GSID - ECOLI - GREMLIN Contacts

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GSID - Glutathione transport system permease protein GsiD

UniProt:	P75799	Sequences: MRLFNWRRQAVLNAMPLVKPDQVRTPWHEFWRRFRRQHMAMTAALFVILLIVVAIFARWIAPYDAENYFDYDNLNNGPSLQHWFGVDSLGRDIFSRVLVGAQISLAAGVFAVFIGAAIGTLLGLLAGYYEGWWDRLIMRICDVLFAFPGILLAIAVVAVLGSGIANVIIAVAIFSIPAFARLVRGNTLVLKQQTFIESARSIGASDMTVLLRHILPGTVSSIVVFFTMRIGTSIISAASLSFLGLGAQPPTPEWGAMLNEARADMVIAPHVAVFPALAIFLTVLAFNLLGDGLRDALDPKIKG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13475
Length:	303 (251)
Sequences:	28792 (18066)
Seq/√Len:	1140.3

ECOLI - GSID DPPC OPPC DDPC SAPC YEJE NIKC YEJB GSIC DDPB DPPB NIKB SAPB OPPB
BACSU - DPPC APPC OPPC OPPB APPB DPPB
HALSA - Q9HMW2 Q9HMI1 Q9HMX1 Q9HMI2 Q9HMW3 Q9HMX0
SULSO - Q97UH2 Q97UG3 Q97VK7 Q97YP2 Q97YP9 Q97VF6 Q97VK6 Q97VF8 Q97UH1 Q97YP1 Q97YQ0 Q97UG4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
187_T	214_I	2.801	1.00
134_D	184_R	2.669	1.00
77_G	81_Q	2.566	1.00
190_L	195_F	2.493	1.00
204_A	208_T	2.451	1.00
200_R	206_D	2.447	1.00
208_T	212_R	2.415	1.00
110_F	168_I	2.405	1.00
103_I	242_F	2.363	1.00
122_L	137_I	2.347	1.00
114_I	172_A	2.345	1.00
190_L	193_Q	2.326	1.00
205_S	208_T	2.266	1.00
207_M	211_L	2.258	1.00
256_A	260_E	2.105	1.00
194_T	197_E	2.073	1.00
196_I	214_I	2.060	1.00
96_R	257_M	2.052	1.00
227_T	290_G	2.017	1.00
196_I	209_V	2.013	1.00
124_L	187_T	1.962	1.00
80_L	83_W	1.906	1.00
125_L	129_Y	1.894	1.00
129_Y	206_D	1.889	1.00
129_Y	133_W	1.881	1.00
92_D	95_S	1.870	1.00
117_A	121_L	1.842	1.00
69_F	73_N	1.816	1.00
179_F	229_R	1.794	1.00
64_D	67_N	1.771	1.00
195_F	217_G	1.755	1.00
190_L	218_T	1.723	1.00
132_W	136_L	1.717	1.00
54_A	101_A	1.713	1.00
128_Y	206_D	1.712	1.00
87_D	91_R	1.710	1.00
127_G	187_T	1.688	1.00
48_I	52_V	1.643	1.00
118_I	121_L	1.635	1.00
89_L	96_R	1.633	1.00
191_K	214_I	1.632	1.00
118_I	176_I	1.627	1.00
84_F	274_F	1.622	1.00
94_F	98_L	1.616	1.00
125_L	133_W	1.605	1.00
115_G	175_S	1.591	1.00
93_I	274_F	1.588	1.00
133_W	137_I	1.575	1.00
106_A	110_F	1.560	1.00
186_N	189_V	1.553	1.00
141_C	180_A	1.549	1.00
82_H	92_D	1.539	1.00
137_I	180_A	1.537	1.00
99_V	102_Q	1.535	1.00
116_A	226_F	1.533	1.00
168_I	172_A	1.528	1.00
128_Y	210_L	1.524	1.00
56_F	59_W	1.521	1.00
261_A	271_V	1.510	1.00
88_S	260_E	1.495	1.00
78_P	83_W	1.490	1.00
91_R	95_S	1.489	1.00
189_V	193_Q	1.451	1.00
258_L	275_P	1.447	1.00
112_V	226_F	1.437	1.00
119_G	179_F	1.435	1.00
76_N	79_S	1.411	1.00
40_A	292_G	1.405	1.00
123_G	127_G	1.400	1.00
198_S	202_I	1.365	1.00
151_L	155_A	1.360	1.00
139_R	142_D	1.327	1.00
224_V	294_R	1.325	1.00
184_R	188_L	1.324	1.00
123_G	183_V	1.311	1.00
119_G	183_V	1.310	1.00
122_L	180_A	1.310	1.00
103_I	106_A	1.292	1.00
132_W	135_R	1.286	1.00
43_A	285_A	1.270	1.00
127_G	191_K	1.266	1.00
126_A	137_I	1.266	1.00
231_G	283_V	1.263	1.00
124_L	210_L	1.262	1.00
269_P	273_V	1.256	1.00
97_V	278_A	1.249	1.00
84_F	94_F	1.247	1.00
165_A	169_I	1.243	1.00
172_A	176_I	1.236	1.00
199_A	213_H	1.232	1.00
293_L	296_A	1.231	1.00
156_V	170_A	1.231	1.00
182_L	225_F	1.227	1.00
294_R	298_D	1.224	1.00
38_H	41_M	1.220	1.00
190_L	196_I	1.219	1.00
190_L	214_I	1.204	1.00
49_L	53_V	1.200	1.00
223_V	297_L	1.200	1.00
79_S	84_F	1.190	1.00
187_T	218_T	1.178	1.00
91_R	96_R	1.176	1.00
107_A	237_A	1.151	1.00
199_A	209_V	1.145	1.00
52_V	56_F	1.140	1.00
199_A	204_A	1.139	1.00
144_L	177_P	1.135	1.00
91_R	99_V	1.133	1.00
78_P	81_Q	1.117	1.00
130_E	191_K	1.115	1.00
124_L	215_L	1.101	1.00
70_D	73_N	1.090	1.00
275_P	279_I	1.089	1.00
197_E	200_R	1.084	1.00
120_T	183_V	1.077	1.00
86_V	92_D	1.062	1.00
292_G	296_A	1.062	1.00
45_L	49_L	1.053	1.00
50_L	280_F	1.052	1.00
176_I	180_A	1.051	1.00
135_R	139_R	1.050	1.00
183_V	222_I	1.049	1.00
147_F	152_L	1.046	1.00
186_N	190_L	1.045	1.00
170_A	174_F	1.042	1.00
183_V	187_T	1.041	1.00
41_M	45_L	1.041	1.00
261_A	272_A	1.039	1.00
208_T	211_L	1.031	1.00
84_F	97_V	1.026	1.00
121_L	124_L	1.019	1.00
43_A	292_G	1.018	1.00
102_Q	106_A	1.017	1.00
163_G	166_N	1.017	1.00
153_A	170_A	1.014	1.00
202_I	213_H	1.012	1.00
161_G	165_A	1.011	1.00
257_M	271_V	1.008	1.00
140_I	144_L	1.008	1.00
259_N	263_A	1.007	1.00
111_A	172_A	1.004	1.00
42_T	45_L	0.989	1.00
57_A	99_V	0.988	1.00
165_A	168_I	0.984	1.00
93_I	271_V	0.983	1.00
134_D	138_M	0.980	1.00
200_R	209_V	0.979	1.00
138_M	180_A	0.971	1.00
199_A	202_I	0.971	1.00
230_I	286_F	0.969	1.00
183_V	218_T	0.968	1.00
96_R	271_V	0.965	1.00
70_D	75_N	0.960	1.00
106_A	164_I	0.960	1.00
45_L	48_I	0.960	1.00
93_I	257_M	0.956	1.00
50_L	282_T	0.955	1.00
100_G	257_M	0.948	1.00
55_I	59_W	0.946	1.00
111_A	115_G	0.946	1.00
130_E	192_Q	0.946	1.00
133_W	136_L	0.944	1.00
47_V	281_L	0.943	1.00
204_A	209_V	0.941	1.00
95_S	99_V	0.936	1.00
274_F	277_L	0.936	1.00
270_H	274_F	0.935	1.00
61_A	95_S	0.934	1.00
47_V	285_A	0.931	1.00
136_L	140_I	0.923	1.00
134_D	188_L	0.918	1.00
220_S	294_R	0.917	1.00
149_G	236_S	0.910	1.00
123_G	187_T	0.902	1.00
79_S	82_H	0.901	1.00
97_V	274_F	0.898	1.00
206_D	209_V	0.898	1.00
131_G	134_D	0.894	1.00
135_R	138_M	0.890	1.00
106_A	109_V	0.889	1.00
82_H	86_V	0.889	1.00
111_A	171_V	0.888	1.00
73_N	76_N	0.886	1.00
120_T	222_I	0.885	1.00
285_A	289_L	0.884	1.00
46_F	285_A	0.871	1.00
44_A	48_I	0.865	1.00
141_C	177_P	0.860	1.00
160_L	166_N	0.860	1.00
218_T	221_S	0.857	1.00
131_G	135_R	0.855	1.00
211_L	214_I	0.847	1.00
63_Y	81_Q	0.845	1.00
63_Y	95_S	0.844	1.00
98_L	102_Q	0.840	1.00
116_A	120_T	0.836	1.00
79_S	83_W	0.835	1.00
225_F	229_R	0.832	1.00
117_A	120_T	0.831	1.00
171_V	236_S	0.829	1.00
43_A	284_L	0.823	1.00
223_V	290_G	0.823	1.00
43_A	288_L	0.822	1.00
286_F	290_G	0.821	1.00
96_R	99_V	0.817	1.00
44_A	289_L	0.815	1.00
164_I	168_I	0.814	1.00
116_A	121_L	0.802	1.00
95_S	98_L	0.796	1.00
86_V	90_G	0.795	1.00
273_V	277_L	0.794	1.00
185_G	188_L	0.794	1.00
121_L	125_L	0.792	1.00
122_L	176_I	0.790	1.00
260_E	263_A	0.786	1.00
166_N	169_I	0.786	1.00
190_L	217_G	0.783	1.00
257_M	275_P	0.783	1.00
149_G	153_A	0.782	1.00
193_Q	197_E	0.782	1.00
101_A	282_T	0.781	1.00
206_D	210_L	0.780	1.00
162_S	166_N	0.774	1.00
156_V	166_N	0.773	1.00
169_I	172_A	0.773	1.00
111_A	233_S	0.770	1.00
187_T	191_K	0.770	1.00
116_A	179_F	0.766	1.00
127_G	188_L	0.758	1.00
39_M	43_A	0.758	1.00
46_F	281_L	0.758	1.00
110_F	242_F	0.757	1.00
78_P	82_H	0.754	1.00
197_E	201_S	0.753	1.00
77_G	80_L	0.752	1.00
62_P	95_S	0.752	1.00
53_V	98_L	0.748	1.00
204_A	213_H	0.747	1.00
110_F	113_F	0.746	1.00
109_V	113_F	0.742	1.00
63_Y	82_H	0.734	1.00
126_A	134_D	0.734	1.00
40_A	44_A	0.733	1.00
259_N	262_R	0.733	1.00
114_I	168_I	0.721	1.00
295_D	301_I	0.712	1.00
104_S	108_G	0.712	1.00
145_F	177_P	0.711	1.00
186_N	221_S	0.709	1.00
56_F	60_I	0.707	1.00
279_I	283_V	0.703	1.00
274_F	278_A	0.701	1.00
281_L	285_A	0.698	1.00
83_W	94_F	0.694	1.00
183_V	186_N	0.694	1.00
161_G	166_N	0.693	1.00
231_G	286_F	0.692	1.00
209_V	214_I	0.689	1.00
87_D	268_A	0.684	1.00
118_I	172_A	0.683	1.00
53_V	57_A	0.679	1.00
175_S	178_A	0.672	1.00
79_S	277_L	0.672	1.00
273_V	276_A	0.672	1.00
62_P	94_F	0.670	1.00
42_T	46_F	0.670	1.00
294_R	301_I	0.668	1.00
207_M	210_L	0.667	1.00
227_T	286_F	0.663	1.00
115_G	172_A	0.663	1.00
53_V	101_A	0.663	1.00
186_N	218_T	0.658	1.00
119_G	123_G	0.655	1.00
98_L	101_A	0.654	1.00
58_R	102_Q	0.653	1.00
59_W	269_P	0.651	1.00
174_F	177_P	0.649	1.00
289_L	293_L	0.649	1.00
260_E	266_V	0.648	1.00
43_A	46_F	0.648	1.00
57_A	60_I	0.645	1.00
118_I	122_L	0.643	1.00
237_A	241_S	0.643	1.00
149_G	152_L	0.641	1.00
70_D	74_L	0.640	1.00
51_I	55_I	0.634	1.00
40_A	288_L	0.633	1.00
235_I	238_A	0.632	1.00
272_A	276_A	0.631	1.00
167_V	237_A	0.626	1.00
50_L	281_L	0.622	1.00
235_I	239_S	0.618	1.00
136_L	139_R	0.618	1.00
283_V	287_N	0.617	1.00
73_N	82_H	0.612	1.00
138_M	141_C	0.610	1.00
162_S	165_A	0.610	1.00
128_Y	191_K	0.602	1.00
83_W	92_D	0.602	1.00
130_E	134_D	0.602	1.00
238_A	256_A	0.600	1.00
63_Y	66_E	0.600	1.00
112_V	229_R	0.600	1.00
137_I	141_C	0.598	1.00
97_V	275_P	0.598	1.00
173_I	176_I	0.598	1.00
41_M	44_A	0.598	1.00
47_V	286_F	0.595	1.00
188_L	191_K	0.595	1.00
51_I	277_L	0.592	1.00
179_F	225_F	0.590	1.00
155_A	159_V	0.588	1.00
101_A	105_L	0.585	1.00
129_Y	210_L	0.585	1.00
179_F	183_V	0.583	1.00
141_C	176_I	0.583	1.00
257_M	260_E	0.583	1.00
112_V	230_I	0.578	1.00
204_A	207_M	0.576	1.00
178_A	229_R	0.575	1.00
258_L	279_I	0.575	1.00
39_M	45_L	0.574	1.00
126_A	138_M	0.574	1.00
105_L	109_V	0.573	1.00
69_F	82_H	0.572	1.00
130_E	188_L	0.572	1.00
110_F	165_A	0.571	1.00
46_F	50_L	0.570	1.00
236_S	239_S	0.570	1.00
234_I	238_A	0.569	1.00
39_M	42_T	0.567	1.00
113_F	117_A	0.566	1.00
166_N	170_A	0.561	1.00
139_R	143_V	0.560	1.00
144_L	176_I	0.558	1.00
288_L	292_G	0.557	1.00
233_S	236_S	0.553	1.00
76_N	82_H	0.551	1.00
128_Y	211_L	0.550	1.00
66_E	69_F	0.550	1.00
50_L	54_A	0.549	1.00
76_N	80_L	0.545	1.00
152_L	174_F	0.543	1.00
108_G	233_S	0.542	1.00
257_M	261_A	0.541	1.00
102_Q	105_L	0.541	1.00
224_V	227_T	0.538	1.00
77_G	82_H	0.537	1.00
211_L	216_P	0.536	1.00
53_V	56_F	0.536	1.00
47_V	289_L	0.536	1.00
149_G	173_I	0.534	1.00
270_H	273_V	0.533	1.00
38_H	42_T	0.532	1.00
43_A	47_V	0.531	1.00
49_L	56_F	0.531	1.00
63_Y	267_I	0.530	1.00
175_S	229_R	0.527	1.00
196_I	200_R	0.526	1.00
96_R	100_G	0.524	1.00
127_G	134_D	0.523	1.00
116_A	222_I	0.522	1.00
39_M	55_I	0.517	1.00
112_V	116_A	0.517	1.00
142_D	145_F	0.517	1.00
177_P	180_A	0.516	1.00
107_A	167_V	0.510	1.00
119_G	180_A	0.510	1.00
169_I	173_I	0.508	1.00
205_S	209_V	0.507	1.00
238_A	259_N	0.506	1.00
182_L	186_N	0.505	1.00
126_A	184_R	0.504	1.00
291_D	294_R	0.501	1.00
108_G	230_I	0.500	1.00
238_A	260_E	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4tquM	1	0.835	99.9	0.628	Contact Map
3d31C	2	0.7624	99.9	0.646	Contact Map
3tuiA	2	0.6667	99.9	0.648	Contact Map
2onkC	2	0.7822	99.9	0.661	Contact Map
3rlfF	1	0.9142	99.9	0.662	Contact Map
4tquN	1	0.8548	99.8	0.678	Contact Map
4ymuD	2	0.6898	99.8	0.681	Contact Map
3rlfG	1	0.8416	99.8	0.685	Contact Map
3j9pD	4	0.7492	30.9	0.95	Contact Map
1pw4A	1	0.6139	16	0.957	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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