1.1821.00
240_V246_R1.1801.00
258_V262_V1.1791.00
71_W78_D1.1781.00
6_I33_M1.1771.00
255_V259_I1.1721.00
88_A173_M1.1691.00
31_Q35_A1.1671.00
25_R29_Q1.1661.00
63_A203_W1.1601.00
17_D250_N1.1531.00
211_V262_V1.1491.00
6_I259_I1.1481.00
22_N25_R1.1411.00
210_V226_A1.1361.00
41_V199_L1.1301.00
41_V63_A1.1291.00
174_V189_G1.1201.00
5_L205_I1.1181.00
120_D124_T1.1161.00
120_D123_K1.1151.00
5_L200_Q1.1141.00
159_P163_K1.1111.00
159_P177_H1.1071.00
212_V223_L1.1071.00
247_A258_V1.1061.00
247_A254_G1.1021.00
148_K184_D1.0991.00
65_V195_G1.0891.00
234_N250_N1.0881.00
72_V198_Q1.0851.00
176_V186_I1.0781.00
6_I38_I1.0761.00
7_A210_V1.0751.00
226_A229_S1.0611.00
81_N147_F1.0541.00
207_D227_G1.0491.00
232_M254_G1.0491.00
10_M54_F1.0381.00
34_K62_I1.0371.00
230_F247_A1.0321.00
236_G239_V1.0301.00
94_E98_T1.0261.00
187_I190_V1.0241.00
153_L157_L1.0171.00
24_E27_M1.0141.00
5_L210_V1.0071.00
31_Q34_K1.0061.00
14_F26_F1.0051.00
257_D261_K1.0051.00
256_L260_D1.0011.00
191_H194_N0.9961.00
211_V230_F0.9871.00
200_Q225_Q0.9831.00
14_F30_Y0.9831.00
235_A240_V0.9761.00
172_I188_P0.9751.00
72_V80_F0.9731.00
230_F245_Y0.9691.00
258_V261_K0.9661.00
216_G236_G0.9641.00
95_H98_T0.9641.00
193_A221_E0.9601.00
211_V228_F0.9591.00
31_Q59_A0.9551.00
196_L226_A0.9541.00
82_G189_G0.9531.00
248_G254_G0.9521.00
199_L203_W0.9441.00
90_A94_E0.9441.00
211_V258_V0.9421.00
233_E240_V0.9391.00
70_G190_V0.9381.00
83_E145_I0.9311.00
48_Y66_A0.9291.00
231_A239_V0.9111.00
163_K166_H0.9081.00
28_A31_Q0.9081.00
197_R207_D0.9071.00
160_Q163_K0.9061.00
200_Q205_I0.9051.00
8_V255_V0.9051.00
73_V78_D0.9011.00
33_M40_F0.9011.00
200_Q227_G0.8991.00
72_V195_G0.8981.00
232_M247_A0.8951.00
217_G220_I0.8931.00
7_A41_V0.8931.00
100_P164_A0.8871.00
79_V202_L0.8871.00
233_E248_G0.8841.00
160_Q164_A0.8831.00
257_D260_D0.8801.00
81_N109_K0.8761.00
66_A71_W0.8711.00
186_I191_H0.8641.00
26_F256_L0.8591.00
210_V227_G0.8531.00
52_I76_G0.8511.00
233_E252_R0.8431.00
95_H100_P0.8391.00
44_S66_A0.8371.00
65_V199_L0.8321.00
153_L158_I0.8321.00
52_I56_P0.8291.00
16_S22_N0.8281.00
73_V76_G0.8281.00
63_A74_S0.8271.00
238_A242_A0.8211.00
84_L187_I0.8191.00
91_T94_E0.8191.00
210_V225_Q0.8121.00
43_A65_V0.8101.00
87_D91_T0.8041.00
63_A199_L0.8011.00
212_V229_S0.7971.00
6_I211_V0.7961.00
227_G244_K0.7961.00
94_E140_D0.7951.00
18_Q251_N0.7911.00
39_R63_A0.7901.00
223_L242_A0.7891.00
175_S185_L0.7881.00
38_I211_V0.7871.00
171_D188_P0.7831.00
48_Y73_V0.7761.00
29_Q32_Q0.7751.00
25_R256_L0.7691.00
66_A73_V0.7681.00
83_E147_F0.7661.00
33_M259_I0.7661.00
8_V14_F0.7631.00
93_V97_L0.7611.00
26_F29_Q0.7591.00
162_Q177_H0.7581.00
174_V191_H0.7561.00
98_T164_A0.7511.00
10_M42_V0.7431.00
95_H169_I0.7431.00
248_G261_K0.7431.00
47_Q67_E0.7421.00
232_M235_A0.7411.00
100_P160_Q0.7301.00
86_K145_I0.7281.00
159_P162_Q0.7281.00
77_K202_L0.7271.00
111_S134_E0.7261.00
123_K127_E0.7231.00
51_L64_F0.7211.00
235_A239_V0.7181.00
223_L243_A0.7111.00
91_T95_H0.7091.00
95_H164_A0.7081.00
190_V194_N0.7061.00
196_L212_V0.7011.00
137_D141_N0.7011.00
194_N198_Q0.7011.00
51_L66_A0.6961.00
42_V51_L0.6921.00
68_N184_D0.6891.00
209_E227_G0.6881.00
122_M125_V0.6871.00
14_F21_Y0.6841.00
126_A133_L0.6831.00
215_D235_A0.6821.00
16_S250_N0.6791.00
137_D140_D0.6761.00
71_W147_F0.6761.00
10_M51_L0.6751.00
48_Y52_I0.6721.00
12_G232_M0.6701.00
60_N63_A0.6671.00
108_G146_F0.6671.00
215_D232_M0.6661.00
97_L104_I0.6631.00
14_F250_N0.6621.00
43_A222_M0.6611.00
245_Y248_G0.6611.00
150_G184_D0.6601.00
245_Y257_D0.6591.00
164_A167_E0.6581.00
197_R200_Q0.6551.00
91_T169_I0.6541.00
118_Y122_M0.6481.00
229_S243_A0.6431.00
229_S239_V0.6411.00
70_G187_I0.6401.00
89_F146_F0.6391.00
213_F230_F0.6361.00
174_V186_I0.6341.00
213_F247_A0.6301.00
221_E224_R0.6281.00
87_D90_A0.6271.00
78_D109_K0.6261.00
14_F42_V0.6261.00
174_V188_P0.6251.00
109_K145_I0.6231.00
118_Y123_K0.6211.00
234_N240_V0.6211.00
253_E256_L0.6211.00
25_R28_A0.6171.00
108_G144_D0.6171.00
127_E130_Y0.6081.00
42_V55_F0.6081.00
10_M14_F0.6081.00
163_K167_E0.6071.00
5_L199_L0.6061.00
148_K178_T0.6021.00
38_I209_E0.6021.00
136_V139_F0.5981.00
55_F64_F0.5981.00
228_F258_V0.5951.00
71_W109_K0.5941.00
29_Q33_M0.5901.00
247_A257_D0.5901.00
256_L259_I0.5881.00
220_I223_L0.5851.00
53_S56_P0.5831.00
93_V106_A0.5831.00
6_I213_F0.5811.00
90_A140_D0.5811.00
231_A242_A0.5801.00
193_A197_R0.5791.00
106_A146_F0.5771.00
105_I150_G0.5740.99
72_V202_L0.5720.99
189_G194_N0.5700.99
239_V243_A0.5690.99
153_L161_V0.5670.99
67_E70_G0.5670.99
67_E147_F0.5660.99
156_E160_Q0.5650.99
33_M256_L0.5620.99
89_F93_V0.5610.99
217_G239_V0.5600.99
43_A68_N0.5590.99
158_I183_I0.5560.99
175_S183_I0.5560.99
8_V33_M0.5540.99
86_K143_E0.5540.99
236_G240_V0.5540.99
15_L250_N0.5530.99
165_L175_S0.5520.99
74_S79_V0.5520.99
205_I210_V0.5520.99
232_M250_N0.5500.99
248_G258_V0.5500.99
74_S202_L0.5490.99
213_F259_I0.5470.99
28_A260_D0.5470.99
109_K144_D0.5460.99
234_N249_S0.5450.99
101_E157_L0.5450.99
72_V199_L0.5410.99
39_R62_I0.5400.99
21_Y27_M0.5330.99
253_E257_D0.5330.99
22_N256_L0.5320.99
4_K38_I0.5310.99
119_D122_M0.5310.99
26_F30_Y0.5300.99
53_S57_E0.5270.99
39_R205_I0.5240.99
51_L54_F0.5210.99
230_F244_K0.5170.99
47_Q50_Q0.5150.99
94_E97_L0.5140.99
154_S157_L0.5140.99
127_E131_H0.5140.99
166_H175_S0.5140.99
30_Y259_I0.5120.99
196_L200_Q0.5090.99
5_L39_R0.5090.99
158_I177_H0.5090.99
126_A132_R0.5080.99
126_A130_Y0.5080.99
34_K59_A0.5070.99
179_G216_G0.5070.99
42_V58_I0.5070.99
67_E182_S0.5060.99
151_L161_V0.5050.99
95_H165_L0.5040.99
14_F255_V0.5040.99
7_A200_Q0.5040.99
108_G111_S0.5040.99
199_L202_L0.5020.99
104_I149_F0.5010.99
205_I227_G0.5010.99
152_N182_S0.5000.99
34_K40_F0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pgvA 3 0.9446 100 0.218 Contact Map
3l7yA 1 0.9668 100 0.219 Contact Map
1rlmA 1 0.9926 100 0.23 Contact Map
1nrwA 1 0.9483 100 0.232 Contact Map
2b30A 2 0.9631 100 0.238 Contact Map
3daoA 1 0.9631 100 0.238 Contact Map
1rkqA 1 0.9705 100 0.246 Contact Map
4qjbA 1 0.9668 100 0.248 Contact Map
1nf2A 4 0.9705 100 0.251 Contact Map
2pq0A 1 0.9446 100 0.261 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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