YLIE - ECOLI - GREMLIN Contacts

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YLIE - Putative cyclic di-GMP phosphodiesterase YliE

UniProt:	P75800	Sequences: MLSLYEKIKIRLIILFLLAALSFIGLFFIINYQLVSERAVKRADSRFELIQKNVGYFFKDIERSALTLKDSLYLLKNTEEIQRAVILKMEMMPFLDSVGLVLDDNKYYLFSRRANDKIVVYHQEQVNGPLVDESGRVIFADFNPSKRPWSVASDDSNNSWNPAYNCFDRPGKKCISFTLHINGKDHDLLAVDKIHVDLNWRYLNEYLDQISANDEVLFLKQGHEIIAKNQLAREKLIIYNSEGNYNIIDSVDTEYIEKTSAVPNNALFEIYFYYPGGNLLNASDKLFYLPFAFIIIVLLVVYLMTTRVFRRQFSEMTELVNTLAFLPDSTDQIEALKIREGDAKEIISIKNSIAEMKDAEIERSNKLLSLISYDQESGFIKNMAIIESNNNQYLAVGIIKLCGLEAVEAVFGVDERNKIVRKLCQRIAEKYAQCCDIVTFNADLYLLLCRENVQTFTRKIAMVNDFDSSFGYRNLRIHKSAICEPLQGENAWSYAEKLKLAISSIRDHMFSEFIFCDDAKLNEIEENIWIARNIRHAMEIGELFLVYQPIVDINTRAILGAEALCRWVSAERGIISPLKFITIAEDIGFINELGYQIIKTAMGEFRHFSQRASLKDDFLLHINVSPWQLNEPHFHERFTTIMKENGLKANSLCVEITETVIERINEHFYLNIEQLRKQGVRISIDDFGTGLSNLKRFYEINPDSIKVDSQFTGDIFGTAGKIVRIIFDLARYNRIPVIAEGVESEDVARELIKLGCVQAQGYLYQKPMPFSAWDKSGKLVKE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13476
Length:	782 (709)
Sequences:	2283 (2039)
Seq/√Len:	76.6

ECOLI - YLIE YEGE DOSP YHJK YFGF GMR CSRD YFEA YLAB YJCC RTN YCGG ADRB
BACSU - YKOW

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
561_A	773_W	6.581	1.00
765_Q	768_M	5.574	1.00
599_K	644_E	5.481	1.00
432_A	435_C	5.357	1.00
709_S	713_G	5.317	1.00
369_S	373_Y	4.729	1.00
553_I	759_A	4.629	1.00
526_E	579_K	4.509	1.00
385_I	446_L	4.342	1.00
742_V	759_A	4.182	1.00
490_N	493_S	4.147	1.00
594_G	628_Q	4.027	1.00
604_E	608_F	3.982	1.00
485_P	488_G	3.800	1.00
676_R	703_D	3.791	1.00
624_V	634_F	3.702	1.00
547_Y	604_E	3.666	1.00
639_T	678_Q	3.602	1.00
641_I	645_N	3.476	1.00
731_R	757_V	3.407	1.00
533_N	569_S	3.287	1.00
600_T	603_G	3.232	1.00
604_E	770_F	3.158	1.00
569_S	573_G	3.092	1.00
544_F	568_V	2.925	1.00
397_G	479_K	2.904	1.00
745_E	749_R	2.855	1.00
552_D	555_T	2.850	1.00
545_L	596_Q	2.814	1.00
565_C	597_I	2.789	1.00
558_I	776_S	2.733	1.00
606_R	610_Q	2.729	1.00
545_L	601_A	2.670	1.00
672_I	682_I	2.605	1.00
570_A	573_G	2.581	1.00
546_V	769_P	2.580	1.00
653_C	704_S	2.578	1.00
460_I	481_A	2.527	1.00
384_A	436_D	2.513	1.00
595_Y	637_R	2.511	1.00
356_M	361_I	2.510	1.00
543_L	565_C	2.483	1.00
698_Y	714_D	2.462	1.00
569_S	572_R	2.442	1.00
413_V	499_K	2.433	1.00
608_F	770_F	2.428	1.00
397_G	460_I	2.421	1.00
745_E	763_L	2.409	1.00
408_E	416_R	2.380	1.00
541_G	600_T	2.361	1.00
400_K	503_S	2.345	1.00
599_K	645_N	2.340	1.00
542_E	569_S	2.339	1.00
748_A	759_A	2.265	1.00
638_F	675_L	2.219	1.00
431_Y	437_I	2.218	1.00
357_K	361_I	2.211	1.00
551_V	764_Y	2.207	1.00
762_Y	767_P	2.201	1.00
442_A	503_S	2.200	1.00
750_E	754_L	2.177	1.00
622_I	652_L	2.141	1.00
769_P	772_A	2.121	1.00
716_F	750_E	2.102	1.00
584_A	593_L	2.096	1.00
545_L	565_C	2.085	1.00
565_C	596_Q	2.082	1.00
356_M	360_E	2.081	1.00
598_I	622_I	2.076	1.00
387_E	436_D	2.073	1.00
596_Q	600_T	2.055	1.00
418_K	421_R	2.024	1.00
389_N	432_A	2.024	1.00
609_S	651_S	2.014	1.00
605_F	647_L	2.012	1.00
550_I	653_C	2.005	1.00
339_R	349_I	1.996	1.00
444_L	499_K	1.992	1.00
361_I	364_S	1.981	1.00
449_C	459_K	1.979	1.00
499_K	503_S	1.977	1.00
419_I	475_L	1.968	1.00
544_F	574_I	1.960	1.00
341_G	344_K	1.953	1.00
345_E	349_I	1.951	1.00
402_C	478_H	1.948	1.00
600_T	604_E	1.947	1.00
683_S	704_S	1.937	1.00
456_F	460_I	1.931	1.00
542_E	567_W	1.921	1.00
545_L	597_I	1.918	1.00
360_E	364_S	1.915	1.00
384_A	387_E	1.885	1.00
602_M	652_L	1.881	1.00
399_I	477_I	1.876	1.00
550_I	704_S	1.874	1.00
395_A	483_C	1.851	1.00
418_K	473_R	1.843	1.00
319_L	323_L	1.843	1.00
344_K	347_I	1.817	1.00
736_P	757_V	1.809	1.00
432_A	459_K	1.799	1.00
488_G	497_K	1.797	1.00
565_C	593_L	1.796	1.00
533_N	572_R	1.790	1.00
642_M	647_L	1.789	1.00
744_S	747_V	1.784	1.00
409_A	503_S	1.776	1.00
704_S	738_I	1.752	1.00
407_V	419_I	1.746	1.00
652_L	680_V	1.720	1.00
364_S	368_L	1.710	1.00
505_I	514_I	1.698	1.00
609_S	648_K	1.698	1.00
681_R	703_D	1.692	1.00
739_A	756_C	1.687	1.00
398_I	502_I	1.685	1.00
413_V	503_S	1.685	1.00
423_L	466_F	1.675	1.00
471_G	474_N	1.666	1.00
624_V	654_V	1.664	1.00
534_I	537_A	1.663	1.00
393_Y	486_L	1.656	1.00
748_A	764_Y	1.655	1.00
405_E	503_S	1.644	1.00
550_I	560_G	1.609	1.00
684_I	702_P	1.604	1.00
404_L	420_V	1.600	1.00
550_I	758_Q	1.597	1.00
568_V	574_I	1.591	1.00
629_L	672_I	1.589	0.99
385_I	448_L	1.587	0.99
608_F	774_D	1.581	0.99
422_K	425_Q	1.579	0.99
409_A	499_K	1.576	0.99
466_F	470_F	1.569	0.99
400_K	506_R	1.564	0.99
715_I	750_E	1.544	0.99
542_E	570_A	1.543	0.99
408_E	442_A	1.537	0.99
400_K	409_A	1.535	0.99
731_R	737_V	1.531	0.99
405_E	499_K	1.530	0.99
354_A	358_D	1.514	0.99
550_I	738_I	1.509	0.99
478_H	503_S	1.507	0.99
534_I	543_L	1.507	0.99
572_R	575_I	1.507	0.99
180_H	190_A	1.490	0.99
452_N	455_T	1.488	0.99
409_A	413_V	1.476	0.99
619_L	681_R	1.473	0.99
727_F	754_L	1.467	0.99
716_F	746_D	1.466	0.99
400_K	499_K	1.451	0.99
578_L	709_S	1.451	0.99
380_I	384_A	1.450	0.99
487_Q	515_F	1.444	0.99
585_E	590_I	1.443	0.99
722_I	729_L	1.439	0.99
403_G	510_F	1.437	0.99
626_P	659_T	1.425	0.99
197_D	200_W	1.419	0.99
569_S	575_I	1.414	0.99
742_V	751_L	1.413	0.99
602_M	641_I	1.410	0.99
716_F	720_G	1.400	0.99
619_L	653_C	1.398	0.99
359_A	362_E	1.391	0.99
530_I	583_I	1.384	0.99
551_V	556_R	1.383	0.99
419_I	470_F	1.383	0.99
441_N	503_S	1.380	0.99
408_E	417_N	1.367	0.98
441_N	444_L	1.355	0.98
358_D	361_I	1.351	0.98
484_E	494_Y	1.347	0.98
485_P	494_Y	1.346	0.98
347_I	350_K	1.345	0.98
416_R	442_A	1.336	0.98
323_L	326_L	1.335	0.98
739_A	751_L	1.331	0.98
341_G	345_E	1.331	0.98
400_K	408_E	1.330	0.98
443_D	506_R	1.327	0.98
748_A	763_L	1.326	0.98
402_C	506_R	1.325	0.98
538_M	543_L	1.322	0.98
344_K	349_I	1.321	0.98
339_R	344_K	1.318	0.98
751_L	756_C	1.300	0.98
720_G	750_E	1.296	0.98
405_E	478_H	1.294	0.98
714_D	718_T	1.293	0.98
724_R	732_Y	1.293	0.98
536_H	542_E	1.293	0.98
581_I	657_T	1.292	0.98
601_A	622_I	1.289	0.98
727_F	756_C	1.280	0.98
642_M	680_V	1.270	0.98
123_Q	128_G	1.270	0.98
484_E	488_G	1.269	0.97
553_I	748_A	1.268	0.97
376_E	408_E	1.266	0.97
367_L	370_L	1.265	0.97
639_T	674_Q	1.264	0.97
460_I	463_V	1.259	0.97
478_H	499_K	1.255	0.97
125_Q	129_P	1.254	0.97
672_I	701_N	1.250	0.97
405_E	444_L	1.250	0.97
598_I	652_L	1.248	0.97
461_A	464_N	1.248	0.97
547_Y	563_A	1.244	0.97
642_M	649_A	1.243	0.97
661_I	696_R	1.241	0.97
322_T	329_S	1.238	0.97
698_Y	718_T	1.236	0.97
376_E	417_N	1.234	0.97
484_E	487_Q	1.234	0.97
373_Y	384_A	1.228	0.97
503_S	506_R	1.220	0.97
478_H	506_R	1.219	0.97
404_L	506_R	1.214	0.97
604_E	774_D	1.210	0.97
315_E	319_L	1.202	0.97
772_A	775_K	1.201	0.96
736_P	758_Q	1.199	0.96
405_E	413_V	1.196	0.96
581_I	585_E	1.192	0.96
398_I	446_L	1.190	0.96
430_K	462_M	1.188	0.96
342_D	347_I	1.186	0.96
400_K	443_D	1.184	0.96
581_I	590_I	1.182	0.96
340_E	344_K	1.175	0.96
442_A	478_H	1.174	0.96
686_D	740_E	1.167	0.96
405_E	442_A	1.166	0.96
470_F	475_L	1.165	0.96
408_E	506_R	1.163	0.96
576_S	582_T	1.162	0.96
759_A	764_Y	1.159	0.96
575_I	582_T	1.155	0.96
442_A	499_K	1.154	0.96
339_R	350_K	1.152	0.96
408_E	443_D	1.151	0.96
598_I	654_V	1.150	0.96
339_R	348_S	1.144	0.95
413_V	442_A	1.141	0.95
401_L	477_I	1.139	0.95
441_N	499_K	1.137	0.95
411_F	528_I	1.135	0.95
338_I	344_K	1.134	0.95
709_S	741_G	1.134	0.95
765_Q	776_S	1.133	0.95
357_K	360_E	1.130	0.95
431_Y	435_C	1.129	0.95
400_K	405_E	1.127	0.95
414_D	492_W	1.125	0.95
657_T	740_E	1.122	0.95
141_D	144_P	1.115	0.95
606_R	609_S	1.113	0.95
404_L	408_E	1.113	0.95
413_V	444_L	1.110	0.95
559_L	758_Q	1.109	0.95
444_L	503_S	1.109	0.95
605_F	620_L	1.107	0.94
724_R	728_D	1.103	0.94
504_S	507_D	1.095	0.94
437_I	470_F	1.093	0.94
65_A	69_K	1.092	0.94
124_E	130_L	1.092	0.94
768_M	776_S	1.091	0.94
344_K	348_S	1.091	0.94
382_N	417_N	1.086	0.94
372_S	383_M	1.082	0.94
725_I	732_Y	1.080	0.94
402_C	510_F	1.078	0.94
546_V	574_I	1.078	0.94
605_F	609_S	1.077	0.94
406_A	531_A	1.075	0.94
444_L	478_H	1.075	0.94
535_R	589_F	1.073	0.93
727_F	731_R	1.073	0.93
416_R	506_R	1.070	0.93
402_C	509_M	1.066	0.93
408_E	444_L	1.065	0.93
333_I	349_I	1.064	0.93
708_D	740_E	1.062	0.93
740_E	762_Y	1.057	0.93
441_N	478_H	1.054	0.93
602_M	645_N	1.053	0.93
401_L	423_L	1.052	0.93
345_E	351_N	1.052	0.93
524_I	528_I	1.048	0.93
647_L	652_L	1.047	0.93
202_Y	205_E	1.047	0.93
567_W	573_G	1.045	0.93
637_R	641_I	1.043	0.93
653_C	683_S	1.042	0.92
707_V	726_I	1.042	0.92
365_N	368_L	1.041	0.92
595_Y	599_K	1.041	0.92
344_K	350_K	1.039	0.92
401_L	499_K	1.037	0.92
527_N	586_D	1.031	0.92
629_L	634_F	1.030	0.92
543_L	596_Q	1.027	0.92
581_I	625_S	1.026	0.92
508_H	514_I	1.025	0.92
602_M	647_L	1.023	0.92
326_L	329_S	1.020	0.92
382_N	413_V	1.020	0.92
409_A	444_L	1.018	0.92
544_F	769_P	1.012	0.91
382_N	499_K	1.010	0.91
634_F	638_F	1.009	0.91
584_A	590_I	1.008	0.91
196_V	199_N	1.007	0.91
330_T	356_M	1.007	0.91
584_A	588_G	1.007	0.91
408_E	499_K	1.006	0.91
360_E	363_R	1.002	0.91
442_A	502_I	1.002	0.91
402_C	503_S	1.000	0.91
727_F	757_V	1.000	0.91
533_N	571_E	0.999	0.91
689_T	710_Q	0.997	0.91
561_A	620_L	0.995	0.91
319_L	322_T	0.994	0.91
338_I	349_I	0.993	0.91
443_D	499_K	0.989	0.90
590_I	657_T	0.985	0.90
665_N	668_F	0.984	0.90
32_Y	36_S	0.984	0.90
427_I	437_I	0.983	0.90
554_N	752_I	0.983	0.90
449_C	456_F	0.981	0.90
622_I	680_V	0.978	0.90
664_I	667_H	0.977	0.90
62_E	65_A	0.976	0.90
747_V	763_L	0.974	0.90
446_L	495_A	0.973	0.90
400_K	416_R	0.973	0.90
426_R	470_F	0.972	0.90
354_A	357_K	0.972	0.90
400_K	413_V	0.972	0.90
405_E	506_R	0.972	0.90
417_N	442_A	0.969	0.89
487_Q	497_K	0.968	0.89
413_V	417_N	0.968	0.89
485_P	497_K	0.966	0.89
550_I	619_L	0.966	0.89
345_E	350_K	0.964	0.89
416_R	443_D	0.962	0.89
416_R	499_K	0.961	0.89
693_N	711_F	0.959	0.89
405_E	408_E	0.959	0.89
316_M	319_L	0.955	0.89
575_I	581_I	0.948	0.88
505_I	509_M	0.945	0.88
121_Y	125_Q	0.944	0.88
403_G	531_A	0.943	0.88
551_V	748_A	0.943	0.88
409_A	417_N	0.943	0.88
601_A	620_L	0.941	0.88
463_V	479_K	0.938	0.88
499_K	506_R	0.936	0.88
533_N	570_A	0.935	0.88
402_C	499_K	0.925	0.87
737_V	757_V	0.924	0.87
424_C	437_I	0.924	0.87
315_E	323_L	0.923	0.87
483_C	515_F	0.921	0.87
176_S	197_D	0.919	0.87
413_V	478_H	0.916	0.87
197_D	201_R	0.914	0.87
330_T	349_I	0.914	0.87
404_L	416_R	0.911	0.86
418_K	422_K	0.910	0.86
606_R	645_N	0.910	0.86
384_A	435_C	0.909	0.86
426_R	469_S	0.908	0.86
606_R	646_G	0.908	0.86
401_L	503_S	0.907	0.86
564_L	577_P	0.906	0.86
460_I	479_K	0.905	0.86
598_I	641_I	0.905	0.86
435_C	459_K	0.903	0.86
536_H	540_I	0.901	0.86
198_L	201_R	0.900	0.86
369_S	378_G	0.897	0.85
715_I	723_V	0.896	0.85
589_F	592_E	0.891	0.85
401_L	405_E	0.890	0.85
634_F	700_I	0.888	0.85
550_I	621_H	0.887	0.85
568_V	573_G	0.886	0.85
702_P	735_I	0.885	0.85
497_K	521_L	0.884	0.85
749_R	753_K	0.884	0.85
405_E	502_I	0.882	0.85
585_E	625_S	0.881	0.84
353_I	356_M	0.880	0.84
642_M	652_L	0.880	0.84
322_T	325_F	0.878	0.84
560_G	653_C	0.878	0.84
413_V	506_R	0.876	0.84
416_R	444_L	0.876	0.84
402_C	413_V	0.874	0.84
749_R	752_I	0.874	0.84
405_E	409_A	0.873	0.84
417_N	499_K	0.873	0.84
676_R	682_I	0.870	0.84
457_T	515_F	0.869	0.84
638_F	654_V	0.868	0.84
609_S	612_A	0.867	0.83
598_I	680_V	0.867	0.83
341_G	349_I	0.866	0.83
316_M	328_D	0.863	0.83
502_I	506_R	0.863	0.83
398_I	405_E	0.860	0.83
531_A	535_R	0.860	0.83
312_Q	315_E	0.859	0.83
349_I	356_M	0.859	0.83
437_I	447_L	0.858	0.83
690_G	740_E	0.857	0.83
408_E	478_H	0.853	0.82
422_K	470_F	0.853	0.82
657_T	686_D	0.853	0.82
533_N	567_W	0.847	0.82
341_G	348_S	0.846	0.82
400_K	404_L	0.845	0.82
376_E	442_A	0.845	0.82
199_N	207_L	0.844	0.82
405_E	443_D	0.842	0.82
704_S	736_P	0.840	0.82
567_W	741_G	0.840	0.82
709_S	738_I	0.839	0.81
547_Y	601_A	0.837	0.81
534_I	589_F	0.832	0.81
416_R	503_S	0.831	0.81
581_I	584_A	0.829	0.81
516_C	521_L	0.829	0.81
324_A	327_P	0.827	0.80
563_A	620_L	0.825	0.80
339_R	347_I	0.825	0.80
463_V	511_S	0.824	0.80
400_K	444_L	0.824	0.80
389_N	436_D	0.823	0.80
374_D	439_T	0.822	0.80
608_F	773_W	0.822	0.80
402_C	444_L	0.821	0.80
773_W	777_G	0.820	0.80
340_E	345_E	0.817	0.80
409_A	442_A	0.816	0.80
370_L	550_I	0.816	0.80
672_I	676_R	0.816	0.80
478_H	502_I	0.815	0.80
400_K	442_A	0.814	0.79
413_V	502_I	0.813	0.79
622_I	654_V	0.811	0.79
363_R	370_L	0.811	0.79
465_D	468_S	0.811	0.79
425_Q	428_A	0.810	0.79
724_R	754_L	0.810	0.79
404_L	443_D	0.808	0.79
422_K	426_R	0.808	0.79
570_A	574_I	0.807	0.79
339_R	345_E	0.807	0.79
375_Q	378_G	0.806	0.79
565_C	574_I	0.806	0.79
707_V	723_V	0.806	0.79
201_R	205_E	0.804	0.79
722_I	726_I	0.804	0.79
404_L	444_L	0.804	0.79
499_K	502_I	0.804	0.79
397_G	447_L	0.802	0.78
583_I	587_I	0.802	0.78
312_Q	316_M	0.802	0.78
382_N	416_R	0.802	0.78
345_E	356_M	0.801	0.78
36_S	40_V	0.800	0.78
558_I	618_F	0.800	0.78
340_E	349_I	0.799	0.78
442_A	506_R	0.799	0.78
51_Q	55_G	0.798	0.78
332_Q	349_I	0.798	0.78
567_W	570_A	0.797	0.78
635_H	678_Q	0.795	0.78
526_E	572_R	0.793	0.78
439_T	442_A	0.793	0.78
366_K	370_L	0.793	0.78
400_K	441_N	0.792	0.78
476_R	511_S	0.790	0.77
43_A	47_F	0.788	0.77
417_N	439_T	0.788	0.77
400_K	478_H	0.784	0.77
46_R	50_I	0.783	0.77
398_I	503_S	0.783	0.77
603_G	645_N	0.782	0.77
553_I	742_V	0.782	0.77
182_N	188_L	0.780	0.76
604_E	607_H	0.780	0.76
661_I	684_I	0.779	0.76
621_H	653_C	0.778	0.76
144_P	149_W	0.777	0.76
517_D	520_K	0.776	0.76
457_T	461_A	0.772	0.76
648_K	651_S	0.772	0.76
366_K	369_S	0.771	0.76
599_K	641_I	0.770	0.76
488_G	494_Y	0.770	0.76
315_E	329_S	0.770	0.76
204_N	207_L	0.769	0.75
530_I	533_N	0.769	0.75
398_I	499_K	0.768	0.75
405_E	416_R	0.768	0.75
611_R	774_D	0.767	0.75
771_S	774_D	0.767	0.75
686_D	690_G	0.767	0.75
727_F	737_V	0.766	0.75
396_V	491_A	0.765	0.75
534_I	584_A	0.765	0.75
413_V	441_N	0.765	0.75
566_R	623_N	0.765	0.75
342_D	345_E	0.764	0.75
415_E	472_Y	0.764	0.75
682_I	701_N	0.763	0.75
403_G	406_A	0.763	0.75
617_D	651_S	0.760	0.75
362_E	366_K	0.760	0.75
382_N	444_L	0.756	0.74
593_L	597_I	0.756	0.74
363_R	367_L	0.756	0.74
551_V	776_S	0.755	0.74
655_E	685_D	0.753	0.74
416_R	478_H	0.753	0.74
55_G	59_K	0.753	0.74
194_I	198_L	0.752	0.74
28_F	32_Y	0.750	0.74
376_E	444_L	0.747	0.73
572_R	579_K	0.747	0.73
400_K	417_N	0.746	0.73
368_L	372_S	0.746	0.73
729_L	733_N	0.745	0.73
453_V	486_L	0.744	0.73
621_H	704_S	0.744	0.73
590_I	627_W	0.743	0.73
402_C	502_I	0.741	0.73
478_H	509_M	0.741	0.73
201_R	204_N	0.741	0.73
399_I	447_L	0.739	0.73
642_M	645_N	0.739	0.73
707_V	711_F	0.738	0.72
427_I	592_E	0.737	0.72
125_Q	128_G	0.736	0.72
673_E	677_K	0.735	0.72
343_A	347_I	0.734	0.72
594_G	659_T	0.734	0.72
318_E	322_T	0.733	0.72
694_L	741_G	0.733	0.72
395_A	456_F	0.729	0.71
398_I	498_L	0.729	0.71
441_N	506_R	0.729	0.71
394_L	700_I	0.727	0.71
382_N	408_E	0.726	0.71
748_A	752_I	0.726	0.71
658_E	740_E	0.726	0.71
316_M	326_L	0.726	0.71
715_I	720_G	0.725	0.71
354_A	360_E	0.724	0.71
607_H	611_R	0.722	0.71
768_M	773_W	0.720	0.71
658_E	690_G	0.718	0.70
654_V	682_I	0.718	0.70
405_E	441_N	0.717	0.70
622_I	638_F	0.717	0.70
340_E	348_S	0.716	0.70
180_H	188_L	0.715	0.70
685_D	740_E	0.715	0.70
721_K	732_Y	0.713	0.70
482_I	498_L	0.713	0.70
386_I	492_W	0.712	0.70
423_L	470_F	0.712	0.70
408_E	503_S	0.711	0.70
341_G	350_K	0.710	0.69
220_K	224_E	0.710	0.69
398_I	413_V	0.709	0.69
686_D	708_D	0.709	0.69
376_E	416_R	0.709	0.69
698_Y	711_F	0.709	0.69
534_I	538_M	0.707	0.69
394_L	448_L	0.706	0.69
694_L	711_F	0.706	0.69
315_E	345_E	0.706	0.69
58_F	67_T	0.706	0.69
629_L	700_I	0.705	0.69
20_A	28_F	0.705	0.69
407_V	416_R	0.705	0.69
654_V	680_V	0.704	0.69
544_F	771_S	0.703	0.69
124_E	195_H	0.703	0.69
315_E	349_I	0.702	0.69
371_I	405_E	0.702	0.69
197_D	202_Y	0.701	0.69
409_A	416_R	0.701	0.69
684_I	705_I	0.701	0.69
705_I	726_I	0.700	0.68
146_K	150_S	0.700	0.68
487_Q	494_Y	0.699	0.68
376_E	409_A	0.699	0.68
700_I	713_G	0.698	0.68
408_E	413_V	0.698	0.68
402_C	416_R	0.698	0.68
592_E	595_Y	0.698	0.68
382_N	440_F	0.698	0.68
61_I	64_S	0.697	0.68
504_S	514_I	0.696	0.68
526_E	530_I	0.696	0.68
598_I	638_F	0.695	0.68
707_V	739_A	0.695	0.68
417_N	443_D	0.694	0.68
546_V	568_V	0.694	0.68
417_N	441_N	0.694	0.68
255_Y	268_F	0.693	0.68
349_I	353_I	0.693	0.68
143_N	147_R	0.693	0.68
402_C	408_E	0.693	0.68
413_V	416_R	0.692	0.68
530_I	567_W	0.692	0.68
566_R	577_P	0.691	0.67
376_E	499_K	0.689	0.67
662_E	665_N	0.689	0.67
569_S	738_I	0.689	0.67
705_I	730_A	0.688	0.67
164_Y	176_S	0.688	0.67
629_L	659_T	0.688	0.67
478_H	510_F	0.685	0.67
587_I	590_I	0.685	0.67
408_E	420_V	0.685	0.67
535_R	660_V	0.683	0.67
629_L	668_F	0.683	0.67
382_N	441_N	0.682	0.66
530_I	572_R	0.682	0.66
653_C	758_Q	0.682	0.66
710_Q	722_I	0.682	0.66
123_Q	131_V	0.682	0.66
624_V	628_Q	0.682	0.66
447_L	462_M	0.682	0.66
587_I	592_E	0.681	0.66
178_T	195_H	0.681	0.66
638_F	680_V	0.679	0.66
174_C	180_H	0.678	0.66
463_V	513_F	0.677	0.66
39_A	43_A	0.677	0.66
622_I	647_L	0.676	0.66
565_C	572_R	0.674	0.65
545_L	563_A	0.674	0.65
711_F	740_E	0.674	0.65
541_G	599_K	0.674	0.65
346_I	349_I	0.671	0.65
564_L	740_E	0.671	0.65
424_C	427_I	0.670	0.65
376_E	404_L	0.670	0.65
339_R	346_I	0.669	0.65
404_L	499_K	0.669	0.65
417_N	478_H	0.668	0.65
344_K	351_N	0.668	0.65
139_F	144_P	0.666	0.65
401_L	441_N	0.666	0.65
541_G	596_Q	0.666	0.65
658_E	686_D	0.666	0.65
388_S	489_E	0.666	0.65
409_A	506_R	0.666	0.65
323_L	329_S	0.665	0.64
251_V	255_Y	0.664	0.64
629_L	660_V	0.663	0.64
400_K	439_T	0.662	0.64
118_I	128_G	0.662	0.64
657_T	690_G	0.661	0.64
315_E	347_I	0.660	0.64
443_D	478_H	0.660	0.64
174_C	178_T	0.659	0.64
355_E	361_I	0.656	0.63
639_T	680_V	0.656	0.63
128_G	132_D	0.656	0.63
385_I	438_V	0.656	0.63
123_Q	129_P	0.655	0.63
35_V	39_A	0.655	0.63
548_Q	692_S	0.654	0.63
376_E	400_K	0.654	0.63
215_E	220_K	0.654	0.63
635_H	639_T	0.652	0.63
299_L	306_T	0.652	0.63
493_S	497_K	0.652	0.63
500_L	516_C	0.651	0.63
566_R	655_E	0.650	0.63
53_N	61_I	0.650	0.63
568_V	572_R	0.650	0.63
564_L	658_E	0.650	0.63
627_W	660_V	0.649	0.63
342_D	349_I	0.649	0.63
316_M	324_A	0.648	0.62
139_F	142_F	0.648	0.62
132_D	137_V	0.648	0.62
382_N	404_L	0.647	0.62
623_N	685_D	0.647	0.62
564_L	655_E	0.647	0.62
389_N	434_C	0.646	0.62
417_N	506_R	0.646	0.62
514_I	517_D	0.646	0.62
693_N	698_Y	0.645	0.62
338_I	350_K	0.644	0.62
705_I	735_I	0.644	0.62
345_E	348_S	0.644	0.62
334_E	349_I	0.644	0.62
453_V	495_A	0.644	0.62
125_Q	131_V	0.643	0.62
748_A	765_Q	0.642	0.62
333_I	355_E	0.642	0.62
409_A	478_H	0.641	0.62
431_Y	447_L	0.641	0.62
656_I	672_I	0.640	0.61
188_L	191_V	0.638	0.61
274_Y	279_L	0.637	0.61
715_I	730_A	0.636	0.61
402_C	443_D	0.635	0.61
424_C	428_A	0.635	0.61
417_N	444_L	0.635	0.61
463_V	476_R	0.634	0.61
684_I	729_L	0.634	0.61
630_N	663_R	0.633	0.61
372_S	510_F	0.633	0.61
123_Q	127_N	0.633	0.61
595_Y	631_E	0.632	0.61
356_M	364_S	0.631	0.60
598_I	602_M	0.631	0.60
446_L	572_R	0.631	0.60
704_S	737_V	0.630	0.60
482_I	497_K	0.630	0.60
333_I	354_A	0.630	0.60
299_L	303_L	0.629	0.60
409_A	441_N	0.629	0.60
198_L	203_L	0.628	0.60
635_H	671_N	0.627	0.60
402_C	405_E	0.627	0.60
414_D	496_E	0.627	0.60
612_A	616_D	0.626	0.60
623_N	655_E	0.626	0.60
312_Q	323_L	0.626	0.60
119_V	124_E	0.626	0.60
427_I	431_Y	0.625	0.60
64_S	67_T	0.625	0.60
316_M	323_L	0.624	0.60
690_G	762_Y	0.624	0.60
160_W	163_A	0.624	0.60
567_W	756_C	0.624	0.60
413_V	443_D	0.623	0.59
376_E	439_T	0.623	0.59
673_E	701_N	0.622	0.59
704_S	758_Q	0.620	0.59
408_E	439_T	0.619	0.59
531_A	560_G	0.619	0.59
686_D	689_T	0.618	0.59
680_V	705_I	0.618	0.59
741_G	747_V	0.618	0.59
581_I	690_G	0.618	0.59
49_L	53_N	0.618	0.59
655_E	706_K	0.617	0.59
204_N	208_D	0.617	0.59
467_D	511_S	0.616	0.59
592_E	628_Q	0.616	0.59
319_L	329_S	0.615	0.58
408_E	441_N	0.614	0.58
352_S	356_M	0.614	0.58
158_N	163_A	0.613	0.58
698_Y	722_I	0.613	0.58
208_D	211_S	0.613	0.58
690_G	708_D	0.612	0.58
359_A	527_N	0.611	0.58
453_V	457_T	0.611	0.58
40_V	44_D	0.610	0.58
671_N	674_Q	0.610	0.58
278_N	282_A	0.610	0.58
500_L	524_I	0.609	0.58
425_Q	429_E	0.607	0.57
380_I	436_D	0.607	0.57
200_W	204_N	0.606	0.57
709_S	762_Y	0.605	0.57
500_L	520_K	0.605	0.57
137_V	144_P	0.605	0.57
441_N	502_I	0.605	0.57
552_D	557_A	0.604	0.57
404_L	503_S	0.604	0.57
713_G	747_V	0.602	0.57
687_F	726_I	0.602	0.57
444_L	506_R	0.601	0.57
585_E	657_T	0.601	0.57
440_F	446_L	0.600	0.57
43_A	69_K	0.600	0.57
350_K	356_M	0.600	0.57
505_I	512_E	0.599	0.56
215_E	229_N	0.599	0.56
656_I	665_N	0.597	0.56
353_I	422_K	0.597	0.56
153_S	156_S	0.597	0.56
591_N	631_E	0.596	0.56
320_V	323_L	0.596	0.56
404_L	439_T	0.595	0.56
544_F	572_R	0.595	0.56
382_N	443_D	0.595	0.56
376_E	506_R	0.594	0.56
216_V	229_N	0.593	0.56
443_D	503_S	0.592	0.56
407_V	485_P	0.592	0.56
402_C	409_A	0.592	0.56
498_L	501_A	0.592	0.56
410_V	528_I	0.592	0.56
487_Q	521_L	0.592	0.56
196_V	200_W	0.592	0.56
567_W	694_L	0.591	0.55
537_A	542_E	0.591	0.55
407_V	491_A	0.591	0.55
564_L	762_Y	0.590	0.55
553_I	593_L	0.590	0.55
401_L	413_V	0.589	0.55
346_I	356_M	0.587	0.55
115_N	118_I	0.585	0.55
640_T	644_E	0.584	0.55
672_I	702_P	0.583	0.54
656_I	660_V	0.583	0.54
128_G	131_V	0.583	0.54
198_L	543_L	0.583	0.54
520_K	694_L	0.583	0.54
545_L	600_T	0.583	0.54
759_A	763_L	0.582	0.54
706_K	760_Q	0.582	0.54
402_C	511_S	0.582	0.54
525_E	529_W	0.582	0.54
669_Y	701_N	0.581	0.54
339_R	343_A	0.580	0.54
330_T	334_E	0.579	0.54
566_R	685_D	0.579	0.54
28_F	43_A	0.579	0.54
118_I	122_H	0.578	0.54
688_G	706_K	0.578	0.54
705_I	731_R	0.578	0.54
25_G	29_I	0.578	0.54
21_L	33_Q	0.577	0.54
657_T	762_Y	0.576	0.54
636_E	674_Q	0.576	0.54
24_I	28_F	0.575	0.53
404_L	478_H	0.575	0.53
199_N	204_N	0.575	0.53
691_L	740_E	0.575	0.53
560_G	758_Q	0.574	0.53
323_L	327_P	0.574	0.53
330_T	357_K	0.574	0.53
404_L	409_A	0.573	0.53
565_C	598_I	0.573	0.53
768_M	772_A	0.572	0.53
43_A	61_I	0.572	0.53
318_E	321_N	0.572	0.53
657_T	689_T	0.571	0.53
626_P	656_I	0.571	0.53
560_G	619_L	0.571	0.53
389_N	435_C	0.571	0.53
716_F	723_V	0.571	0.53
198_L	205_E	0.571	0.53
404_L	442_A	0.571	0.53
385_I	672_I	0.569	0.53
432_A	436_D	0.569	0.53
402_C	476_R	0.569	0.53
577_P	740_E	0.568	0.53
396_V	448_L	0.568	0.53
118_I	123_Q	0.568	0.53
309_F	312_Q	0.568	0.53
552_D	559_L	0.567	0.52
551_V	558_I	0.566	0.52
398_I	479_K	0.566	0.52
382_N	400_K	0.564	0.52
657_T	711_F	0.563	0.52
484_E	515_F	0.563	0.52
124_E	131_V	0.562	0.52
567_W	709_S	0.562	0.52
413_V	439_T	0.562	0.52
338_I	348_S	0.562	0.52
372_S	384_A	0.561	0.52
311_R	314_S	0.561	0.52
50_I	61_I	0.561	0.52
550_I	612_A	0.560	0.52
605_F	645_N	0.559	0.51
531_A	583_I	0.559	0.51
397_G	481_A	0.558	0.51
139_F	150_S	0.558	0.51
322_T	327_P	0.558	0.51
655_E	740_E	0.557	0.51
371_I	503_S	0.557	0.51
480_S	498_L	0.556	0.51
202_Y	206_Y	0.556	0.51
476_R	503_S	0.556	0.51
655_E	658_E	0.556	0.51
161_N	268_F	0.556	0.51
217_L	223_H	0.555	0.51
403_G	586_D	0.555	0.51
700_I	776_S	0.555	0.51
322_T	326_L	0.554	0.51
353_I	358_D	0.554	0.51
432_A	440_F	0.553	0.51
409_A	502_I	0.553	0.51
116_D	124_E	0.552	0.51
416_R	420_V	0.552	0.51
32_Y	43_A	0.552	0.51
560_G	634_F	0.551	0.50
463_V	477_I	0.551	0.50
707_V	756_C	0.550	0.50
201_R	214_D	0.550	0.50
686_D	711_F	0.548	0.50
330_T	350_K	0.548	0.50
708_D	762_Y	0.547	0.50
698_Y	721_K	0.547	0.50
770_F	774_D	0.546	0.50
623_N	740_E	0.546	0.50
195_H	199_N	0.546	0.50
658_E	688_G	0.546	0.50
350_K	537_A	0.545	0.50
509_M	516_C	0.544	0.50
306_T	310_R	0.543	0.49
244_N	248_I	0.543	0.49
705_I	723_V	0.543	0.49
436_D	675_L	0.542	0.49
349_I	352_S	0.542	0.49
629_L	671_N	0.542	0.49
199_N	202_Y	0.542	0.49
218_F	256_I	0.542	0.49
24_I	66_L	0.541	0.49
685_D	706_K	0.541	0.49
675_L	682_I	0.540	0.49
202_Y	207_L	0.540	0.49
397_G	449_C	0.539	0.49
481_A	515_F	0.539	0.49
516_C	678_Q	0.539	0.49
401_L	444_L	0.539	0.49
376_E	478_H	0.538	0.49
338_I	341_G	0.538	0.49
402_C	477_I	0.538	0.49
381_K	404_L	0.538	0.49
376_E	405_E	0.537	0.49
456_F	459_K	0.537	0.49
307_R	312_Q	0.537	0.49
564_L	623_N	0.536	0.49
208_D	214_D	0.536	0.49
686_D	693_N	0.536	0.49
612_A	651_S	0.536	0.49
395_A	462_M	0.535	0.48
225_I	230_Q	0.535	0.48
308_V	311_R	0.535	0.48
561_A	605_F	0.535	0.48
705_I	733_N	0.535	0.48
40_V	43_A	0.535	0.48
688_G	740_E	0.534	0.48
469_S	691_L	0.534	0.48
466_F	477_I	0.534	0.48
476_R	524_I	0.534	0.48
331_D	334_E	0.533	0.48
169_R	203_L	0.533	0.48
357_K	364_S	0.533	0.48
588_G	657_T	0.533	0.48
567_W	729_L	0.532	0.48
481_A	513_F	0.532	0.48
700_I	758_Q	0.532	0.48
182_N	190_A	0.532	0.48
410_V	524_I	0.531	0.48
713_G	718_T	0.531	0.48
394_L	483_C	0.531	0.48
590_I	628_Q	0.531	0.48
310_R	314_S	0.530	0.48
169_R	174_C	0.529	0.48
745_E	748_A	0.529	0.48
62_E	66_L	0.528	0.47
387_E	451_E	0.528	0.47
43_A	55_G	0.528	0.47
367_L	704_S	0.527	0.47
27_F	34_L	0.526	0.47
608_F	612_A	0.526	0.47
608_F	680_V	0.525	0.47
459_K	640_T	0.525	0.47
367_L	423_L	0.524	0.47
560_G	741_G	0.524	0.47
405_E	510_F	0.524	0.47
400_K	509_M	0.524	0.47
530_I	661_I	0.524	0.47
655_E	688_G	0.523	0.47
726_I	738_I	0.523	0.47
119_V	125_Q	0.523	0.47
63_R	67_T	0.522	0.47
369_S	372_S	0.522	0.47
721_K	725_I	0.522	0.47
27_F	30_I	0.522	0.47
275_P	285_K	0.521	0.47
402_C	419_I	0.521	0.47
371_I	444_L	0.521	0.47
402_C	442_A	0.521	0.47
595_Y	628_Q	0.519	0.46
714_D	721_K	0.519	0.46
257_E	261_A	0.519	0.46
742_V	748_A	0.519	0.46
297_V	301_V	0.518	0.46
653_C	681_R	0.518	0.46
712_T	756_C	0.518	0.46
275_P	279_L	0.518	0.46
119_V	122_H	0.518	0.46
62_E	67_T	0.517	0.46
631_E	668_F	0.517	0.46
590_I	602_M	0.516	0.46
184_K	187_D	0.515	0.46
403_G	684_I	0.513	0.46
685_D	688_G	0.513	0.46
641_I	644_E	0.513	0.46
21_L	24_I	0.513	0.46
693_N	696_R	0.513	0.46
243_G	259_T	0.513	0.46
439_T	506_R	0.513	0.46
421_R	425_Q	0.513	0.46
695_K	710_Q	0.512	0.45
40_V	48_E	0.512	0.45
200_W	203_L	0.511	0.45
123_Q	130_L	0.511	0.45
565_C	592_E	0.511	0.45
687_F	696_R	0.511	0.45
443_D	480_S	0.511	0.45
635_H	674_Q	0.510	0.45
57_F	60_D	0.510	0.45
346_I	350_K	0.510	0.45
642_M	648_K	0.509	0.45
601_A	638_F	0.509	0.45
661_I	758_Q	0.508	0.45
577_P	762_Y	0.507	0.45
305_T	309_F	0.507	0.45
195_H	200_W	0.506	0.45
625_S	751_L	0.506	0.45
395_A	499_K	0.506	0.45
538_M	575_I	0.505	0.45
385_I	403_G	0.505	0.45
144_P	150_S	0.504	0.44
631_E	634_F	0.504	0.44
422_K	684_I	0.504	0.44
667_H	671_N	0.503	0.44
367_L	584_A	0.503	0.44
603_G	607_H	0.502	0.44
410_V	661_I	0.502	0.44
372_S	380_I	0.502	0.44
548_Q	566_R	0.502	0.44
370_L	484_E	0.502	0.44
398_I	440_F	0.502	0.44
404_L	441_N	0.502	0.44
561_A	618_F	0.501	0.44
689_T	740_E	0.501	0.44
534_I	567_W	0.500	0.44
485_P	515_F	0.500	0.44
384_A	502_I	0.500	0.44
646_G	652_L	0.500	0.44

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4rnhA	2	0.5128	100	0.403	Contact Map
4j40A	2	0.3197	100	0.413	Contact Map
3pjxA	1	0.5141	100	0.432	Contact Map
3gfzA	2	0.4693	100	0.5	Contact Map
4hjfA	1	0.3312	100	0.521	Contact Map
4hu4A	1	0.3107	100	0.593	Contact Map
4kieA	1	0.3312	100	0.594	Contact Map
3sy8A	6	0.4987	100	0.598	Contact Map
4rniA	2	0.3223	100	0.598	Contact Map
2r6oA	2	0.3274	100	0.599	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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