GREMLIN Database
GSIC - Glutathione transport system permease protein GsiC
UniProt: P75798 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13474
Length: 306 (280)
Sequences: 23909 (15622)
Seq/√Len: 933.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_Q63_H3.3361.00
59_Q67_H3.2041.00
28_H64_Q3.1171.00
196_F223_G2.8001.00
66_W70_S2.6541.00
70_S74_Q2.6321.00
45_A49_E2.5571.00
20_S65_F2.4601.00
199_V204_Y2.4131.00
53_Q58_D2.3971.00
209_R215_E2.3951.00
97_P255_W2.3731.00
104_T177_S2.3521.00
217_W221_K2.3361.00
116_A132_S2.3231.00
260_R264_D2.3131.00
129_D193_R2.2671.00
199_V202_E2.2411.00
205_M223_G2.1401.00
216_T220_L2.1141.00
21_V65_F2.1041.00
214_S217_W2.0711.00
213_V217_W2.0701.00
33_D52_R2.0431.00
236_G292_V2.0311.00
108_W181_G1.9931.00
62_Y66_W1.9901.00
90_E261_L1.9501.00
86_P89_D1.8791.00
111_I115_A1.8721.00
48_I52_R1.8621.00
47_V50_L1.8181.00
205_M218_V1.8031.00
83_S90_E1.7951.00
200_L223_G1.7731.00
203_D206_R1.7731.00
118_I196_F1.7451.00
127_W131_L1.7241.00
63_H67_H1.7121.00
44_D47_V1.7091.00
50_L54_Q1.7071.00
121_A196_F1.6921.00
87_V276_A1.6771.00
19_V282_S1.6571.00
88_A92_A1.6391.00
49_E52_R1.6341.00
199_V227_A1.6121.00
85_R89_D1.5901.00
177_S181_G1.5821.00
33_D36_R1.5791.00
188_M238_Q1.5791.00
71_N76_D1.5771.00
119_I128_P1.5701.00
128_P132_S1.5681.00
123_W126_R1.5651.00
49_E53_Q1.5531.00
67_H70_S1.5361.00
204_Y226_N1.5291.00
169_S172_H1.5231.00
112_F185_A1.5151.00
112_F115_A1.5121.00
73_V76_D1.5081.00
124_R215_E1.4821.00
109_A184_V1.4811.00
77_F276_A1.4751.00
207_T211_K1.4571.00
100_W104_T1.4201.00
262_L277_E1.4201.00
233_T296_Y1.4081.00
232_V299_I1.4021.00
199_V223_G1.4001.00
265_S273_V1.3971.00
16_L283_L1.3941.00
117_G121_A1.3861.00
132_S189_A1.3801.00
110_V235_M1.3751.00
199_V205_M1.3741.00
93_S96_M1.3731.00
80_S85_R1.3671.00
119_I123_W1.3571.00
67_H71_N1.3531.00
295_L298_A1.3351.00
146_A150_L1.3341.00
113_G192_T1.3311.00
60_P63_H1.3261.00
23_V95_F1.3221.00
151_L179_T1.3171.00
17_F21_V1.3011.00
136_A189_A1.2971.00
72_A77_F1.2961.00
106_M235_M1.2951.00
97_P100_W1.2951.00
77_F88_A1.2861.00
113_G188_M1.2771.00
17_F65_F1.2741.00
85_R93_S1.2731.00
51_V54_Q1.2701.00
181_G185_A1.2541.00
51_V55_L1.2501.00
193_R197_V1.2481.00
100_W169_S1.2341.00
6_I10_L1.2271.00
59_Q62_Y1.2241.00
240_G285_F1.2231.00
10_L14_P1.2181.00
85_R90_E1.2161.00
25_L28_H1.2111.00
139_G186_A1.2091.00
120_A132_S1.2041.00
127_W130_R1.2021.00
191_F234_M1.2001.00
211_K222_H1.1951.00
116_A189_A1.1931.00
117_G192_T1.1751.00
121_A200_L1.1751.00
123_W128_P1.1661.00
118_I219_V1.1631.00
125_N129_D1.1601.00
81_M264_D1.1511.00
35_A48_I1.1491.00
21_V25_L1.1351.00
63_H66_W1.1341.00
56_G59_Q1.1311.00
296_Y300_N1.1241.00
192_T231_V1.1201.00
174_I178_L1.1191.00
12_L286_I1.1171.00
261_L273_V1.1121.00
142_F147_L1.1041.00
79_L86_P1.1001.00
208_A222_H1.0981.00
271_Y275_Q1.0941.00
208_A213_V1.0941.00
90_E273_V1.0911.00
179_T183_A1.0881.00
208_A218_V1.0851.00
198_D202_E1.0681.00
123_W215_E1.0571.00
20_S68_Y1.0451.00
277_E281_F1.0421.00
229_I296_Y1.0421.00
195_S198_D1.0371.00
196_F227_A1.0361.00
192_T196_F1.0341.00
294_V298_A1.0251.00
135_I139_G1.0211.00
50_L53_Q1.0151.00
89_D93_S1.0131.00
75_G86_P1.0101.00
100_W173_Y1.0081.00
56_G67_H1.0011.00
71_N74_Q0.9851.00
105_S181_G0.9781.00
288_I292_V0.9731.00
134_T137_V0.9691.00
36_R48_I0.9651.00
114_M192_T0.9631.00
115_A118_I0.9581.00
148_G179_T0.9531.00
217_W220_L0.9501.00
69_I72_A0.9481.00
14_P17_F0.9371.00
18_I22_L0.9351.00
133_M189_A0.9341.00
105_S180_L0.9231.00
90_E93_S0.9231.00
170_W174_I0.9211.00
263_V267_E0.9181.00
118_I224_L0.9181.00
5_V294_V0.9151.00
195_S199_V0.9121.00
215_E218_V0.9111.00
39_A43_A0.9111.00
46_Q50_L0.9061.00
13_I17_F0.9061.00
92_A96_M0.9041.00
28_H61_L0.9001.00
239_F288_I0.8991.00
144_A249_V0.8911.00
185_A189_A0.8901.00
262_L265_S0.8881.00
130_R133_M0.8841.00
232_V292_V0.8771.00
4_Y297_A0.8761.00
89_D92_A0.8741.00
121_A197_V0.8741.00
129_D197_V0.8731.00
209_R218_V0.8721.00
227_A230_P0.8691.00
39_A51_V0.8691.00
192_T227_A0.8671.00
100_W103_I0.8661.00
178_L181_G0.8661.00
94_R261_L0.8651.00
173_Y177_S0.8601.00
213_V218_V0.8571.00
130_R134_T0.8561.00
14_P18_I0.8521.00
80_S270_D0.8511.00
131_L135_I0.8501.00
124_R128_P0.8481.00
10_L294_V0.8461.00
206_R209_R0.8451.00
87_V273_V0.8441.00
101_L250_E0.8401.00
53_Q59_Q0.8381.00
151_L175_L0.8381.00
79_L84_R0.8341.00
66_W69_I0.8341.00
265_S274_I0.8321.00
155_F175_L0.8301.00
105_S109_A0.8291.00
12_L290_L0.8271.00
77_F91_I0.8231.00
125_N130_R0.8161.00
174_I177_S0.8151.00
25_L61_L0.8101.00
103_I107_V0.8091.00
9_L290_L0.8081.00
171_Q175_L0.8071.00
91_I276_A0.8051.00
65_F69_I0.8041.00
291_V295_L0.8011.00
150_L154_V0.7971.00
113_G117_G0.7941.00
15_T287_L0.7911.00
128_P131_L0.7911.00
30_L89_D0.7871.00
261_L277_E0.7861.00
114_M231_V0.7861.00
208_A211_K0.7851.00
108_W177_S0.7831.00
110_V115_A0.7821.00
240_G288_I0.7821.00
16_L287_L0.7781.00
104_T255_W0.7771.00
297_A303_I0.7761.00
26_F93_S0.7731.00
287_L291_V0.7721.00
46_Q49_E0.7691.00
136_A186_A0.7691.00
220_L223_G0.7691.00
72_A279_L0.7671.00
96_M100_W0.7671.00
117_G196_F0.7651.00
116_A185_A0.7641.00
264_D268_M0.7641.00
92_A95_F0.7641.00
87_V261_L0.7621.00
19_V284_E0.7581.00
98_T102_T0.7541.00
110_V188_M0.7541.00
261_L265_S0.7491.00
206_R210_A0.7491.00
32_G269_R0.7481.00
115_A119_I0.7471.00
17_F69_I0.7461.00
283_L287_L0.7441.00
215_E219_V0.7421.00
213_V222_H0.7421.00
91_I280_L0.7411.00
70_S73_V0.7381.00
28_H271_Y0.7371.00
218_V223_G0.7341.00
184_V187_V0.7331.00
172_H175_L0.7331.00
281_F285_F0.7321.00
140_I186_A0.7311.00
234_M238_Q0.7291.00
16_L286_I0.7281.00
20_S279_L0.7281.00
144_A148_G0.7211.00
45_A48_I0.7211.00
21_V61_L0.7071.00
296_Y303_I0.7051.00
246_S249_V0.7031.00
43_A48_I0.6991.00
195_S227_A0.6921.00
171_Q174_I0.6901.00
113_G189_A0.6901.00
75_G79_L0.6891.00
275_Q278_I0.6881.00
129_D133_M0.6881.00
106_M239_F0.6861.00
111_I114_M0.6821.00
119_I124_R0.6801.00
35_A52_R0.6791.00
109_A181_G0.6781.00
81_M272_P0.6731.00
91_I277_E0.6661.00
68_Y72_A0.6661.00
124_R219_V0.6661.00
120_A129_D0.6661.00
22_L95_F0.6651.00
275_Q279_L0.6651.00
112_F181_G0.6621.00
276_A280_L0.6601.00
76_D86_P0.6591.00
21_V62_Y0.6571.00
285_F289_N0.6541.00
5_V11_G0.6521.00
105_S246_S0.6481.00
103_I239_F0.6461.00
101_L177_S0.6451.00
124_R201_S0.6451.00
23_V278_I0.6441.00
22_L92_A0.6421.00
272_P276_A0.6401.00
38_I51_V0.6391.00
112_F116_A0.6391.00
43_A47_V0.6381.00
236_G288_I0.6361.00
170_W173_Y0.6341.00
99_L103_I0.6321.00
110_V114_M0.6321.00
192_T195_S0.6321.00
156_S175_L0.6311.00
148_G252_V0.6301.00
32_G74_Q0.6291.00
144_A182_A0.6261.00
9_L12_L0.6261.00
96_M99_L0.6251.00
294_V297_A0.6251.00
297_A304_R0.6241.00
276_A279_L0.6241.00
69_I73_V0.6211.00
266_V269_R0.6211.00
147_L182_A0.6211.00
183_A186_A0.6211.00
216_T219_V0.6201.00
180_L249_V0.6201.00
195_S230_P0.6191.00
131_L134_T0.6151.00
25_L29_M0.6131.00
15_T283_L0.6091.00
7_K10_L0.6091.00
251_K260_R0.6091.00
47_V51_V0.6071.00
72_A75_G0.6051.00
188_M192_T0.6051.00
120_A133_M0.6041.00
132_S136_A0.6001.00
24_F28_H0.5991.00
194_A197_V0.5961.00
186_A189_A0.5951.00
251_K263_V0.5911.00
95_F99_L0.5911.00
35_A51_V0.5901.00
70_S75_G0.5891.00
184_V241_F0.5891.00
187_V234_M0.5881.00
95_F284_E0.5881.00
144_A147_L0.5861.00
35_A39_A0.5851.00
104_T107_V0.5841.00
104_T170_W0.5821.00
202_E206_R0.5801.00
191_F195_S0.5801.00
11_G14_P0.5791.00
104_T174_I0.5781.00
8_R11_G0.5761.00
90_E94_R0.5761.00
15_T286_I0.5751.00
156_S171_Q0.5751.00
247_I251_K0.5741.00
274_I278_I0.5701.00
175_L178_L0.5691.00
76_D88_A0.5681.00
102_T246_S0.5671.00
238_Q241_F0.5661.00
248_V251_K0.5641.00
199_V226_N0.5621.00
61_L64_Q0.5621.00
247_I263_V0.5611.00
175_L179_T0.5581.00
134_T138_S0.5541.00
187_V238_Q0.5531.00
152_I156_S0.5521.00
107_V111_I0.5521.00
32_G75_G0.5471.00
63_H70_S0.5441.00
192_T224_L0.5431.00
262_L281_F0.5421.00
228_M231_V0.5411.00
144_A183_A0.5411.00
139_G182_A0.5391.00
184_V238_Q0.5381.00
124_R197_V0.5371.00
213_V216_T0.5371.00
251_K264_D0.5371.00
13_I291_V0.5361.00
133_M136_A0.5331.00
197_V200_L0.5321.00
179_T249_V0.5281.00
80_S83_S0.5281.00
250_E254_N0.5251.00
228_M232_V0.5251.00
214_S218_V0.5241.00
31_P89_D0.5241.00
181_G184_V0.5231.00
72_A76_D0.5211.00
188_M234_M0.5211.00
205_M209_R0.5171.00
248_V252_V0.5151.00
182_A185_A0.5151.00
15_T19_V0.5141.00
137_V140_I0.5131.00
229_I303_I0.5111.00
196_F200_L0.5091.00
9_L13_I0.5091.00
256_P260_R0.5081.00
290_L294_V0.5071.00
125_N200_L0.5041.00
264_D267_E0.5031.00
260_R263_V0.5021.00
249_V252_V0.5021.00
178_L182_A0.5011.00
187_V241_F0.5011.00
31_P88_A0.5001.00
220_L225_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiA 2 0.683 99.9 0.638 Contact Map
4tquM 1 0.8431 99.9 0.641 Contact Map
3rlfF 1 0.8529 99.9 0.665 Contact Map
4ymuD 2 0.6863 99.8 0.68 Contact Map
2onkC 2 0.8105 99.8 0.682 Contact Map
3d31C 2 0.7941 99.8 0.683 Contact Map
4tquN 1 0.8333 99.8 0.7 Contact Map
3rlfG 1 0.8497 99.8 0.704 Contact Map
2yevC 1 0.0948 4.7 0.965 Contact Map
3tdsE 3 0.317 4 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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