GREMLIN Database
GSID - Glutathione transport system permease protein GsiD
UniProt: P75799 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13475
Length: 303 (251)
Sequences: 28792 (18066)
Seq/√Len: 1140.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
187_T214_I2.8011.00
134_D184_R2.6691.00
77_G81_Q2.5661.00
190_L195_F2.4931.00
204_A208_T2.4511.00
200_R206_D2.4471.00
208_T212_R2.4151.00
110_F168_I2.4051.00
103_I242_F2.3631.00
122_L137_I2.3471.00
114_I172_A2.3451.00
190_L193_Q2.3261.00
205_S208_T2.2661.00
207_M211_L2.2581.00
256_A260_E2.1051.00
194_T197_E2.0731.00
196_I214_I2.0601.00
96_R257_M2.0521.00
227_T290_G2.0171.00
196_I209_V2.0131.00
124_L187_T1.9621.00
80_L83_W1.9061.00
125_L129_Y1.8941.00
129_Y206_D1.8891.00
129_Y133_W1.8811.00
92_D95_S1.8701.00
117_A121_L1.8421.00
69_F73_N1.8161.00
179_F229_R1.7941.00
64_D67_N1.7711.00
195_F217_G1.7551.00
190_L218_T1.7231.00
132_W136_L1.7171.00
54_A101_A1.7131.00
128_Y206_D1.7121.00
87_D91_R1.7101.00
127_G187_T1.6881.00
48_I52_V1.6431.00
118_I121_L1.6351.00
89_L96_R1.6331.00
191_K214_I1.6321.00
118_I176_I1.6271.00
84_F274_F1.6221.00
94_F98_L1.6161.00
125_L133_W1.6051.00
115_G175_S1.5911.00
93_I274_F1.5881.00
133_W137_I1.5751.00
106_A110_F1.5601.00
186_N189_V1.5531.00
141_C180_A1.5491.00
82_H92_D1.5391.00
137_I180_A1.5371.00
99_V102_Q1.5351.00
116_A226_F1.5331.00
168_I172_A1.5281.00
128_Y210_L1.5241.00
56_F59_W1.5211.00
261_A271_V1.5101.00
88_S260_E1.4951.00
78_P83_W1.4901.00
91_R95_S1.4891.00
189_V193_Q1.4511.00
258_L275_P1.4471.00
112_V226_F1.4371.00
119_G179_F1.4351.00
76_N79_S1.4111.00
40_A292_G1.4051.00
123_G127_G1.4001.00
198_S202_I1.3651.00
151_L155_A1.3601.00
139_R142_D1.3271.00
224_V294_R1.3251.00
184_R188_L1.3241.00
123_G183_V1.3111.00
119_G183_V1.3101.00
122_L180_A1.3101.00
103_I106_A1.2921.00
132_W135_R1.2861.00
43_A285_A1.2701.00
127_G191_K1.2661.00
126_A137_I1.2661.00
231_G283_V1.2631.00
124_L210_L1.2621.00
269_P273_V1.2561.00
97_V278_A1.2491.00
84_F94_F1.2471.00
165_A169_I1.2431.00
172_A176_I1.2361.00
199_A213_H1.2321.00
293_L296_A1.2311.00
156_V170_A1.2311.00
182_L225_F1.2271.00
294_R298_D1.2241.00
38_H41_M1.2201.00
190_L196_I1.2191.00
190_L214_I1.2041.00
49_L53_V1.2001.00
223_V297_L1.2001.00
79_S84_F1.1901.00
187_T218_T1.1781.00
91_R96_R1.1761.00
107_A237_A1.1511.00
199_A209_V1.1451.00
52_V56_F1.1401.00
199_A204_A1.1391.00
144_L177_P1.1351.00
91_R99_V1.1331.00
78_P81_Q1.1171.00
130_E191_K1.1151.00
124_L215_L1.1011.00
70_D73_N1.0901.00
275_P279_I1.0891.00
197_E200_R1.0841.00
120_T183_V1.0771.00
86_V92_D1.0621.00
292_G296_A1.0621.00
45_L49_L1.0531.00
50_L280_F1.0521.00
176_I180_A1.0511.00
135_R139_R1.0501.00
183_V222_I1.0491.00
147_F152_L1.0461.00
186_N190_L1.0451.00
170_A174_F1.0421.00
183_V187_T1.0411.00
41_M45_L1.0411.00
261_A272_A1.0391.00
208_T211_L1.0311.00
84_F97_V1.0261.00
121_L124_L1.0191.00
43_A292_G1.0181.00
102_Q106_A1.0171.00
163_G166_N1.0171.00
153_A170_A1.0141.00
202_I213_H1.0121.00
161_G165_A1.0111.00
257_M271_V1.0081.00
140_I144_L1.0081.00
259_N263_A1.0071.00
111_A172_A1.0041.00
42_T45_L0.9891.00
57_A99_V0.9881.00
165_A168_I0.9841.00
93_I271_V0.9831.00
134_D138_M0.9801.00
200_R209_V0.9791.00
138_M180_A0.9711.00
199_A202_I0.9711.00
230_I286_F0.9691.00
183_V218_T0.9681.00
96_R271_V0.9651.00
70_D75_N0.9601.00
106_A164_I0.9601.00
45_L48_I0.9601.00
93_I257_M0.9561.00
50_L282_T0.9551.00
100_G257_M0.9481.00
55_I59_W0.9461.00
111_A115_G0.9461.00
130_E192_Q0.9461.00
133_W136_L0.9441.00
47_V281_L0.9431.00
204_A209_V0.9411.00
95_S99_V0.9361.00
274_F277_L0.9361.00
270_H274_F0.9351.00
61_A95_S0.9341.00
47_V285_A0.9311.00
136_L140_I0.9231.00
134_D188_L0.9181.00
220_S294_R0.9171.00
149_G236_S0.9101.00
123_G187_T0.9021.00
79_S82_H0.9011.00
97_V274_F0.8981.00
206_D209_V0.8981.00
131_G134_D0.8941.00
135_R138_M0.8901.00
106_A109_V0.8891.00
82_H86_V0.8891.00
111_A171_V0.8881.00
73_N76_N0.8861.00
120_T222_I0.8851.00
285_A289_L0.8841.00
46_F285_A0.8711.00
44_A48_I0.8651.00
141_C177_P0.8601.00
160_L166_N0.8601.00
218_T221_S0.8571.00
131_G135_R0.8551.00
211_L214_I0.8471.00
63_Y81_Q0.8451.00
63_Y95_S0.8441.00
98_L102_Q0.8401.00
116_A120_T0.8361.00
79_S83_W0.8351.00
225_F229_R0.8321.00
117_A120_T0.8311.00
171_V236_S0.8291.00
43_A284_L0.8231.00
223_V290_G0.8231.00
43_A288_L0.8221.00
286_F290_G0.8211.00
96_R99_V0.8171.00
44_A289_L0.8151.00
164_I168_I0.8141.00
116_A121_L0.8021.00
95_S98_L0.7961.00
86_V90_G0.7951.00
273_V277_L0.7941.00
185_G188_L0.7941.00
121_L125_L0.7921.00
122_L176_I0.7901.00
260_E263_A0.7861.00
166_N169_I0.7861.00
190_L217_G0.7831.00
257_M275_P0.7831.00
149_G153_A0.7821.00
193_Q197_E0.7821.00
101_A282_T0.7811.00
206_D210_L0.7801.00
162_S166_N0.7741.00
156_V166_N0.7731.00
169_I172_A0.7731.00
111_A233_S0.7701.00
187_T191_K0.7701.00
116_A179_F0.7661.00
127_G188_L0.7581.00
39_M43_A0.7581.00
46_F281_L0.7581.00
110_F242_F0.7571.00
78_P82_H0.7541.00
197_E201_S0.7531.00
77_G80_L0.7521.00
62_P95_S0.7521.00
53_V98_L0.7481.00
204_A213_H0.7471.00
110_F113_F0.7461.00
109_V113_F0.7421.00
63_Y82_H0.7341.00
126_A134_D0.7341.00
40_A44_A0.7331.00
259_N262_R0.7331.00
114_I168_I0.7211.00
295_D301_I0.7121.00
104_S108_G0.7121.00
145_F177_P0.7111.00
186_N221_S0.7091.00
56_F60_I0.7071.00
279_I283_V0.7031.00
274_F278_A0.7011.00
281_L285_A0.6981.00
83_W94_F0.6941.00
183_V186_N0.6941.00
161_G166_N0.6931.00
231_G286_F0.6921.00
209_V214_I0.6891.00
87_D268_A0.6841.00
118_I172_A0.6831.00
53_V57_A0.6791.00
175_S178_A0.6721.00
79_S277_L0.6721.00
273_V276_A0.6721.00
62_P94_F0.6701.00
42_T46_F0.6701.00
294_R301_I0.6681.00
207_M210_L0.6671.00
227_T286_F0.6631.00
115_G172_A0.6631.00
53_V101_A0.6631.00
186_N218_T0.6581.00
119_G123_G0.6551.00
98_L101_A0.6541.00
58_R102_Q0.6531.00
59_W269_P0.6511.00
174_F177_P0.6491.00
289_L293_L0.6491.00
260_E266_V0.6481.00
43_A46_F0.6481.00
57_A60_I0.6451.00
118_I122_L0.6431.00
237_A241_S0.6431.00
149_G152_L0.6411.00
70_D74_L0.6401.00
51_I55_I0.6341.00
40_A288_L0.6331.00
235_I238_A0.6321.00
272_A276_A0.6311.00
167_V237_A0.6261.00
50_L281_L0.6221.00
235_I239_S0.6181.00
136_L139_R0.6181.00
283_V287_N0.6171.00
73_N82_H0.6121.00
138_M141_C0.6101.00
162_S165_A0.6101.00
128_Y191_K0.6021.00
83_W92_D0.6021.00
130_E134_D0.6021.00
238_A256_A0.6001.00
63_Y66_E0.6001.00
112_V229_R0.6001.00
137_I141_C0.5981.00
97_V275_P0.5981.00
173_I176_I0.5981.00
41_M44_A0.5981.00
47_V286_F0.5951.00
188_L191_K0.5951.00
51_I277_L0.5921.00
179_F225_F0.5901.00
155_A159_V0.5881.00
101_A105_L0.5851.00
129_Y210_L0.5851.00
179_F183_V0.5831.00
141_C176_I0.5831.00
257_M260_E0.5831.00
112_V230_I0.5781.00
204_A207_M0.5761.00
178_A229_R0.5751.00
258_L279_I0.5751.00
39_M45_L0.5741.00
126_A138_M0.5741.00
105_L109_V0.5731.00
69_F82_H0.5721.00
130_E188_L0.5721.00
110_F165_A0.5711.00
46_F50_L0.5701.00
236_S239_S0.5701.00
234_I238_A0.5691.00
39_M42_T0.5671.00
113_F117_A0.5661.00
166_N170_A0.5611.00
139_R143_V0.5601.00
144_L176_I0.5581.00
288_L292_G0.5571.00
233_S236_S0.5531.00
76_N82_H0.5511.00
128_Y211_L0.5501.00
66_E69_F0.5501.00
50_L54_A0.5491.00
76_N80_L0.5451.00
152_L174_F0.5431.00
108_G233_S0.5421.00
257_M261_A0.5411.00
102_Q105_L0.5411.00
224_V227_T0.5381.00
77_G82_H0.5371.00
211_L216_P0.5361.00
53_V56_F0.5361.00
47_V289_L0.5361.00
149_G173_I0.5341.00
270_H273_V0.5331.00
38_H42_T0.5321.00
43_A47_V0.5311.00
49_L56_F0.5311.00
63_Y267_I0.5301.00
175_S229_R0.5271.00
196_I200_R0.5261.00
96_R100_G0.5241.00
127_G134_D0.5231.00
116_A222_I0.5221.00
39_M55_I0.5171.00
112_V116_A0.5171.00
142_D145_F0.5171.00
177_P180_A0.5161.00
107_A167_V0.5101.00
119_G180_A0.5101.00
169_I173_I0.5081.00
205_S209_V0.5071.00
238_A259_N0.5061.00
182_L186_N0.5051.00
126_A184_R0.5041.00
291_D294_R0.5011.00
108_G230_I0.5001.00
238_A260_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquM 1 0.835 99.9 0.628 Contact Map
3d31C 2 0.7624 99.9 0.646 Contact Map
3tuiA 2 0.6667 99.9 0.648 Contact Map
2onkC 2 0.7822 99.9 0.661 Contact Map
3rlfF 1 0.9142 99.9 0.662 Contact Map
4tquN 1 0.8548 99.8 0.678 Contact Map
4ymuD 2 0.6898 99.8 0.681 Contact Map
3rlfG 1 0.8416 99.8 0.685 Contact Map
3j9pD 4 0.7492 30.9 0.95 Contact Map
1pw4A 1 0.6139 16 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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