GREMLIN Database
YLII - Soluble aldose sugar dehydrogenase YliI
UniProt: P75804 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13480
Length: 371 (318)
Sequences: 6260 (4415)
Seq/√Len: 247.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
187_T191_E4.3231.00
99_R119_Y4.0371.00
117_V162_I3.7511.00
91_A97_S3.6611.00
307_K320_V3.5381.00
248_K278_E3.4541.00
210_S213_I3.2591.00
222_N227_A2.9621.00
222_N225_S2.9451.00
42_F349_P2.8441.00
159_Y187_T2.7871.00
155_D161_F2.6441.00
134_T137_R2.5711.00
245_Q248_K2.5631.00
43_L50_L2.4851.00
307_K322_S2.4451.00
53_L57_E2.4161.00
119_Y133_R2.4081.00
309_F353_L2.3781.00
47_H60_H2.3371.00
227_A243_I2.3261.00
348_G352_Y2.3231.00
28_E368_S2.3211.00
348_G354_Y2.3111.00
91_A188_D2.2691.00
118_G132_F2.1821.00
221_M228_L2.1811.00
155_D159_Y2.1171.00
29_V363_E2.0991.00
317_D333_R2.0701.00
176_L211_Y2.0561.00
183_L230_L2.0491.00
29_V32_D2.0421.00
297_N347_T2.0391.00
159_Y185_R1.9741.00
102_L120_G1.9331.00
64_G73_G1.9131.00
104_Y118_G1.9061.00
93_D97_S1.9031.00
51_I61_W1.8241.00
230_L244_P1.8201.00
58_L102_L1.7841.00
99_R121_R1.7731.00
255_A277_T1.7501.00
210_S244_P1.7481.00
25_V301_F1.7461.00
255_A274_V1.7251.00
241_I308_L1.7201.00
40_L356_L1.7191.00
53_L59_R1.6881.00
163_A219_M1.6721.00
296_Y309_F1.6671.00
295_F308_L1.6581.00
51_I364_L1.6271.00
216_P230_L1.6151.00
294_A347_T1.6081.00
156_G221_M1.5961.00
233_H289_A1.5841.00
42_F49_M1.5731.00
299_D305_Q1.5521.00
255_A279_Q1.5291.00
92_P154_F1.5261.00
219_M230_L1.5251.00
312_A315_D1.5181.00
42_F346_R1.5001.00
117_V152_L1.4861.00
333_R336_T1.4731.00
161_F228_L1.4551.00
282_F321_M1.4401.00
185_R207_E1.4381.00
28_E366_K1.4331.00
59_R70_P1.4171.00
254_L277_T1.4161.00
300_K352_Y1.4071.00
352_Y366_K1.4021.00
121_R131_D1.4011.00
153_V221_M1.3911.00
186_L207_E1.3771.00
209_W246_K1.3741.00
89_V152_L1.3631.00
41_A90_L1.3621.00
47_H62_Q1.3571.00
103_S150_G1.3421.00
318_V355_V1.3341.00
310_I321_M1.3261.00
174_Q249_N1.3211.00
294_A345_V1.3201.00
106_E137_R1.3151.00
164_L184_V1.3101.00
120_G132_F1.3101.00
245_Q278_E1.3031.00
162_I186_L1.2991.00
241_I310_I1.2961.00
222_N295_F1.2801.00
356_L364_L1.2791.00
182_K208_I1.2731.00
52_T88_V1.2631.00
318_V345_V1.2631.00
213_I232_E1.2581.00
27_V365_L1.2551.00
26_N368_S1.2531.00
122_L125_D1.2391.00
232_E240_E1.2361.00
116_A137_R1.2361.00
39_A344_D1.2341.00
257_W283_Y1.2251.00
213_I244_P1.2231.00
220_A295_F1.2211.00
296_Y347_T1.2131.00
106_E116_A1.2121.00
320_V332_G1.2111.00
29_V365_L1.2091.00
146_N168_N1.2091.00
154_F188_D1.2051.00
229_W281_V1.1981.00
43_L47_H1.1901.00
263_G266_I1.1801.00
231_N310_I1.1751.00
82_Q85_L1.1681.00
136_F179_L1.1661.00
223_P295_F1.1641.00
274_V277_T1.1611.00
208_I211_Y1.1581.00
293_M310_I1.1551.00
123_S130_T1.1511.00
231_N293_M1.1501.00
89_V154_F1.1371.00
74_V77_V1.1361.00
161_F221_M1.1311.00
31_Q61_W1.1261.00
41_A88_V1.1231.00
183_L219_M1.1221.00
293_M308_L1.1191.00
103_S117_V1.1171.00
187_T205_R1.1141.00
260_N264_F1.1071.00
62_Q65_K1.1051.00
324_N327_K1.1051.00
21_A27_V1.0961.00
31_Q34_L1.0911.00
296_Y302_P1.0901.00
290_V312_A1.0871.00
50_L100_I1.0851.00
311_G342_I1.0801.00
120_G129_V1.0791.00
63_A66_G1.0711.00
258_G283_Y1.0691.00
37_P51_I1.0681.00
355_V367_V1.0661.00
58_L88_V1.0511.00
147_H214_R1.0511.00
36_H54_R1.0401.00
34_L37_P1.0351.00
289_A314_K1.0341.00
59_R66_G1.0321.00
324_N329_T1.0301.00
235_P256_T1.0261.00
163_A216_P1.0141.00
49_M354_Y1.0141.00
99_R133_R1.0081.00
155_D221_M1.0021.00
153_V219_M0.9991.00
40_L346_R0.9981.00
91_A101_W0.9971.00
25_V304_W0.9961.00
179_L184_V0.9871.00
123_S126_L0.9841.00
172_T178_K0.9841.00
34_L59_R0.9801.00
231_N241_I0.9771.00
311_G345_V0.9761.00
352_Y368_S0.9731.00
27_V335_L0.9691.00
69_A73_G0.9681.00
282_F331_D0.9651.00
236_R262_S0.9631.00
322_S329_T0.9571.00
172_T175_D0.9561.00
319_I333_R0.9521.00
121_R133_R0.9431.00
86_L105_S0.9421.00
124_D127_S0.9351.00
37_P53_L0.9321.00
357_T365_L0.9281.00
91_A99_R0.9251.00
116_A134_T0.9191.00
242_N250_Y0.9161.00
159_Y188_D0.9111.00
232_E242_N0.9111.00
183_L244_P0.9101.00
243_I281_V0.9031.00
318_V342_I0.8991.00
152_L162_I0.8971.00
178_K182_K0.8971.00
344_D356_L0.8931.00
288_P314_K0.8921.00
304_W309_F0.8901.00
35_D57_E0.8871.00
101_W188_D0.8851.00
303_Q332_G0.8851.00
136_F186_L0.8771.00
296_Y301_F0.8761.00
241_I284_W0.8710.99
309_F320_V0.8670.99
176_L208_I0.8640.99
163_A183_L0.8630.99
147_H215_N0.8610.99
335_L355_V0.8600.99
50_L122_L0.8530.99
43_L46_N0.8530.99
288_P312_A0.8510.99
207_E246_K0.8440.99
222_N297_N0.8410.99
34_L53_L0.8390.99
154_F160_L0.8390.99
190_G205_R0.8380.99
179_L207_E0.8360.99
172_T180_Q0.8360.99
187_T190_G0.8360.99
42_F354_Y0.8330.99
50_L60_H0.8320.99
35_D53_L0.8320.99
221_M226_N0.8300.99
353_L367_V0.8240.99
42_F348_G0.8220.99
357_T363_E0.8220.99
229_W243_I0.8210.99
151_R163_A0.8210.99
121_R130_T0.8170.99
70_P73_G0.8140.99
323_V328_V0.8100.99
298_S347_T0.8060.99
312_A317_D0.8060.99
179_L205_R0.8050.99
161_F209_W0.8040.99
43_L60_H0.8030.99
184_V208_I0.8030.99
65_K69_A0.8020.99
342_I355_V0.7970.99
54_R79_A0.7960.99
117_V135_V0.7930.99
62_Q66_G0.7920.99
184_V207_E0.7900.99
300_K368_S0.7890.99
21_A335_L0.7860.99
35_D55_G0.7860.99
117_V160_L0.7830.99
91_A154_F0.7830.99
183_L216_P0.7820.99
41_A346_R0.7810.99
34_L51_I0.7810.99
158_G188_D0.7800.99
239_D290_V0.7800.99
66_G70_P0.7800.99
162_I184_V0.7790.99
156_G226_N0.7760.99
128_K131_D0.7730.99
118_G134_T0.7720.99
313_L358_D0.7710.99
235_P238_G0.7670.99
117_V186_L0.7670.99
209_W244_P0.7660.99
30_L364_L0.7650.99
70_P74_V0.7590.99
236_R259_I0.7570.99
302_P305_Q0.7560.99
19_W335_L0.7560.99
41_A89_V0.7550.99
172_T176_L0.7550.99
220_A308_L0.7530.99
257_W279_Q0.7520.98
139_M164_L0.7520.98
40_L51_I0.7500.98
294_A353_L0.7470.98
321_M328_V0.7430.98
36_H358_D0.7420.98
140_P180_Q0.7380.98
218_G231_N0.7350.98
159_Y191_E0.7350.98
22_P25_V0.7330.98
355_V365_L0.7290.98
88_V102_L0.7290.98
147_H166_E0.7270.98
159_Y189_Q0.7270.98
335_L367_V0.7270.98
319_I331_D0.7250.98
273_I279_Q0.7240.98
27_V367_V0.7230.98
98_R121_R0.7110.98
25_V334_I0.7100.98
244_P250_Y0.7090.98
182_K211_Y0.7080.98
50_L90_L0.7070.98
340_Q363_E0.7060.98
52_T102_L0.7000.98
228_L244_P0.6960.98
227_A245_Q0.6960.98
347_T353_L0.6940.97
40_L49_M0.6930.97
101_W135_V0.6920.97
254_L274_V0.6920.97
287_S312_A0.6910.97
335_L338_R0.6900.97
234_G239_D0.6900.97
164_L182_K0.6880.97
100_I120_G0.6850.97
57_E70_P0.6840.97
101_W119_Y0.6830.97
216_P219_M0.6780.97
123_S128_K0.6770.97
308_L323_V0.6760.97
231_N290_V0.6750.97
285_K288_P0.6740.97
63_A73_G0.6730.97
219_M228_L0.6710.97
97_S188_D0.6700.97
71_L122_L0.6700.97
220_A294_A0.6690.97
232_E239_D0.6660.97
297_N305_Q0.6660.97
92_P97_S0.6640.97
341_R358_D0.6640.97
43_L90_L0.6630.97
90_L100_I0.6620.97
106_E134_T0.6600.97
98_R124_D0.6590.97
263_G267_P0.6590.97
83_G148_F0.6570.96
91_A98_R0.6550.96
39_A87_D0.6550.96
185_R209_W0.6540.96
217_Q291_S0.6510.96
152_L160_L0.6450.96
309_F334_I0.6450.96
294_A346_R0.6450.96
222_N226_N0.6410.96
151_R217_Q0.6410.96
301_F352_Y0.6400.96
222_N229_W0.6400.96
184_V206_A0.6370.96
262_S265_K0.6360.96
259_I283_Y0.6340.96
74_V102_L0.6300.96
291_S343_R0.6260.95
229_W295_F0.6260.95
322_S332_G0.6250.95
21_A24_T0.6230.95
165_G215_N0.6220.95
317_D336_T0.6200.95
167_N180_Q0.6180.95
245_Q250_Y0.6180.95
217_Q233_H0.6180.95
304_W320_V0.6160.95
49_M364_L0.6150.95
170_R260_N0.6140.95
104_Y116_A0.6130.95
86_L150_G0.6120.95
214_R251_G0.6120.95
233_H290_V0.6110.95
223_P297_N0.6100.95
295_F306_Q0.6090.95
220_A293_M0.6080.95
205_R208_I0.6050.94
179_L182_K0.6010.94
61_W65_K0.6010.94
234_G240_E0.6010.94
38_W217_Q0.5980.94
292_G344_D0.5980.94
29_V33_K0.5960.94
32_D363_E0.5960.94
292_G345_V0.5950.94
85_L102_L0.5950.94
261_Y264_F0.5940.94
77_V80_H0.5910.94
176_L182_K0.5900.94
60_H127_S0.5880.94
39_A151_R0.5880.94
63_A69_A0.5870.94
151_R219_M0.5870.94
292_G311_G0.5850.93
99_R188_D0.5820.93
183_L213_I0.5820.93
297_N306_Q0.5810.93
166_E181_G0.5800.93
296_Y300_K0.5780.93
303_Q307_K0.5760.93
89_V160_L0.5750.93
322_S330_E0.5740.93
38_W343_R0.5730.93
339_G365_L0.5720.93
122_L126_L0.5720.93
47_H63_A0.5710.93
328_V331_D0.5710.93
160_L186_L0.5700.93
211_Y249_N0.5690.92
259_I279_Q0.5670.92
293_M311_G0.5670.92
152_L163_A0.5670.92
63_A70_P0.5660.92
105_S148_F0.5640.92
291_S313_L0.5630.92
282_F310_I0.5630.92
222_N306_Q0.5610.92
282_F328_V0.5610.92
130_T133_R0.5600.92
39_A88_V0.5600.92
233_H314_K0.5590.92
38_W233_H0.5580.92
312_A319_I0.5540.91
278_E281_V0.5530.91
343_R358_D0.5530.91
102_L118_G0.5520.91
56_G83_G0.5490.91
304_W332_G0.5490.91
348_G366_K0.5460.91
135_V138_Q0.5450.91
31_Q51_I0.5440.91
241_I293_M0.5440.91
173_A182_K0.5430.91
334_I367_V0.5430.91
58_L71_L0.5430.91
82_Q146_N0.5420.91
101_W154_F0.5420.91
150_G163_A0.5410.90
238_G256_T0.5400.90
179_L206_A0.5380.90
168_N171_P0.5370.90
322_S331_D0.5350.90
213_I216_P0.5350.90
37_P356_L0.5350.90
18_L21_A0.5340.90
244_P248_K0.5340.90
166_E180_Q0.5340.90
186_L205_R0.5330.90
164_L179_L0.5330.90
295_F323_V0.5310.90
44_P47_H0.5310.90
146_N166_E0.5300.90
76_D127_S0.5300.90
183_L228_L0.5280.89
296_Y305_Q0.5270.89
61_W66_G0.5270.89
72_S129_V0.5260.89
61_W364_L0.5220.89
223_P227_A0.5220.89
145_G168_N0.5220.89
241_I312_A0.5210.89
60_H69_A0.5210.89
69_A72_S0.5200.89
58_L85_L0.5190.89
106_E141_K0.5180.89
103_S162_I0.5180.89
240_E243_I0.5170.88
296_Y306_Q0.5170.88
38_W52_T0.5160.88
150_G162_I0.5160.88
49_M356_L0.5150.88
103_S152_L0.5130.88
284_W288_P0.5130.88
357_T361_S0.5130.88
281_V327_K0.5120.88
153_V220_A0.5120.88
303_Q306_Q0.5110.88
155_D185_R0.5100.88
78_W145_G0.5090.88
305_Q347_T0.5090.88
30_L49_M0.5080.88
255_A273_I0.5080.88
315_D319_I0.5080.88
30_L354_Y0.5060.87
40_L364_L0.5030.87
284_W287_S0.5030.87
341_R357_T0.5020.87
263_G268_E0.5020.87
301_F309_F0.5020.87
175_D178_K0.5020.87
71_L74_V0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1cruA 2 0.9569 100 0.303 Contact Map
2wg3C 1 0.8491 100 0.303 Contact Map
2g8sA 2 0.9353 100 0.333 Contact Map
3a9gA 1 0.8787 100 0.47 Contact Map
2ismA 2 0.8464 100 0.482 Contact Map
3dasA 1 0.8598 100 0.529 Contact Map
3ww9A 1 0.6712 99.8 0.762 Contact Map
3wwaA 1 0.6739 99.8 0.773 Contact Map
3s94A 1 0.7817 99.8 0.779 Contact Map
4a0pA 1 0.8383 99.8 0.784 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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