GREMLIN Database
YLIF - Putative lipoprotein YliF
UniProt: P75801 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13477
Length: 442 (427)
Sequences: 5674 (5460)
Seq/√Len: 264.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
359_P363_G5.8821.00
330_K436_R5.6601.00
293_N297_L5.1101.00
324_C406_I4.7961.00
324_C389_L4.6861.00
322_Y410_H4.3491.00
309_F374_A4.2361.00
412_N415_P3.5791.00
303_A351_V3.5351.00
313_L417_V3.4161.00
345_E348_M3.3631.00
416_T419_R3.3191.00
304_M308_S3.2501.00
415_P423_L2.8441.00
434_N438_Q2.7011.00
358_I365_V2.6971.00
303_A365_V2.6271.00
309_F366_Y2.6111.00
346_V402_L2.5861.00
328_V350_V2.5271.00
431_S438_Q2.4881.00
304_M364_K2.4541.00
329_D405_S2.4301.00
341_L422_M2.4171.00
422_M426_E2.4151.00
354_L365_V2.4051.00
285_V289_Y2.3601.00
322_Y385_L2.3591.00
328_V347_L2.3011.00
331_F347_L2.2001.00
334_I346_V2.1911.00
381_T384_E2.1761.00
425_D429_Y2.1741.00
312_D315_A2.1531.00
340_H429_Y2.1091.00
325_L428_L2.0741.00
340_H425_D2.0721.00
385_L389_L2.0501.00
281_S285_V2.0421.00
308_S312_D2.0401.00
377_Y388_I2.0261.00
403_S437_A2.0051.00
325_L421_K1.9881.00
349_K352_K1.9661.00
312_D364_K1.9581.00
328_V404_T1.9431.00
349_K353_I1.9381.00
316_L378_T1.9131.00
336_D429_Y1.9011.00
289_Y292_Y1.8701.00
332_K336_D1.8691.00
389_L408_V1.8591.00
368_F374_A1.8501.00
296_F308_S1.8431.00
308_S364_K1.8241.00
370_G429_Y1.8211.00
388_I391_E1.7891.00
324_C375_V1.7821.00
346_V371_D1.7301.00
321_G376_I1.7281.00
430_K434_N1.7221.00
332_K340_H1.7191.00
408_V439_I1.7121.00
332_K429_Y1.6961.00
312_D366_Y1.6881.00
336_D340_H1.6871.00
292_Y296_F1.6711.00
431_S435_G1.6511.00
326_F404_T1.6501.00
345_E349_K1.6381.00
326_F406_I1.6301.00
327_D429_Y1.6081.00
309_F313_L1.6061.00
324_C377_Y1.6011.00
368_F421_K1.5851.00
352_K355_K1.5821.00
409_A420_L1.5631.00
371_D403_S1.5561.00
369_G429_Y1.5541.00
395_F398_G1.5451.00
301_T347_L1.5431.00
412_N423_L1.5351.00
173_S177_M1.5301.00
358_I392_I1.5301.00
149_H152_S1.5041.00
297_L304_M1.5021.00
411_S415_P1.4751.00
430_K433_K1.4711.00
342_L345_E1.4551.00
336_D425_D1.4501.00
308_S366_Y1.4481.00
351_V354_L1.4391.00
278_L281_S1.4381.00
299_D307_K1.4301.00
321_G411_S1.4291.00
385_L408_V1.4291.00
71_E75_L1.4221.00
300_L347_L1.4201.00
172_D175_N1.4201.00
92_Y96_P1.4191.00
286_K289_Y1.4171.00
296_F304_M1.4141.00
313_L376_I1.4081.00
325_L368_F1.4041.00
57_R60_A1.3981.00
53_A56_R1.3981.00
334_I400_I1.3981.00
199_F277_G1.3931.00
369_G372_E1.3791.00
309_F376_I1.3781.00
363_G391_E1.3731.00
330_K333_N1.3711.00
328_V403_S1.3701.00
325_L374_A1.3681.00
369_G425_D1.3651.00
340_H372_E1.3601.00
31_V35_V1.3541.00
386_L390_K1.3461.00
342_L395_F1.3441.00
326_F354_L1.3331.00
409_A424_A1.3241.00
247_C250_L1.3211.00
316_L321_G1.3151.00
411_S420_L1.3091.00
335_N343_G1.3071.00
304_M366_Y1.2981.00
311_E315_A1.2921.00
306_R310_D1.2921.00
322_Y408_V1.2851.00
308_S311_E1.2681.00
333_N371_D1.2611.00
24_C28_T1.2601.00
330_K371_D1.2591.00
366_Y374_A1.2521.00
332_K425_D1.2421.00
274_L281_S1.2261.00
368_F371_D1.2251.00
90_Y95_G1.2201.00
169_L173_S1.2191.00
327_D340_H1.2071.00
281_S284_D1.2011.00
358_I375_V1.1981.00
327_D332_K1.1911.00
354_L392_I1.1911.00
46_A50_A1.1901.00
258_G261_E1.1871.00
389_L406_I1.1861.00
196_N280_F1.1771.00
60_A64_I1.1691.00
380_G385_L1.1641.00
238_L246_S1.1611.00
212_P216_Y1.1521.00
380_G384_E1.1481.00
184_G188_T1.1381.00
353_I393_V1.1361.00
415_P420_L1.1191.00
394_H399_S1.1151.00
407_G424_A1.1091.00
374_A421_K1.1041.00
372_E429_Y1.0971.00
414_C423_L1.0961.00
409_A423_L1.0941.00
330_K428_L1.0931.00
34_R37_S1.0931.00
274_L278_L1.0921.00
331_F346_V1.0911.00
357_Q391_E1.0901.00
155_F158_G1.0891.00
351_V365_V1.0821.00
327_D432_K1.0791.00
372_E425_D1.0781.00
394_H397_V1.0731.00
377_Y385_L1.0721.00
359_P391_E1.0671.00
358_I388_I1.0661.00
340_H370_G1.0631.00
358_I363_G1.0611.00
267_N270_F1.0591.00
294_S307_K1.0561.00
323_L421_K1.0541.00
282_A285_V1.0541.00
235_F238_L1.0511.00
325_L424_A1.0511.00
312_D376_I1.0491.00
296_F311_E1.0471.00
417_V421_K1.0441.00
370_G425_D1.0431.00
42_V46_A1.0421.00
336_D372_E1.0411.00
326_F375_V1.0401.00
350_V402_L1.0331.00
177_M181_F1.0331.00
371_D428_L1.0291.00
325_L371_D1.0231.00
265_I274_L1.0211.00
45_T48_A1.0031.00
131_G134_S1.0001.00
258_G262_K0.9991.00
304_M312_D0.9971.00
299_D310_D0.9961.00
173_S176_L0.9951.00
327_D336_D0.9941.00
53_A57_R0.9921.00
115_C118_I0.9901.00
331_F431_S0.9891.00
155_F162_F0.9861.00
156_L159_L0.9791.00
382_L410_H0.9771.00
329_D428_L0.9751.00
321_G420_L0.9691.00
92_Y95_G0.9661.00
359_P362_K0.9621.00
213_T216_Y0.9611.00
38_L42_V0.9541.00
322_Y380_G0.9541.00
359_P380_G0.9501.00
56_R60_A0.9471.00
433_K436_R0.9451.00
296_F307_K0.9441.00
306_R344_D0.9411.00
45_T49_V0.9411.00
176_L179_S0.9361.00
333_N337_T0.9351.00
254_V261_E0.9341.00
155_F160_E0.9341.00
309_F421_K0.9311.00
303_A354_L0.9311.00
285_V288_L0.9291.00
165_L170_A0.9291.00
54_E57_R0.9291.00
268_N271_E0.9271.00
336_D369_G0.9261.00
166_S169_L0.9261.00
291_M294_S0.9231.00
276_G279_F0.9191.00
409_A415_P0.9171.00
112_K115_C0.9151.00
405_S435_G0.9151.00
240_A244_G0.9121.00
363_G388_I0.9101.00
328_V371_D0.9051.00
427_R431_S0.9041.00
297_L303_A0.9011.00
423_L427_R0.8991.00
310_D418_E0.8941.00
250_L258_G0.8921.00
428_L436_R0.8921.00
329_D435_G0.8911.00
235_F239_V0.8891.00
251_V258_G0.8891.00
114_Y118_I0.8861.00
286_K290_S0.8861.00
190_D193_N0.8831.00
334_I342_L0.8821.00
312_D316_L0.8801.00
327_D425_D0.8801.00
297_L302_K0.8791.00
185_K189_G0.8791.00
345_E396_Q0.8771.00
385_L410_H0.8741.00
256_N261_E0.8731.00
346_V395_F0.8711.00
375_V392_I0.8711.00
346_V393_V0.8701.00
41_S45_T0.8681.00
341_L345_E0.8671.00
291_M296_F0.8641.00
324_C408_V0.8611.00
253_R258_G0.8571.00
88_P95_G0.8531.00
34_R38_L0.8531.00
335_N370_G0.8511.00
350_V354_L0.8481.00
15_I18_M0.8471.00
367_R370_G0.8471.00
115_C122_V0.8420.99
175_N178_F0.8400.99
365_V375_V0.8390.99
199_F207_H0.8390.99
134_S138_K0.8380.99
411_S414_C0.8330.99
323_L374_A0.8260.99
387_S391_E0.8250.99
269_H272_R0.8240.99
275_D282_A0.8230.99
139_T146_P0.8230.99
371_D437_A0.8220.99
329_D403_S0.8220.99
89_S92_Y0.8210.99
236_A240_A0.8190.99
353_I357_Q0.8180.99
284_D287_K0.8170.99
357_Q392_I0.8130.99
184_G191_E0.8110.99
30_M33_E0.8090.99
329_D436_R0.8070.99
429_Y432_K0.8060.99
188_T192_Y0.8060.99
86_V89_S0.8030.99
99_I102_D0.8030.99
183_N186_P0.8030.99
126_H129_N0.8010.99
197_A200_T0.8010.99
74_L78_L0.8010.99
251_V261_E0.8000.99
196_N200_T0.7990.99
178_F181_F0.7990.99
170_A177_M0.7990.99
409_A427_R0.7960.99
334_I395_F0.7880.99
130_T133_I0.7870.99
327_D369_G0.7860.99
39_K43_I0.7840.99
73_Q76_V0.7820.99
170_A173_S0.7780.99
30_M34_R0.7770.99
54_E58_S0.7750.99
78_L81_A0.7750.99
384_E387_S0.7750.99
32_K36_Y0.7740.99
191_E194_A0.7720.99
412_N420_L0.7700.99
382_L386_L0.7700.99
371_D431_S0.7690.99
409_A414_C0.7670.99
390_K439_I0.7670.99
157_L163_S0.7650.99
271_E274_L0.7630.99
386_L439_I0.7610.99
332_K372_E0.7600.99
297_L308_S0.7580.99
195_K200_T0.7560.99
238_L242_I0.7550.99
71_E74_L0.7540.99
336_D370_G0.7540.99
141_V144_L0.7540.99
419_R423_L0.7540.99
256_N259_I0.7540.99
175_N179_S0.7530.99
331_F427_R0.7520.99
49_V52_I0.7500.99
270_F273_V0.7490.99
403_S435_G0.7490.99
264_A267_N0.7480.99
341_L368_F0.7480.99
329_D431_S0.7470.99
214_G218_F0.7460.99
191_E197_A0.7460.99
228_V232_I0.7440.99
155_F169_L0.7420.99
284_D288_L0.7420.99
52_I55_Y0.7390.99
264_A268_N0.7390.99
306_R368_F0.7380.99
435_G438_Q0.7370.99
278_L285_V0.7350.99
329_D429_Y0.7340.99
275_D279_F0.7330.99
160_E163_S0.7300.99
318_E359_P0.7280.99
354_L375_V0.7260.98
97_Y100_S0.7250.98
200_T211_L0.7230.98
265_I270_F0.7230.98
154_I159_L0.7190.98
168_S172_D0.7180.98
352_K356_S0.7180.98
23_A27_Y0.7160.98
313_L421_K0.7150.98
380_G410_H0.7150.98
428_L431_S0.7140.98
35_V39_K0.7130.98
393_V398_G0.7130.98
338_F400_I0.7130.98
184_G187_V0.7130.98
419_R422_M0.7120.98
293_N302_K0.7100.98
342_L400_I0.7100.98
64_I68_N0.7070.98
327_D371_D0.7070.98
230_T234_F0.7060.98
252_R255_I0.7050.98
429_Y436_R0.7040.98
187_V191_E0.7040.98
131_G142_Y0.7020.98
114_Y117_D0.7000.98
20_S24_C0.6990.98
163_S166_S0.6990.98
310_D314_K0.6970.98
109_E112_K0.6930.98
340_H369_G0.6920.98
268_N272_R0.6910.98
338_F346_V0.6900.98
51_N54_E0.6900.98
187_V190_D0.6890.98
302_K348_M0.6890.98
359_P388_I0.6890.98
84_D87_S0.6880.98
257_R260_V0.6860.98
294_S297_L0.6850.98
346_V368_F0.6840.98
316_L364_K0.6830.98
265_I272_R0.6830.98
190_D196_N0.6810.98
88_P92_Y0.6800.98
186_P200_T0.6800.98
18_M22_V0.6800.98
257_R261_E0.6780.98
190_D199_F0.6770.98
156_L161_R0.6740.98
131_G141_V0.6730.98
371_D438_Q0.6730.98
404_T428_L0.6700.97
383_E386_L0.6690.97
70_T77_G0.6680.97
125_R128_K0.6680.97
347_L350_V0.6680.97
322_Y389_L0.6680.97
323_L409_A0.6680.97
342_L398_G0.6670.97
281_S289_Y0.6660.97
116_A119_M0.6640.97
78_L82_Y0.6630.97
59_V62_D0.6620.97
277_G281_S0.6620.97
346_V366_Y0.6610.97
331_F371_D0.6610.97
241_V245_A0.6580.97
197_A217_V0.6580.97
157_L160_E0.6580.97
188_T191_E0.6570.97
97_Y101_S0.6530.97
323_L376_I0.6530.97
56_R59_V0.6530.97
16_F19_I0.6520.97
139_T142_Y0.6520.97
405_S431_S0.6520.97
267_N272_R0.6520.97
371_D425_D0.6480.97
343_G370_G0.6470.97
194_A198_I0.6460.97
377_Y380_G0.6460.97
332_K370_G0.6450.97
255_I260_V0.6450.97
350_V404_T0.6450.97
287_K290_S0.6440.97
265_I268_N0.6420.97
371_D435_G0.6400.97
274_L285_V0.6400.97
338_F371_D0.6400.97
378_T385_L0.6400.97
163_S167_K0.6400.97
318_E362_K0.6390.97
265_I269_H0.6390.97
43_I46_A0.6390.97
335_N344_D0.6380.97
155_F159_L0.6370.97
328_V428_L0.6330.96
254_V258_G0.6330.96
279_F282_A0.6330.96
38_L50_A0.6330.96
35_V38_L0.6300.96
415_P419_R0.6290.96
295_A308_S0.6290.96
177_M180_L0.6280.96
288_L291_M0.6270.96
40_Q44_D0.6260.96
118_I128_K0.6260.96
331_F403_S0.6250.96
382_L385_L0.6230.96
403_S436_R0.6220.96
22_V25_G0.6200.96
371_D429_Y0.6190.96
135_F139_T0.6170.96
306_R372_E0.6170.96
279_F285_V0.6160.96
355_K365_V0.6160.96
210_Y215_L0.6160.96
202_S206_E0.6150.96
310_D313_L0.6150.96
338_F428_L0.6140.96
329_D372_E0.6130.96
186_P190_D0.6130.96
333_N338_F0.6120.96
57_R61_I0.6100.96
346_V428_L0.6090.96
311_E364_K0.6090.96
156_L160_E0.6070.95
156_L162_F0.6070.95
278_L282_A0.6070.95
132_F136_D0.6060.95
371_D436_R0.6060.95
250_L254_V0.6060.95
364_K376_I0.6060.95
44_D48_A0.6050.95
157_L169_L0.6050.95
118_I122_V0.6030.95
28_T32_K0.6020.95
52_I57_R0.6020.95
165_L169_L0.6010.95
386_L408_V0.5980.95
220_Y224_V0.5970.95
221_K224_V0.5960.95
389_L404_T0.5960.95
371_D439_I0.5960.95
253_R260_V0.5950.95
250_L261_E0.5930.95
28_T31_V0.5920.95
369_G405_S0.5910.95
199_F211_L0.5910.95
90_Y94_V0.5910.95
300_L335_N0.5890.95
295_A425_D0.5880.95
251_V254_V0.5860.95
410_H420_L0.5840.94
113_N117_D0.5840.94
70_T73_Q0.5840.94
169_L177_M0.5840.94
288_L294_S0.5830.94
72_E76_V0.5830.94
405_S429_Y0.5830.94
293_N366_Y0.5820.94
228_V231_L0.5820.94
235_F246_S0.5810.94
327_D370_G0.5810.94
190_D197_A0.5810.94
169_L174_E0.5780.94
282_A289_Y0.5780.94
314_K417_V0.5770.94
63_L66_T0.5770.94
113_N118_I0.5760.94
118_I129_N0.5760.94
267_N271_E0.5750.94
252_R258_G0.5750.94
97_Y102_D0.5740.94
254_V257_R0.5730.94
336_D343_G0.5730.94
331_F350_V0.5720.94
341_L418_E0.5700.94
131_G140_F0.5700.94
329_D432_K0.5690.94
38_L45_T0.5680.94
190_D198_I0.5670.94
190_D195_K0.5670.94
417_V420_L0.5660.93
49_V53_A0.5660.93
327_D343_G0.5640.93
209_A212_P0.5620.93
363_G377_Y0.5600.93
205_M211_L0.5580.93
25_G29_Q0.5580.93
310_D366_Y0.5570.93
326_F365_V0.5560.93
73_Q77_G0.5530.93
344_D370_G0.5520.93
321_G410_H0.5520.93
46_A49_V0.5490.92
317_P320_G0.5490.92
334_I337_T0.5490.92
408_V427_R0.5490.92
346_V359_P0.5480.92
323_L420_L0.5480.92
141_V147_V0.5480.92
211_L283_A0.5470.92
266_I272_R0.5460.92
153_L156_L0.5450.92
295_A336_D0.5450.92
172_D179_S0.5440.92
157_L162_F0.5430.92
237_A250_L0.5430.92
79_R83_A0.5410.92
299_D302_K0.5400.92
334_I338_F0.5400.92
161_R166_S0.5390.92
85_S91_L0.5390.92
183_N196_N0.5390.92
229_C232_I0.5380.92
55_Y58_S0.5370.92
20_S23_A0.5360.91
33_E36_Y0.5350.91
171_M175_N0.5350.91
346_V353_I0.5340.91
143_Y147_V0.5310.91
321_G421_K0.5310.91
53_A59_V0.5300.91
328_V334_I0.5290.91
140_F146_P0.5280.91
254_V259_I0.5280.91
170_A174_E0.5270.91
133_I136_D0.5270.91
37_S40_Q0.5270.91
190_D201_V0.5270.91
290_S293_N0.5270.91
319_K379_G0.5260.91
253_R261_E0.5260.91
63_L67_L0.5260.91
334_I401_N0.5250.91
195_K199_F0.5250.91
329_D340_H0.5240.91
369_G432_K0.5240.91
158_G161_R0.5230.90
306_R340_H0.5220.90
23_A26_I0.5210.90
338_F398_G0.5190.90
393_V400_I0.5190.90
329_D437_A0.5190.90
103_E106_Q0.5180.90
329_D389_L0.5180.90
158_G167_K0.5180.90
193_N211_L0.5170.90
53_A60_A0.5170.90
327_D335_N0.5170.90
45_T53_A0.5170.90
406_I439_I0.5160.90
111_E115_C0.5160.90
205_M209_A0.5160.90
141_V146_P0.5150.90
167_K177_M0.5150.90
198_I201_V0.5140.90
236_A244_G0.5140.90
248_L251_V0.5130.90
117_D129_N0.5130.90
421_K424_A0.5130.90
14_L27_Y0.5120.90
237_A246_S0.5120.90
253_R259_I0.5110.89
337_T425_D0.5110.89
235_F244_G0.5100.89
140_F144_L0.5090.89
259_I263_E0.5090.89
240_A245_A0.5070.89
334_I393_V0.5070.89
144_L147_V0.5060.89
189_G192_Y0.5060.89
85_S95_G0.5050.89
79_R82_Y0.5050.89
236_A243_S0.5010.89
300_L429_Y0.5010.89
24_C27_Y0.5000.88
140_F145_Y0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w25A 2 0.8778 100 0.501 Contact Map
3ezuA 2 0.6584 100 0.512 Contact Map
4j40A 2 0 100 0.513 Contact Map
4h54A 2 0.5747 100 0.516 Contact Map
3pjxA 1 0.371 100 0.524 Contact Map
4rnhA 2 0.3213 100 0.537 Contact Map
3ignA 1 0.3394 100 0.538 Contact Map
3qyyA 1 0.3258 100 0.54 Contact Map
3i5cA 2 0.3982 100 0.544 Contact Map
3tvkA 1 0.3394 100 0.544 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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