GSIC - ECOLI - GREMLIN Contacts

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GSIC - Glutathione transport system permease protein GsiC

UniProt:	P75798	Sequences: MLNYVIKRLLGLIPTLFIVSVLVFLFVHMLPGDPARLIAGPEADAQVIELVRQQLGLDQPLYHQFWHYISNAVQGDFGLSMVSRRPVADEIASRFMPTLWLTITSMVWAVIFGMAAGIIAAVWRNRWPDRLSMTIAVSGISFPAFALGMLLIQVFSVELGWLPTVGADSWQHYILPSLTLGAAVAAVMARFTRASFVDVLSEDYMRTARAKGVSETWVVLKHGLRNAMIPVVTMMGLQFGFLLGGSIVVEKVFNWPGLGRLLVDSVEMRDYPVIQAEILLFSLEFILINLVVDVLYAAINPAIRYK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13474
Length:	306 (280)
Sequences:	23909 (15622)
Seq/√Len:	933.6

ECOLI - GSIC DDPB DPPB NIKB YEJB OPPB SAPB YEJE DPPC SAPC NIKC DDPC GSID OPPC
BACSU - APPB OPPB DPPB DPPC APPC OPPC
HALSA - Q9HMX0 Q9HMI2 Q9HMW3 Q9HMW2 Q9HMI1 Q9HMX1
SULSO - Q97VF8 Q97YQ0 Q97VK6 Q97UH1 Q97YP1 Q97UG4 Q97VK7 Q97UG3 Q97YP9 Q97UH2 Q97YP2 Q97VF6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
59_Q	63_H	3.336	1.00
59_Q	67_H	3.204	1.00
28_H	64_Q	3.117	1.00
196_F	223_G	2.800	1.00
66_W	70_S	2.654	1.00
70_S	74_Q	2.632	1.00
45_A	49_E	2.557	1.00
20_S	65_F	2.460	1.00
199_V	204_Y	2.413	1.00
53_Q	58_D	2.397	1.00
209_R	215_E	2.395	1.00
97_P	255_W	2.373	1.00
104_T	177_S	2.352	1.00
217_W	221_K	2.336	1.00
116_A	132_S	2.323	1.00
260_R	264_D	2.313	1.00
129_D	193_R	2.267	1.00
199_V	202_E	2.241	1.00
205_M	223_G	2.140	1.00
216_T	220_L	2.114	1.00
21_V	65_F	2.104	1.00
214_S	217_W	2.071	1.00
213_V	217_W	2.070	1.00
33_D	52_R	2.043	1.00
236_G	292_V	2.031	1.00
108_W	181_G	1.993	1.00
62_Y	66_W	1.990	1.00
90_E	261_L	1.950	1.00
86_P	89_D	1.879	1.00
111_I	115_A	1.872	1.00
48_I	52_R	1.862	1.00
47_V	50_L	1.818	1.00
205_M	218_V	1.803	1.00
83_S	90_E	1.795	1.00
200_L	223_G	1.773	1.00
203_D	206_R	1.773	1.00
118_I	196_F	1.745	1.00
127_W	131_L	1.724	1.00
63_H	67_H	1.712	1.00
44_D	47_V	1.709	1.00
50_L	54_Q	1.707	1.00
121_A	196_F	1.692	1.00
87_V	276_A	1.677	1.00
19_V	282_S	1.657	1.00
88_A	92_A	1.639	1.00
49_E	52_R	1.634	1.00
199_V	227_A	1.612	1.00
85_R	89_D	1.590	1.00
177_S	181_G	1.582	1.00
33_D	36_R	1.579	1.00
188_M	238_Q	1.579	1.00
71_N	76_D	1.577	1.00
119_I	128_P	1.570	1.00
128_P	132_S	1.568	1.00
123_W	126_R	1.565	1.00
49_E	53_Q	1.553	1.00
67_H	70_S	1.536	1.00
204_Y	226_N	1.529	1.00
169_S	172_H	1.523	1.00
112_F	185_A	1.515	1.00
112_F	115_A	1.512	1.00
73_V	76_D	1.508	1.00
124_R	215_E	1.482	1.00
109_A	184_V	1.481	1.00
77_F	276_A	1.475	1.00
207_T	211_K	1.457	1.00
100_W	104_T	1.420	1.00
262_L	277_E	1.420	1.00
233_T	296_Y	1.408	1.00
232_V	299_I	1.402	1.00
199_V	223_G	1.400	1.00
265_S	273_V	1.397	1.00
16_L	283_L	1.394	1.00
117_G	121_A	1.386	1.00
132_S	189_A	1.380	1.00
110_V	235_M	1.375	1.00
199_V	205_M	1.374	1.00
93_S	96_M	1.373	1.00
80_S	85_R	1.367	1.00
119_I	123_W	1.357	1.00
67_H	71_N	1.353	1.00
295_L	298_A	1.335	1.00
146_A	150_L	1.334	1.00
113_G	192_T	1.331	1.00
60_P	63_H	1.326	1.00
23_V	95_F	1.322	1.00
151_L	179_T	1.317	1.00
17_F	21_V	1.301	1.00
136_A	189_A	1.297	1.00
72_A	77_F	1.296	1.00
106_M	235_M	1.295	1.00
97_P	100_W	1.295	1.00
77_F	88_A	1.286	1.00
113_G	188_M	1.277	1.00
17_F	65_F	1.274	1.00
85_R	93_S	1.273	1.00
51_V	54_Q	1.270	1.00
181_G	185_A	1.254	1.00
51_V	55_L	1.250	1.00
193_R	197_V	1.248	1.00
100_W	169_S	1.234	1.00
6_I	10_L	1.227	1.00
59_Q	62_Y	1.224	1.00
240_G	285_F	1.223	1.00
10_L	14_P	1.218	1.00
85_R	90_E	1.216	1.00
25_L	28_H	1.211	1.00
139_G	186_A	1.209	1.00
120_A	132_S	1.204	1.00
127_W	130_R	1.202	1.00
191_F	234_M	1.200	1.00
211_K	222_H	1.195	1.00
116_A	189_A	1.193	1.00
117_G	192_T	1.175	1.00
121_A	200_L	1.175	1.00
123_W	128_P	1.166	1.00
118_I	219_V	1.163	1.00
125_N	129_D	1.160	1.00
81_M	264_D	1.151	1.00
35_A	48_I	1.149	1.00
21_V	25_L	1.135	1.00
63_H	66_W	1.134	1.00
56_G	59_Q	1.131	1.00
296_Y	300_N	1.124	1.00
192_T	231_V	1.120	1.00
174_I	178_L	1.119	1.00
12_L	286_I	1.117	1.00
261_L	273_V	1.112	1.00
142_F	147_L	1.104	1.00
79_L	86_P	1.100	1.00
208_A	222_H	1.098	1.00
271_Y	275_Q	1.094	1.00
208_A	213_V	1.094	1.00
90_E	273_V	1.091	1.00
179_T	183_A	1.088	1.00
208_A	218_V	1.085	1.00
198_D	202_E	1.068	1.00
123_W	215_E	1.057	1.00
20_S	68_Y	1.045	1.00
277_E	281_F	1.042	1.00
229_I	296_Y	1.042	1.00
195_S	198_D	1.037	1.00
196_F	227_A	1.036	1.00
192_T	196_F	1.034	1.00
294_V	298_A	1.025	1.00
135_I	139_G	1.021	1.00
50_L	53_Q	1.015	1.00
89_D	93_S	1.013	1.00
75_G	86_P	1.010	1.00
100_W	173_Y	1.008	1.00
56_G	67_H	1.001	1.00
71_N	74_Q	0.985	1.00
105_S	181_G	0.978	1.00
288_I	292_V	0.973	1.00
134_T	137_V	0.969	1.00
36_R	48_I	0.965	1.00
114_M	192_T	0.963	1.00
115_A	118_I	0.958	1.00
148_G	179_T	0.953	1.00
217_W	220_L	0.950	1.00
69_I	72_A	0.948	1.00
14_P	17_F	0.937	1.00
18_I	22_L	0.935	1.00
133_M	189_A	0.934	1.00
105_S	180_L	0.923	1.00
90_E	93_S	0.923	1.00
170_W	174_I	0.921	1.00
263_V	267_E	0.918	1.00
118_I	224_L	0.918	1.00
5_V	294_V	0.915	1.00
195_S	199_V	0.912	1.00
215_E	218_V	0.911	1.00
39_A	43_A	0.911	1.00
46_Q	50_L	0.906	1.00
13_I	17_F	0.906	1.00
92_A	96_M	0.904	1.00
28_H	61_L	0.900	1.00
239_F	288_I	0.899	1.00
144_A	249_V	0.891	1.00
185_A	189_A	0.890	1.00
262_L	265_S	0.888	1.00
130_R	133_M	0.884	1.00
232_V	292_V	0.877	1.00
4_Y	297_A	0.876	1.00
89_D	92_A	0.874	1.00
121_A	197_V	0.874	1.00
129_D	197_V	0.873	1.00
209_R	218_V	0.872	1.00
227_A	230_P	0.869	1.00
39_A	51_V	0.869	1.00
192_T	227_A	0.867	1.00
100_W	103_I	0.866	1.00
178_L	181_G	0.866	1.00
94_R	261_L	0.865	1.00
173_Y	177_S	0.860	1.00
213_V	218_V	0.857	1.00
130_R	134_T	0.856	1.00
14_P	18_I	0.852	1.00
80_S	270_D	0.851	1.00
131_L	135_I	0.850	1.00
124_R	128_P	0.848	1.00
10_L	294_V	0.846	1.00
206_R	209_R	0.845	1.00
87_V	273_V	0.844	1.00
101_L	250_E	0.840	1.00
53_Q	59_Q	0.838	1.00
151_L	175_L	0.838	1.00
79_L	84_R	0.834	1.00
66_W	69_I	0.834	1.00
265_S	274_I	0.832	1.00
155_F	175_L	0.830	1.00
105_S	109_A	0.829	1.00
12_L	290_L	0.827	1.00
77_F	91_I	0.823	1.00
125_N	130_R	0.816	1.00
174_I	177_S	0.815	1.00
25_L	61_L	0.810	1.00
103_I	107_V	0.809	1.00
9_L	290_L	0.808	1.00
171_Q	175_L	0.807	1.00
91_I	276_A	0.805	1.00
65_F	69_I	0.804	1.00
291_V	295_L	0.801	1.00
150_L	154_V	0.797	1.00
113_G	117_G	0.794	1.00
15_T	287_L	0.791	1.00
128_P	131_L	0.791	1.00
30_L	89_D	0.787	1.00
261_L	277_E	0.786	1.00
114_M	231_V	0.786	1.00
208_A	211_K	0.785	1.00
108_W	177_S	0.783	1.00
110_V	115_A	0.782	1.00
240_G	288_I	0.782	1.00
16_L	287_L	0.778	1.00
104_T	255_W	0.777	1.00
297_A	303_I	0.776	1.00
26_F	93_S	0.773	1.00
287_L	291_V	0.772	1.00
46_Q	49_E	0.769	1.00
136_A	186_A	0.769	1.00
220_L	223_G	0.769	1.00
72_A	279_L	0.767	1.00
96_M	100_W	0.767	1.00
117_G	196_F	0.765	1.00
116_A	185_A	0.764	1.00
264_D	268_M	0.764	1.00
92_A	95_F	0.764	1.00
87_V	261_L	0.762	1.00
19_V	284_E	0.758	1.00
98_T	102_T	0.754	1.00
110_V	188_M	0.754	1.00
261_L	265_S	0.749	1.00
206_R	210_A	0.749	1.00
32_G	269_R	0.748	1.00
115_A	119_I	0.747	1.00
17_F	69_I	0.746	1.00
283_L	287_L	0.744	1.00
215_E	219_V	0.742	1.00
213_V	222_H	0.742	1.00
91_I	280_L	0.741	1.00
70_S	73_V	0.738	1.00
28_H	271_Y	0.737	1.00
218_V	223_G	0.734	1.00
184_V	187_V	0.733	1.00
172_H	175_L	0.733	1.00
281_F	285_F	0.732	1.00
140_I	186_A	0.731	1.00
234_M	238_Q	0.729	1.00
16_L	286_I	0.728	1.00
20_S	279_L	0.728	1.00
144_A	148_G	0.721	1.00
45_A	48_I	0.721	1.00
21_V	61_L	0.707	1.00
296_Y	303_I	0.705	1.00
246_S	249_V	0.703	1.00
43_A	48_I	0.699	1.00
195_S	227_A	0.692	1.00
171_Q	174_I	0.690	1.00
113_G	189_A	0.690	1.00
75_G	79_L	0.689	1.00
275_Q	278_I	0.688	1.00
129_D	133_M	0.688	1.00
106_M	239_F	0.686	1.00
111_I	114_M	0.682	1.00
119_I	124_R	0.680	1.00
35_A	52_R	0.679	1.00
109_A	181_G	0.678	1.00
81_M	272_P	0.673	1.00
91_I	277_E	0.666	1.00
68_Y	72_A	0.666	1.00
124_R	219_V	0.666	1.00
120_A	129_D	0.666	1.00
22_L	95_F	0.665	1.00
275_Q	279_L	0.665	1.00
112_F	181_G	0.662	1.00
276_A	280_L	0.660	1.00
76_D	86_P	0.659	1.00
21_V	62_Y	0.657	1.00
285_F	289_N	0.654	1.00
5_V	11_G	0.652	1.00
105_S	246_S	0.648	1.00
103_I	239_F	0.646	1.00
101_L	177_S	0.645	1.00
124_R	201_S	0.645	1.00
23_V	278_I	0.644	1.00
22_L	92_A	0.642	1.00
272_P	276_A	0.640	1.00
38_I	51_V	0.639	1.00
112_F	116_A	0.639	1.00
43_A	47_V	0.638	1.00
236_G	288_I	0.636	1.00
170_W	173_Y	0.634	1.00
99_L	103_I	0.632	1.00
110_V	114_M	0.632	1.00
192_T	195_S	0.632	1.00
156_S	175_L	0.631	1.00
148_G	252_V	0.630	1.00
32_G	74_Q	0.629	1.00
144_A	182_A	0.626	1.00
9_L	12_L	0.626	1.00
96_M	99_L	0.625	1.00
294_V	297_A	0.625	1.00
297_A	304_R	0.624	1.00
276_A	279_L	0.624	1.00
69_I	73_V	0.621	1.00
266_V	269_R	0.621	1.00
147_L	182_A	0.621	1.00
183_A	186_A	0.621	1.00
216_T	219_V	0.620	1.00
180_L	249_V	0.620	1.00
195_S	230_P	0.619	1.00
131_L	134_T	0.615	1.00
25_L	29_M	0.613	1.00
15_T	283_L	0.609	1.00
7_K	10_L	0.609	1.00
251_K	260_R	0.609	1.00
47_V	51_V	0.607	1.00
72_A	75_G	0.605	1.00
188_M	192_T	0.605	1.00
120_A	133_M	0.604	1.00
132_S	136_A	0.600	1.00
24_F	28_H	0.599	1.00
194_A	197_V	0.596	1.00
186_A	189_A	0.595	1.00
251_K	263_V	0.591	1.00
95_F	99_L	0.591	1.00
35_A	51_V	0.590	1.00
70_S	75_G	0.589	1.00
184_V	241_F	0.589	1.00
187_V	234_M	0.588	1.00
95_F	284_E	0.588	1.00
144_A	147_L	0.586	1.00
35_A	39_A	0.585	1.00
104_T	107_V	0.584	1.00
104_T	170_W	0.582	1.00
202_E	206_R	0.580	1.00
191_F	195_S	0.580	1.00
11_G	14_P	0.579	1.00
104_T	174_I	0.578	1.00
8_R	11_G	0.576	1.00
90_E	94_R	0.576	1.00
15_T	286_I	0.575	1.00
156_S	171_Q	0.575	1.00
247_I	251_K	0.574	1.00
274_I	278_I	0.570	1.00
175_L	178_L	0.569	1.00
76_D	88_A	0.568	1.00
102_T	246_S	0.567	1.00
238_Q	241_F	0.566	1.00
248_V	251_K	0.564	1.00
199_V	226_N	0.562	1.00
61_L	64_Q	0.562	1.00
247_I	263_V	0.561	1.00
175_L	179_T	0.558	1.00
134_T	138_S	0.554	1.00
187_V	238_Q	0.553	1.00
152_I	156_S	0.552	1.00
107_V	111_I	0.552	1.00
32_G	75_G	0.547	1.00
63_H	70_S	0.544	1.00
192_T	224_L	0.543	1.00
262_L	281_F	0.542	1.00
228_M	231_V	0.541	1.00
144_A	183_A	0.541	1.00
139_G	182_A	0.539	1.00
184_V	238_Q	0.538	1.00
124_R	197_V	0.537	1.00
213_V	216_T	0.537	1.00
251_K	264_D	0.537	1.00
13_I	291_V	0.536	1.00
133_M	136_A	0.533	1.00
197_V	200_L	0.532	1.00
179_T	249_V	0.528	1.00
80_S	83_S	0.528	1.00
250_E	254_N	0.525	1.00
228_M	232_V	0.525	1.00
214_S	218_V	0.524	1.00
31_P	89_D	0.524	1.00
181_G	184_V	0.523	1.00
72_A	76_D	0.521	1.00
188_M	234_M	0.521	1.00
205_M	209_R	0.517	1.00
248_V	252_V	0.515	1.00
182_A	185_A	0.515	1.00
15_T	19_V	0.514	1.00
137_V	140_I	0.513	1.00
229_I	303_I	0.511	1.00
196_F	200_L	0.509	1.00
9_L	13_I	0.509	1.00
256_P	260_R	0.508	1.00
290_L	294_V	0.507	1.00
125_N	200_L	0.504	1.00
264_D	267_E	0.503	1.00
260_R	263_V	0.502	1.00
249_V	252_V	0.502	1.00
178_L	182_A	0.501	1.00
187_V	241_F	0.501	1.00
31_P	88_A	0.500	1.00
220_L	225_R	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3tuiA	2	0.683	99.9	0.638	Contact Map
4tquM	1	0.8431	99.9	0.641	Contact Map
3rlfF	1	0.8529	99.9	0.665	Contact Map
4ymuD	2	0.6863	99.8	0.68	Contact Map
2onkC	2	0.8105	99.8	0.682	Contact Map
3d31C	2	0.7941	99.8	0.683	Contact Map
4tquN	1	0.8333	99.8	0.7	Contact Map
3rlfG	1	0.8497	99.8	0.704	Contact Map
2yevC	1	0.0948	4.7	0.965	Contact Map
3tdsE	3	0.317	4	0.966	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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